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  1. Hepatocellular carcinoma (HCC) is a common malignant tumor in China. Advanced treatment like transcatheter hepatic arterial chemoembolization (TACE) has prolonged the lives of many HCC patients. However, the p...

    Authors: Xialei Liu, Lewei Yang, Dong Jiang, Wuzhu Lu and Yongyu Zhang

    Citation: Cancer Cell International 2020 20:295

    Content type: Primary research

    Published on:

  2. Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unc...

    Authors: Zhenyu Li, Yun Feng, Zhen Zhang, Xiaozhong Cao and Xiubo Lu

    Citation: Cancer Cell International 2020 20:294

    Content type: Primary research

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  3. In cervical cancer, most patients die of metastasis. The epithelial-to-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of cervical cancer. C-phycocyanin ...

    Authors: Huanhuan Ji, Guoxiang Liu, Jingjing Han, Feng Zhu, Xiaolei Dong and Bing Li

    Citation: Cancer Cell International 2020 20:292

    Content type: Primary research

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  4. Bladder cancer is having a gradually increasing incidence in China. Except for the traditional chemotherapy drugs, there are no emerging new drugs for almost 30 years in bladder cancer. New potential therapeut...

    Authors: Songtao Cheng, Tianchen Peng, Xiaolu Zhu, Fenfang Zhou, Gang Wang, Lingao Ju, Yu Xiao, Xuefeng Liu and Xinghuan Wang

    Citation: Cancer Cell International 2020 20:290

    Content type: Primary research

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  5. Cisplatin (DDP) is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and long-term DDP stimulation increased resistance of NSCLC cells to this drug by enriching cancer stem cells (CS...

    Authors: Yongsheng Zhao, Renyan Zheng, Jian Chen and Dong Ning

    Citation: Cancer Cell International 2020 20:289

    Content type: Primary research

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  6. At the present time, colorectal cancer (CRC) is still known as a disease with a high mortality rate. Theranostics are flawless scenarios that link diagnosis with therapy, including precision medicine as a crit...

    Authors: Somayeh Vafaei, Raheleh Roudi, Zahra Madjd, Amir Reza Aref and Marzieh Ebrahimi

    Citation: Cancer Cell International 2020 20:288

    Content type: Review

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  7. Cervical cancer (CC) is the second leading cause of cancer deaths in women worldwide, still lacking effective biomarkers and therapies for diagnosis and treatment. CircRNAs are a class of endogenous RNAs that ...

    Authors: Shuaisai Zhang, Zhengli Chen, Jinxue Sun, Na An and Qinghua Xi

    Citation: Cancer Cell International 2020 20:287

    Content type: Primary research

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  8. Although tremendous improvement has been seen in cancer diagnosis and treatment, its morbidity and mortality is still high due to lack of ideal biomarkers. An increasing number of studies have demonstrated tha...

    Authors: Haixiang Shen, Qiwang Mo, Xin Xu and Ben Liu

    Citation: Cancer Cell International 2020 20:286

    Content type: Review

    Published on:

  9. Survival outcomes are significantly different in stage II colorectal cancer (CRC) patients with diverse clinicopathological features. The objective of this study is to establish a credible prognostic nomogram ...

    Authors: Shaobo Mo, Zheng Zhou, Yaqi Li, Xiang Hu, Xiaoji Ma, Long Zhang, Sanjun Cai and Junjie Peng

    Citation: Cancer Cell International 2020 20:285

    Content type: Primary research

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  10. Evidence suggests that altered DNA methylation plays a causative role in the occurrence, progression and prognosis of gastric cancer (GC). Thus, methylated-differentially expressed genes (MDEGs) could potentia...

    Authors: Yang Li, Rongrong Sun, Youwei Zhang, Yuan Yuan and Yufeng Miao

    Citation: Cancer Cell International 2020 20:284

    Content type: Primary research

    Published on:

  11. Prostate cancer (PCa) greatly threatens men’s lives, with high incidence and mortality. Recently, the research of long non-coding RNAs (lncRNAs) has made breakthroughs in the development of human cancers. This...

