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  1. Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibitio...

    Authors: Hiroko Tabunoki, Naoki Saito, Khanit Suwanborirux, Kornvika Charupant and Jun-ichi Satoh
    Citation: Cancer Cell International 2012 12:14
  2. The Notch signaling pathway is crucial in T-cell development, Notch 1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To investigate the feature of Notch 1 mutation and its corres...

    Authors: Chunlan Lin, Haitao Zheng, Chunyan Wang, Lijian Yang, Shaohua Chen, Bo Li, Yubing Zhou, Huo Tan and Yangqiu Li
    Citation: Cancer Cell International 2012 12:13
  3. GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT...

    Authors: Danielle Park, Joyce Chiu, Gabriel G Perrone, Pierre J Dilda and Philip J Hogg
    Citation: Cancer Cell International 2012 12:11
  4. Although the primary risk factors for developing oral cancers are well understood, less is known about the relationship among the secondary factors that may modulate the progression of oral cancers, such as hi...

    Authors: Michael Moody, Oanh Le, Megan Rickert, Jeremy Manuele, Sarah Chang, Gary Robinson, Jeffrey Hajibandeh, John Silvaroli, Mark A Keiserman, Christine J Bergman and Karl Kingsley
    Citation: Cancer Cell International 2012 12:10
  5. Recently electroporation using biphasic pulses was successfully applied in clinical developments for treating tumours in humans and animals. We evaluated the effects of electrical treatment on cell adhesion be...

    Authors: Viktoria N Pehlivanova, Iana H Tsoneva and Rumiana D Tzoneva
    Citation: Cancer Cell International 2012 12:9
  6. The effect of cell injury and apoptosis induced by ultrasound with contrast agent has been verified. Contrast agent enhanced apoptosis and expression of genes that related to apoptosis and are responsive to ul...

    Authors: Zao Jiang, Wei Wu and Meng-lu Qian
    Citation: Cancer Cell International 2012 12:8
  7. A potential strategy for the diagnosis of lung cancer is to exploit the distinct metabolic signature of this disease by way of biomarkers found in different sample types. In this study, we investigated whether...

    Authors: Yosuke Hanai, Ken Shimono, Hiroaki Oka, Yoshinobu Baba, Kunio Yamazaki and Gary K Beauchamp
    Citation: Cancer Cell International 2012 12:7
  8. Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and...

    Authors: Devan E Thompson, Megan D Siwicky and Roger A Moorehead
    Citation: Cancer Cell International 2012 12:6
  9. Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeut...

    Authors: Elizabeth Hijona, Jesús María Banales, Lander Hijona, Juan Francisco Medina, Juan Arenas, Marta Herreros-Villanueva, Pablo Aldazabal and Luis Bujanda
    Citation: Cancer Cell International 2012 12:5
  10. Removal of numerous classes of chemical pollutants from the industrial wastewater such as textile, pharmaceutical and olive mill using conventional wastewater treatment, is incomplete and several studies sugge...

    Authors: Hedi Ben Mansour, Afef Dellai and Yosra Ayed
    Citation: Cancer Cell International 2012 12:4
  11. The aim of this study was to evaluate the biological and pharmaceutical activities of 14 amphiphilic liquid-crystalline compounds (LCs), i.e, phenylpyrimidine derivatives possessing D-glucamine and cyanobiphenyl ...

    Authors: Junya Ishikawa, Yuuka Takahashi, Masaharu Hazawa, Yukako Fukushi, Atsushi Yoshizawa and Ikuo Kashiwakura
    Citation: Cancer Cell International 2012 12:3
  12. Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administra...

    Authors: Micaela Martinez, Nadia Ono, Marina Planutiene, Kestutis Planutis, Edward L Nelson and Randall F Holcombe
    Citation: Cancer Cell International 2012 12:2

    The Erratum to this article has been published in Cancer Cell International 2013 13:80

  13. Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments. Identifying novel drug targets for this indicat...

    Authors: Friedrich G Kapp, Anette Sommer, Thomas Kiefer, Gottfried Dölken and Bernard Haendler
    Citation: Cancer Cell International 2012 12:1
  14. Currently, Atypical Teratoid Rhabdoid Tumor (AT/RT) constitutes one of the most difficult to treat malignancies in pediatrics. Hence, new knowledge of potential targets for therapeutics and the development of ...

    Authors: Aarthi Jayanthan, Delphine Bernoux, Pinaki Bose, Karl Riabowol and Aru Narendran
    Citation: Cancer Cell International 2011 11:44
  15. In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity. Since 2ME2 has limited biological acces...

    Authors: Michelle H Visagie and Anna M Joubert
    Citation: Cancer Cell International 2011 11:43
  16. Dysregulation of many apoptotic related genes and androgens are critical in the development, progression, and treatment of prostate cancer. The differential sensitivity of tumour cells to TRAIL-induced apoptos...

