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  1. Recently, we have reported the induction of apoptosis by 2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-NC) in HepG2, T47D and HCT116 cells with low nano molar IC50 values. In this study, anti...

    Authors: Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand and Shima Hallaj Neishabouri
    Citation: Cancer Cell International 2015 15:55
    Content type: Primary research Published on:

  2. Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome re...

    Authors: Siaw Shi Boon and Sai-Peng Sim
    Citation: Cancer Cell International 2015 15:54
    Content type: Primary research Published on:

  3. The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsi...

    Authors: Chang-Yi Xiao, Bing-Bing Fu, Zhi-Ying Li, Gohar Mushtaq, Mohammad Amjad Kamal, Jia-Hua Li, Gui-Cheng Tang and Shuo-Shuang Xiao
    Citation: Cancer Cell International 2015 15:53
    Content type: Primary research Published on:

  4. Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors of Hpa can prevent the growth and metastasis of malignant tumor cells, and suramin...

    Authors: HuaPing Li, HuaLi Li, HongJie Qu, MingZhu Zhao, Bo Yuan, MingHua Cao and JinQuan Cui
    Citation: Cancer Cell International 2015 15:52
    Content type: Primary research Published on:

  5. The WASP (Wiskott-Aldrich syndrome protein) and WAVE (WASP Verpolin homologous) family of proteins are structurally related and responsible for regulation of actin polymerization through their interaction with...

    Authors: Muhammad Moazzam, Lin Ye, Ping-Hui Sun, Howard Kynaston and Wen G Jiang
    Citation: Cancer Cell International 2015 15:51
    Content type: Primary research Published on:

  6. Despite the clinical response of conventional anticancer therapy, including chemotherapeutic treatments, radiation therapy and corticosteroids, tumorigenic B-cell lymphomas show an incomplete response to clini...

    Authors: Nunzia Migliaccio, Camillo Palmieri, Immacolata Ruggiero, Giuseppe Fiume, Nicola M Martucci, Iris Scala, Ileana Quinto, Giuseppe Scala, Annalisa Lamberti and Paolo Arcari
    Citation: Cancer Cell International 2015 15:50
    Content type: Primary research Published on:

  7. MicroRNA is a type of endogenous non-coding RNA implicated in various cellular processes, and has been intensely investigated in the field of cancer research for many years. Here, we investigated the functions...

    Authors: Wei Zhang, Ye-qing Mao, Hua Wang, Wen-juan Yin, Shao-xing Zhu and Wei-cheng Wang
    Citation: Cancer Cell International 2015 15:49
    Content type: Primary research Published on:

  8. Lung adenocarcinoma (LAC), the primary histological type of non-small cell lung cancer (NSCLC), has displayed an increasing incidence and mortality worldwide. However, therapeutic approaches were limited. Dysr...

    Authors: Juan Li, Ping Li, Wei Zhao, Rui Yang, Shanshan Chen, Yong Bai, Shaozhi Dun, Xiaonan Chen, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Guoqiang Zhao and Guojun Zhang
    Citation: Cancer Cell International 2015 15:48
    Content type: Primary research Published on:

  9. Most of the knowledge about the mechanisms of multidrug resistance in lung cancer has been achieved through the use of cell lines isolated from tumours cultivated either in suspensions of isolated cells or in ...

    Authors: Raúl Barrera-Rodríguez and Jorge Morales Fuentes
    Citation: Cancer Cell International 2015 15:47
    Content type: Primary research Published on:

  10. Natural products with diverse bioactivities are becoming an important source of novel agents with medicinal potential. Cancer is a devastating disease that causes the death of millions of people each year. Thu...

    Authors: Mohamed Salah I Abaza, Khaled Y Orabi, Ebtehal Al-Quattan and Raja’a J Al-Attiyah
    Citation: Cancer Cell International 2015 15:46
    Content type: Primary research Published on:

  11. B7-homologue 3 (B7-H3), a recently identified immunoregulatory protein, has been shown to be overexpressed in human hepatocellular carcinoma (HCC). However, whether the dynamic expression pattern of B7-H3 cont...

    Authors: Fu-biao Kang, Ling Wang, Heng-chuan Jia, Dong Li, Hai-jun Li, Yin-ge Zhang and Dian-xing Sun
    Citation: Cancer Cell International 2015 15:45
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:570

  12. Wilms’ tumor (WT) is one of the most common malignant neoplasms of the urinary tract in children. Anaplastic histology (unfavorable histology) accounts for about 10% of whole WTs, and it is the single most imp...

