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  1. The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3...

    Authors: Antonella Calogero, Vincenza Lombari, Giorgia De Gregorio, Antonio Porcellini, Severine Ucci, Antonietta Arcella, Riccardo Caruso, Franco Maria Gagliardi, Alberto Gulino, Gaetano Lanzetta, Luigi Frati, Dan Mercola and Giuseppe Ragona
    Citation: Cancer Cell International 2004 4:1
  2. Styrylpyrone derivative (SPD) is a plant-derived pharmacologically active compound extracted from Goniothalamus sp. Previously, we have reported that SPD inhibited the proliferation of MCF-7 human breast cancer c...

    Authors: Alvin Teck Chien Lee, Hawariah Lope Pihie Azimahtol and Ann Na Tan
    Citation: Cancer Cell International 2003 3:16
  3. Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is p...

    Authors: Camilla Hollander, Max Nyström, Sabina Janciauskiene and Ulla Westin
    Citation: Cancer Cell International 2003 3:14
  4. The β-catenin link between membrane-bound cadherins and the actin cytoskeleton regulates cell adhesion and consequently metastasis. Abnormal stabilisation of β-catenin enhances its transcriptional activities. ...

    Authors: Lindsay JG Jones and Rob B Veale
    Citation: Cancer Cell International 2003 3:13
  5. One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell c...

    Authors: Jay E Reeder, Mark P Sowden, Edward M Messing, Peter Klover, Emma Villa-Moruzzi and John W Ludlow
    Citation: Cancer Cell International 2003 3:12
  6. Malignant rhabdoid tumors (MRTs) are extremely aggressive and resist current radio- and chemotherapic treatments. To gain insight into the dysfunctions of MRT cells, the apoptotic response of a model cell line...

    Authors: Silvano Nocentini
    Citation: Cancer Cell International 2003 3:11
  7. Human MCF-7 cells have been studied extensively as a model for breast cancer cell growth. Many reports have established that serum-starved MCF-7 cells can be induced to proliferate upon the sole addition of 17...

    Authors: Irene HL Hamelers, Richard FMA van Schaik, John S Sussenbach and Paul H Steenbergh
    Citation: Cancer Cell International 2003 3:10
  8. Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not i...

    Authors: Abd E Elkak, Robert F Newbold, Valene Thomas and Kefah Mokbel
    Citation: Cancer Cell International 2003 3:9
  9. An important physiological function of the normal prostate gland is the synthesis and secretion of a citrate rich prostatic fluid. In prostate cancer, citrate production levels are reduced as a result of alter...

    Authors: Ali Mobasheri, Richard Fox, Iain Evans, Fay Cullingham, Pablo Martín-Vasallo and Christopher S Foster
    Citation: Cancer Cell International 2003 3:8
  10. The molecular mechanisms by which iron is physiologically transported trough the cellular membranes are still only partially understood. Several studies indicate that a reduction step of ferric iron to ferrous...

    Authors: Silvia Dominici, Lisa Pieri, Mario Comporti and Alfonso Pompella
    Citation: Cancer Cell International 2003 3:7
  11. Changes of membrane lipids in cisplatin-sensitive A549 and cisplatin-resistant A549/DDP cells during the apoptotic process induced by a clinical dose of cisplatin (30 μM) were detected by 1H and 31P-NMR spectrosc...

    Authors: Zhenhua Huang, Yufeng Tong, Jinfeng Wang and Youguo Huang
    Citation: Cancer Cell International 2003 3:5
  12. The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an imp...

    Authors: Yuri Kudinov, Charles L Wiseman and Alexander I Kharazi
    Citation: Cancer Cell International 2003 3:4
  13. d-α-tocopherol is a naturally occurring form of vitamin E not previously known to have antitumor activity. Synthetic vitamin E (sE) is a commonly used dietary supplement consisting of a mixture of d-α-tocopher...

    Authors: Ivan L Cameron, Jesus Munoz, Christopher J Barnes and W Elaine Hardman
    Citation: Cancer Cell International 2003 3:3
  14. Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tum...

