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  1. The HSP70 family of heat shock protein plays a critical role in protein synthesis and transport to maintain protein homeostasis. Several studies have indicated that HSP70s are related to the development and oc...

    Authors: Ben Wang, Tian Lan, Han Xiao, Zhong-Huo Chen, Chao Wei, Lei-Feng Chen, Jia-Fu Guan, Rong-Fa Yuan, Xin Yu, Zhi-Gang Hu, Hua-Jun Wu, Zhi Dai and Kai Wang

    Citation: Cancer Cell International 2021 21:286

    Content type: Primary research

    Published on:

  2. Multiple myeloma (MM) is a highly aggressive and incurable clonal plasma cell disease with a high rate of recurrence. Thus, the development of new therapies is urgently needed. DCZ0805, a novel compound synthe...

    Authors: Xuejie Gao, Bo Li, Anqi Ye, Houcai Wang, Yongsheng Xie, Dandan Yu, Zhijian Xu, Bingqing Shi, Hui Zhang, Qilin Feng, Ke Hu, Yong Zhang, Cheng Huang, Guang Yang, Jumei Shi and Weiliang Zhu

    Citation: Cancer Cell International 2021 21:285

    Content type: Primary research

    Published on:

  3. Ovarian cancer (OC) is a high-mortality gynecological cancer that is typically treated with cisplatin, although such treatment often results in chemoresistance. Ovarian cancer resistance is usually related to ...

    Authors: Yue Wu, Ting Wang, Lin Xia and Mei Zhang

    Citation: Cancer Cell International 2021 21:284

    Content type: Primary research

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  4. Stromal components of the tumor microenvironment contribute to bladder cancer progression, and Cancer-Associated Fibroblasts (CAFs) were reported to play an important role. Accumulating pieces of evidence indi...

    Authors: YiHeng Du, Xiang Jiang, Bo Wang, Jin Cao, Yi Wang, Jiang Yu, XiZhi Wang and HaiTao Liu

    Citation: Cancer Cell International 2021 21:283

    Content type: Primary research

    Published on:

  5. This study aimed to analyze the lymphocyte subsets, their activities and their dynamic changes during immunochemotherapy in patients newly diagnosed with diffuse large B cell lymphoma (DLBCL).

    Authors: Hongyan Hou, Ying Luo, Guoxing Tang, Bo Zhang, Renren Ouyang, Ting Wang, Min Huang, Shiji Wu, Dengju Li and Feng Wang

    Citation: Cancer Cell International 2021 21:282

    Content type: Primary research

    Published on:

  6. Systematic profiling studies have implicated regulators of pre-mRNA splicing as important disease determinants in gastric cancer (GC), but the underlying mechanisms have remained elusive. Here we focused on hn...

    Authors: Wei-zhao Peng, Jin Zhao, Xin Liu, Chao-feng Li, Shuang Si and Ren Ma

    Citation: Cancer Cell International 2021 21:281

    Content type: Primary research

    Published on:

  7. Long non-coding RNAs (lncRNAs) have been certified to play vital biological functions in glioma and have received considerable attention in the recent literature. Nonetheless, the role of LINC01158 in glioma r...

    Authors: Zhenxing Sun, Naili Wei, Shenglian Yao, Guihuai Wang, Yaxing Sun, Zhenze Wang and Dan Yuan

    Citation: Cancer Cell International 2021 21:280

    Content type: Primary research

    Published on:

  8. Bortezomib (BTZ) is an inhibitor of the proteasome that has been used to treat patients with mantle cell lymphoma (MCL), but the resistance to BTZ in clinical cases remains a major drawback. BACH2 is a lymphoi...

    Authors: Min Feng, Jia Wang, Ming Sun, Guilan Li, BingXiang Li and Han Zhang

    Citation: Cancer Cell International 2021 21:279

    Content type: Primary research

    Published on:

  9. Epstein Barr-virus (EBV) is related to several cancers. Long non-coding RNAs (lncRNAs) act by regulating target genes and are involved in tumourigenesis. However, the role of lncRNAs in EBV-associated cancers ...

    Authors: Yitong Liu, Zhizhong Hu, Yang Zhang and Chengkun Wang

    Citation: Cancer Cell International 2021 21:278

    Content type: Review

    Published on:

  10. Precise quantification of microRNA is challenging since circulating mRNA and rRNA in the blood are usually degraded. Therefore, it is necessary to identify specific biomarkers for ovarian cancer. This study ai...

