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  1. Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prost...

    Authors: Chengsen Xue, Hilda A Pasolli, Irene Piscopo, Daniel J Gros, Christina Liu, Yamei Chen and Jen Wei Chiao
    Citation: Cancer Cell International 2014 14:30
    Content type: Primary research Published on:

  2. Nkx2.8 (Nk2 homeobox 8) is a novel NK-2 gene family member that has been implicated in the progression of human cancer. Its role in the progression of HCC remains unknown. In this study, we investigated the ex...

    Authors: Lei Qu, Biao Deng, Yue Zeng and Zhongwei Cao
    Citation: Cancer Cell International 2014 14:28
    Content type: Primary research Published on:

  4. Primary and secondary brain cancers are highly treatment resistant, and their marked angiogenesis attracts interest as a potential therapeutic target. Recent observations reveal that the microvascular endothel...

    Authors: Natsuko Nomura, Sandra Pastorino, Pengfei Jiang, Gage Lambert, John R Crawford, Marco Gymnopoulos, David Piccioni, Tiffany Juarez, Sandeep C Pingle, Milan Makale and Santosh Kesari
    Citation: Cancer Cell International 2014 14:26
    Content type: Primary research Published on:

  5. Rituximab in the combination of CHOP chemotherapy has been widely used as the standard treatment for several kinds of B-cell non-Hodgkin lymphoma (B-NHL). Inactivation of phosphorylation of STAT3 plays an essenti...

    Authors: Yunfei Hu, Ning Ding, Xuan Jin, Lixia Feng, Lingyan Ping, Yuqin Song and Jun Zhu
    Citation: Cancer Cell International 2014 14:25
    Content type: Primary research Published on:

  6. Nasopharyngeal carcinoma (NPC) is a common malignancy in China and Southeast Asia. Radiotherapy is the major treatment modality for patients with NPC, but does not always achieve fully satisfactory outcomes. S...

    Authors: Yanyang Liu, Zhixi Li, Lu Wu, Zi Wang, Xia Wang, Yang Yu, Qian Zhao and Feng Luo
    Citation: Cancer Cell International 2014 14:24
    Content type: Primary research Published on:

  7. The enumeration and characterization of circulating tumor cells (CTCs) in the blood of cancer patients is useful for cancer prognostic and treatment monitoring purposes. The number of CTCs present in patient b...

    Authors: Jianbing Qin, Jodi R Alt, Bradford A Hunsley, Thomas L Williams and M Rohan Fernando
    Citation: Cancer Cell International 2014 14:23
    Content type: Primary research Published on:

  9. Breast cancer is the most common malignancy in women throughout the world. Mitochondria play important roles in cellular energy production, free radical generation and apoptosis. Identification of mitochondria...

    Authors: Massoud Ghaffarpour, Reza Mahdian, Forouzandeh Fereidooni, Behnam Kamalidehghan, Nasrin Moazami and Massoud Houshmand
    Citation: Cancer Cell International 2014 14:21
    Content type: Primary research Published on:

  10. In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established th...

    Authors: Tsung-Hsien Wu, Yu-Wei Chou, Pei-Hung Chiu, Ming-Jer Tang, Chun-Wen Hu and Ming-Long Yeh
    Citation: Cancer Cell International 2014 14:20
    Content type: Primary research Published on:

  11. We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced...

    Authors: Geordon Avery-Cooper, Meghan Doerr, Richard WD Gilbert, Mahmoud Youssef, Amy Richard, Patricia Huether and Alicia M Viloria-Petit
    Citation: Cancer Cell International 2014 14:19
    Content type: Primary research Published on:

  12. General transcription is required for the growth and survival of all living cells. However, tumor cells require extraordinary levels of transcription, including the transcription of ribosomal RNA genes by RNA ...

