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  1. Cervical cancer (CC) is the leading cause of cancer-related death in women. A limited number of studies have investigated whether immune-prognostic features can be used to predict the prognosis of CC. This stu...

    Authors: Ya-Nan Pi, Jun-Nan Guo, Ge Lou and Bin-Bin Cui
    Citation: Cancer Cell International 2021 21:639
    Content type: Primary Research Published on:

  2. The emergence of chemoresistance to 5-fluorouracil (5-FU)-based chemotherapy is the main cause of treatment failure in advanced and metastatic colorectal cancer (CRC) patients. Long noncoding RNAs (lncRNAs) ha...

    Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu and Xin Wang
    Citation: Cancer Cell International 2021 21:638
    Content type: Primary Research Published on:

  3. Esophageal carcinogenesis is a multifactorial process in which genetic and environmental factors interact to activate intracellular signals, leading to the uncontrolled survival and growth of esophageal squamo...

    Authors: Jia Zhao, Guangyu Jin, Xudong Liu, Kai Wu, Yang Yang, Zhanfeng He, Donglei Liu, Chunyang Zhang, Dengyan Zhu, Jia Jiao, Xiangnan Li and Song Zhao
    Citation: Cancer Cell International 2021 21:637
    Content type: Primary Research Published on:

  4. Circular RNAs (circRNAs), which are endogenous non-coding RNAs, are associated with various biological processes including development, homeostatic maintenance, and pathological responses. Accumulating evidenc...

    Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian and Weilin Wang
    Citation: Cancer Cell International 2021 21:636
    Content type: Primary Research Published on:

  5. The tumor microenvironment (TME) is critical in the progression and metastasis of skin cutaneous melanoma (SKCM). Differences in tumor-infiltrating immune cells (TICs) and their gene expression have been linke...

    Authors: Peipei Yang, Wanrong Chen, Hua Xu, Junhan Yang, Jinghang Jiang, Yunhui Jiang and Ganglin Xu
    Citation: Cancer Cell International 2021 21:635
    Content type: Primary Research Published on:

  6. Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumour. In recent years, the tumour microenvironment (TME) has been reported to be associated with the development of tumours. However, the relationship betwee...

    Authors: Tian Xia, Lian Meng, Zhijuan Zhao, Yujun Li, Hao Wen, Hao Sun, Tiantian Zhang, Jingxian Wei, Feng Li and Chunxia Liu
    Citation: Cancer Cell International 2021 21:634
    Content type: Primary Research Published on:

  7. Current treatment options for glioma are limited, and the prognosis of patients with glioma is poor as the available drugs show low therapeutic efficacy. Furthermore, the molecular mechanisms associated with g...

    Authors: Lun Li, Yi Yang, Zhenshuang Wang, Chengran Xu, Jinhai Huang and Guangyu Li
    Citation: Cancer Cell International 2021 21:633
    Content type: Primary Research Published on:

  8. The precancerous disease of breast cancer is an inevitable stage in the tumorigenesis and development of breast neoplasms. Quercetin (Que) has shown great potential in breast cancer treatment by inhibiting cel...

    Authors: Dan Qiu, Xianxin Yan, Xinqin Xiao, Guijuan Zhang, Yanqiu Wang, Jingyu Cao, Ruirui Ma, Shouyi Hong and Min Ma
    Citation: Cancer Cell International 2021 21:632
    Content type: Primary Research Published on:

  9. A number of studies have indicated that Ubiquitin-conjugating enzyme E2T (UBE2T), as an oncogene, promotes progression and metastasis of lung cancer, including lung adenocarcinoma (LUAD), but it is completely ...

    Authors: Yongbing Chen, Haihua Hong, Qingqing Wang, Junqiang Li, Wenfeng Zhang, Tingting Chen and Pu Li
    Citation: Cancer Cell International 2021 21:631
    Content type: Primary Research Published on:

  10. Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors. Howev...