    Authors: Huijuan Wu, Xin Tian and Chaoyang Zhu

    Citation: Cancer Cell International 2020 20:283

    Content type: Primary research

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  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wanqing Weng, Zhongjing Zhang, Weiguo Huang, Xiangxiang Xu, Boda Wu, Tingbo Ye, Yunfeng Shan, Keqing Shi and Zhuo Lin

    Citation: Cancer Cell International 2020 20:282

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2020 20:231

  13. Metastasis is a major cause of failed colorectal cancer (CRC) treatment. While lung metastasis (LM) is observed in 10–15% of patients with CRC, the genetic mechanisms that cause CRC to metastasize to the lung ...

    Authors: Nan Zhang, Jiabo Di, Zaozao Wang, Pin Gao, Beihai Jiang and Xiangqian Su

    Citation: Cancer Cell International 2020 20:281

    Content type: Primary research

    Published on:

  14. Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inact...

    Authors: Lindsey R. Conroy, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Shesh N. Rai and Brian F. Clem

    Citation: Cancer Cell International 2020 20:280

    Content type: Primary research

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  15. Alternative splicing (AS) may cause structural and functional variations in the protein to promote the proliferation of tumor cells. However, there is no comprehensive analysis of the clinical significance of ...

    Authors: Chuan Liu, Chuan Hu, Zhi Li, Jing Feng, Jiale Huang, Bowen Yang and Ti Wen

    Citation: Cancer Cell International 2020 20:279

    Content type: Primary research

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  16. Oncolytic viruses have emerged as an alternative therapeutic modality for cancer as they can replicate specifically in tumour cells and induce toxic effects leading to apoptosis. Despite the great potentials a...

    Authors: Syed Umar Faruq Syed Najmuddin, Zahiah Mohamed Amin, Sheau Wei Tan, Swee Keong Yeap, Jeevanathan Kalyanasundram, Muhamad Alhapis Che Ani, Abhimanyu Veerakumarasivam, Soon Choy Chan, Suet Lin Chia, Khatijah Yusoff and Noorjahan Banu Alitheen

    Citation: Cancer Cell International 2020 20:278

    Content type: Primary research

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  17. There have been attempts to develop novel anti-tumor drugs in cancer therapy. Although satisfying results have been observed at a consequence of application of chemotherapeutic agents, the cancer cells are cap...

    Authors: Milad Ashrafizadeh, Masoud Najafi, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian

    Citation: Cancer Cell International 2020 20:277

    Content type: Review

    Published on:

  18. As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs).

    Authors: Rui Cao, Lushun Yuan, Bo Ma, Gang Wang and Ye Tian

    Citation: Cancer Cell International 2020 20:276

    Content type: Primary research

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  19. Radioresistance is an obstacle to limit efficacy of radiotherapy. Meanwhile, long non-coding RNAs (lncRNAs) have been reported to affect radioresistance. Here, we aimed to investigate lncRNAs involving radiore...

    Authors: Yufeng Jiang, Wei Li, Yang Yan, Xudong Yao, Wenyu Gu and Haimin Zhang

    Citation: Cancer Cell International 2020 20:274

    Content type: Primary research

    Published on:

  20. Long non-coding RNAs (LncRNAs) are a class of newly identified transcripts recognized as critical governors of gene expression during human carcinogenesis, whereas their tumor-suppressive or tumor-promoting ef...

    Authors: Xiongdong Zhong, Xianchang Yu, Xiaoyan Wen, Lei Chen and Ni Gu

    Citation: Cancer Cell International 2020 20:272

    Content type: Primary research

    Published on:

  21. Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resist...

    Authors: Shu-Guang Liu, Zhi-Xia Yue, Zhi-Gang Li, Rui-Dong Zhang, Hu-Yong Zheng, Xiao-Xi Zhao and Chao Gao

    Citation: Cancer Cell International 2020 20:271

    Content type: Primary research

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  22. Ovarian cancer (OvCa) is one of the most fatal cancers among females in the world. With growing numbers of individuals diagnosed with OvCa ending in deaths, it is urgent to further explore the potential mechan...

