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  1. Persistent hypoxia stimulation, one of the most critical microenvironmental factors, accelerates the acquisition of epithelial–mesenchymal transition (EMT) phenotypes in lung cancer cells. Loss of phosphatase ...

    Authors: Takashi Kohnoh, Naozumi Hashimoto, Akira Ando, Koji Sakamoto, Shinichi Miyazaki, Daisuke Aoyama, Masaaki Kusunose, Motohiro Kimura, Norihito Omote, Kazuyoshi Imaizumi, Tsutomu Kawabe and Yoshinori Hasegawa
    Citation: Cancer Cell International 2016 16:33
    Content type: Primary research Published on:

  2. Glioblastoma (GBM) is considered to be one of the most aggressive tumors of the central nervous system (CNS). Even with the use of modern treatment protocols, the prognosis remains reserved, with children with...

    Authors: Pamela Viani de Andrade, Augusto Faria Andrade, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone and Elvis Terci Valera
    Citation: Cancer Cell International 2016 16:31
    Content type: Primary research Published on:

  3. Cisplatin (DDP)-based chemotherapy is the mainstay of first-line therapy for lung cancer. However, their efficacy is often limited by the existence or development of chemoresistance. The aim of this study was ...

    Authors: Weili Li, Wenzhe Wang, Mingjian Ding, Xiaoliang Zheng, Shenglin Ma and Xiaoju Wang
    Citation: Cancer Cell International 2016 16:30
    Content type: Primary Research Published on:

  4. Endometrial cancer (EC) is the most common form of malignant gynecological tumor. Treatment with cisplatin (CDDP) is the mainstay of EC chemotherapy. The apoptotic machinery is regarded as an important etiolog...

    Authors: Yongli Zhang, FeiZhou Jiang, Wei Bao, Huilin Zhang, XiaoYing He, Huihui Wang and Xiaoping Wan
    Citation: Cancer Cell International 2016 16:29
    Content type: Primary Research Published on:

  5. Lung cancer bone metastasis causes poor prognosis. Basigin-2, a novel cancer-associated biomarker, is upregulated in lung cancer and has been linked with tumor progression. But little is known about the role o...

    Authors: Cheng-Gong Liao, Li Yao, Wei Xie, Lili Liu, Sheng-Da Wu, Ning Lu, Jian-Guo Huang, Ling-Min Kong and He-Long Zhang
    Citation: Cancer Cell International 2016 16:28
    Content type: Primary Research Published on:

  6. Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct ind...

    Authors: Martina Broecker-Preuss, Nina Becher-Boveleth, Stefan Müller and Klaus Mann
    Citation: Cancer Cell International 2016 16:27
    Content type: Primary research Published on:

  7. Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). BBC has no targeted therapies, making the need for mechanistic insight urgent. Reducing adiposity in adu...

    Authors: Yuanyuan Qin, Sneha Sundaram, Luma Essaid, Xin Chen, Samantha M. Miller, Feng Yan, David B. Darr, Joseph A. Galanko, Stephanie A. Montgomery, Michael B. Major, Gary L. Johnson, Melissa A. Troester and Liza Makowski
    Citation: Cancer Cell International 2016 16:26
    Content type: Primary research Published on:

  8. Epidermal growth factor receptor (EGFR) is an important oncogenic protein in multiple types of cancer. Endocytosis and degradation of epidermal growth factor receptor (EGFR) are two key steps for down-regulati...

    Authors: Ke Peng, Qian Dai, Jing Wei, Genbao Shao, Aiqin Sun, Wannian Yang and Qiong Lin
    Citation: Cancer Cell International 2016 16:25
    Content type: Primary research Published on:

  9. Understanding the cause of therapeutic resistance and identifying new biomarkers in breast cancer to predict therapeutic responses will help optimise patient care. Calcium (Ca2+)-signalling is important in a vari...

    Authors: Elena Pera, Elke Kaemmerer, Michael J. G. Milevskiy, Kunsala T. D. S. Yapa, Jake S. O’Donnell, Melissa A. Brown, Fiona Simpson, Amelia A. Peters, Sarah J. Roberts-Thomson and Gregory R. Monteith
    Citation: Cancer Cell International 2016 16:24
    Content type: Primary research Published on:

  10. Breast cancer is a heterogeneous disorder for which the underlying genetic basis remains unclear. We developed a method for identifying adenomatous polyposis coli (APC) mutations and we evaluated the possible ass...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Shu-Fen Yang, Cheng-Mao Ho and Jan-Gowth Chang
    Citation: Cancer Cell International 2016 16:23
    Content type: Primary research Published on:

  13. Prostate stem cell antigen (PSCA) expression has been shown to correlate with prostatic carcinogenesis and prostate cancer (PCa) progression. The underlying mechanisms for these processes are currently unknown...

