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  1. Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper...

    Authors: Hideo Watanabe, Kenzo Soejima, Hiroyuki Yasuda, Ichiro Kawada, Ichiro Nakachi, Satoshi Yoda, Katsuhiko Naoki and Akitoshi Ishizaka
    Citation: Cancer Cell International 2008 8:15
  2. Human herpesvirus (HHV)-8 associated oncogenesis, a state of immune impairment, a local inflammatory environment, angiogenesis and HIV infection occurring concurrently are important factors for the development...

    Authors: Neil H Wood and Liviu Feller
    Citation: Cancer Cell International 2008 8:14
  3. Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases...

    Authors: Ahmed Yaqinuddin, Sohail A Qureshi, Romena Qazi and Farhat Abbas
    Citation: Cancer Cell International 2008 8:13
  4. Breast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor. In fact ...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan
    Citation: Cancer Cell International 2008 8:12
  5. A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. Novel cancer treatment strategies take advantage of tumor-induced vascularisation by c...

    Authors: Jamie M Heinzman, Stacey L Brower and Jason E Bush
    Citation: Cancer Cell International 2008 8:11
  6. Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed. One...

    Authors: Shengwen Calvin Li and William Gunter Loudon
    Citation: Cancer Cell International 2008 8:9
  7. 4-Hydroxycoumarin (4-HC) is a coumarin that lacks anticoagulant activity. 4-HC affects the cytoskeletal stability and decreases cell adhesion and motility of the melanoma cell line B16-F10. Together with integ...

    Authors: Marco A Velasco-Velázquez, Nohemí Salinas-Jazmín, Nicandro Mendoza-Patiño and Juan J Mandoki
    Citation: Cancer Cell International 2008 8:8
  8. Breast cancer is the most common cause of cancer death in the western world. The expression differences of many proteins are associated with breast cancer progression or suppression. The purpose of the study w...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan
    Citation: Cancer Cell International 2008 8:6
  9. c-kit is expressed in various cell types during development and it has been linked to the promotion of cellular migration, proliferation and/or survival of melanoblasts, hematopoietic progenitors and primordial g...

    Authors: Maricel V Maffini, Ana M Soto, Carlos Sonnenschein, Nikoletta Papadopoulos and Theoharis C Theoharides
    Citation: Cancer Cell International 2008 8:5
  10. Truncated variants of Ku86 protein have previously been detected in 86% to 100% of freshly isolated patient multiple myeloma (MM) cells. Since, the Ku70/Ku86 heterodimer functions as the regulatory subunit of ...

    Authors: Charles A Gullo, Feng Ge, Geraline Cow and Gerrard Teoh
    Citation: Cancer Cell International 2008 8:4
  11. Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged an...

    Authors: Greg Shaw and David M Prowse
    Citation: Cancer Cell International 2008 8:3
  12. Tyrosine kinase inhibitors (TKIs) have gained much attention in recent years as targeted agents for the treatment of a wide range of human cancers. We have investigated the effect of the TKIs gefitinib and van...

    Authors: Mattias K Andersson and Pierre Åman
    Citation: Cancer Cell International 2008 8:1
  13. Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune system, through regulation of...

    Authors: Aaron L Miller, Spogmai Komak, M Scott Webb, Edward H Leiter and E Brad Thompson
    Citation: Cancer Cell International 2007 7:18
  14. The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, an...

    Authors: Sebastian Di Cesare, Jean-Claude Marshall, Bruno F Fernandes, Patrick Logan, Emilia Antecka, Vasco Bravo Filho and Miguel N Burnier Jr
    Citation: Cancer Cell International 2007 7:17
  15. Integrins are transmembrane adhesion receptors that provide the physical link between the actin cytoskeleton and the extracellular matrix. It has been well established that integrins play a major role in vario...