    Authors: San-Gang Wu, Ping Zhou, Jian-Xian Chen, Jian Lei, Li Hua, Yong Dong, Min Hu, Chen-Lu Lian, Li-Chao Yang and Juan Zhou

    Citation: Cancer Cell International 2021 21:277

    Content type: Primary research

    Published on:

  11. Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our stud...

    Authors: Wen Yin, Hecheng Zhu, Jun Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Lei Wang, Ming Zhao, Xingjun Jiang, Caiping Ren and Guihua Tang

    Citation: Cancer Cell International 2021 21:276

    Content type: Primary research

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  13. Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long inte...

    Authors: Menggang Zhang, Fang Gao, Xiao Yu, Qiyao Zhang, Zongzong Sun, Yuting He and Wenzhi Guo

    Citation: Cancer Cell International 2021 21:274

    Content type: Review

    Published on:

  14. Chemoresistance is one of the major obstacles for cancer therapy in the clinic. Circular RNAs (circRNAs) are involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and chemoresistance. This ...

    Authors: Fanyong Qu, Lina Wang, Caiyan Wang, Lingxia Yu, Kaikai Zhao and Hao Zhong

    Citation: Cancer Cell International 2021 21:273

    Content type: Primary research

    Published on:

  16. The implication of circular RNAs (circRNAs) in human cancers has aroused much concern. In this study, we investigated the function of circ_0000745 and its potential functional mechanisms in oral squamous cell ...

    Authors: Kuangzheng Li, Xiaosheng Fan, Ziyi Yan, Jia Zhan, Fangyun Cao and Yixia Jiang

    Citation: Cancer Cell International 2021 21:271

    Content type: Primary research

    Published on:

  17. Artificial intelligence (AI) is the use of mathematical algorithms to mimic human cognitive abilities and to address difficult healthcare challenges including complex biological abnormalities like cancer. The ...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Haleema Sadia, Ijaz A. Qureshi, Asma Irshad, Rais Ahmed, Kausar Malik, Shahid Raza, Asif Abbas, Raffaele Pezzani and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:270

    Content type: Review

    Published on:

  18. Endometrial cancer (EC) is one of the three malignant reproductive tumours that threaten women’s lives and health. Glycerophospholipids (GPLs) are important bioactive lipids involved in various physiological a...

    Authors: Tianyi Zhao, Yifang Zhang, Xiaohong Ma, Lina Wei, Yixin Hou, Rui Sun and Jie Jiang

    Citation: Cancer Cell International 2021 21:269

    Content type: Primary research

    Published on:

  19. Accumulating evidences indicate that the signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) plays a key role in the development and progression of many human cancers. However, the underlying mech...

    Authors: Qin Huo, Xi He, Zhenwei Li, Fan Yang, Shengnan He, Ling Shao, Ye Hu, Siqi Chen and Ni Xie

    Citation: Cancer Cell International 2021 21:268

    Content type: Primary research

    Published on:

  20. Triple-negative breast cancer (TNBC) is more commonly associated with young patients, featuring high histological grade, visceral metastasis, and distant recurrence. Follistatin (FST) is a secreted extracellul...

    Authors: Sainan Liu, Bin Liu, Qian Zhao, Jikang Shi, Yulu Gu, Yanbo Guo, Yong Li, Yunkai Liu, Yi Cheng, Yichun Qiao and Yawen Liu

    Citation: Cancer Cell International 2021 21:267

    Content type: Primary research

    Published on:

  21. The clinical outcome of patients with a diagnosis of hormone receptor (HR)+ breast cancer has improved remarkably since the arrival of endocrine therapy. Yet, resistance to standard treatments is a major clini...

    Authors: Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Marco Invernizzi, Elena Guerini-Rocco, Svasti Haricharan and Nicola Fusco

    Citation: Cancer Cell International 2021 21:266

    Content type: Review

    Published on:

  22. Accumulating evidence implies that autophagy plays a critical role in breast cancer development and progression. It is crucial to screen out autophagy-related encoding genes (ARGs) with prognostic value in bre...

    Authors: Xiaoying Li, Yu Cao, Xinmiao Yu, Feng Jin and Yang Li

    Citation: Cancer Cell International 2021 21:265

    Content type: Primary research

    Published on:

  23. Gastric cancer (GC) is general disease in human digestive system with malignancy. Emerging findings indicated that hsa_circ_0031452 (circHECTD1) was strictly associated with carcinogenesis. Nevertheless, the r...