    Authors: Wei Xu, Yifan Li, Xiaojian Ye, Yunhan Ji, Yu Chen, Xiangyang Zhang and Zhikun Li
    Citation: Cancer Cell International 2021 21:630
    Content type: Primary Research Published on:

  11. MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional impact with...

    Authors: Praveen Sharma, Vibhuti Sharma, Tarunveer Singh Ahluwalia, Nilambra Dogra, Santosh Kumar and Sandeep Singh
    Citation: Cancer Cell International 2021 21:629
    Content type: Primary Research Published on:

  12. Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancers, which is the most common malignant tumor worldwide. Polypeptide extract from scorpion venom (PESV) has been reported to inhibit NS...

    Authors: Hong Zhang, Haojian Zhang, Jiye Zhu, Huan Liu and Qin Zhou
    Citation: Cancer Cell International 2021 21:628
    Content type: Primary Research Published on:

  13. Cancer cachexia is a wasting disorder characterized by significant weight loss, and is attributed to skeletal muscle weakness. In the process of cancer development, microRNAs act as oncogenes or tumor suppress...

    Authors: Kairu Xie, Hairong Xiong, Wen Xiao, Zhiyong Xiong, Wenjun Hu, Jiaxin Ye, Ning Xu, Jian Shi, Changfei Yuan, Zhixian Chen, Daojia Miao, Xiaoping Zhang and Hongmei Yang
    Citation: Cancer Cell International 2021 21:627
    Content type: Primary Research Published on:

  14. Controversial findings have been reported in the impact of speckle-type POZ protein (SPOP) on clinicopathological features and prognosis in diverse cancers. We conducted this meta-analysis to confirm whether S...

    Authors: Yan He, Jun Chen, Xingchen Peng, Yanli Xia and Yonglin Su
    Citation: Cancer Cell International 2021 21:626
    Content type: Review Published on:

  15. This article aimed to explore the prognostic and immunological roles of AXL gene in clear cell renal cell carcinoma (ccRCC) for overall survival (OS) and to identify the LncRNA/RBP/AXL mRNA networks.

    Authors: Yi Wang, Ye Tian, Shouyong Liu, Zengjun Wang and Qianwei Xing
    Citation: Cancer Cell International 2021 21:625
    Content type: Primary Research Published on:

  16. Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells...

    Authors: Zhuochen Zhao, Junhu Wan, Manman Guo, Zhengwu Yang, Zhuofang Li, Yangxia Wang and Liang Ming
    Citation: Cancer Cell International 2021 21:624
    Content type: Primary Research Published on:

  17. Acquired glucocorticoid (GC) resistance remains the main obstacle in acute lymphoblastic leukemia (ALL) therapy. The aim of the present study was to establish a novel GC-resistant B-ALL cell line and investiga...

    Authors: Yuanyuan Li, Chuan Zuo and Ling Gu
    Citation: Cancer Cell International 2021 21:623
    Content type: Primary Research Published on:

  18. Morphine, a µ-opioid receptor (MOR) agonist, has been shown to be related to the activity of cancer cells, and a higher morphine dosage reduces the survival time of patients with lung cancer. However, the effe...

    Authors: Xingyun Liu, Jia Yang, Chengwei Yang, Xiang Huang, Mingming Han, Fang Kang and Juan Li
    Citation: Cancer Cell International 2021 21:622
    Content type: Primary Research Published on:

  19. The aim of this study was to construct a model based on the prognostic features associated with epithelial–mesenchymal transition (EMT) to explore the various mechanisms and therapeutic strategies available fo...

    Authors: Dafeng Xu, Yu Wang, Jincai Wu, Shixun Lin, Yonghai Chen and Jinfang Zheng
    Citation: Cancer Cell International 2021 21:621
    Content type: Primary Research Published on:

  20. Pancreatic cancer has been a threateningly lethal malignant tumor worldwide. Despite the promising survival improvement in other cancer types attributing to the fast development of molecular precise medicine, ...