    Authors: Sophia Havaki, Mirsini Kouloukoussa, Kawther Amawi, Yiannis Drosos, Leonidas D Arvanitis, Nikos Goutas, Dimitrios Vlachodimitropoulos, Stamatis D Vassilaros, Eleni Z Katsantoni, Irene Voloudakis-Baltatzis, Vassiliki Aleporou-Marinou, Christos Kittas and Evangelos Marinos
    Citation: Cancer Cell International 2007 7:16
  16. Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine...

    Authors: Khaldoun Al-Romaih, Gino R Somers, Jane Bayani, Simon Hughes, Mona Prasad, Jean-Claude Cutz, Hui Xue, Maria Zielenska, Yuzhuo Wang and Jeremy A Squire
    Citation: Cancer Cell International 2007 7:14
  17. Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hyp...

    Authors: Michael D Hughes, Erilda Kapllani, Ashlynn E Alexander, Robert D Burk and Alan R Schoenfeld
    Citation: Cancer Cell International 2007 7:13
  18. Uncovering the molecular mechanism underlying expansion of hematopoietic stem and progenitor cells is critical to extend current therapeutic applications and to understand how its deregulation relates to leuke...

    Authors: Oswaldo Keith Okamoto, Ana Carolina SR Carvalho, Luciana C Marti, Ricardo Z Vêncio and Carlos A Moreira-Filho
    Citation: Cancer Cell International 2007 7:11
  19. Pancratistatin (PST), a compound extracted from an Amaryllidaceae (AMD) family plant, has been shown to specifically induce apoptosis in cancer cells with no/minimal toxic effect on normal cells. A systematic syn...

    Authors: Carly Griffin, Natasha Sharda, Divya Sood, Jerald Nair, James McNulty and Siyaram Pandey
    Citation: Cancer Cell International 2007 7:10
  20. For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in ...

    Authors: Jayesh Sagar, Boussad Chaib, Kevin Sales, Marc Winslet and Alexander Seifalian
    Citation: Cancer Cell International 2007 7:9
  21. Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis. Elevation of the cathepsins of the cysteine protease fam...

    Authors: Zhen Yang and James L Cox
    Citation: Cancer Cell International 2007 7:8
  22. Fish oil is known to protect from many types of cancers of the colon, liver, breast, prostate and lung [13]. The objective of the present study was to evaluate the role of fish oil [Maxepa, supplemented at a dos...

    Authors: Sangita Manna, Tridib Chakraborty, Suresh Damodaran, Kartick Samanta, Basabi Rana and Malay Chatterjee
    Citation: Cancer Cell International 2007 7:6
  23. The pharmacologic modulatory effects of the antibiotic, tunicamycin (TM), on multidrug-resistant human UWOV2 ovarian cancer cells are reported. The UWOV2 cell line was derived from a cystadenocarcinoma in a pa...

    Authors: Donavon C Hiss, Gary A Gabriels and Peter I Folb
    Citation: Cancer Cell International 2007 7:5
  24. Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subseq...

    Authors: Aaron L Miller, Anna S Garza, Betty H Johnson and E Brad Thompson
    Citation: Cancer Cell International 2007 7:3
  25. Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to clonal expansion ...

    Authors: Gabriel D Dakubo, John P Jakupciak, Mark A Birch-Machin and Ryan L Parr
    Citation: Cancer Cell International 2007 7:2
  26. Prolactinoma is the most frequent pituitary tumor in humans. The dopamine D2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyper...

    Authors: Yan-Nian Jiang, Yi-Hung Li, Meng-Wei Ke, Ting-Yu Tseng, Yueh-Bih Tang, Mu-Chiou Huang, Winston Teng-Kuei Cheng and Yu-Ten Ju
    Citation: Cancer Cell International 2007 7:1
  27. Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes...

    Authors: Sydney Ch'ng, Michael Sullivan, Lan Yuan, Paul Davis and Swee T Tan
    Citation: Cancer Cell International 2006 6:28
  28. It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulat...

