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  1. Despite the significant progress in decreasing the occurrence and mortality of hepatocellular carcinoma (HCC), it remains a public health issue worldwide on the basis of its late presentation and tumor recurre...

    Authors: Qikuan He, Pengyi Guo, Zhiyuan Bo, Haitao Yu, Jinhuan Yang, Yi Wang and Gang Chen
    Citation: Cancer Cell International 2022 22:249
  2. A considerable number of glioblastoma (GBM) patients developed drug resistance to Temozolomide (TMZ) during chemotherapy, resulting in therapeutic failure and tumor recurrence. However, the exact mechanism of ...

    Authors: Shuai Yuan, Qi Yan, Zhi-yong Zhao, Jing-long Zhang, He Zhang, Hang Yin and Zhi Yuan
    Citation: Cancer Cell International 2022 22:248
  3. Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and...

    Authors: Ramin Amirsasan, Maryam Akbarzadeh and Shabnam Akbarzadeh
    Citation: Cancer Cell International 2022 22:247
  4. MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic a...

    Authors: Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad and William C. Cho
    Citation: Cancer Cell International 2022 22:246
  5. Breast cancer is the most common type of cancer in women and the second leading cause of cancer death in female. Triple-negative breast cancer has a more aggressive proliferation and a poorer clinical diagnosi...

    Authors: Hamid Bakherad, Fahimeh Ghasemi, Maryam Hosseindokht and Hamed Zare
    Citation: Cancer Cell International 2022 22:245
  6. Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer and the third most frequent cause of tumour-related mortality worldwide. Currently, several surgical and medical therapeutic strategies ...

    Authors: Asmaa F. Khafaga, Shaker A. Mousa, Lotfi Aleya and Mohamed M. Abdel-Daim
    Citation: Cancer Cell International 2022 22:243
  7. Nicotinamide adenine dinucleotide (NAD) is the core of cellular energy metabolism. NAMPT, Sirtuins, PARP, CD38, and other molecules in this classic metabolic pathway affect many key cellular functions and are ...

    Authors: QinChen Xu, Xiaoyan Liu, Ghazal Mohseni, Xiaodong Hao, Yidan Ren, Yiwei Xu, Huiru Gao, Qin Wang and Yunshan Wang
    Citation: Cancer Cell International 2022 22:242
  8. NF-E2-related factor 2 (Nrf2) transcription factor has contradictory roles in cancer, which can act as a tumor suppressor or a proto-oncogene in different cell conditions (depending on the cell type and the co...

    Authors: Atefeh Khodakarami, Sara Adibfar, Vahid Karpisheh, Shiva Abolhasani, Pooya Jalali, Hamed Mohammadi, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat-Farsangi and Farhad Jadidi-Niaragh
    Citation: Cancer Cell International 2022 22:241
  9. Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNA...

    Authors: Min Su, Jinming Tang, Desong Yang, Zhining Wu, Qianjin Liao, Hui Wang, Yuhang Xiao and Wenxiang Wang
    Citation: Cancer Cell International 2022 22:240
  10. The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogenei...

    Authors: Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Qamar Raza, Haleema Sadia, Shahid Raza, Munir Bhinder, Daniela Calina, Javad Sharifi-Rad and William C. Cho
    Citation: Cancer Cell International 2022 22:239
  11. The B-cell lymphoma 6 (BCL6) oncogene is required for the survival of diffuse large B-cell lymphoma (DLBCL), which is incurable using conventional chemotherapy. Thus, it is imperative to improve the survival of p...

    Authors: Yunying Zhu, Chenshuang Lei, Qian Jiang, Qinhua Yu and Liannv Qiu
    Citation: Cancer Cell International 2022 22:236
  12. Colorectal cancer is the third and most significant cause of death and fourth most common cancer in the world. Chemotherapy can be introduced in the cases of locally or distantly invasive colorectal cancer. In...

    Authors: Arghavan Kouroshnia, Sirous Zeinali, Shiva Irani and Akram Sadeghi
    Citation: Cancer Cell International 2022 22:235
  13. Cancer is one of the major causes of mortality worldwide, therefore it is considered a major health concern. Breast cancer is the most frequent type of cancer which affects women on a global scale. Various cur...

    Authors: Vamika Karn, Sandhya Sandhya, Wayne Hsu, Deepak Parashar, Himanshu Narayan Singh, Niraj Kumar Jha, Saurabh Gupta, Navneet Kumar Dubey and Sanjay Kumar
    Citation: Cancer Cell International 2022 22:234
  14. Breast cancer (BC) represents aggressive cancer affecting most women’s lives globally. Metastasis and recurrence are the two most common factors in a breast cancer patient's poor prognosis. Cancer stem cells (...

