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  1. Breast cancer (BC) threatens the health of women around the world. Researchers have proved that hsa_circ_0005505 (circ_IRAK3) facilitates BC cell invasion and migration, but the regulatory mechanisms of circ_I...

    Authors: Fang Wang, Jingruo Li, Lin Li, Zhuo Chen, Nan Wang, Mingzhi Zhu, Hailong Mi, Youyi Xiong, Guangcheng Guo and Yuanting Gu
    Citation: Cancer Cell International 2022 22:81
    Content type: Primary research Published on:

  2. The gasdermins (GSDMs) family is proposed to be pore-forming effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our increasing knowledge of GSDMD, GSDME and GSDMB, the biologic...

    Authors: Mingchao Mu, Qiaoling Yu, Qin Zhang, Jing Guo, Xingjie Wang, Xuejun Sun and Junhui Yu
    Citation: Cancer Cell International 2022 22:80
    Content type: Primary research Published on:

  4. The role of circular RNAs (circRNAs) and microRNAs (miRNAs) in osteosarcoma (OS) development has not been fully elucidated. Further, the contribution of the immune response to OS progression is not well define...

    Authors: Zhihao Chen, Liubing Li, Ziyuan Li, Xi Wang, Mingxiao Han, Zongshuai Gao, Min Wang, Gangfeng Hu, Xiaolu Xie, Hong Du, Zonggang Xie and Haifang Zhang
    Citation: Cancer Cell International 2022 22:78
    Content type: Primary research Published on:

  6. Thyroid cancer is the most common malignant endocrine tumour, and metastasis has become the main reason for treatment failure. However, the underlying molecular mechanism of thyroid cancer metastasis remains p...

    Authors: Yankun Zhang, Min Sun, Lifen Gao, Xiaohong Liang, Chunhong Ma, Jinghui Lu and Xuetian Yue
    Citation: Cancer Cell International 2022 22:76
    Content type: Primary research Published on:

  7. Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women in China. In previous studies, Sestrin2 was demonstrated to have functions in CRC. However, the relationship between ...

    Authors: Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li and Zhongxue Fu
    Citation: Cancer Cell International 2022 22:75
    Content type: Primary research Published on:

  8. Although the prognosis for most patients with papillary thyroid cancer (PTC) is good, the present treatment is ineffective for 5–10% patients. Several studies found sodium–glucose cotransporter 2 (SGLT2) inhib...

    Authors: Yan Wang, Longyan Yang, Lin Mao, Lijie Zhang, Yingjun Zhu, Yongsong Xu, Yanan Cheng, Rongxin Sun, Yuanyuan Zhang, Jing Ke and Dong Zhao
    Citation: Cancer Cell International 2022 22:74
    Content type: Primary research Published on:

  9. Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced hepatocellular carcinoma. Sorafeni...

    Authors: Ruyin Chen, Qiong Li, Shuaishuai Xu, Chanqi Ye, Tian Tian, Qi Jiang, Jianzhen Shan and Jian Ruan
    Citation: Cancer Cell International 2022 22:73
    Content type: Review Published on:

  10. N6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications of RNA. However, there is limited information about the potential roles of m6A regulators in tumor immunity. Therefore, in t...

    Authors: Jianfeng Cui, Yaofeng Zhu, Xiaochen Liu, Wenfu Wang, Xuewen Jiang, Yangyang Xia, Guanwen Zhou, Shouzhen Chen and Benkang Shi
    Citation: Cancer Cell International 2022 22:72
    Content type: Primary research Published on:

  11. Colorectal cancer (CRC) is the second most common cause of cancer mortality and a major health challenge worldwide. Despite advances in therapeutic and diagnostic methods, there is still a poor prognosis in CR...

    Authors: Amir Abbas Hamidi, Ghazaleh Khalili-Tanha, Zahra Nasrpour Navaei and Meysam Moghbeli
    Citation: Cancer Cell International 2022 22:71
    Content type: Review Published on:

  12. Fermitin family member 1 (FERMT1) is significantly overexpressed in human cancers and associated with poor prognosis, but its contributions to tumorigenesis and nasopharyngeal carcinoma (NPC) progression remai...

    Authors: Lingling Li, Piao Li, Wei Zhang, Haiting Zhou, Ergang Guo, Guoqing Hu and Linli Zhang
    Citation: Cancer Cell International 2022 22:70
    Content type: Primary research Published on:

  13. Gastric cancer (GC), the most commonly diagnosed cancer worldwide with poor 5-year survival rate in advanced stages. Although immune-related and survival-related biomarkers, which typically comprise aberrantly...

