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  1. Lenvatinib and lenvatinib-based combination treatments are widely used in patients with unresectable hepatocellular carcinoma (uHCC) in clinical practice, but their curative effect and safety need further stud...

    Authors: Yun Zhu, Penghui Sun, Kunyuan Wang, Shuzhe Xiao, Yanling Cheng, Xiangzhao Li, Biao Wang, Jiancong Li, Wenxuan Yu and Yang Cheng

    Citation: Cancer Cell International 2021 21:503

    Content type: Primary research

    Published on:

  2. Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs (tRNA-derived stress-induced RNA), an emerging category of regulatory RNA molecules derived from transfer RNAs (tRNAs)...

    Authors: Yongqiang Zhou, Jinjing Hu, Lu Liu, Mengchao Yan, Qiyu Zhang, Xiaojing Song, Yan Lin, Dan Zhu, Yongjian Wei, Zongli Fu, Liming Hu, Yue Chen and Xun Li

    Citation: Cancer Cell International 2021 21:502

    Content type: Primary research

    Published on:

  3. Recent reports suggest that the long non-coding RNA LBX2 antisense RNA 1 (LBX2-AS1) acts as an important regulator in cancer progression, but its significance in colorectal cancer (CRC) remains undetermined.

    Authors: Yu-Nan Ma, Yong-Gang Hong, Guan-Yu Yu, Si-yuan Jiang, Bo-lun Zhao, An Guo, Yao Wang, Xiao-ming Cui, Li-Qiang Hao and Hao Zheng

    Citation: Cancer Cell International 2021 21:501

    Content type: Primary research

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  4. The prognosis of hepatocellular carcinoma (HCC) is not optimistic. Our study focused on present inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), gam...

    Authors: Wenlong Wu, Quancheng Wang, Dandan Han, Jianhui Li, Ye Nie, Dongnan Guo, Long Yang, Kaishan Tao, Xuan Zhang and Kefeng Dou

    Citation: Cancer Cell International 2021 21:500

    Content type: Primary research

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  5. Cancers are regarded as one of the main causes of death and result in high health burden worldwide. The management of cancer include chemotherapy, surgery and radiotherapy. The chemotherapy, which involves the...

    Authors: Ahmed Olatunde, Manisha Nigam, Rahul Kunwar Singh, Abhaya Shikhar Panwar, Abdulwahab Lasisi, Fahad A. Alhumaydhi, Vijay Jyoti kumar, Abhay Prakash Mishra and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:499

    Content type: Review

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  6. Primary breast double-hit lymphoma (PB-DHL) is a rare, highly aggressive malignancy that poses challenges regarding accurate diagnosis and selecting optimal treatment regimens.

    Authors: Tingting Zhang, Yuanfeng Zhang, Hairong Fei, Xue Shi, Liang Wang, Peijun Wang, Jie Yu, Yuyan Shen and Sizhou Feng

    Citation: Cancer Cell International 2021 21:498

    Content type: Primary research

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  7. Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnost...

    Authors: Mandana Ameli-Mojarad, Melika Ameli-Mojarad, Mahrooyeh Hadizadeh, Chris Young, Hosna Babini, Ehsan Nazemalhosseini-Mojarad and Maziar Ashrafian Bonab

    Citation: Cancer Cell International 2021 21:496

    Content type: Review

    Published on:

  8. Increasing studies focused on the regulatory roles of circular RNAs (circRNAs) in diverse cancers. This study was to evaluate the function and mechanism of circRNA Scm-like with four malignant brain tumor doma...

    Authors: Zhiwei Chang, Yang Fu, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao and Yanru Qin

    Citation: Cancer Cell International 2021 21:495

    Content type: Primary research

    Published on:

  9. Papillary thyroid carcinoma (PTC), with a rapidly increasing incidence, is the most prevalent malignant cancer of the thyroid. However, its pathogenesis is unclear and its specific clinical indicators have not...