    Authors: David Vindrieux, Marie Réveiller, Jacqueline Chantepie, Sadok Yakoub, Catherine Deschildre, Alain Ruffion, Marian Devonec, Mohamed Benahmed and Renée Grataroli
    Citation: Cancer Cell International 2011 11:42
  17. Neuron specific enolase (ENO2, γ-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. The goal of the present study was to determine if ENO2 expression in the...

    Authors: Maureen A Soh, Scott H Garrett, Seema Somji, Jane R Dunlevy, Xu Dong Zhou, Mary Ann Sens, Chandra S Bathula, Christina Allen and Donald A Sens
    Citation: Cancer Cell International 2011 11:41
  18. Hepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette...

    Authors: Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Susanne Serba, Markus W Büchler and Peter Schemmer
    Citation: Cancer Cell International 2011 11:40
  19. During cell division, replication of the genomic DNA is performed by high-fidelity DNA polymerases but these error-free enzymes can not synthesize across damaged DNA. Specialized DNA polymerases, so called DNA...

    Authors: Philip A Knobel and Thomas M Marti
    Citation: Cancer Cell International 2011 11:39
  20. This study was designed to evaluate the potential chemopreventive activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (...

    Authors: Hala O El Mesallamy, Nadia S Metwally, Mahmoud S Soliman, Kawkab A Ahmed and Mai M Abdel Moaty
    Citation: Cancer Cell International 2011 11:38
  21. In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.

    Authors: Jihed Boubaker, Wissem Bhouri, Mohamed Ben Sghaier, Ines Bouhlel, Ines Skandrani, Kamel Ghedira and Leila Chekir-Ghedira
    Citation: Cancer Cell International 2011 11:37
  22. Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular mach...

    Authors: SNCVL Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, JL Aditya, Ravindra M Kumbhare, Utpal Bhadra and Manika Pal Bhadra
    Citation: Cancer Cell International 2011 11:36
  23. The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT)...

    Authors: Jessica T Li, Ka Bian, Alan L Zhang, Dong H Kim, William W Ashley, Rahul Nath, Ian McCutcheon, Bingliang Fang and Ferid Murad
    Citation: Cancer Cell International 2011 11:35
  24. Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its a...

    Authors: Melissa E Smith, Bhaskar C Das and Ganjam V Kalpana
    Citation: Cancer Cell International 2011 11:34
  25. Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors, a concept that is known as cancer immunosurveillan...

    Authors: Heba A Alshaker and Khalid Z Matalka
    Citation: Cancer Cell International 2011 11:33
  26. Cell fusion induced by polyethylene glycol (PEG) is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherap...

    Authors: Filippo Pedrazzoli, Iraklis Chrysantzas, Luca Dezzani, Vittorio Rosti, Massimo Vincitorio and Giammaria Sitar
    Citation: Cancer Cell International 2011 11:32
  27. The objective of this study was to investigate whether the levels of glucose or certain amino acids could regulate the expression of a cell cycle repressor protein p27(Kip1), thereby dictating the risk of canc...

    Authors: Isao Eto
    Citation: Cancer Cell International 2011 11:31
  28. The synergic action of KHCO3 and D-ribose is tested on A72 and HTB-126 cell lines proliferation using K:D-Rib solution. Altered Na+/K+ ATPase expression and activity were shown in patients with cancer. Studies in...

    Authors: Simonetta Croci, Luca Bruni, Simona Bussolati, Marianna Castaldo and Maurizio Dondi
    Citation: Cancer Cell International 2011 11:30
  29. The inhibition of Br east Ca ncer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been iden...

    Authors: Johanne I Weberpals, Anna M O'Brien, Nima Niknejad, Kyla D Garbuio, Katherine V Clark-Knowles and Jim Dimitroulakos
    Citation: Cancer Cell International 2011 11:29
  30. Molecular classification of human breast cancers has identified at least 5 distinct tumor subtypes; luminal A, luminal B, Her2-enriched, basal-like and claudin-low. The claudin-low subtype was identified in 20...

    Authors: Craig I Campbell, Devan E Thompson, Megan D Siwicky and Roger A Moorehead
    Citation: Cancer Cell International 2011 11:28
  31. In this study, we pilot tested an in vitro assay of cancer killing activity (CKA) in circulating leukocytes of 22 cancer cases and 25 healthy controls.

    Authors: Michael J Blanks, John R Stehle Jr, Wei Du, Jonathan M Adams, Mark C Willingham, Glenn O Allen, Jennifer J Hu, James Lovato, Istvan Molnar and Zheng Cui
    Citation: Cancer Cell International 2011 11:26
  32. Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer c...

