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  1. Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering the chromatin structure. Aberrant activation of HMTs has been...

    Authors: Amandda Évelin Silva-Carvalho, Luma Dayane Carvalho Filiú-Braga, Gabriela Muller Reche Bogéa, Alan Jhones Barbosa de Assis, Fábio Pittella-Silva and Felipe Saldanha-Araujo
    Citation: Cancer Cell International 2024 24:243
  2. As one of the significant challenges to human health, cancer has long been a focal point in medical treatment. With ongoing advancements in the field of medicine, numerous methodologies for cancer therapy have...

    Authors: Zhuo Yan, Zhengbo Zhang, Yanan Chen, Jianghua Xu, Jilong Wang and Zhangquan Wang
    Citation: Cancer Cell International 2024 24:242
  3. Pancreatic cancer, characterized by its poor prognosis, exhibits a marked resistance to conventional chemotherapy and immunotherapy, underscoring the urgent need for more effective treatment modalities. In lig...

    Authors: Yiwei Wang, Ting Xu, Hongcheng Wang, Guanggai Xia and Xinyu Huang
    Citation: Cancer Cell International 2024 24:241
  4. DNA methylation is an important molecular modification that plays a key role in the expression of cancer genes. Evaluation of epigenetic changes, hypomethylation and hypermethylation, in specific genes are app...

    Authors: Farhad Jeddi, Elnaz Faghfuri, Sahar Mehranfar and Narges Soozangar
    Citation: Cancer Cell International 2024 24:240
  5. In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective so...

    Authors: Wei Lin, Xiaojun Wang, Mingxin Diao, Yangwei Wang, Rong Zhao, Jiaping Chen, Yongde Liao, Qinghong Long and Yunchong Meng
    Citation: Cancer Cell International 2024 24:239
  6. Coiled-coil domain containing 88C (CCDC88C) is a component of non-canonical Wnt signaling, and its dysregulation causes colorectal cancer metastasis. Dysregulated expression of CCDC88C was observed in lymph no...

    Authors: Boya Deng, Siyang Zhang, Yingying Zhou, Ting Sun, Ying Zhu, Jing Fei, Ailin Li and Yuan Miao
    Citation: Cancer Cell International 2024 24:237
  7. Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become ...

    Authors: Feng Long, Xue Li, Jingyu Pan, Hailin Ye, Cuixia Di, Yong Huang, Jiawei Li, Xuan Zhou, Huiyi Yi, Qiaozhen Huang and Jing Si
    Citation: Cancer Cell International 2024 24:236
  8. Colorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present in approximately 50% of colorectal cancer patients, are a considerable...

    Authors: Shipeng Dai, Fan Xu, Xiaozhang Xu, Tian Huang, Yiming Wang, Hongyu Wang, Yucheng Xie, Lei Yue, Wenhu Zhao, Yongxiang Xia, Jian Gu and Xiaofeng Qian
    Citation: Cancer Cell International 2024 24:235
  9. MicroRNAs (miRNAs), as a class of nonprotein-coding RNAs, post-transcriptionally regulate the expression of target genes by base pairing to 3’-untranslated regions (3'‐UTRs). Nuclear factor E2-related factor 2...

    Authors: Reza Panahizadeh, Mohammad Amin Vatankhah, Ali Safari, Hesam Danesh, Negin Nazmi, Pourya Gholizadeh, Narges Soozangar and Farhad Jeddi
    Citation: Cancer Cell International 2024 24:234
  10. MicroRNAs (miRNAs) are small RNA molecules that regulate genes and are involved in various biological processes, including cancer development. Researchers have been exploring the potential of miRNAs as therape...

    Authors: Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohammad Rahmati, Mohammad Eftekhari, Arash Safari and Masoud Najafi
    Citation: Cancer Cell International 2024 24:233
  11. The clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently subject to certain limitations in clinical trials, including the challe...

    Authors: Lanqi Cen, Zhe Zhang, Yi Sun, Nandie Wu, Jie Shao, Zhaoye Qian, Manman Tian, Yaohua Ke and Baorui Liu
    Citation: Cancer Cell International 2024 24:232
  12. Secretory cells in the fallopian tube fimbria epithelium (FTE) are regarded as the main cells of origin of ovarian high-grade serous carcinoma (HGSC). Ovulation is the main cause of FTE oncogenesis, which proc...

