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  1. Primary Research

    Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma

    Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought t...

    Qiong Wang, Zhongwu Li, Yaping Wu, Rong Huang, Yumin Zhu, Wei Zhang, Yanling Wang and Jie Cheng

    Cancer Cell International 2017 17:107

    Published on: 21 November 2017

  2. Primary Research

    Microencapsulation of low-passage poorly-differentiated human mucoepidermoid carcinoma cells by alginate microcapsules: in vitro profiling of angiogenesis-related molecules

    Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly different...

    Sen Yang and Li-Juan Guo

    Cancer Cell International 2017 17:106

    Published on: 21 November 2017

  3. Primary Research

    Volatile organic metabolites identify patients with gastric carcinoma, gastric ulcer, or gastritis and control patients

    Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In...

    Hongshuang Tong, Yue Wang, Yue Li, Shujuan Liu, Chunjie Chi, Desheng Liu, Lei Guo, Enyou Li and Changsong Wang

    Cancer Cell International 2017 17:108

    Published on: 21 November 2017

  4. Primary Research

    Restoration of miR-29b exerts anti-cancer effects on glioblastoma

    Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 sub...

    Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim and Chul-Kee Park

    Cancer Cell International 2017 17:104

    Published on: 17 November 2017

  5. Primary Research

    Role of microRNA-33a in regulating the expression of PD-1 in lung adenocarcinoma

    MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cyt...

    Laura Boldrini, Mirella Giordano, Cristina Niccoli, Franca Melfi, Marco Lucchi, Alfredo Mussi and Gabriella Fontanini

    Cancer Cell International 2017 17:105

    Published on: 17 November 2017

  6. Primary research

    CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma

    Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem ...

    Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen

    Cancer Cell International 2017 17:103

    Published on: 14 November 2017

  7. Primary Research

    MicroRNA-214-3p inhibits proliferation and cell cycle progression by targeting MELK in hepatocellular carcinoma and correlates cancer prognosis

    MicroRNAs are considered as potential regulators in various biological pathways and contribute to the diagnosis and prognosis of cancers. MicroRNA-214-3p (miR-214-3p) was proved to be correlated with various c...

    Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang

    Cancer Cell International 2017 17:102

    Published on: 7 November 2017

  8. Review

    Targeting deubiquitinating enzymes in cancer stem cells

    Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential...

    Hu Lei, Huizhuang Shan and Yingli Wu

    Cancer Cell International 2017 17:101

    Published on: 3 November 2017

  9. Correction

    Correction to: The role of pparγ and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation

    Upon publication of the original article [1], it was noticed that corresponding author status has been erroneously attributed to José Antonio Fagundes Assumpção. The corresponding author of this manuscript should...

    José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Cancer Cell International 2017 17:99

    Published on: 2 November 2017

    The original article was published in Cancer Cell International 2017 17:82

  10. Review

    An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia

    Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-re...

    Lisa Repsold, Roger Pool, Mohammed Karodia, Gregory Tintinger and Annie Margaretha Joubert

    Cancer Cell International 2017 17:89

    Published on: 30 October 2017

  11. Primary Research

    miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1

    miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC), a series of miRNAs have been proven to involve into CRC carcinogenesis, invasion and metastasis. Aberrant miR-42...

    Wen-Ting Wei, Xin-Xin Nian, Shu-Yang Wang, Hong-Li Jiao, Yong-Xia Wang, Zhi-Yuan Xiao, Run-Wei Yang, Yan-Qing Ding, Ya-Ping Ye and Wen-Ting Liao

    Cancer Cell International 2017 17:91

    Published on: 28 October 2017

  12. Primary Research

    High brain acid soluble protein 1(BASP1) is a poor prognostic factor for cervical cancer and promotes tumor growth

    The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of ce...

    Huiru Tang, Yan Wang, Bing Zhang, Shiqiu Xiong, Liangshuai Liu, Wei Chen, Guosheng Tan and Heping Li

    Cancer Cell International 2017 17:97

    Published on: 24 October 2017

  13. Primary Research

    miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer

    The tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure.

    Gang Chen, Mingfeng He, Yin Yin, Ting Yan, Wenfang Cheng, Zebo Huang, Lan Zhang, Huo Zhang, Ping Liu, Wei Zhu and Yichao Zhu

    Cancer Cell International 2017 17:95

    Published on: 24 October 2017

  14. Primary Research

    Sporadic PCDH18 somatic mutations in EpCAM-positive hepatocellular carcinoma

    The relationship between specific genome alterations and hepatocellular carcinoma (HCC) cancer stem cells (CSCs) remains unclear. In this study, we evaluated the relationship between somatic mutations and epit...

    Takehiro Hayashi, Taro Yamashita, Hikari Okada, Kouki Nio, Yasumasa Hara, Yoshimoto Nomura, Tomoyuki Hayashi, Yoshiro Asahina, Mariko Yoshida, Naoki Oishi, Hajime Sunagozaka, Hajime Takatori, Masao Honda and Shuichi Kaneko

    Cancer Cell International 2017 17:94

    Published on: 23 October 2017

  15. Primary Research

    The role of miR-485-5p/NUDT1 axis in gastric cancer

    Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). However, the mechanisms underlying gastric carcinogenesis and the dys-regulation of NUD...

    Jingjing Duan, Haiyang Zhang, Shuang Li, Xinyi Wang, Haiou Yang, Shunchang Jiao and Yi Ba

    Cancer Cell International 2017 17:92

    Published on: 17 October 2017

  16. Primary Research

    Integrated genomic characterization of cancer genes in glioma

    Cancers are caused by the acquisition of somatic mutations. Numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely ...

    Aijun Liang, Bin Zhou and Wei Sun

    Cancer Cell International 2017 17:90

    Published on: 13 October 2017

  17. Primary Research

    Down-regulation of IFITM1 and its growth inhibitory role in cervical squamous cell carcinoma

    Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. Howev...

    Weinan Zheng, Zhimin Zhao, Xinan Yi, Qiangqiang Zuo, Hongtao Li, Xiaoqing Guo, Dongmei Li, Hongchang He, Zemin Pan, Peiwen Fan, Feng Li, Yanhong Liao and Renfu Shao

    Cancer Cell International 2017 17:88

    Published on: 10 October 2017

  18. Primary Research

    Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line

    Glioblastoma is the most common and aggressive brain tumor associated with a poor prognosis. Plant homeodomain finger protein 20 (PHF20) is highly expressed in primary human gliomas and its expression is assoc...

    Tianlong Liu, Tiejun Zhang, Feng Zhou, Jitao Wang, Xiaohu Zhai, Nan Mu, Jongsun Park, Minna Liu, Wenxing Liu, Peijin Shang, Yi Ding, Aidong Wen and Yuwen Li

    Cancer Cell International 2017 17:87

    Published on: 4 October 2017

  19. Primary Research

    Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis

    Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemothe...

    Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen and Shi-Bing Su

    Cancer Cell International 2017 17:84

    Published on: 26 September 2017

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