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  1. While breast cancer (BC) is the major cause of death among women worldwide, there is no guarantee of better patient survival because many of these patients develop primarily metastases, despite efforts to dete...

    Authors: Vivian Labovsky, Valeria B Fernández Vallone, Leandro M Martinez, Julian Otaegui and Norma A Chasseing
    Citation: Cancer Cell International 2012 12:29
    Content type: Primary research Published on:

  2. Head and neck squamous cell carcinoma (HNSCC) is the 5th most common cancer worldwide. Locally advanced HNSCC are treated with either radiation or chemo-radiotherapy, but still associated with high mortality r...

    Authors: Nehad M Alajez, Joseph D Mocanu, Tiffany Krushel, John C Bell and Fei-Fei Liu
    Citation: Cancer Cell International 2012 12:27
    Content type: Primary research Published on:

  4. We have investigated the role of erythroid transcription factors mRNA expression in patients with acute myeloid leukemia (AML) in the context of cytogenetic and other prognostic molecular markers, such as FMS-...

    Authors: Rosa Ayala, Joaquin Martínez-López and Florinda Gilsanz
    Citation: Cancer Cell International 2012 12:25
    Content type: Primary research Published on:

  5. Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal tra...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer
    Citation: Cancer Cell International 2012 12:24
    Content type: Review Published on:

  6. Our previous work found that mouse embryos could invade malignant cancer cells. In the process of implantation, embryo trophoblast cells express matrix metalloproteinases and the invasive ability of trophoblas...

    Authors: Xiaoyan Ding, Liaoqiong Fang, Hong Zhang, Hai Qiao and Zhi-biao Wang
    Citation: Cancer Cell International 2012 12:23
    Content type: Primary research Published on:

  8. The outcome of chemotherapy in breast cancer is strongly influenced by multidrug resistance (MDR). Several surrogate markers of chemoresistance have been identified including - CD24 (cluster differentiation 24...

    Authors: Neil D Jelly, Issam I Hussain, Jennifer Eremin, Oleg Eremin and Mohamed El-Sheemy
    Citation: Cancer Cell International 2012 12:21
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2013 13:96

  9. Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. ...

    Authors: Johan Kjellström, Stina M Oredsson and Johan Wennerberg
    Citation: Cancer Cell International 2012 12:20
    Content type: Primary research Published on:

  10. Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical ...

    Authors: Afef Dellai, Monia Deghrigue, Audrey Laroche-Clary, Hedi Ben Masour, Nabil Chouchane, Jacques Robert and Abderrahman Bouraoui
    Citation: Cancer Cell International 2012 12:18
    Content type: Primary research Published on:

  11. Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and it...

    Authors: Casey M Turk, Katerina D Fagan-Solis, Kristin E Williams, Joseph M Gozgit, Sallie Smith-Schneider, Sharon A Marconi, Christopher N Otis, Giovanna M Crisi, Douglas L Anderton, Manfred W Kilimann and Kathleen F Arcaro
    Citation: Cancer Cell International 2012 12:17
    Content type: Primary research Published on:

  12. This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract an...

    Authors: Afef Dellai, Hedi Ben Mansour, Audrey Clary-Laroche, Monia Deghrigue and Abderrahman Bouraoui
    Citation: Cancer Cell International 2012 12:15
    Content type: Primary research Published on:

  13. Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibitio...

    Authors: Hiroko Tabunoki, Naoki Saito, Khanit Suwanborirux, Kornvika Charupant and Jun-ichi Satoh
    Citation: Cancer Cell International 2012 12:14
    Content type: Primary research Published on:

  14. The Notch signaling pathway is crucial in T-cell development, Notch 1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To investigate the feature of Notch 1 mutation and its corres...

    Authors: Chunlan Lin, Haitao Zheng, Chunyan Wang, Lijian Yang, Shaohua Chen, Bo Li, Yubing Zhou, Huo Tan and Yangqiu Li
    Citation: Cancer Cell International 2012 12:13
    Content type: Primary research Published on:

  16. GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT...

    Authors: Danielle Park, Joyce Chiu, Gabriel G Perrone, Pierre J Dilda and Philip J Hogg
    Citation: Cancer Cell International 2012 12:11
    Content type: Primary research Published on:

  17. Although the primary risk factors for developing oral cancers are well understood, less is known about the relationship among the secondary factors that may modulate the progression of oral cancers, such as hi...

    Authors: Michael Moody, Oanh Le, Megan Rickert, Jeremy Manuele, Sarah Chang, Gary Robinson, Jeffrey Hajibandeh, John Silvaroli, Mark A Keiserman, Christine J Bergman and Karl Kingsley
    Citation: Cancer Cell International 2012 12:10
    Content type: Primary research Published on:

  18. Recently electroporation using biphasic pulses was successfully applied in clinical developments for treating tumours in humans and animals. We evaluated the effects of electrical treatment on cell adhesion be...