    Authors: Jun Wang, Beidi Wang, Biting Zhou, Jing Chen, Jia Qi, Le Shi, Shaojun Yu, Guofeng Chen, Muxing Kang, Xiaoli Jin, Lie Wang, Jinghong Xu, Linghua Zhu and Jian Chen
    Citation: Cancer Cell International 2022 22:69
    Content type: Primary research Published on:

  14. The Kirsten ras oncogene KRAS is a member of the small GTPase superfamily participating in the RAS/MAPK pathway. A single amino acid substitution in KRAS gene has been shown to activate the encoded protein result...

    Authors: Soudeh Ghafouri-Fard, Zeinab Shirvani-Farsani, Bashdar Mahmud Hussen, Mohammad Taheri and Reza Jalili Khoshnoud
    Citation: Cancer Cell International 2022 22:68
    Content type: Review Published on:

  15. Copine1 (CPNE1), the first discovered CPNE1 family member, participates in the process of carcinogenesis and development of diverse tumors. Our study aimed to investigate the expression and prognostic value of...

    Authors: Jinfang Su, Yongbiao Huang, Yali Wang, Rui Li, Wanjun Deng, Hao Zhang and Huihua Xiong
    Citation: Cancer Cell International 2022 22:67
    Content type: Primary research Published on:

  16. Clear cell renal cell carcinoma (ccRCC) is one of the most lethal malignancies in the urinary system and the existing immunotherapy has not achieved satisfactory outcomes. Therefore, this study aims at establi...

    Authors: Daojia Miao, Jian Shi, Zhiyong Xiong, Wen Xiao, Xiangui Meng, Qingyang Lv, Kairu Xie, Hongmei Yang and Xiaoping Zhang
    Citation: Cancer Cell International 2022 22:66
    Content type: Primary research Published on:

  17. Tumor microenvironments are characterized by resistance to chemotherapeutic agents and radiotherapy. Hypoxia plays an important role in the development of tumor resistance, as well as the generation of metasta...

    Authors: Dengke Zhang, Fazong Wu, Jingjing Song, Miaomiao Meng, Xiaoxi Fan, Chenying Lu, Qiaoyou Weng, Shiji Fang, Liyun Zheng, Bufu Tang, Yang Yang, Jianfei Tu, Min Xu, Zhongwei Zhao and Jiansong Ji
    Citation: Cancer Cell International 2022 22:65
    Content type: Primary research Published on:

  18. Osteosarcoma (OS) is a tumour with a high malignancy level and a poor prognosis. First-line chemotherapy for OS has not been improved for many decades. Bromodomain and extraterminal domain (BET) and histone de...

    Authors: Bo Yu, Lang Liu, Feng Cai, Yuanxiang Peng, Xiaofeng Tang, Duo Zeng, Teng Li, Feifei Zhang, Yiping Liang, Xuhui Yuan, Jiayu Li, Zhengzai Dai, Qi Liao and Xiao-Bin Lv
    Citation: Cancer Cell International 2022 22:64
    Content type: Primary research Published on:

  19. Authors: Feng Qiu, Bin Qiao, Nan Zhang, Zheng Fang, Lu Feng, Shanfeng Zhang and Weiliu Qiu
    Citation: Cancer Cell International 2022 22:63
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:412

  20. Head and neck squamous cell carcinoma (HNSCC) is a major threat to public health. Pyroptosis is a form of inflammatory programmed cell death that is still incompletely understood. The role of pyroptotic cell d...

    Authors: Weiwen Zhu, Jiayi Zhang, Mengyao Wang, Rundong Zhai, Yanbin Xu, Jie Wang, Mengqi Wang, Hang Zhang and Laikui Liu
    Citation: Cancer Cell International 2022 22:62
    Content type: Primary research Published on:

  21. Radioiodine (RAI) is the mainstay of treatment for differentiated thyroid carcinoma (DTC) following total thyroidectomy. Nevertheless, about 5% of patients with DTC are RAI-refractory (RAI-R). Understanding th...

    Authors: Hilda Samimi and Vahid Haghpanah
    Citation: Cancer Cell International 2022 22:61
    Content type: Hypothesis Published on:

  22. Present work systematically reviewed relevant literature based on 18F-FDG PET parameters and conducted a meta-analysis to examine the prognostic value of maximal standard uptake value (SUVmax), total lesional ...

    Authors: Weibo Wen, Dongyuan Xu, Yongnan Piao and Xiangdan Li
    Citation: Cancer Cell International 2022 22:60
    Content type: Review Published on:

  23. The prevalence of lung adenocarcinoma (LUAD) has increased, thus novel biomarkers for its early diagnosis is becoming more important than ever. tRNA-derived small RNA (tsRNA) is a new class of non-coding RNA w...

