Navada S, Lai P, Schwartz A, Kalemkerian G: Temporal trends in small cell lung cancer: analysis of the National Surveillance, Epidemiology, and End-Results (SEER) database. J Clin Oncol. 2006, 24 (18): 384S-384S.
Google Scholar
Mitsudomi T, Yatabe Y: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer. FEBS J. 2010, 277 (2): 301-308. 10.1111/j.1742-4658.2009.07448.x.
Article
PubMed
CAS
Google Scholar
Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005, 2 (3): e73-10.1371/journal.pmed.0020073.
Article
PubMed Central
PubMed
Google Scholar
Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell. 2007, 129 (7): 1261-1274. 10.1016/j.cell.2007.06.009.
Article
PubMed Central
PubMed
CAS
Google Scholar
Liu P, Cheng H, Roberts TM, Zhao JJ: Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009, 8 (8): 627-644. 10.1038/nrd2926.
Article
PubMed Central
PubMed
CAS
Google Scholar
Brognard J, Clark AS, Ni Y, Dennis PA: Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 2001, 61 (10): 3986-3997.
PubMed
CAS
Google Scholar
Tang J, He Q, Guo R, Chang X: Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer. 2006, 51 (2): 181-191. 10.1016/j.lungcan.2005.10.003.
Article
PubMed
Google Scholar
Lee SH, Kim HS, Park WS, Kim SY, Lee KY, Kim SH, Lee JY, Yoo NJ: Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study. APMIS. 2002, 110 (7–8): 587-592.
Article
PubMed
CAS
Google Scholar
Roberts PJ, Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007, 26 (22): 3291-3310. 10.1038/sj.onc.1210422.
Article
PubMed
CAS
Google Scholar
Chen F, Wang W, El-Deiry WS: Current strategies to target p53 in cancer. Biochem Pharmacol. 2010, 80 (5): 724-730. 10.1016/j.bcp.2010.04.031.
Article
PubMed
CAS
Google Scholar
German JB, Walzem RL: The health benefits of wine. Annu Rev Nutr. 2000, 20: 561-593. 10.1146/annurev.nutr.20.1.561.
Article
PubMed
CAS
Google Scholar
Elattar TM, Virji AS: The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res. 1999, 19 (6B): 5407-5414.
PubMed
CAS
Google Scholar
Wallenborg K, Vlachos P, Eriksson S, Huijbregts L, Arner E, Joseph B, Hermanson O: Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1. Exp Cell Res. 2009, 315 (8): 1360-1371. 10.1016/j.yexcr.2009.02.022.
Article
PubMed
CAS
Google Scholar
Kampa M, Hatzoglou A, Notas G, Damianaki A, Bakogeorgou E, Gemetzi C, Kouroumalis E, Martin PM, Castanas E: Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Nutr Cancer. 2000, 37 (2): 223-233. 10.1207/S15327914NC372_16.
Article
PubMed
CAS
Google Scholar
Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin PM, Castanas E: Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem. 2000, 78 (3): 429-441. 10.1002/1097-4644(20000901)78:3<429::AID-JCB8>3.0.CO;2-M.
Article
PubMed
CAS
Google Scholar
Baur J, Sinclair D: Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006, 5 (6): 493-506. 10.1038/nrd2060.
Article
PubMed
CAS
Google Scholar
Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T: Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol. 2011, 6: 144-10.1186/1748-717X-6-144.
Article
PubMed Central
PubMed
CAS
Google Scholar
Prescott E, Groenbaek M, Becker U, Soerensen T: Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage. Am J Epidemiol. 1999, 149 (5): 463-470. 10.1093/oxfordjournals.aje.a009834.
Article
PubMed
CAS
Google Scholar
Benedetti A, Parent M, Siemiatycki J: Consumption of alcoholic beverages and risk of lung cancer: results from two case–control studies in Montreal, Canada. Cancer Causes Control. 2006, 17 (4): 469-480. 10.1007/s10552-005-0496-y.
