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  1. Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of...

    Authors: Mine Erguven, Ayhan Bilir, Nuray Yazihan, Ezgi Ermis, Akin Sabanci, Esin Aktas, Yavuz Aras and Vehbi Alpman
    Citation: Cancer Cell International 2011 11:18
    Content type: Primary research Published on:

  2. Aimed to facilitate candidate biomarkers selection and improve network-based multi-target therapy, we perform comparative proteomics research on muscle-invasive bladder transitional cell carcinoma. Laser captu...

    Authors: Hai Tao Niu, Zhen Dong, Gang Jiang, Ting Xu, Yan Qun Liu, Yan Wei Cao, Jun Zhao and Xin Sheng Wang
    Citation: Cancer Cell International 2011 11:17
    Content type: Primary research Published on:

  4. Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory ...

    Authors: Susana del Toro-Arreola, Naela Arreygue-Garcia, Adriana Aguilar-Lemarroy, Angel Cid-Arregui, Miriam Jimenez-Perez, Jesse Haramati, Patricio Barros-Nuñez, Oscar Gonzalez-Ramella, Alicia del Toro-Arreola, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores, Alejandro Bravo-Cuellar, Adrian Daneri-Navarro and Luis F Jave-Suarez
    Citation: Cancer Cell International 2011 11:15
    Content type: Primary research Published on:

  5. MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cance...

    Authors: Jessica Carlsson, Sabina Davidsson, Gisela Helenius, Mats Karlsson, Zelmina Lubovac, Ove Andrén, Björn Olsson and Karin Klinga-Levan
    Citation: Cancer Cell International 2011 11:14
    Content type: Primary research Published on:

  6. Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two m...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou, Danai Daliani and Christos N Papandreou
    Citation: Cancer Cell International 2011 11:13
    Content type: Primary research Published on:

  7. Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring ole...

    Authors: Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan and Amin Malik Shah Abdul Majid
    Citation: Cancer Cell International 2011 11:12
    Content type: Primary research Published on:

  8. Breast cancer is one of the most prevalent cancers in the world and more than one million women are diagnosed leading to 410,000 deaths every year. In our previous studies new chalcone-imidazolone conjugates w...

    Authors: M Janaki Ramaiah, SNCVL Pushpavalli, G Rama Krishna, Pranjal Sarma, Debasmita Mukhopadhyay, Ahmed Kamal, Utpal Bhadra and Manika Pal Bhadra
    Citation: Cancer Cell International 2011 11:11
    Content type: Primary research Published on:

  9. Authors: Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, Audrey Rousseau, Blandine Boisselier, Ahmed Idbaih, Charles Félix Calvo, Pascal Leuraud, Myriam Lassalle, Soufiane El Hallani, Jean-Yves Delattre and Marc Sanson
    Citation: Cancer Cell International 2011 11:10
    Content type: Erratum Published on:

    The original article was published in Cancer Cell International 2010 10:1

  10. There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene M...

    Authors: Frida Abel, Daniel Dalevi, Maria Nethander, Rebecka Jörnsten, Katleen De Preter, Joëlle Vermeulen, Raymond Stallings, Per Kogner, John Maris and Staffan Nilsson
    Citation: Cancer Cell International 2011 11:9
    Content type: Primary research Published on:

  11. Bladder cancer is the commonest type of malignant tumors as a result of schistosomaisis which is a major healthy problem in many subtropical developing countries. The aim of this study is to comparatively eluc...

    Authors: Nadia S Metwally, Sanaa A Ali, Azza M Mohamed, Hussein M Khaled and Samia A Ahmed
    Citation: Cancer Cell International 2011 11:8
    Content type: Primary research Published on:

  13. The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channel...

    Authors: Viren Asher, Averil Warren, Robert Shaw, Heidi Sowter, Anish Bali and Raheela Khan
    Citation: Cancer Cell International 2011 11:6
    Content type: Primary research Published on:

  14. Less than 30% of malignant gliomas respond to adjuvant chemotherapy. Here, we have asked whether variations in the constitutive expression of early-growth response factor 1 (EGR-1) predicted acute cytotoxicity...

    Authors: Antonella Calogero, Antonio Porcellini, Vincenza Lombari, Cinzia Fabbiano, Antonietta Arcella, Massimo Miscusi, Donatella Ponti and Giuseppe Ragona
    Citation: Cancer Cell International 2011 11:5
    Content type: Primary research Published on:

  15. Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of act...

    Authors: Mario Menschikowski, Albert Hagelgans, Oliver Tiebel, Ludwig Klinsmann, Graeme Eisenhofer and Gabriele Siegert
    Citation: Cancer Cell International 2011 11:4
    Content type: Primary research Published on:

  16. The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical treatment of recurrent disease. Hypoxia is an environmental selection pressure that contributes to the developmen...

    Authors: Lara Milane, Zhenfeng Duan and Mansoor Amiji
    Citation: Cancer Cell International 2011 11:3
    Content type: Primary research Published on:

  17. Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have ...