    Authors: Jun Wang, Xianyu Liu, Weifang Cui, Qun Xie, Wei Peng, Heng Zhang, Yang Gao, Chunfang Zhang and Chaojun Duan
    Citation: Cancer Cell International 2022 22:59
    Content type: Primary research Published on:

  24. Colorectal cancer (CRC) has become the second deadliest cancer in the world and severely threatens human health. An increasing number of studies have focused on the role of the RNA helicase DEAD-box (DDX) fami...

    Authors: Xin Zhou, Zhihong Liu, Tengfei He, Cuifeng Zhang, Manman Jiang, Yuxiao Jin, Ziyu Wu, Changji Gu, Wei Zhang and Xiaodong Yang
    Citation: Cancer Cell International 2022 22:58
    Content type: Primary research Published on:

  25. Hepatocellular carcinoma (HCC) often presents with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge in personalized medicine....

    Authors: Nan Zhao, Yanhui Zhang, Runfen Cheng, Danfang Zhang, Fan Li, Yuhong Guo, Zhiqiang Qiu, Xueyi Dong, Xinchao Ban, Baocun Sun and Xiulan Zhao
    Citation: Cancer Cell International 2022 22:57
    Content type: Primary research Published on:

  28. Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) are typically characterized by metastasis and chemoresistance. Cell lines are important model systems for developing new therapeutic s...

    Authors: Eva-Maria Packeiser, Leila Taher, Weibo Kong, Mathias Ernst, Julia Beck, Marion Hewicker-Trautwein, Bertram Brenig, Ekkehard Schütz, Hugo Murua Escobar and Ingo Nolte
    Citation: Cancer Cell International 2022 22:54
    Content type: Primary research Published on:

  29. Cysteine cathepsin C encoded by the CTSC gene is an important member of the cysteine cathepsin family that plays a key role regulation of many types of tumors. However, whether CTSC is involved in the pathologica...

    Authors: Xingbo Cheng, Zhishuai Ren, Zhendong Liu, Xiang Sun, Rongjun Qian, Chen Cao, Binfeng Liu, Jialin Wang, Hongbo Wang, Yuqi Guo and Yanzheng Gao
    Citation: Cancer Cell International 2022 22:53
    Content type: Primary research Published on:

  30. Triple-receptor negative breast cancer (TNBC) is an aggressive breast tumor subtype that generally has a poor prognosis. This study aimed to investigate the role and regulatory mechanisms of Zinc finger MIZ-ty...

    Authors: Xiaopan Zou, Yan Liu, Jun Di, Wei Wei, Nobumoto Watanabe, Jiang Li and Xiaomeng Li
    Citation: Cancer Cell International 2022 22:52
    Content type: Primary Research Published on:

  31. Colorectal cancer (CRC) is a malignant tumor affecting people worldwide. Long noncoding RNAs (lncRNAs) is a crucial factor modulating various cancer progression, including CRC. Long intergenic non-protein codi...

    Authors: Shoushan Nan, Shuangxia Zhang, Rong Jin and Juelei Wang
    Citation: Cancer Cell International 2022 22:51
    Content type: Primary research Published on:

  32. Gastric cancer (GC) has a poor prognosis and limited therapeutic options. As a new promising cancer therapeutic approach, chimeric antigen receptor (CAR)-T cells represent a potential GC treatment. We investig...

    Authors: Fengqiang Sun, Xiaomei Yu, Ruixue Ju, Zhanzhao Wang and Yuhui Wang
    Citation: Cancer Cell International 2022 22:50
    Content type: Primary research Published on:

  33. The function of spindle apparatus coiled-coil protein 1 (SPDL1) as a cancer-promoting gene has been reported in a number of studies. However, the pan-cancer analysis of SPDL1 is still lacking. Here, we perform...

    Authors: Peng Song, Dilinaer Wusiman, Fenglan Li, Xiaoxuan Wu, Lei Guo, Wenbin Li, Shugeng Gao and Jie He
    Citation: Cancer Cell International 2022 22:49
    Content type: Primary research Published on:

  34. N6-Methyladenosine (m6A), the most abundant internal modification associated with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the expression of genes involved in many physiologica....

    Authors: Shanshan Wang, Wei Lv, Tao Li, Shubing Zhang, Huihui Wang, Xuemei Li, Lianzi Wang, Dongyue Ma, Yan Zang, Jilong Shen, Yuanhong Xu and Wei Wei
    Citation: Cancer Cell International 2022 22:48
    Content type: Review Published on:

  35. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the major causes of cancer-related death. Thymidylate synthase (TYMS) catalyzes the methylation of deoxy guanosine to d...

