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  1. Angiogenic switch is a hallmark feature of transition from low-grade to high-grade cervical intraepithelial neoplasia (CIN) in cervical cancer progression. Therefore, early events leading to locally-advanced c...

    Authors: Anjali Bhat, Joni Yadav, Kulbhushan Thakur, Nikita Aggarwal, Tanya Tripathi, Arun Chhokar, Tejveer Singh, Mohit Jadli and Alok Chandra Bharti

    Citation: Cancer Cell International 2021 21:319

    Content type: Primary research

    Published on:

  2. The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of ...

    Authors: Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins…

    Citation: Cancer Cell International 2021 21:318

    Content type: Review

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  3. Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differential...

    Authors: Pranavi Garlapati, Jinjie Ling, Paul J. Chiao and Jie Fu

    Citation: Cancer Cell International 2021 21:317

    Content type: Review

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  4. Laryngeal carcinoma is a primary malignant tumor originating from the laryngeal mucosa, and its pathogenesis is not fully understood. It is a rare type of cancer that shows a downward trend in the 5-year survi...

    Authors: Yan Huang, Min Gu, Yiting Tang, Zhiqiang Sun, Judong Luo and Zhe Li

    Citation: Cancer Cell International 2021 21:316

    Content type: Review

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  5. RSF1, remodelling and spacing factor 1, is an important interphase centromere protein and is overexpressed in many types of cancers and correlated with poor overall survival. RSF1 has functions mainly in maint...

    Authors: Guiyang Cai, Qing Yang and Wei Sun

    Citation: Cancer Cell International 2021 21:315

    Content type: Review

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  6. Epithelial ovarian cancer remains one of the leading causes of cancer deaths among women worldwide, and advanced epithelial ovarian cancer frequently metastasizes to the omentum. The characteristics of metasta...

    Authors: Kosuke Yoshida, Nobuhisa Yoshikawa, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi and Hiroaki Kajiyama

    Citation: Cancer Cell International 2021 21:314

    Content type: Primary research

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  7. Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or...

    Authors: Jieyu He, Lin Ling, Zhongyue Liu, Xiaolei Ren, Lu Wan, Chao Tu and Zhihong Li

    Citation: Cancer Cell International 2021 21:313

    Content type: Review

    Published on:

  8. Circular RNAs (circRNAs) have been implicated in the initiation and development of breast cancer as functional non-coding RNAs (ncRNA). The roles of circRNAs as the competing endogenous RNAs (ceRNAs) to sponge...

    Authors: Farzaneh Darbeheshti, Elham Zokaei, Yaser Mansoori, Sima Emadi Allahyari, Zeeba Kamaliyan, Sepideh Kadkhoda, Javad Tavakkoly Bazzaz, Nima Rezaei and Abbas Shakoori

    Citation: Cancer Cell International 2021 21:312

    Content type: Primary research

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  9. Myocardial damage is a mostly incurable complication of multiple myeloma (MM) that seriously affects the treatment outcome and quality of life of patients. Exosomal circular RNAs (exo-circRNAs) play an importa...

    Authors: Runjie Sun, Wei Liu, Yangang Zhao, Haoyu Chen, Zhenzhen Wang, Yanyu Zhang, Xiaoqi Sun and Xing Cui

    Citation: Cancer Cell International 2021 21:311

    Content type: Primary research

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  10. Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis...

    Authors: You Qin, Fei Peng, Lisha Ai, Shidai Mu, Yuting Li, Chensu Yang and Yu Hu

    Citation: Cancer Cell International 2021 21:310

    Content type: Review

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  11. High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as...

    Authors: Karim Nagi, Ishita Gupta, Nawaf Jurdi, Ayesha Jabeen, Amber Yasmeen, Gerald Batist, Semir Vranic and Ala-Eddin Al-Moustafa

    Citation: Cancer Cell International 2021 21:308

    Content type: Primary research

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  12. An increasing number of studies have shown that circular RNAs (circRNAs) play important roles in the regulation of tumor progression. Therefore, we explored the expression characteristics, function, and relate...

    Authors: Yi Liu, Simin Chen, Gang Peng, Yiwei Liao, Xuegong Fan, Zuping Zhang and Chenfu Shen

    Citation: Cancer Cell International 2021 21:307

    Content type: Primary research

    Published on:

  13. Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refra...