    Authors: Bashdar Mahmud Hussen, Ramiar Kamal Kheder, Sara Tharwat Abdullah, Hazha Jamal Hidayat, Heshu Sulaiman Rahman, Abbas Salihi, Mohammad Taheri and Soudeh Ghafouri-Fard
    Citation: Cancer Cell International 2022 22:233
  15. Glioblastoma is a highly aggressive brain tumor. A big effort is required to find novel molecules which can cross the blood–brain barrier and efficiently kill these tumor cells. In this perspective, trehalose ...

    Authors: Barbara Del Bello, Alessandra Gamberucci, Paola Marcolongo and Emilia Maellaro
    Citation: Cancer Cell International 2022 22:232
  16. The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available.

    Authors: Xuxue Guo, Mei Huang, Haonan Zhang, Qianhui Chen, Ying Hu, Yan Meng, Changjie Wu, Chenge Tu, Yongfeng Liu, Aimin Li, Qingyuan Li, Peirong Zhou and Side Liu
    Citation: Cancer Cell International 2022 22:230
  17. Colon adenocarcinoma (COAD) is one of the major varieties of malignant tumors threatening human health today. Immune checkpoint inhibitors (ICIs) have recently begun to emerge as an effective option for the tr...

    Authors: Weiming Mou, Lingxuan Zhu, Tao Yang, Anqi Lin, Qiong Lyu, Linlang Guo, Zaoqu Liu, Quan Cheng, Jian Zhang and Peng Luo
    Citation: Cancer Cell International 2022 22:229
  18. Prostate cancer (PCa) is one of the most common malignant tumors in the male urinary system. In recent years, the morbidity and mortality of PCa have been increasing due to the limited effects of existing trea...

    Authors: Chuigong Yu, Yu Fan, Yu Zhang, Lupeng Liu and Gang Guo
    Citation: Cancer Cell International 2022 22:228
  19. A growing body of evidence has suggested the involvement of metabolism in the occurrence and development of tumors. But the link between metabolism and laryngeal squamous cell carcinoma (LSCC) has rarely been ...

    Authors: Yujie Shen, Qiang Huang, Yifan Zhang, Chi-Yao Hsueh and Liang Zhou
    Citation: Cancer Cell International 2022 22:226
  20. Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumor...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:225
  21. Glioma is the most common malignant tumor of the central nervous system and is associated with a poor prognosis. This study aimed to explore the function of growth factor receptor-bound protein 10(GRB 10) in g...

    Authors: Yuanbing Chen, Miao Tang, Jianbing Xiong, Qiongjue Gao, Wuyang Cao and Jun Huang
    Citation: Cancer Cell International 2022 22:223
  22. Intravenous daratumumab (DARA IV) has been increasingly used in the treatment of amyloid light-chain (AL) amyloidosis. However, the outcomes for patients administered with DARA IV have not been aggregated. The...

    Authors: Chunyan Sun, Xiaohong Wang, Renyi Zhang, Lingjie Xu, Bin Wang and Jian Li
    Citation: Cancer Cell International 2022 22:222
  23. Unlike other members of the VEGF family, the function of VEGF-B in tumor progression remains to be elucidated. Thus, the present study aimed to determine the function of VEGF-B in human choriocarcinoma cells b...

    Authors: Qianxia Tan, Jingting Cai, Jingping Peng, Cui Hu, ChenChun Wu and Huining Liu
    Citation: Cancer Cell International 2022 22:221
  24. Pancreatic cancer is the most lethal type of malignancy and is characterized by high invasiveness without severe symptoms. It is difficult to detect PC at an early stage because of the low diagnostic accuracy ...

    Authors: Haotian Wu, Suwen Ou, Hongli Zhang, Rui Huang, Shan Yu, Ming Zhao and Sheng Tai
    Citation: Cancer Cell International 2022 22:220
  25. Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many c...

    Authors: Mingming Jin, Xiyu Liu, Yue Wu, Yuqing Lou, Xue Li and Gang Huang
    Citation: Cancer Cell International 2022 22:219
  26. Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear.

    Authors: Anna Kurpińska, Joanna Suraj-Prażmowska, Marta Stojak, Joanna Jarosz, Łukasz Mateuszuk, Ewa Niedzielska-Andres, Magdalena Smolik, Joanna Wietrzyk, Ivars Kalvins, Maria Walczak and Stefan Chłopicki
    Citation: Cancer Cell International 2022 22:218
  27. The oncogenic role of doublecortin-like kinase 1 (DCLK1) as a putative cancer stem cell (CSC) marker has been clarified in colorectal cancer (CRC). Isoform-specific functions of DCLK1 have shed new light on di...