    Authors: Yizhuo Lu, Long Li, Lianghui Li, Guoyang Wu and Guoyan Liu

    Citation: Cancer Cell International 2021 21:264

    Content type: Primary research

    Published on:

  24. Our study aims to investigate the mechanism of the miR-129-5p/SPN axis in clear cell renal cell carcinoma (ccRCC), providing a novel direction for the targeted therapy of ccRCC.

    Authors: Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao and Yifei Liu

    Citation: Cancer Cell International 2021 21:263

    Content type: Primary research

    Published on:

  25. It has been intensively reported that the immunosuppressive tumor microenvironment (TME) results in tumor resistance to immunotherapy, especially immune checkpoint blockade and chimeric T cell antigen therapy....

    Authors: Yalei Zhang, Ye Li, Kun Chen, Ling Qian and Peng Wang

    Citation: Cancer Cell International 2021 21:262

    Content type: Review

    Published on:

  26. Burkitt lymphoma (BL) is a highly aggressive, fast-growing B-cell non-Hodgkin's lymphoma, manifested in several subtypes, including sporadic, endemic, and immunodeficiency-related forms, the mechanism of which...

    Authors: Zhao Wang, Meiting Chen, Xiaojie Fang, Huangming Hong, Yuyi Yao and He Huang

    Citation: Cancer Cell International 2021 21:261

    Content type: Primary research

    Published on:

  28. Exploring the molecular mechanisms of lung adenocarcinoma (LUAD) is beneficial for developing new therapeutic strategies and predicting prognosis. This study was performed to select core genes related to LUAD ...

    Authors: Huan Deng, Qingqing Hang, Dijian Shen, Yibi Zhang and Ming Chen

    Citation: Cancer Cell International 2021 21:259

    Content type: Primary research

    Published on:

  29. Colorectal cancer (CRC), with a growing incidence trend worldwide, is resistant to apoptosis and has uncontrolled proliferation. It is recently reported that probiotic microorganisms exert anticancer effects. ...

    Authors: Zeinab Faghfoori, Mohammad Hasan Faghfoori, Amir Saber, Azimeh Izadi and Ahmad Yari Khosroushahi

    Citation: Cancer Cell International 2021 21:258

    Content type: Primary research

    Published on:

  30. CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, howe...

    Authors: Dexin Shen, Yayun Fang, Fenfang Zhou, Zhao Deng, Kaiyu Qian, Gang Wang, Yu Xiao, Lingao Ju and Xinghuan Wang

    Citation: Cancer Cell International 2021 21:257

    Content type: Primary research

    Published on:

  32. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01958-0

    Authors: Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu and Hua Tang

    Citation: Cancer Cell International 2021 21:255

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2017 17:36

  33. Hepatocellular carcinoma is one of the most common malignant tumors worldwide and the fourth leading cause of cancer-related deaths. The prognosis of hepatocellular carcinoma patients is extremely poor due to ...

    Authors: Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen and Shuying Chen

    Citation: Cancer Cell International 2021 21:254

    Content type: Review

    Published on:

  34. Regulatory factor X1 (RFX1) is an evolutionary conserved transcriptional factor that influences a wide range of cellular processes such as cell cycle, cell proliferation, differentiation, and apoptosis, by reg...

    Authors: Joby Issac, Pooja S. Raveendran and Ani V. Das

    Citation: Cancer Cell International 2021 21:253

    Content type: Review

    Published on:

  35. The role of HHLA2, a new immune checkpoint ligand, is gradually being elucidated in various solid tumours. However, its role in ovarian cancer remains unclear; thus, its expression profile and clinical signifi...

    Authors: Guocai Xu, Yuanyuan Shi, Xiaoting Ling, Dongyan Wang, Yunyun Liu, Huaiwu Lu, Yongpai Peng and Bingzhong Zhang

    Citation: Cancer Cell International 2021 21:252

    Content type: Primary research

    Published on:

  36. Bladder cancer is the leading causes of cancer-associated mortality and seriously affects population health. Hypoxia plays a key role in tumor development and immune escape, which contributes to malignant beha...

    Authors: Xianchao Sun, Zhen Zhou, Ying Zhang, Jinyou Wang, Xiaofeng Zhao, Liang Jin, Tingshuai Zhai, Xiang Liu, Jiaxin Zhang, Wangli Mei, Bihui Zhang, Ming Luo, Xudong Yao and Lin Ye

    Citation: Cancer Cell International 2021 21:251

    Content type: Primary research

    Published on:

  37. The hsa_circ_0004771 derived from NRIP1 (called circ_NRIP1) is a recently identified oncogenic circRNA. Here, we intended to investigate the role and mechanism of circ_NRIP1 in esophageal squamous cell carcino...