    Authors: Rong Wei, Guoye Qi, Zixin Zeng, Ningning Shen, Ziyue Wang, Honghong Shen, Lifang Gao, Chen Song, Wenxia Ma and Chen Wang
    Citation: Cancer Cell International 2021 21:620
    Content type: Primary Research Published on:

  21. Neuroblastoma (NB) is a common solid malignancy in children that is associated with a poor prognosis. Although the novel small molecular compound Dimethylaminomicheliolide (DMAMCL) has been shown to induce cel...

    Authors: Simeng Zhang, Zhongyan Hua, Gen Ba, Ning Xu, Jianing Miao, Guifeng Zhao, Wei Gong, Zhihui Liu, Carol J. Thiele and Zhijie Li
    Citation: Cancer Cell International 2021 21:619
    Content type: Primary Research Published on:

  22. Papillary thyroid carcinoma (PTC) is a common endocrine tumor. Increasing evidence has shown that microRNA dysfunction is involved in the occurrence and development of cancer. The expression of MicroRNA-30b-5p...

    Authors: Ye Wang, Congjun Wang, Zhao Fu, Siwen Zhang and Junqiang Chen
    Citation: Cancer Cell International 2021 21:618
    Content type: Primary Research Published on:

  24. UCA1 is frequently upregulated in a variety of cancers, including CRC, and it can play an oncogenic role by various mechanisms. However, how UCA1 is regulated in cancer is largely unknown. In this study, we ai...

    Authors: Rong-Zhang He, Jing Jiang, Xinglin Hu, Ming Lei, Jia Li, Weihao Luo, Lili Duan, Zheng Hu, Yin-Yuan Mo, Di-Xian Luo and Wan-Xin Peng
    Citation: Cancer Cell International 2021 21:616
    Content type: Primary research Published on:

  25. There is mounting evidence that demonstrated the association of aberrant NEDD4L expression with diverse human cancers. However, the expression pattern and clinical implication of NEDD4L in acute myeloid leukemia ...

    Authors: Ming-qiang Chu, Liu-chao Zhang, Qian Yuan, Ting-juan Zhang and Jing-dong Zhou
    Citation: Cancer Cell International 2021 21:615
    Content type: Primary Research Published on:

  26. Most previous studies compared the risk for non-melanoma skin cancer (NMSC) in biologic-treated common inflammatory diseases with the general population. Whether the increased NMSC risk is caused by the diseas...

    Authors: Ruolin Liu, Qianyi Wan, Rui Zhao, Haitao Xiao, Ying Cen and Xuewen Xu
    Citation: Cancer Cell International 2021 21:614
    Content type: Review Published on:

  27. Bladder cancer (BLCA) is the most common genitourinary tumor but lacks specific diagnostic biomarkers. Recent years have witnessed significant advances in the use and approval of immune checkpoint blockade (IC...

    Authors: YiHeng Du, Jin Cao, Xiang Jiang, XiaoWei Cai, Bo Wang, Yi Wang, XiZhi Wang and BoXin Xue
    Citation: Cancer Cell International 2021 21:613
    Content type: Primary research Published on:

  28. Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers....

    Authors: Shabnam Sharmin, Md. Mizanur Rahaman, Miquel Martorell, Jorge Sastre-Serra, Javad Sharifi-Rad, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu and Mohammad Torequl Islam
    Citation: Cancer Cell International 2021 21:612
    Content type: Review Published on:

  29. The underlying circular RNAs (circRNAs)-related competitive endogenous RNA (ceRNA) mechanisms of pathogenesis and prognosis in non-small cell lung cancer (NSCLC) remain unclear.

    Authors: Jia Yang, Ran Hao, Yunlong Zhang, Haibin Deng, Wenjing Teng and Zhongqi Wang
    Citation: Cancer Cell International 2021 21:611
    Content type: Primary research Published on:

  30. The accumulation of single nucleotide variants (SNVs) and the emergence of neoantigens can affect tumour proliferation and the immune microenvironment. However, the SNV-related immune microenvironment characte...