    Authors: Ran Kang, Shankun Zhao, Luhao Liu, Futian Li, Ermao Li, Lianmin Luo, Lihua Xu, ShawPong Wan and Zhigang Zhao
    Citation: Cancer Cell International 2016 16:20
    Content type: Primary research Published on:

  14. Cancer stem cells contribute to tumor initiation, heterogeneity, and recurrence, and are critical targets in cancer therapy. Sprouty4 (Spry4) is a potent inhibitor of signal transduction pathways elicited by r...

    Authors: Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua and Xuehui Yang
    Citation: Cancer Cell International 2016 16:19
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2017 17:53

  15. The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute’s...

    Authors: Jóhannes Reynisson, Jagdish K. Jaiswal, David Barker, Stacey A. N. D’mello, William A. Denny, Bruce C. Baguley and Euphemia Y. Leung
    Citation: Cancer Cell International 2016 16:18
    Content type: Primary research Published on:

  16. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) and microRNA (miRNA) let-7a-1 act as tumor suppressors in many types of cancers including lung cancer. In the present study, we aim to investi...

    Authors: Yani Lin, Jian Zhao, Xiaoyan Hu, Lina Wang, Liming Liang and Weiwen Chen
    Citation: Cancer Cell International 2016 16:17
    Content type: Primary research Published on:

  17. We aimed to discover the potential microRNA (miRNA) targets and to explore the underlying molecular mechanisms of clear cell renal cell carcinoma (ccRCC).

    Authors: Yongsheng Chen, Lichen Teng, Wenhua Liu, Yan Cao, Dexin Ding, Wentao Wang, Hui Chen, Changfu Li and Ruihua An
    Citation: Cancer Cell International 2016 16:16
    Content type: Primary research Published on:

  18. Sushi Domain Containing 2 (SUSD2) has been identified as a regulator of colon and breast cancer. Increasing evidence suggests that SUSD2 plays a key role in tumorigenesis. However, the SUSD2 expression status ...

    Authors: Xin-rui Liu, Cui-xia Cai, Li-min Luo, Wen-Ling Zheng, Rong Shi, Jun Zeng, You-qin Xu, Min Wei and Wen-li Ma
    Citation: Cancer Cell International 2016 16:15
    Content type: Primary research Published on:

  19. Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible fo...

    Authors: Martin Sramek, Jakub Neradil, Jaroslav Sterba and Renata Veselska
    Citation: Cancer Cell International 2016 16:14
    Content type: Primary research Published on:

  21. Prostate cancer (PCa) remains to be a diagnostic challenge due to its variable presentation and the lack of reliable diagnosis tool. MicroRNAs (miRNAs) regulate gene in extensive range of pathophysiologic proc...

    Authors: Jiaqi Wang, Huamao Ye, Dandan Zhang, Yijun Hu, Xiya Yu, Long Wang, Changjing Zuo, Yongwei Yu, Guixia Xu and Shanrong Liu
    Citation: Cancer Cell International 2016 16:12
    Content type: Primary Research Published on:

  22. Previous reports showed that the Steroidal Glycoalkaloid Solamargine inhibited proliferation of non-melanoma skin cancer cells. However, Solamargine was not tested systematically on different types of melanoma...

    Authors: Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber and Sirin A. Adham
    Citation: Cancer Cell International 2016 16:11
    Content type: Primary research Published on:

  23. The use of the dietary polyphenols as chemosensitizing agents to enhance the efficacy of conventional cytostatic drugs has recently gained the attention of scientists and clinicians as a plausible approach fo...

    Authors: Anna Klimaszewska-Wisniewska, Marta Halas-Wisniewska, Tadeusz Tadrowski, Maciej Gagat, Dariusz Grzanka and Alina Grzanka
    Citation: Cancer Cell International 2016 16:10
    Content type: Primary research Published on:

  24. The most common genetic changes identified in human NSCLC are Kras mutations (10–30 %) and p53 mutation or loss (50–70 %). Moreover, NSCLC with mutations in Kras and p53 poorly respond to current therapies, so...

    Authors: Huanan Wang, Lei Wang, Yingjie Zhang, Ji Wang, Yibin Deng and Degui Lin
    Citation: Cancer Cell International 2016 16:9
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2016 16:38

  25. Most women with primary breast cancers that express estrogen receptor alpha (ER or ESR1) are treated with endocrine therapies including the anti-estrogen tamoxifen, but resistance to these anti-endocrine ther...

    Authors: Lily M. Fitzgerald, Eva P. Browne, Kevin D. Christie, Elizabeth C. Punska, Leo O. Simmons, Kristin E. Williams, Brian T. Pentecost, Rahul M. Jawale, Christopher N. Otis and Kathleen F. Arcaro
    Citation: Cancer Cell International 2016 16:8
    Content type: Primary research Published on:

  26. Through research carried out in the last 25 years about the breast cancer etiology, it has been possible to estimate that less than 10 % of patients who are diagnosed with the condition are carriers of some ge...