    Authors: Viktoria N Pehlivanova, Iana H Tsoneva and Rumiana D Tzoneva
    Citation: Cancer Cell International 2012 12:9
    Content type: Primary research Published on:

  19. The effect of cell injury and apoptosis induced by ultrasound with contrast agent has been verified. Contrast agent enhanced apoptosis and expression of genes that related to apoptosis and are responsive to ul...

    Authors: Zao Jiang, Wei Wu and Meng-lu Qian
    Citation: Cancer Cell International 2012 12:8
    Content type: Primary research Published on:

  20. A potential strategy for the diagnosis of lung cancer is to exploit the distinct metabolic signature of this disease by way of biomarkers found in different sample types. In this study, we investigated whether...

    Authors: Yosuke Hanai, Ken Shimono, Hiroaki Oka, Yoshinobu Baba, Kunio Yamazaki and Gary K Beauchamp
    Citation: Cancer Cell International 2012 12:7
    Content type: Primary research Published on:

  21. Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and...

    Authors: Devan E Thompson, Megan D Siwicky and Roger A Moorehead
    Citation: Cancer Cell International 2012 12:6
    Content type: Primary research Published on:

  22. Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeut...

    Authors: Elizabeth Hijona, Jesús María Banales, Lander Hijona, Juan Francisco Medina, Juan Arenas, Marta Herreros-Villanueva, Pablo Aldazabal and Luis Bujanda
    Citation: Cancer Cell International 2012 12:5
    Content type: Primary research Published on:

  23. Removal of numerous classes of chemical pollutants from the industrial wastewater such as textile, pharmaceutical and olive mill using conventional wastewater treatment, is incomplete and several studies sugge...

    Authors: Hedi Ben Mansour, Afef Dellai and Yosra Ayed
    Citation: Cancer Cell International 2012 12:4
    Content type: Primary research Published on:

  24. The aim of this study was to evaluate the biological and pharmaceutical activities of 14 amphiphilic liquid-crystalline compounds (LCs), i.e, phenylpyrimidine derivatives possessing D-glucamine and cyanobiphenyl ...

    Authors: Junya Ishikawa, Yuuka Takahashi, Masaharu Hazawa, Yukako Fukushi, Atsushi Yoshizawa and Ikuo Kashiwakura
    Citation: Cancer Cell International 2012 12:3
    Content type: Primary research Published on:

  25. Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administra...

    Authors: Micaela Martinez, Nadia Ono, Marina Planutiene, Kestutis Planutis, Edward L Nelson and Randall F Holcombe
    Citation: Cancer Cell International 2012 12:2
    Content type: Editorial Published on:

    The Erratum to this article has been published in Cancer Cell International 2013 13:80

  26. Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments. Identifying novel drug targets for this indicat...

    Authors: Friedrich G Kapp, Anette Sommer, Thomas Kiefer, Gottfried Dölken and Bernard Haendler
    Citation: Cancer Cell International 2012 12:1
    Content type: Primary research Published on:

  27. Currently, Atypical Teratoid Rhabdoid Tumor (AT/RT) constitutes one of the most difficult to treat malignancies in pediatrics. Hence, new knowledge of potential targets for therapeutics and the development of ...

    Authors: Aarthi Jayanthan, Delphine Bernoux, Pinaki Bose, Karl Riabowol and Aru Narendran
    Citation: Cancer Cell International 2011 11:44
    Content type: Primary research Published on:

  28. In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity. Since 2ME2 has limited biological acces...

    Authors: Michelle H Visagie and Anna M Joubert
    Citation: Cancer Cell International 2011 11:43
    Content type: Primary research Published on:

  29. Dysregulation of many apoptotic related genes and androgens are critical in the development, progression, and treatment of prostate cancer. The differential sensitivity of tumour cells to TRAIL-induced apoptos...

    Authors: David Vindrieux, Marie Réveiller, Jacqueline Chantepie, Sadok Yakoub, Catherine Deschildre, Alain Ruffion, Marian Devonec, Mohamed Benahmed and Renée Grataroli
    Citation: Cancer Cell International 2011 11:42
    Content type: Primary research Published on:

  30. Neuron specific enolase (ENO2, γ-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. The goal of the present study was to determine if ENO2 expression in the...

    Authors: Maureen A Soh, Scott H Garrett, Seema Somji, Jane R Dunlevy, Xu Dong Zhou, Mary Ann Sens, Chandra S Bathula, Christina Allen and Donald A Sens
    Citation: Cancer Cell International 2011 11:41
    Content type: Primary research Published on:

  31. Hepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette...

    Authors: Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Susanne Serba, Markus W Büchler and Peter Schemmer
    Citation: Cancer Cell International 2011 11:40
    Content type: Primary research Published on:

  32. During cell division, replication of the genomic DNA is performed by high-fidelity DNA polymerases but these error-free enzymes can not synthesize across damaged DNA. Specialized DNA polymerases, so called DNA...

    Authors: Philip A Knobel and Thomas M Marti
    Citation: Cancer Cell International 2011 11:39
    Content type: Review Published on:

  33. This study was designed to evaluate the potential chemopreventive activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (...