Article
PubMed
Google Scholar
Maxwell S, Cruickshank A, Thorpe G: Red wine and antioxidant activity in serum. Lancet. 1994, 344 (8916): 193-194.
Article
PubMed
CAS
Google Scholar
Grønbaek M, Becker U, Johansen D, Gottschau A, Schnohr P, Hein HO, Jensen G, Sørensen TI: Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med. 2000, 133 (6): 411-419. 10.7326/0003-4819-133-6-200009190-00008.
Article
PubMed
Google Scholar
Hakimuddin F, Paliyath G, Meckling K: Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. J Agric Food Chem. 2006, 54 (20): 7912-7923. 10.1021/jf060834m.
Article
PubMed
CAS
Google Scholar
Briviba K, Pan L, Rechkemmer G: Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. J Nutr. 2002, 132 (9): 2814-2818.
PubMed
CAS
Google Scholar
Lee KW, Kang NJ, Heo YS, Rogozin EA, Pugliese A, Hwang MK, Bowden GT, Bode AM, Lee HJ, Dong Z: Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res. 2008, 68 (3): 946-955. 10.1158/0008-5472.CAN-07-3140.
Article
PubMed Central
PubMed
CAS
Google Scholar
Aggarwal B, Bhardwaj A, Aggarwal R, Seeram N, Shishodia S, Takada Y: Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004, 24 (5): A 2783-A 2840.
Google Scholar
Yang CS, Landau JM, Huang MT, Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001, 21: 381-406. 10.1146/annurev.nutr.21.1.381.
Article
PubMed
CAS
Google Scholar
Albert S, Serova M, Dreyer C, Sablin MP, Faivre S, Raymond E: New inhibitors of the mammalian target of rapamycin signaling pathway for cancer. Expert Opin Investig Drugs. 2010, 19 (8): 919-930. 10.1517/13543784.2010.499121.
Article
PubMed
CAS
Google Scholar
Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F: Metformin in cancer therapy: a new perspective for an old antidiabetic drug?. Mol Cancer Ther. 2010, 9 (5): 1092-1099. 10.1158/1535-7163.MCT-09-1186.
Article
PubMed
CAS
Google Scholar
Kueck A, Opipari AW, Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR: Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol. 2007, 107 (3): 450-457. 10.1016/j.ygyno.2007.07.065.
Article
PubMed
CAS
Google Scholar
Zhu Z, Jiang W, McGinley JN, Thompson HJ: 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005, 65 (15): 7023-7030. 10.1158/0008-5472.CAN-05-0453.
Article
PubMed
CAS
Google Scholar
Hernandez LG, Forkert PG: Inhibition of vinyl carbamate-induced mutagenicity and clastogenicity by the garlic constituent diallyl sulfone in F1 (Big Blue x A/J) transgenic mice. Carcinogenesis. 2007, 28 (8): 1824-1830. 10.1093/carcin/bgm051. Epub 2007 Mar 6
Article
PubMed
CAS
Google Scholar
Tsakiridis T, Cutz JC, Singh G, Hirte H, Okawara G, Corbett T, Sur R, Cai W, Whelan T, Wright JR: Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy. J Thorac Oncol. 2008, 3 (7): 716-722. 10.1097/JTO.0b013e31817c6094.
Article
PubMed
Google Scholar
Kurtze I, Sonnemann J, Beck JF: KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib. Oncol Rep. 2011, 25 (4): 1021-1029.
PubMed
CAS
Google Scholar
Sparwel J, Vantler M, Caglayan E, Kappert K, Fries J, Dietrich H, Bohm M, Erdmann E, Rosenkranz S: Differential effects of red and white wines on inhibition of the platelet-derived growth factor receptor: impact of the mash fermentation. Cardiovasc Res. 2009, 81 (4): 758-770.
Article
PubMed
CAS
Google Scholar
Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L: Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotechnol. 2006, 135 (3): 181-192. 10.1385/ABAB:135:3:181.