    Authors: Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang and Alexander Tobias Teichmann

    Citation: Cancer Cell International 2021 21:306

    Content type: Review

    Published on:

  14. This study incorporates fundamental research referring to considerable amounts of gene-sequencing data and bioinformatics tools to analyze the pathological mechanisms of diffuse large B-cell lymphoma (DLBCL).

    Authors: Yuying Cui, Hui Xu, Yu Yang, Dongmei Zhao, Yu Wen, Chao Lv, Hongbin Qiu and Chennan Wang

    Citation: Cancer Cell International 2021 21:305

    Content type: Primary research

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  15. Echinacoside (ECH) is the main active ingredient of Cistanches Herba, which is known to have therapeutic effects on metastatic tumors. However, the effects of ECH on liver cancer are still unclear. This study was...

    Authors: Wen Li, Jing Zhou, Yajie Zhang, Jing Zhang, Xue Li, Qiao Yan, Jiabing Han and Fangdi Hu

    Citation: Cancer Cell International 2021 21:304

    Content type: Primary research

    Published on:

  16. Various diagnostic and prognostic tools exist in colorectal cancer (CRC) due to multiple genetic and epigenetic alterations causing the disease. Today, the expression of RNAs is being used as prognostic marker...

    Authors: Fahimeh Fattahi, Jafar Kiani, Mahdi Alemrajabi, Ahmadreza Soroush, Marzieh Naseri, Mohammad Najafi and Zahra Madjd

    Citation: Cancer Cell International 2021 21:303

    Content type: Primary research

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  17. Malignant tumours of the female reproductive system threaten the lives and health of women worldwide, with ovarian cancer having the highest mortality rate. Based on previous work, this study analysed the expr...

    Authors: Xiao Li, Caixia Wang, Shuang Wang, Yuexin Hu, Shan Jin, Ouxuan Liu, Rui Gou, Xin Nie, Juanjuan Liu and Bei Lin

    Citation: Cancer Cell International 2021 21:302

    Content type: Primary research

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  18. Osteosarcoma (OS) is a common malignant bone tumor with poor prognosis. We previously reviewed that CD146 is correlated with multiple cancer progression, while its impact on OS is currently not systematically ...

    Authors: Xing Lei, Kewei Wang, Wenbo Wang, Hao Jin, Wenguang Gu, Zhiguo Chen, Wei Wang, Kaituo Gao and Huan Wang

    Citation: Cancer Cell International 2021 21:300

    Content type: Primary research

    Published on:

  19. Colorectal cancer (CRC) is the leading cause of cancer deaths and most common malignant tumors worldwide. Immune-related genes (IRGs) can predict prognoses of patients and the effects of immunotherapy. A serie...

    Authors: Xuankun Yang, Jia Yan, Yahui Jiang and Yaxu Wang

    Citation: Cancer Cell International 2021 21:299

    Content type: Primary research

    Published on:

  20. The natural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to the NK cells from adult donors. This i...

    Authors: Alireza Shokouhifar, Gholamreza Anani Sarab, Mahboubeh Yazdanifar, Mohammad Fereidouni, Masoumeh Nouri and Marzieh Ebrahimi

    Citation: Cancer Cell International 2021 21:298

    Content type: Primary research

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  21. Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has ...

    Authors: Wang Zhang, Zhendong Liu, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Yanbiao Wang, Zhishuai Ren, Binfeng Liu, Zhenfeng Jiang, Yanzheng Gao and Zhiguo Lin

    Citation: Cancer Cell International 2021 21:297

    Content type: Primary research

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu and Yanxiang Cheng

    Citation: Cancer Cell International 2021 21:296

    Content type: Correction

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    The original article was published in Cancer Cell International 2020 20:519

  23. As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the ...

    Authors: Tiecheng Wang, Jiakang Jin, Chao Qian, Jianan Lou, Jinti Lin, Ankai Xu, Kaishun Xia, Libin Jin, Bing Liu, Huimin Tao, Zhengming Yang and Wei Yu

    Citation: Cancer Cell International 2021 21:295

    Content type: Review

    Published on:

  24. Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short. Our study aims to establis...

    Authors: Aisha Al-Dherasi, Qi-Tian Huang, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Chao Huang, Haithm Mousa, Dongcen Ge, Sufiyan Sufiyan, Wanting Bai, Ruimei Liu, Yanyan Shao…

    Citation: Cancer Cell International 2021 21:294

    Content type: Primary research

    Published on:

  25. The expression of forkhead box protein H1 (FOXH1) is frequently upregulated in various cancers. However, the molecular mechanisms underlying the association between FOXH1 expression and lung cancer progression...