    Authors: Hala O El Mesallamy, Nadia S Metwally, Mahmoud S Soliman, Kawkab A Ahmed and Mai M Abdel Moaty
    Citation: Cancer Cell International 2011 11:38
    Content type: Primary research Published on:

  34. In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.

    Authors: Jihed Boubaker, Wissem Bhouri, Mohamed Ben Sghaier, Ines Bouhlel, Ines Skandrani, Kamel Ghedira and Leila Chekir-Ghedira
    Citation: Cancer Cell International 2011 11:37
    Content type: Primary research Published on:

  35. Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular mach...

    Authors: SNCVL Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, JL Aditya, Ravindra M Kumbhare, Utpal Bhadra and Manika Pal Bhadra
    Citation: Cancer Cell International 2011 11:36
    Content type: Primary research Published on:

  36. The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT)...

    Authors: Jessica T Li, Ka Bian, Alan L Zhang, Dong H Kim, William W Ashley, Rahul Nath, Ian McCutcheon, Bingliang Fang and Ferid Murad
    Citation: Cancer Cell International 2011 11:35
    Content type: Primary research Published on:

  37. Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its a...

    Authors: Melissa E Smith, Bhaskar C Das and Ganjam V Kalpana
    Citation: Cancer Cell International 2011 11:34
    Content type: Primary research Published on:

  38. Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors, a concept that is known as cancer immunosurveillan...

    Authors: Heba A Alshaker and Khalid Z Matalka
    Citation: Cancer Cell International 2011 11:33
    Content type: Review Published on:

  39. Cell fusion induced by polyethylene glycol (PEG) is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherap...

    Authors: Filippo Pedrazzoli, Iraklis Chrysantzas, Luca Dezzani, Vittorio Rosti, Massimo Vincitorio and Giammaria Sitar
    Citation: Cancer Cell International 2011 11:32
    Content type: Primary research Published on:

  40. The objective of this study was to investigate whether the levels of glucose or certain amino acids could regulate the expression of a cell cycle repressor protein p27(Kip1), thereby dictating the risk of canc...

    Authors: Isao Eto
    Citation: Cancer Cell International 2011 11:31
    Content type: Primary research Published on:

  41. The synergic action of KHCO3 and D-ribose is tested on A72 and HTB-126 cell lines proliferation using K:D-Rib solution. Altered Na+/K+ ATPase expression and activity were shown in patients with cancer. Studies in...

    Authors: Simonetta Croci, Luca Bruni, Simona Bussolati, Marianna Castaldo and Maurizio Dondi
    Citation: Cancer Cell International 2011 11:30
    Content type: Primary research Published on:

  42. The inhibition of Br east Ca ncer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been iden...

    Authors: Johanne I Weberpals, Anna M O'Brien, Nima Niknejad, Kyla D Garbuio, Katherine V Clark-Knowles and Jim Dimitroulakos
    Citation: Cancer Cell International 2011 11:29
    Content type: Primary research Published on:

  43. Molecular classification of human breast cancers has identified at least 5 distinct tumor subtypes; luminal A, luminal B, Her2-enriched, basal-like and claudin-low. The claudin-low subtype was identified in 20...

    Authors: Craig I Campbell, Devan E Thompson, Megan D Siwicky and Roger A Moorehead
    Citation: Cancer Cell International 2011 11:28
    Content type: Primary research Published on:

  45. In this study, we pilot tested an in vitro assay of cancer killing activity (CKA) in circulating leukocytes of 22 cancer cases and 25 healthy controls.

    Authors: Michael J Blanks, John R Stehle Jr, Wei Du, Jonathan M Adams, Mark C Willingham, Glenn O Allen, Jennifer J Hu, James Lovato, Istvan Molnar and Zheng Cui
    Citation: Cancer Cell International 2011 11:26
    Content type: Primary research Published on:

  46. Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer c...

    Authors: Brandon M Schickling, Nukhet Aykin-Burns, Kimberly K Leslie, Douglas R Spitz and Victoria P Korovkina
    Citation: Cancer Cell International 2011 11:25
    Content type: Primary research Published on:

  47. In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical ...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer
    Citation: Cancer Cell International 2011 11:24
    Content type: Review Published on:

  48. Brain-derived neurotrophic factor (BDNF) has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, inclu...

    Authors: Neill Patani, Wen G Jiang and Kefah Mokbel
    Citation: Cancer Cell International 2011 11:23
    Content type: Primary research Published on:

  49. Previously we have shown that oncogenic Ha-Ras stimulated in vivo metastasis through RalGEF-Ral signaling. RalA and RalB are highly homologous small G proteins belonging to Ras superfamily. They can be activated ...

    Authors: Vera A Rybko, Anna V Knizhnik, Andrei V Komelkov, Vasily N Aushev, Lyubov S Trukhanova and Elena M Tchevkina
    Citation: Cancer Cell International 2011 11:22
    Content type: Primary research Published on:

  50. Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tis...

    Authors: Christa Nagler, Cornelia Hardt, Kurt S Zänker and Thomas Dittmar
    Citation: Cancer Cell International 2011 11:21
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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