    Authors: Shifan Zhou, Zhizhong Guo, Chaofeng Zhou, Yu Zhang and Sai Wang

    Citation: Cancer Cell International 2021 21:250

    Content type: Primary research

    Published on:

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang

    Citation: Cancer Cell International 2021 21:248

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:167

  40. In vivo imaging using fluorescence is used in cancer biology for the detection, measurement and monitoring of tumours. This can be achieved with the expression of fluorescent proteins such as iRFP, which emits...

    Authors: C. Hall, Y. von Grabowiecki, S. P. Pearce, C. Dive, S. Bagley and P. A. J. Muller

    Citation: Cancer Cell International 2021 21:247

    Content type: Primary research

    Published on:

  41. Renal clear cell carcinoma (ccRCC) is one of the most common malignant tumors, whose incidence is increasing year by year. IRF6 plays an important role in the occurrence of tumors, although there is yet no rep...

    Authors: Xinwei Ma, Xiaoqi Wang, Qian Dong, Hongquan Pang, Jianming Xu, Junkang Shen and Jianbing Zhu

    Citation: Cancer Cell International 2021 21:246

    Content type: Primary research

    Published on:

  42. Osteosarcoma patients often experience poor outcomes despite chemotherapy treatment, likely due in part to various mechanisms of tumor cell innate and/or acquired drug resistance. Exosomes, microvesicles secre...

    Authors: Marcus A. Weinman, Stephen A. Ramsey, Haley J. Leeper, Jacqueline V. Brady, Andrew Schlueter, Stanislau Stanisheuski, Claudia S. Maier, Tasha Miller, Carl E. Ruby and Shay Bracha

    Citation: Cancer Cell International 2021 21:245

    Content type: Primary research

    Published on:

  43. Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems. Therefore, to enhance the delivery and ...

    Authors: Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi and Ala Habibian

    Citation: Cancer Cell International 2021 21:244

    Content type: Primary research

    Published on:

  44. S100A11 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. The dysregulated expression of the S100A11 gene has been implicated in tumour metastasis. However, the role of ...

    Authors: Yuxin Cui, Liting Li, Zhilei Li, Jie Yin, Jane Lane, Jiafu Ji and Wen G. Jiang

    Citation: Cancer Cell International 2021 21:243

    Content type: Primary research

    Published on:

  45. Bladder cancer is a frequently diagnosed urinary system tumor, whose mortality remains rising. Minichromosome maintenance eight homologous recombination repair factor (MCM8), a newly discovered MCM family memb...

    Authors: Wei Zhu, Fei Gao, Hongyi Zhou, Ke Jin, Jianfeng Shao and Zhuoqun Xu

    Citation: Cancer Cell International 2021 21:242

    Content type: Primary research

    Published on:

  46. Although miR-190 has been reported to be related to human diseases, especially in the development and progression of cancer, its expression in human bladder cancer (BC) and potential contribution to BC remain ...

    Authors: Shirui Huang, Xiaohui Hua, Mengjiao Kuang, Junlan Zhu, Haiqi Mu, Zhongxian Tian, Xiaoqun Zheng and Qipeng Xie

    Citation: Cancer Cell International 2021 21:241

    Content type: Primary research

    Published on:

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei and Huawei Yang

    Citation: Cancer Cell International 2021 21:240

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:55

  48. Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. The majority of clinically used PD-1/PD-L1 inhibitors are monoclonal...

    Authors: Chang Liu, Navindra P. Seeram and Hang Ma

    Citation: Cancer Cell International 2021 21:239

    Content type: Review

    Published on:

  49. Colon cancer is a malignant gastrointestinal tumour with high incidence, mortality and metastasis rates worldwide. Aloe-emodin is a monomer compound derived from hydroxyanthraquinone. Aloe-emodin produces a wi...

    Authors: Dongxiao Jiang, Shufei Ding, Zhujun Mao, Liyan You and Yeping Ruan

    Citation: Cancer Cell International 2021 21:238

    Content type: Primary research

    Published on:

  50. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu and Dong Chen

    Citation: Cancer Cell International 2021 21:237

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2019 19:271

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Cancer Cell International

ISSN: 1475-2867

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