    Authors: Claudia Villicaña, Grisel Cruz and Mario Zurita
    Citation: Cancer Cell International 2014 14:18
    Content type: Review Published on:

  13. The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the 5′UTR is similar to prokaryotic 23S...

    Authors: Louise D Dahl, Thomas J Corydon, Liina Ränkel, Karen Margrethe Nielsen, Ernst-Martin Füchtbauer and Charlotte R Knudsen
    Citation: Cancer Cell International 2014 14:17
    Content type: Primary research Published on:

  14. Liver X receptors (LXRs) are nuclear receptors that function as ligand-activated transcription factors regulating lipid metabolism and inflammation. Recent discoveries found LXRs could regulate tumor growth in...

    Authors: Wenjun Zhang, Hua Jiang, Jianlin Zhang, Yinfan Zhang, Antang Liu, Yaozhong Zhao, Xiaohai Zhu, Zihao Lin and Xiangbin Yuan
    Citation: Cancer Cell International 2014 14:16
    Content type: Primary research Published on:

  15. Wnt5a is classified as a non-transforming Wnt family member and plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in osteosarcoma progression remains poorly defined. In thi...

    Authors: Ailiang Zhang, Shuanghua He, Xiaoliang Sun, Lianghua Ding, Xinnan Bao and Neng Wang
    Citation: Cancer Cell International 2014 14:15
    Content type: Primary research Published on:

  16. Two novel triple negative breast cancer cell lines, NIPBC-1 and NIPBC-2 were successfully established from primary tumors of two young breast cancer patients aged 39 and 38 years respectively, diagnosed as inf...

    Authors: Santhi Latha Pandrangi, Sarangadhara Appala Raju Bagadi, Navin Kumar Sinha, Manoj Kumar, Rima Dada, Meena Lakhanpal, Abha Soni, Shreshtha Malvia, Sheeba Simon, Chintamani Chintamani, Ravindar Singh Mohil, Dinesh Bhatnagar and Sunita Saxena
    Citation: Cancer Cell International 2014 14:14
    Content type: Primary research Published on:

  17. The resistance of cancerous cells to chemotherapy remains the main limitation for cancer treatment at present. Doxorubicin (DOX) is a potent antitumor drug that activates the ubiquitin-proteasome system, but u...

    Authors: Pablo César Ortiz-Lazareno, Alejandro Bravo-Cuellar, José Manuel Lerma-Díaz, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, Jorge Ramiro Domínguez-Rodríguez, Oscar González-Ramella, Ruth De Célis, Paulina Gómez-Lomelí and Georgina Hernández-Flores
    Citation: Cancer Cell International 2014 14:13
    Content type: Primary research Published on:

  19. Esophageal squamous incidence in many developed countries has increased dramatically over last decades, while the underlying mechanism of the biogenesis of ES was still unknown.

    Authors: Bo Ye, Chun-Yu Ji, Yi Zhao, Wang Li, Jian Feng and Xu Zhang
    Citation: Cancer Cell International 2014 14:12
    Content type: Primary research Published on:

  20. Although advanced gastric cancer has many limitations and response rate is marginal in chemotherapy. Overexpression of human epidermal growth factor receptor 2(HER-2/neu) gene and its protein are associated with ...

    Authors: Hai Cui, Ying Cheng, Su-Zhou Piao, Yun-Jie Xu, Hong-Hua Sun, Xian Cui, Xiang-Zi Li, Song-Nan Zhang, Long-Zhen Piao, Yong-Min Jin, Zhen-hua Lin and Xiong-Hu Shen
    Citation: Cancer Cell International 2014 14:10
    Content type: Primary research Published on:

  21. Immunosuppression in breast cancer has been reported in women and in the highly metastatic mouse mammary tumor model 4 T1. The immunosuppressive environment complicates the use of the humoral response against ...

    Authors: Mariana Díaz-Zaragoza, Ricardo Hernández and Pedro Ostoa-Saloma
    Citation: Cancer Cell International 2014 14:9
    Content type: Primary research Published on:

  22. A recombinant antitumor/antiviral protein (Novaferon, Nova) is a new type of interferon, which is produced by artificial design technology combining DNA-shuffling and High Throughput Screening (HTS).