    Authors: Jun Zhang, Xian Zhang, Shasha Yang, Yanqiu Bao, Dongyuan Xu and Lan Liu

    Citation: Cancer Cell International 2021 21:293

    Content type: Primary research

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  26. Lung adenocarcinoma (LAD) is one of the most frequently diagnosed pathological categories of human lung cancer. Nevertheless, the link between long non-coding RNA (lncRNA) LINC01116 and LAD remains poorly inve...

    Authors: Ping Ren, Liang Chang, Xiaodong Hong, Lei Xing and Hong Zhang

    Citation: Cancer Cell International 2021 21:292

    Content type: Primary research

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  27. Pancreatic cancer (PC) is a highly fatal and aggressive disease with its incidence and mortality quite discouraging. An effective prediction model is urgently needed for the accurate assessment of patients’ pr...

    Authors: Yuan Chen, Ruiyuan Xu, Rexiati Ruze, Jinshou Yang, Huanyu Wang, Jianlu Song, Lei You, Chengcheng Wang and Yupei Zhao

    Citation: Cancer Cell International 2021 21:291

    Content type: Primary research

    Published on:

  28. Interferon regulatory factor-1 (IRF1) affects the proliferation of colorectal cancer (CRC). Recombinant interferon inducible protein 35 (IFI35) participates in immune regulation and cell proliferation. The aim...

    Authors: Yan Hu, Bing Wang, Ke Yi, Qingjun Lei, Guanghui Wang and Xiaohui Xu

    Citation: Cancer Cell International 2021 21:290

    Content type: Primary research

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  29. Mitochondrial pyruvate carrier 1 (MPC1) is a key metabolic protein that regulates the transport of pyruvate into the mitochondrial inner membrane. MPC1 deficiency may cause metabolic reprogramming. However, wh...

    Authors: Chen Xue, Ganglei Li, Zhengyi Bao, Ziyuan Zhou and Lanjuan Li

    Citation: Cancer Cell International 2021 21:288

    Content type: Review

    Published on:

  30. Colorectal cancer (CRC) is the third most diagnosed and second leading cause of cancer death worldwide. Hallmark proteins processing is usually dysregulated in cancers. Finding key regulatory molecules is of g...

    Authors: Tengfei Liu, Binbin Liu, Yiting Liu, Xingzhi Feng, Xuefei Jiang, Jiahui Long, Qianling Gao and Zihuan Yang

    Citation: Cancer Cell International 2021 21:287

    Content type: Primary research

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  31. The HSP70 family of heat shock protein plays a critical role in protein synthesis and transport to maintain protein homeostasis. Several studies have indicated that HSP70s are related to the development and oc...

    Authors: Ben Wang, Tian Lan, Han Xiao, Zhong-Huo Chen, Chao Wei, Lei-Feng Chen, Jia-Fu Guan, Rong-Fa Yuan, Xin Yu, Zhi-Gang Hu, Hua-Jun Wu, Zhi Dai and Kai Wang

    Citation: Cancer Cell International 2021 21:286

    Content type: Primary research

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  32. Multiple myeloma (MM) is a highly aggressive and incurable clonal plasma cell disease with a high rate of recurrence. Thus, the development of new therapies is urgently needed. DCZ0805, a novel compound synthe...

    Authors: Xuejie Gao, Bo Li, Anqi Ye, Houcai Wang, Yongsheng Xie, Dandan Yu, Zhijian Xu, Bingqing Shi, Hui Zhang, Qilin Feng, Ke Hu, Yong Zhang, Cheng Huang, Guang Yang, Jumei Shi and Weiliang Zhu

    Citation: Cancer Cell International 2021 21:285

    Content type: Primary research

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  33. Ovarian cancer (OC) is a high-mortality gynecological cancer that is typically treated with cisplatin, although such treatment often results in chemoresistance. Ovarian cancer resistance is usually related to ...

    Authors: Yue Wu, Ting Wang, Lin Xia and Mei Zhang

    Citation: Cancer Cell International 2021 21:284

    Content type: Primary research

    Published on:

  34. Stromal components of the tumor microenvironment contribute to bladder cancer progression, and Cancer-Associated Fibroblasts (CAFs) were reported to play an important role. Accumulating pieces of evidence indi...

    Authors: YiHeng Du, Xiang Jiang, Bo Wang, Jin Cao, Yi Wang, Jiang Yu, XiZhi Wang and HaiTao Liu

    Citation: Cancer Cell International 2021 21:283

    Content type: Primary research

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  35. This study aimed to analyze the lymphocyte subsets, their activities and their dynamic changes during immunochemotherapy in patients newly diagnosed with diffuse large B cell lymphoma (DLBCL).