    Authors: Yonglian Huang, Hengwei Zhang, Lidong Wang, Chenxi Liu, Mingyue Guo, Hao Tan and Zhen Liu

    Citation: Cancer Cell International 2021 21:494

    Content type: Primary research

    Published on:

  10. Gastric cancer (GC) is one of the most common and fatal cancers worldwide. Effective biomarkers to aid the early diagnosis of GC, as well as predict the course of disease, are urgently needed. Hence, we explor...

    Authors: Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin and Weihua Fu

    Citation: Cancer Cell International 2021 21:493

    Content type: Primary research

    Published on:

  11. Toosendanin (TSN) is a triterpenoid compound mainly used as an ascaris repellant. Recent studies have shown that it possesses antitumor effects in many types of tumor cells. However, the effects of TSN on glio...

    Authors: Chaochao Zhang, Haijun Gao, Ziqiang Liu, Jiacheng Lai, Zhixin Zhan, Yong Chen and Haiyan Huang

    Citation: Cancer Cell International 2021 21:492

    Content type: Primary research

    Published on:

  12. T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therap...

    Authors: Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng and Yangqiu Li

    Citation: Cancer Cell International 2021 21:490

    Content type: Primary research

    Published on:

  13. As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory drugs. As a genetic drug carrier, exosomes are beneficial to improve t...

    Authors: Wen Zhou, Mingming Xu, Zhipeng Wang and Mingjun Yang

    Citation: Cancer Cell International 2021 21:485

    Content type: Primary research

    Published on:

  14. Colorectal cancer (CRC) is one of the most malignant cancer types, characterized by elevated mortality rate and treatment resistance. Despite the progress achieved in the explanation of the molecular basis of ...

    Authors: Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar and Fatemeh Pakdaman

    Citation: Cancer Cell International 2021 21:483

    Content type: Minireview

    Published on:

  15. DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs), whose function in hepatocellular carcinoma has...

    Authors: Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan and Sha-Sha Fan

    Citation: Cancer Cell International 2021 21:482

    Content type: Primary research

    Published on:

  16. Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop n...

    Authors: Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei and Lin Chen

    Citation: Cancer Cell International 2021 21:481

    Content type: Primary research

    Published on:

  17. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditi...

    Authors: Xiao Li, Hongming Zhu, Weixuan Sun, Xingru Yang, Qing Nie and Xuedong Fang

    Citation: Cancer Cell International 2021 21:479

    Content type: Review

    Published on:

  18. The long noncoding RNA gastric cancer associated transcript 3 (GACAT3) has been demonstrated to be implicated in the carcinogenesis and progression of many malignancies. However, GACAT3’s levels and role in es...

    Authors: Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang and Yuhang Xiao

    Citation: Cancer Cell International 2021 21:478

    Content type: Primary research

    Published on:

  19. Long noncoding RNAs (lncRNAs) have been elucidated to participate in the development and progression of various cancers. In this study, we aimed to explore the underlying functions and mechanisms of LINC00958 ...

    Authors: Hong Liang, Qiuyan Zhao, Zhonglin Zhu, Chao Zhang and Hui Zhang

    Citation: Cancer Cell International 2021 21:477

    Content type: Primary research

    Published on:

  20. Muscle-invasive bladder cancer (MIBC) is one of the most important type of bladder cancer, with a high morbidity and mortality rate. Studies have found that long non-coding RNA (lncRNA) plays a key role in mai...

    Authors: Yingchun Liang, Fangdie Ye, Zhang Cheng, Yuxi Ou, Lujia Zou, Yun Hu, Jimeng Hu and Haowen Jiang

    Citation: Cancer Cell International 2021 21:476

    Content type: Primary research

    Published on:

  21. Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system. However, the prognostic value of XDH...