    Authors: Meng Li, Chunming Rao, Dening Pei, Lan Wang, Yonghong Li, Kai Gao, Minrong Wang and Junzhi Wang
    Citation: Cancer Cell International 2014 14:8
    Content type: Primary research Published on:

  23. The telomere binding proteins play an important role in telomere function, which contribute greatly to the radio resistant in human cancers. This research is designed to investigate the relationship among the ...

    Authors: Zheng Li, Xiaoxi Yang, Nengxing Xia, Lei Yang, Haijun Yu, Fuxiang Zhou, Conghua X and Yunfeng Zhou
    Citation: Cancer Cell International 2014 14:7
    Content type: Primary research Published on:

  24. Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other ...

    Authors: Carly C Barron, Jessy Moore, Theodoros Tsakiridis, Gary Pickering and Evangelia Tsiani
    Citation: Cancer Cell International 2014 14:6
    Content type: Primary research Published on:

  25. Rituximab plus CHOP (R-CHOP) significantly improved the outcome of diffuse large B cell lymphoma (DLBCL), a common sub-type of non-Hodgkin lymphoma. But 40% – 50% of DLBCL patients cannot be cured by this regi...

    Authors: Zhiying Fu, Jun Zhu, Wen Zheng, Weiping Liu, Zhitao Ying, Yan Xie, Xiaopei Wang, Ningjing Lin, Meifeng Tu, Lingyan Ping, Lijuan Deng, Chen Zhang, Ning Ding and Yuqin Song
    Citation: Cancer Cell International 2014 14:5
    Content type: Primary research Published on:

  26. Sorafenib was the first Food and Drug Administration approved anti-angiogenic therapy for renal cell carcinoma (RCC). Currently, there are no validated predictive biomarkers for sorafenib. Our purpose was to d...

    Authors: Saadia A Aziz, Joshua A Sznol, Laurence Albiges, Christopher Zito, Lucia B Jilaveanu, Robert L Camp, Bernard Escudier and Harriet M Kluger
    Citation: Cancer Cell International 2014 14:4
    Content type: Primary research Published on:

  27. Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer ...

    Authors: Wenjuan Qi, Chao Zhao, Lijun Zhao, Ning Liu, Xiaoping Li, Weidong Yu and Lihui Wei
    Citation: Cancer Cell International 2014 14:3
    Content type: Primary research Published on:

  28. CDK11p58 is one of the large families of p34cdc2-related kinases whose functions are linked with cell cycle progression, tumorigenesis and apoptotic signaling. Our previous investigation demonstrated that CDK11p5...

    Authors: Yayun Chi, Lisha Wang, Xiuying Xiao, Ping Wei, Yiqin Wang and Xiaoyan Zhou
    Citation: Cancer Cell International 2014 14:9000
    Content type: Primary research Published on:

  29. The anticancer effects of ceramide have been reported in many types of cancers but less in lung cancer. In this study, we used C2-ceramide to further investigate its possible anticancer effects and mechanisms on ...

    Authors: I-Ling Lin, Han-Lin Chou, Jin-Ching Lee, Feng-Wei Chen, Yao Fong, Wei-Chiao Chang, Hurng Wern Huang, Chang-Yi Wu, Wen-Tsan Chang, Hui-Min David Wang and Chien-Chih Chiu
    Citation: Cancer Cell International 2014 14:1
    Content type: Primary research Published on:

  30. Over the last few years, studies have suggested that oxidative stress plays a role in the regulation of hematopoietic cell homeostasis. In particular, the effects of hydrogen peroxide (H2O2) range from hematopoie...

    Authors: Amanda Nogueira-Pedro, Thalyta Aparecida Munhoz Cesário, Carolina Carvalho Dias, Clarice Silvia Taemi Origassa, Lilian Piñero Marcolin Eça, Edgar Julian Paredes-Gamero and Alice Teixeira Ferreira
    Citation: Cancer Cell International 2013 13:123
    Content type: Primary research Published on:

  31. A new human myeloma cell line, MMLAL, was established from the myelomatous pleural effusion of a 73-year-old Chinese patient suffering from symptomatic International stage III IgG/lambda myeloma. After a brief...