    Authors: Hong Jiang, Jennifer Coleman, Robin Miskimins and W Keith Miskimins
    Citation: Cancer Cell International 2003 3:2
  15. Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs), the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidati...

    Authors: Yoshihiro Fujii, Katsuyuki Tomita, Hiroyuki Sano, Akira Yamasaki, Yutaka Hitsuda, Ian M Adcock and Eiji Shimizu
    Citation: Cancer Cell International 2002 2:16
  16. The effects of the vitamin A metabolite retinoic acid (RA) are mediated at the transcriptional level by retinoic acid receptors (RAR). These proteins are part of a superfamily of transcription factors which ac...

    Authors: David L Crowe and Randie Kim
    Citation: Cancer Cell International 2002 2:15
  17. We previously reported the usefulness of the αGal epitope as a target molecule for gene therapy against cancer. To induce cancer cell specific transcription of the αGal epitope, an expression vector which synt...

    Authors: Tokihiko Sawada, Osamu Yamada, Naoko Yoshimura, Keiko Hatori, Shohei Fuchinoue and Satoshi Teraoka
    Citation: Cancer Cell International 2002 2:14
  18. A kinetic model has been developed to study cancer growth. Cancer growth has been considered as interaction between various independent but interacting compartments. The model considers cell growth and metasta...

    Authors: Siddhartha Jain
    Citation: Cancer Cell International 2002 2:13
  19. The C1D gene is expressed in a broad spectrum of mammalian cells and tissues but its product induces apoptotic cell death when exceeding a critical level. Critical levels are achieved in a fraction of cells by...

    Authors: Karsten Rothbarth, Hermann Stammer and Dieter Werner
    Citation: Cancer Cell International 2002 2:12
  20. It is postulated that the unusual manifestations of Kaposis's sarcoma cells in nonendothelial brain tissues and on eyeballs in advanced acquired immune deficiency syndrome (AIDS) cases are metastasized AIDS-Ka...

    Authors: Mahruf U Rahman and Amitabha Mazumder
    Citation: Cancer Cell International 2002 2:11
  21. Supplementing mice with high levels of dietary n-3 polyunsaturated fatty acids (PUFAs) increases the n-3 PUFAs in cell membranes, increases the susceptibility of the cells for lipid peroxidation (LPO) and decr...

    Authors: W Elaine Hardman, Jesus Munoz Jr and Ivan L Cameron
    Citation: Cancer Cell International 2002 2:10
  22. Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compou...

    Authors: B Szende, Gy Szökán, E Tyihá, K Pál, R Gáborjányi, M Almás and A R Khlafulla
    Citation: Cancer Cell International 2002 2:4
  23. The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts o...

    Authors: Paul A Harris, Justin Lamb, Brian Heaton and Denys N Wheatley
    Citation: Cancer Cell International 2002 2:3
  24. The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb phosphorylatio...

    Authors: Bryan E Strauss, Ricardo BV Fontes, Claudimara FP Lotfi, Ana Lucia Skorupa, Ione Bartol, José Cipolla-Neto and Eugenia Costanzi-Strauss
    Citation: Cancer Cell International 2002 2:2
  25. We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the β-actin gene as a reference molecule for measuring of mRNA st...

    Authors: Guy J Leclerc, Gilles M Leclerc and Julio C Barredo
    Citation: Cancer Cell International 2002 2:1
  26. 5-AzaCytidine (AzaC) is a DNA demethylating drugs that has been shown to inhibit cell growth and to induce apoptosis in certain cancer cells. Induced expression of the galectin1 (Gal1) protein, a galactoside-b...

    Authors: Florence Poirier, Philippe Bourin, Dominique Bladier, Raymonde Joubert-Caron and Michel Caron
    Citation: Cancer Cell International 2001 1:2
  27. Mitotic death is a delayed response of p53 mutant tumours that are resistant to genotoxic damage. Questions surround why this response is so delayed and how its mechanisms serve a survival function. After unco...

    Authors: Jekaterina Erenpreisa and M S Cragg
    Citation: Cancer Cell International 2001 1:1

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