    Authors: Zhen Lin, Yi-Zhao Xie, Ming-Chun Zhao, Pin-Pin Hou, Juan Tang and Guang-Liang Chen

    Citation: Cancer Cell International 2021 21:475

    Content type: Primary research

    Published on:

  22. Breast cancer is the most common cancer in women, and its high mortality has become one of the biggest health problems globally. Several studies have reported an association between breast cancer and ATM gene ...

    Authors: Masoumeh Moslemi, Maryam Vafaei, Pouria Khani, Marzieh Soheili, Reza Nedaeinia, Mostafa Manian, Yousef Moradi and Ehsan Sohrabi

    Citation: Cancer Cell International 2021 21:474

    Content type: Review

    Published on:

  23. Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. However, major limitations are the ava...

    Authors: Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan and Priya Ramanathan

    Citation: Cancer Cell International 2021 21:473

    Content type: Primary research

    Published on:

  24. CD9 is implicated in cancer progression and metastasis by its role in suppressing cancer cell proliferation and survival. However, the prognostic and clinicopathological significance of CD9 expression is contr...

    Authors: Hyun Min Koh, Bo Gun Jang, Dong Hui Lee and Chang Lim Hyun

    Citation: Cancer Cell International 2021 21:472

    Content type: Review

    Published on:

  25. Hepatocellular carcinoma (HCC) is an aggressive cancer with a high rate of death globally. The use of bioinformatics may help to identify immune cell-related genes both as targets for potential immunotherapies...

    Authors: Chen Xue, Xinyu Gu and Lanjuan Li

    Citation: Cancer Cell International 2021 21:471

    Content type: Primary research

    Published on:

  26. Understanding the molecular mechanisms of cancer biology introduces targeted therapy as a complementary method along with other conventional therapies. Recombinant immunotoxins are tumor specific antibodies th...

    Authors: Reza Mahmoudi, Hassan Dianat-Moghadam, Mansour Poorebrahim, Samaneh Siapoush, Vahdat Poortahmasebi, Reza Salahlou and Mohammad Rahmati

    Citation: Cancer Cell International 2021 21:470

    Content type: Review

    Published on:

  27. Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have demonstrated an association between overexpressed and activated STAT3 a...

    Authors: Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri and Saeed Samarghandian

    Citation: Cancer Cell International 2021 21:468

    Content type: Review

    Published on:

  28. Prostate cancer (PCa) is still a serious male malignant disease across the world. However, no exact pathogenesis had been explained. Although adenylosuccinate lyase (ADSL) gene was identified to be important i...

    Authors: Jinling Liao, Qiong Song, Jie Li, Kechen Du, Yang Chen, Chunlin Zou and Zengnan Mo

    Citation: Cancer Cell International 2021 21:467

    Content type: Primary research

    Published on:

  29. Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence is the main cause of treatment failure. The changes in apoptosis and au...

    Authors: Hu Qiu, Haixia Song, Man Luo, Shaobo Ke, Wei Shi, Jiamei Chen, Wensi Zhao, Hesheng Luo and Yongshun Chen

    Citation: Cancer Cell International 2021 21:466

    Content type: Primary research

    Published on:

  30. To evaluate the clinical effectiveness of a novel CellDetect staining technique, compared with fluorescent in situ hybridization (FISH), and urine cytology, in the diagnosis of urothelial carcinoma (UC).

    Authors: Donghao Shang, Yuting Liu, Xiuhong Xu, Zhenghao Chen and Daye Wang

    Citation: Cancer Cell International 2021 21:465

    Content type: Primary research

    Published on:

  31. Interferon-alpha (IFN-α) is a general therapeutic regimen to be utilized in hepatocellular carcinoma (HCC). However, regulatory mechanisms of IFN-α on competing endogenous RNAs (ceRNAs) level in anti-HCC relap...