    Authors: Che-Fang Hsu, Vaishnavi Seenan, Liang-Yuan Wang, Pao-Chu Chen, Dah-Ching Ding and Tang-Yuan Chu
    Citation: Cancer Cell International 2024 24:231
  13. The hemoglobin-albumin-lymphocyte-platelet (HALP) score functions as a comprehensive index that assesses the systemic inflammatory response, nutritional, and immune status. This study aimed to explore the rela...

    Authors: Tongchao Jiang, Haishuang Sun, Shuyu Xue, Tiankai Xu, Wen Xia, Ying Wang, Ling Guo and Huanxin Lin
    Citation: Cancer Cell International 2024 24:230
  14. Small extracellular vesicles (sEVs) are cell-derived, nanometer-sized particles enclosed by a lipid bilayer. All kinds of biological molecules, including proteins, DNA fragments, RNA, lipids, and metabolites, ...

    Authors: Zhihao Yang, HaoYuan Wu, ZhiWei Wang, ErBao Bian and Bing Zhao
    Citation: Cancer Cell International 2024 24:229
  15. In the treatment of oral cavity cancer, margin status is one of the most critical prognostic factors. Positive margins are associated with higher local recurrence and lower survival rates. Therefore, the unive...

    Authors: L. Dirheimer, T. Pons, A. François, L. Lamy, S. Cortese, F. Marchal and L. Bezdetnaya
    Citation: Cancer Cell International 2024 24:228
  16. Malignant Pleural Mesothelioma (MPM) is a rare malignancy with a poor prognosis. Current therapies are unsatisfactory and novel cures are urgently needed. In a previous drug screening, we identified thonzonium...

    Authors: Irene Dell’Anno, Federica Morani, Simone Patergnani, Antonio Daga, Paolo Pinton, Carlotta Giorgi, Luciano Mutti, Federica Gemignani and Stefano Landi
    Citation: Cancer Cell International 2024 24:226
  17. Despite the improved survival observed in PD-1/PD-L1 blockade therapy, a substantial proportion of cancer patients, including those with non-small cell lung cancer (NSCLC), still lack a response.

    Authors: Xi Zhang, Rui Chen, Zirong Huo, Wenqing Li, Mengju Jiang, Guodong Su, Yuru Liu, Yu Cai, Wuhao Huang, Yuyan Xiong and Shengguang Wang
    Citation: Cancer Cell International 2024 24:225
  18. Despite effective strategies, resistance in EGFR mutated lung cancer remains a challenge. Metabolic reprogramming is one of the main mechanisms of tumor drug resistance. A class of drugs known as “statins” inh...

    Authors: Jie Liu, Jialei Fu, Ping Fu, Menghan Liu, Zining Liu and Bao Song
    Citation: Cancer Cell International 2024 24:224
  19. Multiple genetic and epigenetic regulatory mechanisms are crucial in the development and tumorigenesis process. Transcriptional regulation often involves intricate relationships and networks with post-transcri...

    Authors: Kesong Shi, Yani Chen, Ruihua Liu, Xinyao Fu, Hua Guo, Tian Gao, Shu Wang, Le Dou, Jiemin Wang, Yuan Wu, Jiale Yu and Haiquan Yu
    Citation: Cancer Cell International 2024 24:223
  20. Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC...

    Authors: Linlin Lv, Shujing Li, Jie Kang, Yulin Li, Nannan Zhao, Dongman Ye, Fengying Qin, Jing Sun, Tao Yu and Huijian Wu
    Citation: Cancer Cell International 2024 24:222
  21. Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...

    Authors: Tao Yan, Qing Jiang, Guangpu Ni, Haofeng Ma, Yun Meng, Guiqiong Kang, Meifang Xu, Fei Peng, Huadong Li, Xin Chen and Mingguang Wang
    Citation: Cancer Cell International 2024 24:221
  22. A reliable preclinical model of patient-derived organoids (PDOs) was developed in a case study of a 69-year-old woman diagnosed with breast cancer (BC) to investigate the tumour evolution before and after neoa...