    Authors: Kwan Yeung Wong, Thomas SK Wan, Chi Chiu So and Chor Sang Chim
    Citation: Cancer Cell International 2013 13:122
    Content type: Primary research Published on:

  32. Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...

    Authors: Tiankang Guo, Jingyu Yang, Jibin Yao, Yongbin Zhang, Mingxu Da and Yaoxing Duan
    Citation: Cancer Cell International 2013 13:121
    Content type: Primary research Published on:

  33. Bladder cancer is a relatively common and potentially life-threatening neoplasm that ranks ninth in terms of worldwide cancer incidence. The aim of this study was to determine deletions and sequence variations...

    Authors: Nasser Shakhssalim, Massoud Houshmand, Behnam Kamalidehghan, Abolfazl Faraji, Reza Sarhangnejad, Sepideh Dadgar, Maryam Mobaraki, Rozita Rosli and Mohammad Hossein Sanati
    Citation: Cancer Cell International 2013 13:120
    Content type: Primary research Published on:

  34. The initiation and progression of various solid tumors, including pancreatic carcinoma, are driven by a population of cells with stem cell properties, namely cancer stem cells (CSCs). Like their normal counter...

    Authors: Haitao Zhu, Dongqing Wang, Yanfang Liu, Zhaoliang Su, Lirong Zhang, Fangfang Chen, Yuepeng Zhou, Yingying Wu, Ming Yu, Zhijian Zhang and Genbao Shao
    Citation: Cancer Cell International 2013 13:119
    Content type: Primary research Published on:

  35. The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.

    Authors: Bin Zhang, Jun Chen, Zhenghua Ren, Yongbin Chen, Jinhui Li, Xia Miao, Yang Song, Tao Zhao, Yurong Li, Yongquan Shi, Dongqing Ren and Junye Liu
    Citation: Cancer Cell International 2013 13:118
    Content type: Primary research Published on:

  36. Chronic myeloid leukemia is a clonal myeloproliferative disorder disease in which BCR/ABL plays an important role as an oncoprotein and molecular target. Despite the success of targeted therapy using tyrosine ...

    Authors: Guoqiang Chang, Hongju Zhang, Jian Wang, Yujuan Zhang, Hua Xu, Chijuan Wang, Hairui Zhang, Li Ma, Qinghua Li and Tianxiang Pang
    Citation: Cancer Cell International 2013 13:117
    Content type: Primary research Published on:

  37. The apoptosis-stimulating protein of p53 (ASPP) family comprises three members, namely, ASPP1, ASPP2, and iASPP. They regulate the promotive effect of p53 on apoptosis. Breast cancer (BC) remains as one of the...

    Authors: Changsong Wang, Chunfang Gao, Yanping Chen, Jian Yin, Ping Wang and Xuexia Lv
    Citation: Cancer Cell International 2013 13:116
    Content type: Primary research Published on:

  38. Lung cancer is the leading cause of cancer-related death in the world, with metastasis as the main reason for the mortality. CELF1 is an RNA-binding protein controlling the post-transcriptional regulation of g...

    Authors: Li-Na Wu, Yi-Jun Xue, Li-Jian Zhang, Xue-Mei Ma and Jin-Feng Chen
    Citation: Cancer Cell International 2013 13:115
    Content type: Primary research Published on:

  39. Although studies have shown the oncogene WT1 is overexpressed in lung cancer, there is no data showing the implication of WT1 in lung cancer biology. In the present study, we first demonstrated that isotype C ...

    Authors: Xi Wang, Ping Gao, Fang Lin, Min Long, Yuanyuan Weng, Yongri Ouyang, Li Liu, Junxia Wei, Xi Chen, Ting He, Huizhong Zhang and Ke Dong
    Citation: Cancer Cell International 2013 13:114
    Content type: Primary research Published on:

  40. Increasing evidence suggest that ubiquitin-proteasome system (UPS) plays a key role in tumorigenesis. HERC4 is a recently identified ubiqutin ligase. However, the expression status and biological functions of ...