    Authors: Hongyan Hou, Ying Luo, Guoxing Tang, Bo Zhang, Renren Ouyang, Ting Wang, Min Huang, Shiji Wu, Dengju Li and Feng Wang

    Citation: Cancer Cell International 2021 21:282

    Content type: Primary research

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  36. Systematic profiling studies have implicated regulators of pre-mRNA splicing as important disease determinants in gastric cancer (GC), but the underlying mechanisms have remained elusive. Here we focused on hn...

    Authors: Wei-zhao Peng, Jin Zhao, Xin Liu, Chao-feng Li, Shuang Si and Ren Ma

    Citation: Cancer Cell International 2021 21:281

    Content type: Primary research

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  37. Long non-coding RNAs (lncRNAs) have been certified to play vital biological functions in glioma and have received considerable attention in the recent literature. Nonetheless, the role of LINC01158 in glioma r...

    Authors: Zhenxing Sun, Naili Wei, Shenglian Yao, Guihuai Wang, Yaxing Sun, Zhenze Wang and Dan Yuan

    Citation: Cancer Cell International 2021 21:280

    Content type: Primary research

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  38. Bortezomib (BTZ) is an inhibitor of the proteasome that has been used to treat patients with mantle cell lymphoma (MCL), but the resistance to BTZ in clinical cases remains a major drawback. BACH2 is a lymphoi...

    Authors: Min Feng, Jia Wang, Ming Sun, Guilan Li, BingXiang Li and Han Zhang

    Citation: Cancer Cell International 2021 21:279

    Content type: Primary research

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  39. Epstein Barr-virus (EBV) is related to several cancers. Long non-coding RNAs (lncRNAs) act by regulating target genes and are involved in tumourigenesis. However, the role of lncRNAs in EBV-associated cancers ...

    Authors: Yitong Liu, Zhizhong Hu, Yang Zhang and Chengkun Wang

    Citation: Cancer Cell International 2021 21:278

    Content type: Review

    Published on:

  40. Precise quantification of microRNA is challenging since circulating mRNA and rRNA in the blood are usually degraded. Therefore, it is necessary to identify specific biomarkers for ovarian cancer. This study ai...

    Authors: San-Gang Wu, Ping Zhou, Jian-Xian Chen, Jian Lei, Li Hua, Yong Dong, Min Hu, Chen-Lu Lian, Li-Chao Yang and Juan Zhou

    Citation: Cancer Cell International 2021 21:277

    Content type: Primary research

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  41. Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our stud...

    Authors: Wen Yin, Hecheng Zhu, Jun Tan, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Lei Wang, Ming Zhao, Xingjun Jiang, Caiping Ren and Guihua Tang

    Citation: Cancer Cell International 2021 21:276

    Content type: Primary research

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  42. Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long inte...

    Authors: Menggang Zhang, Fang Gao, Xiao Yu, Qiyao Zhang, Zongzong Sun, Yuting He and Wenzhi Guo

    Citation: Cancer Cell International 2021 21:274

    Content type: Review

    Published on:

  43. Chemoresistance is one of the major obstacles for cancer therapy in the clinic. Circular RNAs (circRNAs) are involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and chemoresistance. This ...

    Authors: Fanyong Qu, Lina Wang, Caiyan Wang, Lingxia Yu, Kaikai Zhao and Hao Zhong

    Citation: Cancer Cell International 2021 21:273

    Content type: Primary research

    Published on:

  44. The implication of circular RNAs (circRNAs) in human cancers has aroused much concern. In this study, we investigated the function of circ_0000745 and its potential functional mechanisms in oral squamous cell ...

    Authors: Kuangzheng Li, Xiaosheng Fan, Ziyi Yan, Jia Zhan, Fangyun Cao and Yixia Jiang

    Citation: Cancer Cell International 2021 21:271

    Content type: Primary research

    Published on:

  45. Artificial intelligence (AI) is the use of mathematical algorithms to mimic human cognitive abilities and to address difficult healthcare challenges including complex biological abnormalities like cancer. The ...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Haleema Sadia, Ijaz A. Qureshi, Asma Irshad, Rais Ahmed, Kausar Malik, Shahid Raza, Asif Abbas, Raffaele Pezzani and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:270

    Content type: Review

    Published on:

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