    Authors: Marco Allán Pérez-Solis, Guadalupe Maya-Nuñez, Patricia Casas-González, Aleida Olivares and Arturo Aguilar-Rojas
    Citation: Cancer Cell International 2016 16:7
    Content type: Review Published on:

  27. This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the us...

    Authors: Sébastien Relier, Laura Yazdani, Oualid Ayad, Armelle Choquet, Jean-François Bourgaux, Michel Prudhomme, Julie Pannequin, Françoise Macari and Alexandre David
    Citation: Cancer Cell International 2016 16:6
    Content type: Primary research Published on:

  28. Despite the fact that melatonin treatment shows some promise in gastric cancer, the molecular mechanisms of gastric cancer cells in response to melatonin remains to be determined.

    Authors: Wenjie Deng, Yujie Zhang, Luo Gu, Jie Cui, Biao Duan, Yueyuan Wang and Jun Du
    Citation: Cancer Cell International 2016 16:5
    Content type: Primary research Published on:

  29. Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to det...

    Authors: A. Jeney, Z. Hujber, N. Szoboszlai, A. Fullár, J. Oláh, É. Pap, Á. Márk, Cs. Kriston, J. Kralovánszky, I. Kovalszky, K. Vékey and A. Sebestyén
    Citation: Cancer Cell International 2016 16:4
    Content type: Primary research Published on:

  30. Breast cancer is the most prevalent malignancies among the women that have a high mortality. Previous studies demonstrated that hypericin, a bioactive component of Hypericum perforatum have a cytotoxic effect on ...

    Authors: Seyed Abbas Mirmalek, Mohammad Amin Azizi, Ehsan Jangholi, Soheila Yadollah-Damavandi, Mohammad Amin Javidi, Yekta Parsa, Tina Parsa, Seyed Alireza Salimi-Tabatabaee, Hossein Ghasemzadeh kolagar and Reza Alizadeh-Navaei
    Citation: Cancer Cell International 2016 16:3
    Content type: Primary Research Published on:

  31. Mutation rates are consistently varied in cancer genome and play an important role in tumorigenesis, however, little has been known about their function potential and impact on the distribution of functional m...

    Authors: Chuance Du, Xiaoyuan Wu and Jia Li
    Citation: Cancer Cell International 2016 16:2
    Content type: Primary Research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2017 17:67

  32. Development of alternative cancer-specific drugs would be of paramount importance to overcome toxicity toward normal tissues and tumor resistance. Here, we investigated the potential anti-tumoral effect of pee...

    Authors: Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, Ons Zakraoui, Sami Fattouch, Habib Karoui and Khadija Essafi-Benkhadir
    Citation: Cancer Cell International 2016 16:1
    Content type: Primary research Published on:

  33. The resulting clinical impact of the combined use of G-CSF with chemotherapy as a chemosensitizing strategy for treatment of acute myeloid leukemia (AML) patients is still controversial. In this study, the eff...

    Authors: Meritxell Nomdedeu, María Carmen Lara-Castillo, Amaia Etxabe, Josep María Cornet-Masana, Marta Pratcorona, Marina Díaz-Beyá, Xavier Calvo, María Rozman, Dolors Costa, Jordi Esteve and Ruth M. Risueño
    Citation: Cancer Cell International 2015 15:122
    Content type: Primary research Published on:

  34. Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has been implicated in alleviation of infertility in Sprague–Dawley rats caused by cisplatin. We evaluated re...

    Authors: Kiran Kumar Soni, Li Tao Zhang, Jae Hyung You, Sung Won Lee, Chul Young Kim, Wan Shou Cui, Han Jung Chae, Hye Kyung Kim and Jong Kwan Park
    Citation: Cancer Cell International 2015 15:121
    Content type: Primary research Published on:

  35. DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway. In the field of cancer research, the role of DIXDC1 is unclear. Our previous in vitro study showed that DIXDC1 enhances...

    Authors: Lei Wang, Cong Tan, Fan Qiao, Weige Wang, Xiangnan Jiang, Peng Lian, Bin Chang and Weiqi Sheng
    Citation: Cancer Cell International 2015 15:120
    Content type: Primary research Published on:

  36. Alizarin and purpurin are di- and trihydroxyanthraquinones derived from Rubia tinctorum L. Previous pharmacological studies have demonstrated that they exhibit certain degree of selective inhibitory effects towar...