    Authors: Serena Mazzucchelli, Lorena Signati, Letizia Messa, Alma Franceschini, Arianna Bonizzi, Lorenzo Castagnoli, Patrizia Gasparini, Clarissa Consolandi, Eleonora Mangano, Paride Pelucchi, Ingrid Cifola, Tania Camboni, Marco Severgnini, Laura Villani, Barbara Tagliaferri, Stephana Carelli…
    Citation: Cancer Cell International 2024 24:220
  23. Lung cancer (LC) ranks second most prevalent cancer in females after breast cancer and second in males after prostate cancer. Based on the GLOBOCAN 2020 report, India represented 5.9% of LC cases and 8.1% of d...

    Authors: Archana Bharti Sonkar, Abhishek Verma, Sneha Yadav, Rohit Kumar, Jyoti Singh, Amit K. Keshari, Soniya Rani, Anurag Kumar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Shubham Rastogi, Mariam K. Alamoudi, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas and Sudipta Saha
    Citation: Cancer Cell International 2024 24:219
  24. Assessment of measurable residual disease (MRD) is an essential prognostic tool for B-lymphoblastic leukaemia (B-ALL). In this study, we evaluated the utility of next-generation sequencing (NGS)–based MRD asse...

    Authors: Won Kee Ahn, Kyunghee Yu, Hongkyung Kim, Seung-Tae Lee, Jong Rak Choi, Jung Woo Han, Chuhl Joo Lyu, Seungmin Hahn and Saeam Shin
    Citation: Cancer Cell International 2024 24:218
  25. Acute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) + Daunorubicin (DNR)), is accompanied by frequent relapses. Many factors are involved in causing c...

    Authors: Mohammad Sadeghi, Asma Moslehi, Hadiseh Kheiry, Fariba Karoon Kiani, Asieh Zarei, Atefeh Khodakarami, Vahid Karpisheh, Ali Masjedi, Badrossadat Rahnama, Mohammad Hojjat-Farsangi, Mortaza Raeisi, Mehdi Yousefi, Ali Akbar Movasaghpour Akbari and Farhad Jadidi-Niaragh
    Citation: Cancer Cell International 2024 24:217
  26. Hepatocellular carcinoma (HCC) poses a significant clinical challenge, necessitating the integration of immunotherapeutic approaches. Palbociclib, a selective CDK4/6 inhibitor, has demon...

    Authors: Xiurong Cai, Guo Yin, Shuai Chen, Frank Tacke, Adrien Guillot and Hanyang Liu
    Citation: Cancer Cell International 2024 24:215
  27. Angiogenesis strongly reflects poor breast cancer outcome and an important contributor to breast cancer (BC) metastasis; therefore, anti-angiogenic intervention is a potential tool for cancer treatment. Howeve...

    Authors: Danhong Wang, Xiaozhen Liu, Weimin Hong, Tianzheng Xiao, Yadan Xu, Xiang Fang, Hongchao Tang, Qinghui Zheng and Xuli Meng
    Citation: Cancer Cell International 2024 24:214
  28. Increasing evidence suggests that DXS253E is critical for cancer development and progression, but the function and potential mechanism of DXS253E in colorectal cancer (CRC) remain largely unknown. In this stud...

    Authors: Pu Xing, Hao Hao, Jiangbo Chen, Xiaowen Qiao, Tongkun Song, Xinying Yang, Kai Weng, Yifan Hou, Jie Chen, Zaozao Wang, Jiabo Di, Beihai Jiang, Jiadi Xing and Xiangqian Su
    Citation: Cancer Cell International 2024 24:213
  29. Gastric cancer is a frequent and lethal solid tumor that has a poor prognosis and treatment result. Reprogramming of nucleotide metabolism is a characteristic of cancer development and progression.

    Authors: Shaofei Chen and Zhiyong Wang
    Citation: Cancer Cell International 2024 24:212
  30. MicroRNA-98 (miR-98) stands as an important molecule in the intricate landscape of oncology. As a subset of microRNAs, these small non-coding RNAs have accompanied a new era in cancer research, underpinning their...

    Authors: Vajihe Hazari, Sahar Ahmad Samali, Payam Izadpanahi, Homa Mollaei, Farzad Sadri and Zohreh Rezaei
    Citation: Cancer Cell International 2024 24:209
  31. Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI re...