    Authors: Seema Somji, Scott H Garrett, Conrad Toni, Xu Dong Zhou, Yun Zheng, Amornpan Ajjimaporn, Mary Ann Sens and Donald A Sens
    Citation: Cancer Cell International 2011 11:2
    Content type: Primary research Published on:

  18. Physiologic wound repair and tissue regeneration are associated with distinct cellular behaviors triggered by tissue damage. Normally quiescent stem cells proliferate to regenerate damaged tissue, while relati...

    Authors: William W Harless
    Citation: Cancer Cell International 2011 11:1
    Content type: Hypothesis Published on:

  19. CCAAT/enhancer binding protein-delta (C/EBP-delta) is a member of the highly conserved C/EBP family of basic region leucine zipper transcription factors. C/EBP family members regulate cell growth and different...

    Authors: Xueyan Yu, Junling Si, Yingjie Zhang and James W DeWille
    Citation: Cancer Cell International 2010 10:48
    Content type: Primary research Published on:

  20. Progerin is a truncated form of lamin A. It is identified in patients with Hutchinson-Gilford progeria syndrome (HGPS), a disease characterized by accelerated aging. The contribution of progerin toward aging h...

    Authors: Yong Tang, Yakun Chen, Hongmei Jiang and Daotai Nie
    Citation: Cancer Cell International 2010 10:47
    Content type: Primary research Published on:

  21. Glutathione peroxidase 3 (GPX3) is one of the key enzymes in the cellular defense against oxidative stress and the hepatocyte growth factor receptor, (MET) has been suggested to be influenced by the GPX3 gene exp...

    Authors: Eva Falck, Sandra Karlsson, Jessica Carlsson,, Gisela Helenius, Mats Karlsson and Karin Klinga-Levan
    Citation: Cancer Cell International 2010 10:46
    Content type: Primary research Published on:

  22. Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize th...

    Authors: Thangarajan Rajkumar, Neelakantan Vijayalakshmi, Gopisetty Gopal, Kesavan Sabitha, Sundersingh Shirley, Uthandaraman M Raja and Seshadri A Ramakrishnan
    Citation: Cancer Cell International 2010 10:45
    Content type: Primary research Published on:

  23. Epithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of EpCAM as a signalling receptor and activator of the wnt pathway, and its expression on tum...

    Authors: Markus Münz, Alexander Murr, Majk Kvesic, Doris Rau, Susanne Mangold, Stefan Pflanz, John Lumsden, Jörg Volkland, Jan Fagerberg, Gert Riethmüller, Dominik Rüttinger, Peter Kufer, Patrick A Baeuerle and Tobias Raum
    Citation: Cancer Cell International 2010 10:44
    Content type: Primary research Published on:

  25. The main morphological features of primitive cells, such as stem and progenitor cells, are that these cells consists only one nucleus. The main purpose of this study was to determine the differentiation capaci...

    Authors: Muhammad Dain Yazid, Shahrul Hisham Zainal Ariffin, Sahidan Senafi, Mohamad Abdul Razak and Rohaya Megat Abdul Wahab
    Citation: Cancer Cell International 2010 10:42
    Content type: Primary research Published on:

  26. Ephrin A1 (EFNA1) is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. In malignancy, the precise role of EFNA1 and its ...

    Authors: Spencer Alford, Adam Watson-Hurthig, Nadia Scott, Amanda Carette, Heather Lorimer, Jessa Bazowski and Perry L Howard
    Citation: Cancer Cell International 2010 10:41
    Content type: Primary research Published on:

  27. Alpha-tocopherol ether-linked acetic acid (α-TEA), an analog of vitamin E (RRR-alpha-tocopherol), is a potent and selective apoptosis-inducing agent for human cancer cells in vivo and in vitro. α-TEA induces apop...

    Authors: Jing Li, Weiping Yu, Richa Tiwary, Sook-Kyung Park, Ailian Xiong, Bob G Sanders and Kimberly Kline
    Citation: Cancer Cell International 2010 10:40
    Content type: Primary research Published on:

  28. The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H...

    Authors: Yingdong Zhang, Junjie Wang, Feng Liu, Zhenyu You, Ruijie Yang and Yong Zhao
    Citation: Cancer Cell International 2010 10:39
    Content type: Primary research Published on:

  31. Survivin is a member of the inhibitor-of-apoptosis (IAP) family which is widely expressed by many different cancers. Overexpression of survivin is associated with drug resistance in cancer cells, and reduced p...

    Authors: Chun Hei Antonio Cheung, Xueying Sun, Jagat R Kanwar, Ji-Zhong Bai, LiTing Cheng and Geoffrey W Krissansen
    Citation: Cancer Cell International 2010 10:36
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2010 10:43

  32. Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain...

    Authors: Héctor E López-Valdés, Luis Beltran-Parrazal, Kevin C Brennan and Andrew C Charles
    Citation: Cancer Cell International 2010 10:35
    Content type: Primary research Published on:

  34. Cytoglobin (Cygb) and neuroglobin (Ngb) are recently identified globin molecules that are expressed in vertebrate tissues. Upregulation of Cygb and Ngb under hypoxic and/or ischemic conditions in vitro and in viv...