    Authors: Jun Lu, Yan-Fang Tao, Zhi-Heng Li, Lan Cao, Shao-Yan Hu, Na-Na Wang, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Li-xiao Xu, Yan-Hong Li, Gang Li, He Zhao, Jian Ni…
    Citation: Cancer Cell International 2015 15:44
    Content type: Primary research Published on:

  13. The primary purpose of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of ATP binding cassette superfamily G member 2 (ABCG2) and outcome of tyrosine kinase inhibition...

    Authors: Xueqin Chen, Dadong Chen, Shaoyu Yang, Ruobing Ma, Yuelong Pan, Xin Li and Shenglin Ma
    Citation: Cancer Cell International 2015 15:43
    Content type: Primary research Published on:

  14. Mesenchymal stem cells (MSCs) in tumors have emerged as progenitors involved in stroma formation and metastasis of cancers, partially owing to their abilities to differentially express paracrine factors relate...

    Authors: Dongmei Chen, Shudan Liu, Huiming Ma, Xueyun Liang, Haibin Ma, Xiurui Yan, Bao Yang, Jun Wei and Xiaoming Liu
    Citation: Cancer Cell International 2015 15:42
    Content type: Primary research Published on:

  16. MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-378-5p is dysregulated in numerous human cancers ...

    Authors: Zhenlei Wang, Bin Ma, Xiaopin Ji, Yang Deng, Tao Zhang, Xiaojian Zhang, Haoji Gao, Hanxing Sun, Haoxuan Wu, Xianze Chen and Ren Zhao
    Citation: Cancer Cell International 2015 15:40
    Content type: Primary research Published on:

  17. Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in respons...

    Authors: Umar Wazir, Mona MAW Orakzai, Zubair S Khanzada, Wen G Jiang, Anup K Sharma, Abdul Kasem and Kefah Mokbel
    Citation: Cancer Cell International 2015 15:39
    Content type: Review Published on:

  18. In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes. miRNAs are a family of small ...

    Authors: Kaladhar B Reddy
    Citation: Cancer Cell International 2015 15:38
    Content type: Review Published on:

  19. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease and still continues to have the worst prognosis of all gastrointestinal malignancies. Reports have demonstrated that secretory leukocyte proteas...

    Authors: Wei Zhang, Jian-Long Yao, Shan-Chao Dong, Feng-Qiang Hou and He-Ping Shi
    Citation: Cancer Cell International 2015 15:37
    Content type: Primary research Published on:

  21. Previous studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-γ polymorphisms and HBV-related li...

    Authors: Yifan Sun, Yu Lu, Li Xie, Yan Deng, Shan Li and Xue Qin
    Citation: Cancer Cell International 2015 15:35
    Content type: Primary research Published on:

  23. Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However, its role in bladder cancer remains poor...

    Authors: Ming-Der Shi, Cheng-Kai Shiao, Yi-Chieh Lee and Yuan-Wei Shih
    Citation: Cancer Cell International 2015 15:33
    Content type: Primary research Published on:

  24. Extracellular double-stranded DNA participates in various processes in an organism. Here we report the suppressive effects of fragmented human double-stranded DNA along or in combination with cyclophosphamide ...

    Authors: Ekaterina A Alyamkina, Valeriy P Nikolin, Nelly A Popova, Alexandra M Minkevich, Artem V Kozel, Evgenia V Dolgova, Yaroslav R Efremov, Sergey I Bayborodin, Oleg M Andrushkevich, Oleg S Taranov, Vladimir V Omigov, Vladimir A Rogachev, Anastasia S Proskurina, Evgeniy I Vereschagin, Elena V Kiseleva, Maria V Zhukova…
    Citation: Cancer Cell International 2015 15:32
    Content type: Primary research Published on:

  25. Osteosarcoma is the most frequent bone cancer in children and young adults. The outcome of patients with advanced disease is dismal. Exploitation of tumor-immune cell interactions may provide novel therapeutic...

    Authors: Jens HW Pahl, Susy J Santos, Marieke L Kuijjer, Gerharda H Boerman, Laurens GL Sand, Karoly Szuhai, Annemarie Cleton-Jansen, R Maarten Egeler, Judith VMG Boveé, Marco W Schilham and Arjan C Lankester
    Citation: Cancer Cell International 2015 15:31
    Content type: Primary research Published on:

  26. Granulocyte colony-stimulating factor (G-CSF) promotes proliferation, survival, and differentiation of myeloid-linage leukemic cells, as well as normal hematopoietic cells. Terminal granulocytic differentiatio...

    Authors: Yoshihito Uchino, Noriyoshi Iriyama, Yoshihiro Hatta and Masami Takei
    Citation: Cancer Cell International 2015 15:30
    Content type: Primary research Published on:

  27. Plectin is one of the cytolinker proteins that play a crucial role in maintaining the integrity of cellular architecture. It is a component of desmosome complexes connecting cytoskeletal proteins and trans-mem...