    Authors: Eszter Lajkó, Péter Bányai, Zsófia Zámbó, László Kursinszki, Éva Szőke and László Kőhidai
    Citation: Cancer Cell International 2015 15:119
    Content type: Primary research Published on:

  37. In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).

    Authors: Ming Sun, Hai-feng Ma, Ye-yun Che and Xin Cui
    Citation: Cancer Cell International 2015 15:118
    Content type: Primary research Published on:

  38. Advances in surgical and medical treatments for ovarian cancer have improved prognoses. Platinum drugs in particular are pivotal for the medical treatment of ovarian cancer. However, previous studies have reve...

    Authors: Shinya Matsuzaki, Kiyoshi Yoshino, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Akiko Okazawa, Tomomi Egawa-Takata, Eiji Kobayashi and Tadashi Kimura
    Citation: Cancer Cell International 2015 15:117
    Content type: Review Published on:

  39. Multidrug resistance is one of the major reasons chemotherapy-based treatments failed in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). Hypoxia is generally associated with tumor chemo-resista...

    Authors: Guifang Yu, Xuezhu Chen, Shudi Chen, Weipeng Ye, Kailian Hou and Min Liang
    Citation: Cancer Cell International 2015 15:116
    Content type: Primary research Published on:

  40. The incidence of gastric cancer is high in Chinese Tibetan. This study aimed to identify the differentially expressed microRNAs (miRNAs) and further explore their potential roles in Tibetan with gastric cancer...

    Authors: Yushuang Luo, Chengwu Zhang, Feng Tang, Junhui Zhao, Cunfang Shen, Cheng Wang, Pengjie Yu, Miaozhou Wang, Yan Li, J. I. Di, Rong Chen and Ge Rili
    Citation: Cancer Cell International 2015 15:115
    Content type: Primary research Published on:

  41. Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme

    Authors: Xiao-Ni Liu, Shuang Wang, Qing Yang, Ya-Jie Wang, De-Xi Chen and Xiao-Xin Zhu
    Citation: Cancer Cell International 2015 15:114
    Content type: Primary research Published on:

  42. Thyroid-derived cell models are commonly used to investigate the characteristics of thyroid cancers. It is noteworthy that each in vitro single cell model system imitates only a few characteristics of thyroid ...

    Authors: Francesca Cammarota, Francesco Fiscardi, Tiziana Esposito, Gabriella de Vita, Marco Salvatore and Mikko O. Laukkanen
    Citation: Cancer Cell International 2015 15:113
    Content type: Primary research Published on:

  43. The factors driving the onset and progression of ovarian cancer are not well understood. Recent reports have identified cell lines that are representative of the genomic pattern of high-grade serous ovarian ca...

    Authors: Danielle L. Bourgeois, Karl A. Kabarowski, Veronica L. Porubsky and Pamela K. Kreeger
    Citation: Cancer Cell International 2015 15:112
    Content type: Primary research Published on:

  44. Aberrant STAT1 signaling is observed in human hepatocellular carcinoma (HCC) and has been associated with the modulation of cell proliferation and survival. However, the role of STAT1 signaling in HCC and its...

    Authors: Jiayu Chen, Haihe Wang, Jing Wang, Shishun Huang and Wei Zhang
    Citation: Cancer Cell International 2015 15:111
    Content type: Primary research Published on:

  45. The estrogen receptor-positive M13SV1 breast epithelial cell line was proposed to be a suitable in vitro model for breast cancer research since two derivatives with graduated tumorigenicity—M13SV1-R2-2 and M13...

    Authors: Sandra Stempin, Anika Engel, Nora Winkler, Thorsten Buhrke and Alfonso Lampen
    Citation: Cancer Cell International 2015 15:110
    Content type: Primary research Published on:

  46. Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be...

    Authors: Ying Bao, Yongliang Lu, Xiang Wang, Wenming Feng, Xinrong Sun, Huihui Guo, Chengwu Tang, Xiaojing Zhang, Qilin Shi and Hongbin Yu
    Citation: Cancer Cell International 2015 15:109
    Content type: Primary research Published on:

  48. Genome-wide miRNA expression profile has identified microRNA (miR)-96 as one of upregulated miRNAs in clinical bladder cancer (BC) tissues compared to normal bladder tissues. The aim of this study was to confi...

    Authors: Ziyu Wu, Kun Liu, Yunyan Wang, Zongyuan Xu, Junsong Meng and Shuo Gu
    Citation: Cancer Cell International 2015 15:107
    Content type: Primary research Published on:

  50. Over expression of Bcl-2 is frequently observed in several types of cancers and it is one of the prognostic markers in breast cancer. The importance of the Bcl-2 protein as ideal therapeutic target is the dual...

    Authors: Abdolhassan Talaiezadeh, Fateme jalali, Hamid Galehdari and Ali Khodadadi
    Citation: Cancer Cell International 2015 15:105
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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