    Authors: Yibin Wu, Longrong Wang, Xiaoshuang Wang, Yiming Zhao, Anrong Mao, Ning Zhang, Jiamin Zhou, Qi Pan, Weiping Zhu and Lu Wang

    Citation: Cancer Cell International 2021 21:464

    Content type: Primary research

    Published on:

  32. LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of N...

    Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu and Zheng Wang

    Citation: Cancer Cell International 2021 21:463

    Content type: Primary research

    Published on:

  33. Accumulating evidence indicates that dysregulation of miR-182-5p can serve as diagnostic and prognostic biomarkers for some cancers, whereas the role of miR-182-5p has not been explored in nasopharyngeal carci...

    Authors: Gang Wang, Fangzheng Zhou, Tong Ou, Haiyan Sun, Zhirui Shan, Yingshen Lu, Gui Chen, Simin Yuan, Xiaowen Zhang and Song Wu

    Citation: Cancer Cell International 2021 21:462

    Content type: Primary research

    Published on:

  34. New effective drugs for prostate cancer (PCa) treatment are urgently needed. Avasimibe was recently identified as a promising drug for anticancer therapies. The main purpose of this study was to explore the ef...

    Authors: Kangping Xiong, Gang Wang, Tianchen Peng, Fenfang Zhou, Siming Chen, Wei Liu, Lingao Ju, Yu Xiao, Kaiyu Qian and Xinghuan Wang

    Citation: Cancer Cell International 2021 21:461

    Content type: Primary research

    Published on:

  35. Autophagy is believed to participate in embryonic development, but whether the expression of autophagy-associated genes undergoes changes during the development of human embryonic kidneys remains unknown.

    Authors: Chen Wen-jin, Pan Xiu-wu, Chu Jian, Xu Da, Chen Jia-xin, Chen Wei-jie, Wang Lin-hui and Cui Xin-gang

    Citation: Cancer Cell International 2021 21:460

    Content type: Primary research

    Published on:

  36. Antisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function, were reported recently to play a crucial role in the process...

    Authors: Biao Liu, Wei Xiang, Jiahao Liu, Jin Tang, Jinrong Wang, Bin Liu, Zhi Long, Long Wang, Guangming Yin and Jianye Liu

    Citation: Cancer Cell International 2021 21:459

    Content type: Review

    Published on:

  37. Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship with NPC remai...

    Authors: Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang and Hongyun Zhao

    Citation: Cancer Cell International 2021 21:458

    Content type: Primary research

    Published on:

  38. In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers, yet there is no pan-cancer analysis of DLGAP5. Therefore, this study aims to analyze the roles o...

    Authors: Neng Tang, Xiaolin Dou, Xing You, Qiman Shi, Mujing Ke and Guodong Liu

    Citation: Cancer Cell International 2021 21:457

    Content type: Primary research

    Published on:

  39. The regulatory roles of long non-coding RNA (lncRNA) CRNDE in temozolomide (TMZ) chemoresistance to glioblastoma multiforme (GBM) are still poorly understood. Therefore, the function, characteristics, and poss...

    Authors: Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu and Qing Liu

    Citation: Cancer Cell International 2021 21:456

    Content type: Primary research

    Published on:

  40. Comprehensive analysis of omics data, such as genome, transcriptome, proteome, metabolome, and interactome, is a crucial technique for elucidating the complex mechanism of cancer onset and progression. Recentl...

    Authors: Ichidai Tanaka, Taiki Furukawa and Masahiro Morise

    Citation: Cancer Cell International 2021 21:454

    Content type: Review

    Published on:

  41. Lung adenocarcinoma (LUAD) remains one of the world’s most known aggressive malignancies with a high mortality rate. Molecular biological analysis and bioinformatics are of great importance as they have recent...

    Authors: Aisha Al-Dherasi, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Raeda Jalayta, Haithm Mousa, Abdullah Al-Danakh, Fawze Alnadari, Marwan Almoiliqy, Salem Baldi, Leming Shi, Dekang Lv…

    Citation: Cancer Cell International 2021 21:451

    Content type: Primary research

    Published on:

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