    Authors: Chiung-Chi Cheng, Yen-Chang Clark Lai, Yih-Shyong Lai, Yung-Hsiang Hsu, Wei-Ting Chao, Kee-Chin Sia, Yu-Hui Tseng and Yi-Hsiang Liu
    Citation: Cancer Cell International 2015 15:29
    Content type: Primary research Published on:

  28. The Editor-in- Chief would like to thank all the reviewers who contributed to the journal in 2014.

    Authors: Denys Wheatley
    Citation: Cancer Cell International 2015 15:28
    Content type: Reviewer acknowledgement Published on:

  29. PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumors, and fu...

    Authors: Xiaoyan Dou, Jing Wei, Aiqin Sun, Genbao Shao, Chandra Childress, Wannian Yang and Qiong Lin
    Citation: Cancer Cell International 2015 15:27
    Content type: Primary research Published on:

  31. Duguelin is a rotenoid extracted from plants and has potent antitumor effects in vitro and in vivo. However, the mechanism underlying the antitumor effect remains unclear. Our preliminary study showed that Deg...

    Authors: Huae Xu, Xiaolin Li, Wenqiu Ding, Xiaoning Zeng, Hui Kong, Hong Wang and Weiping Xie
    Citation: Cancer Cell International 2015 15:25
    Content type: Primary research Published on:

  32. Emerging evidence indicates that dysregulated long intervening non-coding RNA (lincRNA) HOTAIR correlates highly with tumor invasion and metastasis but a link between the high expression of HOTAIR and the meta...

    Authors: Jing Wang, Dengyu Chen, Xiangfeng He, Yuxia Zhang, Fangfang Shi, Di Wu, Junsong Chen, Ying Zhang, Fengsu Zhao and Jun Dou
    Citation: Cancer Cell International 2015 15:24
    Content type: Primary research Published on:

  33. Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin ...

    Authors: Alana Doonachar, Michael D Gallo, Donald Doukas, Rajiv Pasricha, Igor Lantsberg and Alan R Schoenfeld
    Citation: Cancer Cell International 2015 15:23
    Content type: Primary research Published on:

  34. In many respects, the most remarkable chemical substances within the genome of eukaryotic cells are remarkable proteins which are the critical structural and functional units of living cells. The specification...

    Authors: Omar S Hajjawi
    Citation: Cancer Cell International 2015 15:22
    Content type: Review Published on:

  35. PPP2R2C encodes a gamma isoform of the regulatory subunit B55 subfamily consisting PP2A heterotrimeric with A and C subunits. Currently, the precise functions of B55gamma in cancer are still under investigatin...

    Authors: Ya-nan Li, Yi-qun Cao, Xi Wu, Guo-sheng Han, Lai-xing Wang, Yu-hui Zhang, Xin Chen, Bin Hao, Zhi-jian Yue and Jian-min Liu
    Citation: Cancer Cell International 2015 15:21
    Content type: Primary research Published on:

  36. The objective of this study was to determine the in vitro tumor-inhibitory effect of a recombinant adenovirus expressing a fusion protein of tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL...

    Authors: Dongxiao Dong, Jing Gao, Ying Sun, Yuqing Long, Meng Li, Dongchao Zhang, Jianfang Gong, Liang Xu, Liuan Li, Shunyi Qin, Jifei Ma and Tianming Jin
    Citation: Cancer Cell International 2015 15:20
    Content type: Primary research Published on:

  37. Aerobic glycolysis rate is higher in breast cancer tissues than adjacent normal tissues which providethe ATP, lactate and anabolic precursors required for tumourgenesis and metastasis. Lactate dehydrogenase (L...

    Authors: Abdolhassan Talaiezadeh, Ali Shahriari, Mohammad Reza Tabandeh, Payam Fathizadeh and Siavash Mansouri
    Citation: Cancer Cell International 2015 15:19
    Content type: Primary research Published on:

  38. Psoriasin (S100A7) plays a role in the malignant potential of several epithelial cancers, and could candidate diagnostic marker or therapeutic target. Nuclear factor kappa B (NF-κB) regulates cancer cell growt...

    Authors: Guijuan Liu, Qiang Wu, Guilan Liu, Xueying Song and Jihong Zhang
    Citation: Cancer Cell International 2015 15:18
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:40

  39. Angiogenesis is a critical step of breast cancer metastasis. Oncogenic Ras promotes the remodeling of cancer microenviroment. Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population em...