    Authors: Yu-Jie Xu, Min-Ke He, Shuang Liu, Li-Chang Huang, Xiao-Yun Bu, Anna Kan and Ming Shi
    Citation: Cancer Cell International 2021 21:610
    Content type: Primary Research Published on:

  31. N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in...

    Authors: Jialu Guo, Jianfeng Zheng, Huizhi Zhang and Jinyi Tong
    Citation: Cancer Cell International 2021 21:609
    Content type: Review Published on:

  32. Gallbladder cancer (GBC) is the most common biliary tract malignancy and has a poor prognosis in patients with GBC. CircRNA TP63 (circTP63) has been implicated in cell proliferation and invasion in some tumor ...

    Authors: Shouhua Wang, Huanjun Tong, Tingting Su, Di Zhou, Weibin Shi, Zhaohui Tang and Zhiwei Quan
    Citation: Cancer Cell International 2021 21:608
    Content type: Primary research Published on:

  33. Uveal melanoma (UM), the most prevalent intraocular tumor in adults, is a highly metastatic and drug resistant lesion. Recent studies have demonstrated cytotoxic and anti-metastatic effects of the antiprogesti...

    Authors: Prisca Bustamante Alvarez, Alexander Laskaris, Alicia A. Goyeneche, Yunxi Chen, Carlos M. Telleria and Julia V. Burnier
    Citation: Cancer Cell International 2021 21:607
    Content type: Primary research Published on:

  34. Sestrin 2, a highly conserved stress-induced protein, participates in the pathological processes of metabolic and age-related diseases. This p53-inducible protein also regulates cell growth and metabolism, whi...

    Authors: Junsheng Qu, Moyi Luo, Jingwen Zhang, Fang Han, Ningning Hou, Ruiyan Pan and Xiaodong Sun
    Citation: Cancer Cell International 2021 21:606
    Content type: Review Published on:

  35. Breast cancer is a common cancer among women in the world. However, its pathogenesis is still to be determined. The role and molecular mechanism of Nucleosome Assembly Protein 1 Like 1 (NAP1L1) in breast cance...

    Authors: Shu Liu, Yewei Zhang, Shien Cui, Dajiang Song, Bo Li, Qian Chen, Guangyu Yao and Bin Gong
    Citation: Cancer Cell International 2021 21:605
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:26

  36. We aimed to comprehensively investigate the optimal cumulative cisplatin dose during concurrent chemoradiotherapy (CC-CCD) for locoregionally advanced nasopharyngeal carcinoma (CA-LANPC) with different tumor r...

    Authors: Ya-Nan Jin, Meng-Yun Qiang, Meng-Meng Liu, Zhi-Bin Cheng, Wang-Jian Zhang, Ian Ryan, Tia Marks, Ji-Jin Yao and Liang-Ping Xia
    Citation: Cancer Cell International 2021 21:604
    Content type: Primary research Published on:

  37. Gastric cancer (GC) is a common malignancy of the digestive system. Antioxidant activity is regarded as a possible mechanism in ectopic cancer. Hence, oxidative stress regulation is being evaluated for cancer ...

    Authors: Jing Lv, Meiqiang Xie, Shufen Zhao, Wensheng Qiu, Shasha Wang and Manming Cao
    Citation: Cancer Cell International 2021 21:603
    Content type: Primary research Published on:

  38. Gastric cancer (GC) is one of the most common malignancies, molecular mechanism of which is still not clear. Aberrant expression of tumor-associated genes is the major cause of tumorigenesis. DBF4 is an import...

    Authors: Tengkai Wang, Rui Ji, Guanqun Liu, Beilei Ma, Zehua Wang and Qian Wang
    Citation: Cancer Cell International 2021 21:602
    Content type: Primary research Published on:

  39. High-dose melphalan (HDMEL, 200 mg/m2) is considered as the standard conditioning regimen for autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM). However, whether the combinat...

    Authors: Fei Gao, Mei-Si Lin, Jie-Shu You, Min-Yue Zhang, Long Cheng, Ke Lin, Peng Zhao and Qi-Yan Chen
    Citation: Cancer Cell International 2021 21:601
    Content type: Review Published on:

  40. Hexokinases 2 (HK2) is a member of the hexokinases, linking with malignant tumor growth and distant metastasis. However, evidence regarding the potential role of HK2 in regulating cell motility and tumor metas...