    Authors: Brandon M Schickling, Nukhet Aykin-Burns, Kimberly K Leslie, Douglas R Spitz and Victoria P Korovkina
    Citation: Cancer Cell International 2011 11:25
  33. In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical ...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer
    Citation: Cancer Cell International 2011 11:24
  34. Brain-derived neurotrophic factor (BDNF) has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, inclu...

    Authors: Neill Patani, Wen G Jiang and Kefah Mokbel
    Citation: Cancer Cell International 2011 11:23
  35. Previously we have shown that oncogenic Ha-Ras stimulated in vivo metastasis through RalGEF-Ral signaling. RalA and RalB are highly homologous small G proteins belonging to Ras superfamily. They can be activated ...

    Authors: Vera A Rybko, Anna V Knizhnik, Andrei V Komelkov, Vasily N Aushev, Lyubov S Trukhanova and Elena M Tchevkina
    Citation: Cancer Cell International 2011 11:22
  36. Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tis...

    Authors: Christa Nagler, Cornelia Hardt, Kurt S Zänker and Thomas Dittmar
    Citation: Cancer Cell International 2011 11:21
  37. Genomic alterations are common features of cancer cells, and some of these changes are proven to be neoplastic-specific. Such alterations may serve as valuable tools for diagnosis and classification of tumors,...

    Authors: Eva Falck, Carola Hedberg, Karin Klinga-Levan and Afrouz Behboudi
    Citation: Cancer Cell International 2011 11:20
  38. Secondary therapy-related acute lymphoblastic leukemia might emerge following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other alternatives should be pursued to treat leukemia.

    Authors: Angelica R Bonilla-Porras, Marlene Jimenez-Del-Rio and Carlos Velez-Pardo
    Citation: Cancer Cell International 2011 11:19
  39. Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of...

    Authors: Mine Erguven, Ayhan Bilir, Nuray Yazihan, Ezgi Ermis, Akin Sabanci, Esin Aktas, Yavuz Aras and Vehbi Alpman
    Citation: Cancer Cell International 2011 11:18
  40. Aimed to facilitate candidate biomarkers selection and improve network-based multi-target therapy, we perform comparative proteomics research on muscle-invasive bladder transitional cell carcinoma. Laser captu...

    Authors: Hai Tao Niu, Zhen Dong, Gang Jiang, Ting Xu, Yan Qun Liu, Yan Wei Cao, Jun Zhao and Xin Sheng Wang
    Citation: Cancer Cell International 2011 11:17
  41. Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory ...

    Authors: Susana del Toro-Arreola, Naela Arreygue-Garcia, Adriana Aguilar-Lemarroy, Angel Cid-Arregui, Miriam Jimenez-Perez, Jesse Haramati, Patricio Barros-Nuñez, Oscar Gonzalez-Ramella, Alicia del Toro-Arreola, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores, Alejandro Bravo-Cuellar, Adrian Daneri-Navarro and Luis F Jave-Suarez
    Citation: Cancer Cell International 2011 11:15
  42. MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cance...

    Authors: Jessica Carlsson, Sabina Davidsson, Gisela Helenius, Mats Karlsson, Zelmina Lubovac, Ove Andrén, Björn Olsson and Karin Klinga-Levan
    Citation: Cancer Cell International 2011 11:14
  43. Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two m...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou, Danai Daliani and Christos N Papandreou
    Citation: Cancer Cell International 2011 11:13
  44. Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring ole...

    Authors: Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan and Amin Malik Shah Abdul Majid
    Citation: Cancer Cell International 2011 11:12
  45. Breast cancer is one of the most prevalent cancers in the world and more than one million women are diagnosed leading to 410,000 deaths every year. In our previous studies new chalcone-imidazolone conjugates w...

    Authors: M Janaki Ramaiah, SNCVL Pushpavalli, G Rama Krishna, Pranjal Sarma, Debasmita Mukhopadhyay, Ahmed Kamal, Utpal Bhadra and Manika Pal Bhadra
    Citation: Cancer Cell International 2011 11:11
  46. Authors: Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, Audrey Rousseau, Blandine Boisselier, Ahmed Idbaih, Charles Félix Calvo, Pascal Leuraud, Myriam Lassalle, Soufiane El Hallani, Jean-Yves Delattre and Marc Sanson
    Citation: Cancer Cell International 2011 11:10

    The original article was published in Cancer Cell International 2010 10:1

  47. There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene M...

    Authors: Frida Abel, Daniel Dalevi, Maria Nethander, Rebecka Jörnsten, Katleen De Preter, Joëlle Vermeulen, Raymond Stallings, Per Kogner, John Maris and Staffan Nilsson
    Citation: Cancer Cell International 2011 11:9

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