    Authors: Barbara Wright, Jacqueline Reimers, Karen Schmidt, Evan Burkala, Nick Davis and Ping Wei
    Citation: Cancer Cell International 2006 6:27
  29. Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpC...

    Authors: Danilo N Odashiro, Alexandre N Odashiro, Patrícia R Pereira, Katyanne Godeiro, Emilia Antecka, Sebastian Di Cesare and Miguel N Burnier Jr
    Citation: Cancer Cell International 2006 6:26
  30. We describe the basic tenets of the current concepts of cancer biology, and review the recent advances on the suppressor role of senescence in tumor growth and the breakdown of this barrier during the origin o...

    Authors: Rengaswami Rajaraman, Duane L Guernsey, Murali M Rajaraman and Selva R Rajaraman
    Citation: Cancer Cell International 2006 6:25
  31. Reports showing susceptibility of multidrug resistant (MDR) cancer cells to immune effectors, together with P-glycoprotein (P-gp) expression in immune effector subsets, including immature natural killer (NK) c...

    Authors: Burhan Savas, Pauline E Kerr and Hugh F Pross
    Citation: Cancer Cell International 2006 6:24
  32. The blood plasma and other intertissue fluids usually contain a certain amount of DNA, getting there due to a natural cell death in the organism. Cells of this organism can capture the extracellular DNA, where...

    Authors: Vladimir A Rogachev, Anastasia Likhacheva, Oksana Vratskikh, Lyudmila V Mechetina, Tamara E Sebeleva, Sergei S Bogachev, Leonid A Yakubov and Mikhail A Shurdov
    Citation: Cancer Cell International 2006 6:23
  33. Despite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived gro...

    Authors: Lucia Taja-Chayeb, Alma Chavez-Blanco, Jorge Martínez-Tlahuel, Aurora González-Fierro, Myrna Candelaria, Jose Chanona-Vilchis, Elizabeth Robles and Alfonso Dueñas-Gonzalez
    Citation: Cancer Cell International 2006 6:22
  34. p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventi...

    Authors: Isao Eto
    Citation: Cancer Cell International 2006 6:20
  35. Human papillomavirus type 16 (HPV-16) E5 protein co-operates with epidermal growth factor to stimulate mitogenesis of murine fibroblasts. Currently, little is known about which viral amino acids are involved i...

    Authors: Rahul Nath, Christine A Mant, Barbara Kell, John Cason and Jon M Bible
    Citation: Cancer Cell International 2006 6:19
  36. Hepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus fi...

    Authors: Mostafa K El Awady, Noha G Badr El Din, Wael T El Garf, Samar S Youssef, Moataza H Omran, Jasmin El Abd and Said A Goueli
    Citation: Cancer Cell International 2006 6:18
  37. Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells rais...

    Authors: Crispin R Dass and Peter FM Choong
    Citation: Cancer Cell International 2006 6:17
  38. Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. ...

    Authors: Britny J Candia, William C Hines, Christopher M Heaphy, Jeffrey K Griffith and Robert A Orlando
    Citation: Cancer Cell International 2006 6:16
  39. Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires a...

    Authors: Krishna Rao, Özge Alper, Kent E Opheim, George Bonnet, Kristine Wolfe, Eileen Bryant, Siobhan O'Hara Larivee, Peggy Porter and James K McDougall
    Citation: Cancer Cell International 2006 6:15
  40. Human papillomavirus has been implicated in virtually all cervical cancers and is believed to be the primary etiological factor that transforms cervical epithelia. The presence of HPV in oral cancers suggests ...

    Authors: Karl Kingsley, Devin Johnson and Susan O'Malley
    Citation: Cancer Cell International 2006 6:14
  41. Integrin-linked kinase (ILK) is a ubiquitously expressed protein kinase that has emerged as one of the points of convergence between integrin- and growth factor-signalling pathways.

    Authors: Glenn A Driver and Robin B Veale
    Citation: Cancer Cell International 2006 6:12

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