    Authors: Wei Li, Rong-Rui Liang, Chong Zhou, Meng-Yao Wu, Lian Lian, Gao-Feng Yuan, Ming-Yun Wang, Xin Xie, Liu-Mei Shou, Fei-Ran Gong, Kai Chen, Wei-Ming Duan and Min Tao
    Citation: Cancer Cell International 2015 15:17
    Content type: Primary research Published on:

  40. Lung cancer is the leading cause of cancer-related morbidity and mortality all over the world. Surgery resection, radiotherapy, chemotherapy, immunotherapy and combined treatments have been discovered and well...

    Authors: Zhenkuan Liu and Shaoxiang Huang
    Citation: Cancer Cell International 2015 15:16
    Content type: Primary research Published on:

  41. Cells with homologous recombination (HR) deficiency, most notably caused by mutations in the BRCA1 or BRCA2 genes, are sensitive to PARP inhibition. Microsatellite instability (MSI) accounts for 10-15% of colorec...

    Authors: Sybil M Genther Williams, Apryle M Kuznicki, Paula Andrade, Brian M Dolinski, Cem Elbi, Ronan C O’Hagan and Carlo Toniatti
    Citation: Cancer Cell International 2015 15:14
    Content type: Primary research Published on:

  42. Cholangiocarcinoma (CCA) is an aggressive disease with limited effective treatment options. The PI3K/Akt/mTOR pathway represents an attractive therapeutic target due to its frequent dysregulation in CCA. MK220...

    Authors: Jacob M Wilson, Selvi Kunnimalaiyaan, Muthusamy Kunnimalaiyaan and T Clark Gamblin
    Citation: Cancer Cell International 2015 15:13
    Content type: Primary research Published on:

  43. Malignant glioma is the most devastating and aggressive tumour in the brain and is characterised by high morbidity, high mortality and extremely poor prognosis. The main purpose of the present study was to inv...

    Authors: Qun Li, Xiang-he Lu, Cheng-de Wang, Lin Cai, Jiang-long Lu, Jin-sen Wu, Qi-chuan Zhuge, Wei-ming Zheng and Zhi-peng Su
    Citation: Cancer Cell International 2015 15:12
    Content type: Primary research Published on:

  45. To determine the effects of arsenic trioxide (ATO) and nilotinib (AMN107, Tasigna) alone or in combination on the proliferation and differentiation of primary leukemic cells from patients with chronic myeloid ...

    Authors: Wei Wang, Fei-fei Lv, Yan Du, Nannan Li, YaLing Chen and LiHong Chen
    Citation: Cancer Cell International 2015 15:10
    Content type: Primary research Published on:

  46. Recepteur d’origine nantais (RON) is a receptor tyrosine kinase whose overexpression has been observed in human gastric cancers. This study aimed to determine whether overexpression of the variant RONΔ160 coul...

    Authors: Dong-Hui Zhou, Chao Li and Li-Na Yang
    Citation: Cancer Cell International 2015 15:9
    Content type: Primary research Published on:

  47. In previous study we showed that caspase-2 plays the role of an apical caspase in cell death induction by taxanes in breast cancer cells. This study deals with the role of other caspases. We tested breast canc...

    Authors: Michael Jelínek, Kamila Balušíková, Martina Schmiedlová, Vlasta Němcová-Fürstová, Jan Šrámek, Jitka Stančíková, Ilaria Zanardi, Iwao Ojima and Jan Kovář
    Citation: Cancer Cell International 2015 15:8
    Content type: Primary research Published on:

  48. Cisplatin (CIS) is one of the most effective anticancer drug used in the treatment of several solid tumors .Its use is limited by its nephrotoxicity. The present study was designed to assess the role of a natu...

    Authors: Abdel-Moneim M Osman, Saud A Telity, Zoheir A Damanhouri, Sameer E Al-Harthy, Huda M Al-Kreathy, Wafaa S Ramadan, Mohamed F Elshal, Lateef M Khan and Fatemah Kamel
    Citation: Cancer Cell International 2015 15:6
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:30

  49. Evasion of apoptosis is a hallmark of cancer cells. One mechanism to deregulate the apoptotic pathway is by upregulation of the anti-apoptotic Bcl-2 family members. Navitoclax (ABT-263) is a Bcl-2/Bcl-xL inhibito...

    Authors: Lloyd T Lam, Haichao Zhang, John Xue, Joel D Leverson and Anahita Bhathena
    Citation: Cancer Cell International 2015 15:5
    Content type: Primary research Published on:

  50. BIX-01294, an euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor, has been reported to induce apoptosis in human neuroblastoma cells and inhibit the proliferation of bladder cancer cells. Howev...

    Authors: Jing Cui, Wendong Sun, Xuexi Hao, Minli Wei, Xiaonan Su, Yajing Zhang, Ling Su and Xiangguo Liu
    Citation: Cancer Cell International 2015 15:4
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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