Article
PubMed
CAS
Google Scholar
Sexton E, Van Themsche C, Leblanc K, Parent S, Lemoine P, Asselin E: Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer. 2006, 5: 45-10.1186/1476-4598-5-45.
Article
PubMed Central
PubMed
Google Scholar
Shih A, Zhang S, Cao HJ, Boswell S, Wu YH, Tang HY, Lennartz MR, Davis FB, Davis PJ, Lin HY: Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha. Mol Cancer Ther. 2004, 3 (11): 1355-1364.
PubMed
CAS
Google Scholar
Kim YA, Choi BT, Lee YT, Park DI, Rhee SH, Park KY, Choi YH: Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep. 2004, 11 (2): 441-446.
PubMed
Google Scholar
Alkhalaf M: Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. Pharmacology. 2007, 80 (2–3): 134-143.
Article
PubMed
CAS
Google Scholar
Murias M, Luczak MW, Niepsuj A, Krajka-Kuzniak V, Zielinska-Przyjemska M, Jagodzinski PP, Jager W, Szekeres T, Jodynis-Liebert J: Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. Toxicol In Vitro. 2008, 22 (5): 1361-1370. 10.1016/j.tiv.2008.03.002.
Article
PubMed
CAS
Google Scholar
Zhang S, Cao HJ, Davis FB, Tang HY, Davis PJ, Lin HY: Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer. 2004, 91 (1): 178-185. 10.1038/sj.bjc.6601902.
Article
PubMed Central
PubMed
CAS
Google Scholar
Vanamala J, Reddivari L, Radhakrishnan S, Tarver C: Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 2010, 10: 238-10.1186/1471-2407-10-238.
Article
PubMed Central
PubMed
Google Scholar
Narayanan BA, Narayanan NK, Re GG, Nixon DW: Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003, 104 (2): 204-212. 10.1002/ijc.10932.
Article
PubMed
CAS
Google Scholar
Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Fernandez-Salguero PM, Castellon EA: Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. J Androl. 2007, 28 (2): 282-293.
Article
PubMed
CAS
Google Scholar
Whyte L, Huang YY, Torres K, Mehta RG: Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007, 67 (24): 12007-12017. 10.1158/0008-5472.CAN-07-2464.
Article
PubMed
CAS
Google Scholar
Walter A, Etienne-Selloum N, Brasse D, Khallouf H, Bronner C, Rio MC, Beretz A, Schini-Kerth VB: Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. FASEB J. 2010, 24 (9): 3360-3369. 10.1096/fj.09-149419.
Article
PubMed
CAS
Google Scholar
Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD: Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A. 1999, 96 (24): 13777-13782. 10.1073/pnas.96.24.13777.
Article
PubMed Central
PubMed
CAS
Google Scholar
Carmi C, Mor M, Petronini PG, Alfieri R: Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer. Biochem Pharmacol. 2012, 84 (11): 1388-1399. 10.1016/j.bcp.2012.07.031.
Article
PubMed
CAS
Google Scholar
Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, Fujii T, Kuwano M: Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation. Mol Cancer Ther. 2004, 3 (4): 465-472.
PubMed
CAS
Google Scholar
Nurgel C, Pickering GJ, Inglis D: Sensory and chemical characteristics of Canadian ice wines. J Sci Food Agric. 2004, 84: 1675-1684. 10.1002/jsfa.1860.
Article
CAS
Google Scholar
Iland P, Brauer N, Edwards G, Weeks S, Wilks E: Chemical Analysis of Grapes and Wines. 2004, Campbelltown, Australia: Wine Promotions Pty Ltd
Google Scholar
Breen DM, Sanli T, Giacca A, Tsiani E: Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem Biophys Res Commun. 2008, 374 (1): 117-122. 10.1016/j.bbrc.2008.06.104.
Article
PubMed
CAS
Google Scholar
Zygmunt K, Faubert B, MacNeil J, Tsiani E: Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. Biochem Biophys Res Commun. 2010, 398 (2): 178-183. 10.1016/j.bbrc.2010.06.048.
Article
PubMed
CAS
Google Scholar