    Authors: Jingxuan Chen, Yun Cai, Rui Xu, Jiadong Pan, Jie Zhou and Jie Mei

    Citation: Cancer Cell International 2020 20:270

    Content type: Primary research

    Published on:

  23. Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable...

    Authors: Feng Wang, Zhiyu Zhang, Qin Li, Tao Yu and Chengbin Ma

    Citation: Cancer Cell International 2020 20:269

    Content type: Primary research

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  24. Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains uncl...

    Authors: Lingling Gao, Xin Nie, Wenchao Zhang, Rui Gou, Yuexin Hu, Yue Qi, Xiao Li, Qing Liu, Juanjuan Liu and Bei Lin

    Citation: Cancer Cell International 2020 20:268

    Content type: Primary research

    Published on:

  25. The effect of lncRNA FTX on non-alcoholic fatty liver disease (NAFLD) conversion to hepatocellular carcinoma (HCC) is unclear.

    Authors: Huajun Wu, Zhiwei Zhong, Anji Wang, Chunhui Yuan, Ke Ning, Huanhuan Hu, Chao Wang and Xiangbao Yin

    Citation: Cancer Cell International 2020 20:266

    Content type: Primary research

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  26. Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and ...

    Authors: Xuejing Yang, Jie Mei, Huiyu Wang, Dingyi Gu, Junli Ding and Chaoying Liu

    Citation: Cancer Cell International 2020 20:265

    Content type: Review

    Published on:

  27. Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer in the world and ranks third among cancer-related deaths worldwide. The tumour microenvironment (TME) plays an important role in tumorigenesis, ...

    Authors: Lin Zhou, Wei Huang, He-Fen Yu, Ya-Juan Feng and Xu Teng

    Citation: Cancer Cell International 2020 20:264

    Content type: Primary research

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  28. The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are the...

    Authors: Nobuo Watanabe, Masako Kidokoro, Makiko Tanaka, Shigeaki Inoue, Tomoatsu Tsuji, Hisako Akatuska, Chisa Okada, Yumi Iida, Yoshinori Okada, Yusuke Suzuki, Takehito Sato, Takashi Yahata, Noriaki Hirayama, Yoshihide Nakagawa and Sadaki Inokuchi

    Citation: Cancer Cell International 2020 20:263

    Content type: Primary research

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  29. Multiple Myeloma (MM) is a hematologic malignant disease whose underlying molecular mechanism has not yet fully understood. Generally, cell adhesion plays an important role in MM progression. In our work, we i...

    Authors: Yue Peng, Dong Wu, Fangmei Li, Peihua Zhang, Yuandong Feng and Aili He

    Citation: Cancer Cell International 2020 20:262

    Content type: Primary research

    Published on:

  30. Circular RNA downstream neighbor of SON (circDONSON) has been revealed to promote gastric cancer (GC) growth and invasion, while the role and molecular mechanism underlying circDONSON in GC cisplatin (DDP) res...

    Authors: Yong Liu, Jianzhong Xu, Min Jiang, Lingna Ni and Yang Ling

    Citation: Cancer Cell International 2020 20:261

    Content type: Primary research

    Published on:

  31. Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognosti...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: Cancer Cell International 2020 20:260

    Content type: Primary research

    Published on:

  32. Osteosarcoma (OS) is a common malignant bone tumor originating in the interstitial tissues and occurring mostly in adolescents and young adults. Energy metabolism is a prerequisite for cancer cell growth, prol...

    Authors: Naiqiang Zhu, Jingyi Hou, Guiyun Ma, Shuai Guo, Chengliang Zhao and Bin Chen

    Citation: Cancer Cell International 2020 20:259

    Content type: Primary research

    Published on:

  33. Cisplatin is widely used as a first-line treatment for non-small cell lung cancer (NSCLC), but chemoresistance remains a major clinical obstacle for efficient use. As a microRNA, miR-223 was reported to promot...