    Authors: Qian Chen, Lu Li, Xian Liu, Qian Feng, Yanru Zhang, Pengsheng Zheng and Nan Cui
    Citation: Cancer Cell International 2021 21:600
    Content type: Primary research Published on:

  41. The high potential for tumor recurrence and chemoresistance is a major challenge of clinical gastric cancer treatment. Increasing evidence suggests that the presence of tumor initiating cells (TICs) is the pri...

    Authors: Shuangya Deng, Lun Li, Shu Xu, Xiaobo Wang and Tong Han
    Citation: Cancer Cell International 2021 21:599
    Content type: Primary research Published on:

  42. Acute myeloid leukemia (AML) is a myeloid neoplasm accounts for 7.6% of hematopoietic malignancies. AML is a complex disease, and understanding its pathophysiology is contributing to the improvement in the tre...

    Authors: You Jiang, Shui-Yan Wu, Yan-Ling Chen, Zi-Mu Zhang, Yan-Fang Tao, Yi Xie, Xin-Mei Liao, Xiao-Lu Li, Gen Li, Di Wu, Hai-Rong Wang, Ran Zuo, Hai-Bo Cao, Jing-Jing Pan, Juan-Juan Yu, Si-Qi Jia…
    Citation: Cancer Cell International 2021 21:598
    Content type: Primary research Published on:

  43. Aberrant autophagy and preternatural elevated glycolysis are prevalent in bladder cancer (BLCA) and are both related to malignant progression. However, the regulatory relationship between autophagy and glycoly...

    Authors: Tinghao Li, Hang Tong, Hubin Yin, Yi Luo, Junlong Zhu, Zijia Qin, Siwen Yin and Weiyang He
    Citation: Cancer Cell International 2021 21:597
    Content type: Primary research Published on:

  44. Previous studies have reported that circular RNA (circRNA) is associated with the pathogenesis of CRC. This study was designed to reveal the mechanism of circ-ring finger protein 121 (circ-RNF121) in colorecta...

    Authors: Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang and Shuang Chen
    Citation: Cancer Cell International 2021 21:596
    Content type: Primary research Published on:

  45. Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had...

    Authors: Xiuyun Xuan, Chunxia Tian, Mengjie Zhao, Yanhong Sun and Changzheng Huang
    Citation: Cancer Cell International 2021 21:595
    Content type: Review Published on:

  46. Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive subtype of Non-Hodgkin’s Lymphoma. CircRNA has shown great potential to become a biomarker in plasma. In this study, we aimed to determine circRN...

    Authors: Mei Mei, Yingjun Wang, Wenting Song, Zhaoming Li, Qilong Wang, Jiayin Li and Mingzhi Zhang
    Citation: Cancer Cell International 2021 21:594
    Content type: Primary research Published on:

  47. The prognosis of high grade serous ovarian cancer (HGSOC) patients is closely related to the immune microenvironment and immune response. Based on this, the purpose of this study was to construct a model to pr...

    Authors: Han Zhang, Yijun Wu, Hao Li, Liping Sun and Xiangkai Meng
    Citation: Cancer Cell International 2021 21:593
    Content type: Primary research Published on:

  49. Ferroptosis is a recently recognised new type of cell death which may be a potential target for cancer therapy. In the present study, we aimed to screen ferroptosis-related differentially expressed long non-co...

    Authors: Xiao-Liang Xing, Zhi-Yong Yao, Jialan Ou, Chaoqun Xing and Feng Li
    Citation: Cancer Cell International 2021 21:591
    Content type: Primary research Published on:

  50. The rhomboids are a family of multi-transmembrane proteins, many of which have been implicated in facilitating tumor progression. Little is yet known, however, about rhomboid-associated biomarkers in cancers. ...

    Authors: Lei Wang, Xiu-Xiu Liu, Yu-Meng Yang, Yan Wang, Yuan-Yuan Song, Shan Gao, Lu-Yuan Li and Zhi-Song Zhang
    Citation: Cancer Cell International 2021 21:590
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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