    Authors: Liang Wang, Caiyan Shi, Jie Yu and Yilin Xu
    Citation: Cancer Cell International 2022 22:47
    Content type: Primary Research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:384

  36. Authors: Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang and Hongyun Zhao
    Citation: Cancer Cell International 2022 22:46
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:458

  37. Authors: Ishita Gupta, Gheyath K. Nasrallah, Anju Sharma, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Ali A. Sultan, Moussa Alkhalaf, Semir Vranic and Ala-Eddin Al Moustafa
    Citation: Cancer Cell International 2022 22:45
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2020 20:107

  38. Malignant melanoma (MM) is highly metastatic and has the highest mortality rate in patients with skin cancer. The ERBB3 binding protein 1 (Ebp1) has been linked to the onset and progression of a number of mali...

    Authors: Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li and Lan Liu
    Citation: Cancer Cell International 2022 22:44
    Content type: Primary research Published on:

  39. N-[2-(5-methoxy-1H-indol-3-yl) ethyl] or simply melatonin is a biogenic amine produced by pineal gland and recently recognized various other organs. Because of a broad range of biological function melatonin is co...

    Authors: Mohammad Mirza-Aghazadeh-Attari, Ainaz Mihanfar, Bahman Yousefi and Maryam Majidinia
    Citation: Cancer Cell International 2022 22:43
    Content type: Review Published on:

  40. Despite advances in the development of efficient chemotherapy, the treatment of colorectal cancer (CRC) remains a challenge due to acquired chemoresistance. It has been reported that microRNAs (miRNAs) dysregu...

    Authors: Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su and Xianglin Yuan
    Citation: Cancer Cell International 2022 22:42
    Content type: Primary research Published on:

  42. Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially d...

    Authors: Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li and Jinsong Yan
    Citation: Cancer Cell International 2022 22:40
    Content type: Primary research Published on:

  43. Theabrownin (TB) is a bioactive component of tea and has been reported to exert effects against many human cancers, but its efficacy and mechanism on hepatocellular carcinoma (HCC) with different p53 genotypes...

    Authors: Jiaan Xu, Xiujuan Xiao, Bo Yan, Qiang Yuan, Xiaoqiao Dong, Quan Du, Jin Zhang, Letian Shan, Zhishan Ding, Li Zhou and Thomas Efferth
    Citation: Cancer Cell International 2022 22:39
    Content type: Primary research Published on:

  44. The tumour heterogeneous make-up of immune cell infiltrates is a key factor for the therapy response and prognosis of hepatocellular carcinoma (HCC). However, it is still a major challenge to comprehensively u...

    Authors: Juan Lu, Yanfei Chen, Xiaoqian Zhang, Jing Guo, Kaijin Xu and Lanjuan Li
    Citation: Cancer Cell International 2022 22:38
    Content type: Primary research Published on:

  46. To determine whether concurrent chemotherapy is necessary during locoregional radiotherapy (RT) after palliative chemotherapy (PCT) in patients with de novo metastatic nasopharyngeal carcinoma (mNPC).

    Authors: Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen and Yun-Fei Xia
    Citation: Cancer Cell International 2022 22:36
    Content type: Primary research Published on:

  47. Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role in the cancer-associated intercellular signaling communication has not yet been explored...

    Authors: Ying Gao, Zheng Yin, Yunling Qi, Hong Peng, Wenbin Ma, Ruizhi Wang and Wen Li
    Citation: Cancer Cell International 2022 22:35
    Content type: Primary research Published on:

  48. Silencing of the periostin gene (POSTN) can inhibit the biological process of several different cancers, and this inhibition may be related to down-regulation of PI3K/AKT signaling. However, the effect of POSTN o...

    Authors: Chaojian Xu, Ziyue Wang, Long Zhang, Yi Feng, Jia Lv, Zhuangzhuang Wu, Rong Yang, Taiyong Wu, Jian Li, Ruhao Zhou, Zhi Tian, Junjun Bai, Huadong Zhang, Yanping Lan and Zhi Lv
    Citation: Cancer Cell International 2022 22:34
    Content type: Primary research Published on:

  49. Epigenetic reprogramming reportedly has a crucial role in prostate cancer (PCa) progression. RNA modification is a hot topic in epigenetics, and N6-methyladenosine (m6A) accounts for approximately 60% of RNA c...

    Authors: Yongjun Quan, Xiaodong Zhang and Hao Ping
    Citation: Cancer Cell International 2022 22:33
    Content type: Primary research Published on:

  50. Glioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety of tumors. This study explored the therapeutic effec...

    Authors: Wei Li, Bai-sheng Huang, Yuan-yuan Xiong, Li-jian Yang and Li-xiang Wu
    Citation: Cancer Cell International 2022 22:32
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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