    Authors: Weina Fan, Ying Xing, Shi Yan, Wei Liu, Jinfeng Ning, Fanglin Tian, Xin Wang, Yuning Zhan, Lixin Luo, Mengru Cao, Jian Huang and Li Cai
    Citation: Cancer Cell International 2024 24:208
  32. Human liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradication of hepatocellular carcinoma (HCC). The sustenance of HLCSLCs’ stemness is hypothesi...

    Authors: Lei Lou, Tingyun Deng, Qing Yuan, Lianghou Wang, Zhi Wang and Xiang Li
    Citation: Cancer Cell International 2024 24:206
  33. The members of the classic B7 family regulate the immune microenvironment of several malignant tumors. However, the potential relationship between the B7 family and the breast cancer (BrCa) tumor immune microe...

    Authors: Jiayu Liu, Cenzhu Wang, Ying Jiang, Yunxu Zhou, Lingyan Chen, Zhiwen Qian, Lu Liu, Danping Wu and Yan Zhang
    Citation: Cancer Cell International 2024 24:205
  34. Aberrant Derlin-1 (DERL1) expression is associated with an overactivation of p-AKT, whose involvement in breast cancer (BRCA) development has been widely speculated. However, the precise mechanism that links D...

    Authors: Yang Bai, Zhanqiang Zhang, Jiong Bi, Qian Tang, Keying Jiang, Chen Yao and Wenjian Wang
    Citation: Cancer Cell International 2024 24:204
  35. Prostate cancer (PC) is a major global health concern affecting male individuals. Among its variants, androgen-independent prostate cancer exhibits slow progression and lacks effective treatment targets, rende...

    Authors: Ying Chang, Jinyuan Sui, Qiang Fu, Zhongqi Lu, Zhengri Piao, Tiefeng Jin and Meihua Zhang
    Citation: Cancer Cell International 2024 24:203
  36. Colorectal cancer (CRC) has the third highest incidence and second mortality rate of malignant tumors globally, highlighting the urgency to explore the mechanisms underlying CRC progression for refined treatme...

    Authors: Wenjie Zhu, Changlei Wu, Zitao Liu, Shimin Zhao, Xiufeng Cheng and Jun Huang
    Citation: Cancer Cell International 2024 24:201
  37. Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored the regulatory effects of epigallocatechin gall...

    Authors: Shun Wang, Ruohuang Wang, Dingtao Hu, Caoxu Zhang, Peng Cao, Jie Huang and Baoqing Wang
    Citation: Cancer Cell International 2024 24:200
  38. The extracellular matrix (ECM) is a dynamic and complex microenvironment that modulates cell behavior and cell fate. Changes in ECM composition and architecture have been correlated with development, different...

    Authors: Madison R. Pickett, Yuan-I Chen, Mohini Kamra, Sachin Kumar, Nikhith Kalkunte, Gabriella P. Sugerman, Kelsey Varodom, Manuel K. Rausch, Janet Zoldan, Hsin-Chin Yeh and Sapun H. Parekh
    Citation: Cancer Cell International 2024 24:199
  39. Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved protein found in various species. To date, multiple studies have demonstrated ...

    Authors: An-Bu Liu, Jia Liu, Sheng Wang, Lei Ma and Jun-Fei Zhang
    Citation: Cancer Cell International 2024 24:198
  40. Syntaxin6 (STX6) is a SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein complex located in the trans-Golgi network and endosomes, which is closely associated with a variety...

    Authors: Li Huang, Xiaoting Zhong, An Li, Fuping Tu, Miao He, Xueming Xu, Xiaohui Liu, Xiaoli Zeng, Jun Chi, Tian Tian, Chunli Wang, Xiangcai Wang and Jianming Ye
    Citation: Cancer Cell International 2024 24:197
  41. Thyroid cancer (TC) is the most common endocrine malignancy. Nowadays, undifferentiated thyroid cancers (UTCs) are still lethal, mostly due to the insurgence of therapy resistance and disease relapse. These ev...

    Authors: Viola Ghiandai, Elisa Stellaria Grassi, Giacomo Gazzano, Laura Fugazzola and Luca Persani
    Citation: Cancer Cell International 2024 24:196

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