    Authors: Hui Zhou, Rong Shi, Min Wei, Wen-Ling Zheng, Jue-Yu Zhou and Wen-Li Ma
    Citation: Cancer Cell International 2013 13:113
    Content type: Primary research Published on:

  41. To investigate the effect of the H-2Kd gene on the lymphocyte membrane, we constructed a small interfering RNA (siRNA) that targets the H-2Kd gene and compared the cytotoxicity of mouse lymphokine-activated kille...

    Authors: Xin Liu, Xin Cui, Ningning Shan, Ying Li, Xiaosheng Fang, Mei Ding and Xin Wang
    Citation: Cancer Cell International 2013 13:112
    Content type: Primary research Published on:

  42. Convincing evidence indicates that statins stimulate apoptotic cell death in several types of proliferating tumor cells in a cholesterol-lowering-independent manner. However, the relationship between apoptosis...

    Authors: Xu-Feng Qi, Dong-Heui Kim, Kyu-Jae Lee, Cheol-Su Kim, Soon-Bong Song, Dong-Qing Cai and Soo-Ki Kim
    Citation: Cancer Cell International 2013 13:111
    Content type: Primary research Published on:

  43. Leukemia is the most common malignant proliferative disease in children. Our previous study found that miR-99a was up-regulated in pediatric primary AML using microRNA expression profiles. Up to date, although...

    Authors: Lidan Zhang, Xiaojuan Li, Zhiyong Ke, Libin Huang, Yanni Liang, Jun Wu, Xiaoli Zhang, Yueqin Chen, Hua Zhang and Xuequn Luo
    Citation: Cancer Cell International 2013 13:110
    Content type: Primary research Published on:

  44. The transcription factor SOX11 is one of members of the SRY box-containing (SOX) family emerging as important transcriptional regulators. In recent years, up-regulation of SOX11 has been detected in various ty...

    Authors: Song Zhang, Shuo Li and Jin-Liang Gao
    Citation: Cancer Cell International 2013 13:109
    Content type: Primary research Published on:

  45. Lup-20(29)-en-3H-ol (Lupeol), a dietary triterpene, has been shown to possess multiple pharmacological activities including anti-tumor effects

    Authors: Fen Liu, Yan He, Yong Liang, Lijun Wen, Yongming Zhu, Yan Wu, Lixiang Zhao, Yunsen Li, Xinliang Mao and Haiyan Liu
    Citation: Cancer Cell International 2013 13:108
    Content type: Primary research Published on:

  46. Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites. FPGS tag SNP rs1544105C > T is located in the gene pro...

    Authors: Shu-Guang Liu, Chao Gao, Rui-Dong Zhang, Ying Jiao, Lei Cui, Wei-Jing Li, Zhen-Ping Chen, Min-Yuan Wu, Hu-Yong Zheng, Xiao-Xi Zhao, Zhi-Xia Yue and Zhi-Gang Li
    Citation: Cancer Cell International 2013 13:107
    Content type: Primary research Published on:

  47. Recent studies indicated that a synthetic oligonucleotide containing un-methylated CpG oligodeoxynucleotides (CpG-ODN) has a potential function for cancer therapy. In this study, we evaluated the chemosensitiz...

    Authors: Sheng-ran Liang, Guang-rui Hu, Li-juan Fang, Su-jing Huang, Jin-song Li, Ming-yi Zhao and Min-jie Meng
    Citation: Cancer Cell International 2013 13:106
    Content type: Primary research Published on:

  48. Taxol (generic name paclitaxel), a plant-derived antineoplastic agent, used widely against breast, ovarian and lung cancer, was originally isolated from the bark of the Pacific yew, Taxus brevifolia. The limited ...

    Authors: Balabhadrapatruni VSK Chakravarthi, Ramanathan Sujay, Gini C Kuriakose, Anjali A Karande and Chelliah Jayabaskaran
    Citation: Cancer Cell International 2013 13:105
    Content type: Primary research Published on:

  49. MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Abnormally expressed miR-224 was found to play a fundamental role in several types of cancer. ...

    Authors: Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou
    Citation: Cancer Cell International 2013 13:104
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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