    Authors: Marwan Emara, A Robert Turner and Joan Allalunis-Turner
    Citation: Cancer Cell International 2010 10:33
    Content type: Primary research Published on:

  35. Activating Transcription Factor (ATF) 3 is a key regulator of the cellular integrated stress response whose expression has also been correlated with pro-apoptotic activities in tumour cell models. Combination ...

    Authors: Carly St Germain, Anna O'Brien and Jim Dimitroulakos
    Citation: Cancer Cell International 2010 10:32
    Content type: Primary research Published on:

  36. Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity a...

    Authors: Jayesh Sagar, Kevin Sales, Jan-Willem Taanman, Sas Dijk and Marc Winslet
    Citation: Cancer Cell International 2010 10:31
    Content type: Primary research Published on:

  37. MCF-10A, immortalized but non-transformed human breast epithelial cells, are widely used in research examining carcinogenesis. The studies presented here were initiated with the observation that MCF-10A cells ...

    Authors: Rita Yusuf and Krystyna Frenkel
    Citation: Cancer Cell International 2010 10:30
    Content type: Primary research Published on:

  38. Melanoma differentiation associated gene-7 (MDA-7), also known as interleukin (IL)-24, is a tumour suppressor gene associated with differentiation, growth and apoptosis. However, the mechanisms underlying its ...

    Authors: Neill Patani, Anthony Douglas-Jones, Robert Mansel, Wen Jiang and Kefah Mokbel
    Citation: Cancer Cell International 2010 10:29
    Content type: Primary research Published on:

  39. Young women diagnosed with breast cancer are known to have a higher mortality rate from the disease than older patients. Specific risk factors leading to this poorer outcome have not been identified. In the pr...

    Authors: Jonathan Eckard, Jisen Dai, Jing Wu, Jinlong Jian, Qing Yang, Haobin Chen, Max Costa, Krystyna Frenkel and Xi Huang
    Citation: Cancer Cell International 2010 10:28
    Content type: Primary research Published on:

  40. D-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in the biosynthesis of heparansulfate proteoglycans. Down-regulation of GLCE expression in human breast tumours suggests a possible involvement of the ge...

    Authors: Tatiana Y Prudnikova, Liudmila A Mostovich, Natalia V Domanitskaya, Tatiana V Pavlova, Vladimir I Kashuba, Eugene R Zabarovsky and Elvira V Grigorieva
    Citation: Cancer Cell International 2010 10:27
    Content type: Primary research Published on:

  41. The cell microenvironment, especially extracellular matrix proteins, plays an important role in tumor cell response to chemotherapeutic drugs. The present study was designed to investigate whether this microen...

    Authors: Emilie Millerot-Serrurot, Marie Guilbert, Nicolas Fourré, Wojciech Witkowski, Georges Said, Laurence Van Gulick, Christine Terryn, Jean-Marie Zahm, Roselyne Garnotel and Pierre Jeannesson
    Citation: Cancer Cell International 2010 10:26
    Content type: Primary research Published on:

  43. We have shown that the microtopography (mT) underlying colon cancer changes as a tumor de-differentiates. We distinguish the well-differentiated mT based on the increasing number of "pits" and poorly different...

    Authors: Rebecca Rapier, Jameela Huq, Ramana Vishnubhotla, Marinka Bulic, Cecile M Perrault, Vitali Metlushko, Michael Cho, Roger Tran Son Tay and Sarah C Glover
    Citation: Cancer Cell International 2010 10:24
    Content type: Primary research Published on:

  44. Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysre...

    Authors: Shyam Nyati, Brian D Ross, Alnawaz Rehemtulla and Mahaveer S Bhojani
    Citation: Cancer Cell International 2010 10:23
    Content type: Review Published on:

  45. The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis ...

    Authors: Nives Pećina-Šlaus
    Citation: Cancer Cell International 2010 10:22
    Content type: Review Published on:

  46. Intravesical immunotherapy with Mycobacterium bovis bacillus Calmette-Guérin has been established as the most effective adjuvant treatment for high risk non-muscle-invasive bladder cancer (NMIBC). We investigated...

    Authors: Katja Schwarzer, Martin Foerster, Thomas Steiner, Inge-Marie Hermann and Eberhard Straube
    Citation: Cancer Cell International 2010 10:21
    Content type: Primary research Published on:

  48. Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the ...

    Authors: Eleanor I Ager, Way W Chong, Shu-wen Wen and Christopher Christophi
    Citation: Cancer Cell International 2010 10:19
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2010 10:37

  49. In this study the effect of myenteric denervation induced by benzalconium chloride (BAC) on distribution of fibrillar components of extracellular matrix (ECM) and inflammatory cells was investigated in gastric...

    Authors: Cássia F Estofolete, Carla Botelho-Machado, Sebastião R Taboga, Sérgio Zucoloto, Ana Cláudia Polli-Lopes and Cristiane D Gil
    Citation: Cancer Cell International 2010 10:18
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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