    Authors: Hui Wang, Jiabin Chen, Shufen Zhang, Xiaoxiao Zheng, Shangzhi Xie, Jiayan Mao, Ying Cai, Xuemei Lu, Liqiang Hu, Jian Shen, Kequn Chai and Wei Chen

    Citation: Cancer Cell International 2020 20:258

    Content type: Primary research

    Published on:

  34. Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression of integrin family members were linked to the prognosis of vario...

    Authors: Tingting Zhu, Ruifang Chen, Jieyu Wang, Huiran Yue, Xin Lu and Jun Li

    Citation: Cancer Cell International 2020 20:257

    Content type: Primary research

    Published on:

  35. Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma.

    Authors: Ling Tang, Jing Long, Keke Li, Xu Zhang, Xiang Chen and Cong Peng

    Citation: Cancer Cell International 2020 20:256

    Content type: Primary research

    Published on:

  36. Bladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigeneti...

    Authors: Zijian Tian, Lingfeng Meng, Xingbo Long, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu and Jianye Wang

    Citation: Cancer Cell International 2020 20:255

    Content type: Primary research

    Published on:

  37. MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH...

    Authors: Babak Otoukesh, Mehdi Abbasi, Habib-o-Lah Gorgani, Hossein Farahini, Mehdi Moghtadaei, Bahram Boddouhi, Peyman Kaghazian, Shayan Hosseinzadeh and Atefe Alaee

    Citation: Cancer Cell International 2020 20:254

    Content type: Review

    Published on:

  38. CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) breast cancer. However, cancers can...

    Authors: Vince Kornél Grolmusz, Jinfeng Chen, Rena Emond, Patrick A. Cosgrove, Lance Pflieger, Aritro Nath, Philip J. Moos and Andrea H. Bild

    Citation: Cancer Cell International 2020 20:253

    Content type: Primary research

    Published on:

  39. Increasing evidence has indicated the important role of long non-coding RNAs (lncRNAs) in regulating the development and progression of cancers, including triple-negative breast cancer (TNBC). Small nucleolar ...

    Authors: Xuan Fang, Jin Zhang, Chunyan Li, Jinjin Liu, Zhendong Shi and Peng Zhou

    Citation: Cancer Cell International 2020 20:252

    Content type: Primary research

    Published on:

  40. Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. The purpose of our study was to investig...

    Authors: Lingyun Guo, Zhenjiang Wang, Yuanyuan Du, Jie Mao, Junqiang Zhang, Zeyuan Yu, Jiwu Guo, Jun Zhao, Huinian Zhou, Haitao Wang, Yanmei Gu and Yumin Li

    Citation: Cancer Cell International 2020 20:251

    Content type: Primary research

    Published on:

  41. Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have a high relapse rate and poor prognosis. This study aims to explore the underlying mechanism of ...

    Authors: Xiaoli Hu, Jiayi Cai, Jianyi Zhu, Wenjing Lang, Jihua Zhong, Hua Zhong and Fangyuan Chen

    Citation: Cancer Cell International 2020 20:250

    Content type: Primary research

    Published on:

  42. Circular RNAs (circRNAs), a subgroup of non-coding RNAs, are recognized as pivotal mediators in various types of cancers. CircRNA_0000284 (circ_0000284) was manifested to participate in the development of non-...

    Authors: Li Li, Qiaohua Zhang and Ke Lian

    Citation: Cancer Cell International 2020 20:247

    Content type: Primary research

    Published on:

  43. Matrine has been reported to exert anti-tumor effects in multiple types of cancers containing hepatocellular carcinoma (HCC). However, the anti-tumor molecular mechanisms of matrine in HCC is still not fully r...

    Authors: Shaobing Lin, Jie Zhuang, Liping Zhu and Zongsheng Jiang

    Citation: Cancer Cell International 2020 20:246

    Content type: Primary research

    Published on:

  44. Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a subst...

    Authors: Xunming Zhao, Weichun Guo, Lixue Zou and Biao Hu

    Citation: Cancer Cell International 2020 20:245

    Content type: Primary research

    Published on:

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