    Authors: Elham Kalantari, Mahdieh Razmi, Fatemeh Tajik, Mohsen Asadi-Lari, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2022 22:217
  28. Colorectal cancer (CRC) with pulmonary metastasis usually indicates a poor prognosis, whereas patients may benefit from adoptive cell therapy. Tumor-specific cytotoxic T lymphocytes (CTLs) have been reported a...

    Authors: Juan Zhang, Lei Wang, Shuyi Li, Xuefeng Gao and Zhong Liu
    Citation: Cancer Cell International 2022 22:216
  29. MIR4435-2HG (LINC00978) is a long non-coding RNA (lncRNA) that acts as an oncogene in almost all cancers. This lncRNA participates in the molecular cascades involved in other disorders such as coronary artery dis...

    Authors: Majid Ghasemian, Masoumeh Rajabibazl, Unes Sahebi, Samira Sadeghi, Reza Maleki, Veys Hashemnia and Reza Mirfakhraie
    Citation: Cancer Cell International 2022 22:215
  30. Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer-related death worldwide with a poor prognosis. Given that DEPDC1B plays a key role in multiple cancers, the role of this molecule in ESC...

    Authors: Yunfeng Yuan, Wei Ping, Ruijie Zhang, Zhipeng Hao and Ni Zhang
    Citation: Cancer Cell International 2022 22:214
  31. Thrombospondin-2 (THBS2) is a versatile glycoprotein that regulates numerous biological functions, including the apoptosis-proliferation balance in endothelial cells, and it has been linked to tumor angiogenes...

    Authors: Xingchen Liao, Wei Wang, Baoping Yu and Shiyun Tan
    Citation: Cancer Cell International 2022 22:213
  32. Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 part...

    Authors: Qiu-Hua Zhong, Si-Wei Zha, Andy T. Y. Lau and Yan-Ming Xu
    Citation: Cancer Cell International 2022 22:212
  33. Studies over the past decade have shown that competitive endogenous RNA (ceRNA) plays an essential role in the tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC). Meanwhile, immune checkp...

    Authors: Yankang Cui, Tianyi Shen, Feng Xu, Jing Zhang, Yuhao Wang, Jiajin Wu, Hengtao Bu, Dian Fu, Bo Fang, Huichen Lv, Suchun Wang, Changjie Shi, Bianjiang Liu, Haowei He, Hao Tang and Jingping Ge
    Citation: Cancer Cell International 2022 22:211
  34. Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recent...

    Authors: Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:209
  35. Radiotherapy is a powerful and widely used technique for the treatment of solid tumors. Beyond its ability to destroy tumor cells, it has been demonstrated that radiotherapy can stimulate the anti-tumor immune...

    Authors: Audrey Darmon, Ping Zhang, Julie Marill, Naeemunnisa Mohamed Anesary, Jordan Da silva and Sébastien Paris
    Citation: Cancer Cell International 2022 22:208
  36. PTENP1 is a long non-coding RNA which has been regarded as a pseudogene of the PTEN tumor suppressor gene. However, it has been shown to be a biologically active transcript that can function as a competing endoge...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Nader Akbari Dilmaghani
    Citation: Cancer Cell International 2022 22:207
  37. Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not o...

    Authors: Praveen Dhyani, Cristina Quispe, Eshita Sharma, Amit Bahukhandi, Priyanka Sati, Dharam Chand Attri, Agnieszka Szopa, Javad Sharifi-Rad, Anca Oana Docea, Ileana Mardare, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:206
  38. Colorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study aimed to investigate the role of metallothionein 2A (MT2A) in the modu...

    Authors: Xi Liu, Jun Quan, Zhaolong Shen, Zequn Zhang, Zhijian Chen, Liang Li, Xiaorong Li, Gui Hu and Xiaofeng Deng
    Citation: Cancer Cell International 2022 22:205
  39. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor, progesterone receptor, and HER2. Our lab previously characterized miR-3189-3p as a...

    Authors: Cecilia Vittori, Duane Jeansonne, Hassan Yousefi, Celeste Faia, Zhen Lin, Krzysztof Reiss and Francesca Peruzzi
    Citation: Cancer Cell International 2022 22:204
  40. Ubiquitination is a basic post-translational modification of intracellular proteins and can be reversed enzymatically by DUBs (deubiquitinating enzymes). More than 90 DUBs have been identified. Among them, the...

    Authors: Zhishuo Zhang, Wenxia Zhao, Yiming Li, Yang Li, Hanzeng Cheng, Liyun Zheng, Xiaoyu Sun, Hao Liu and Rongguang Shao
    Citation: Cancer Cell International 2022 22:203
  41. Breast cancer is the most common malignancy affecting women, yet effective targets and related candidate compounds for breast cancer treatment are still lacking. The lipogenic enzyme, stearoyl-CoA desaturase-1...

    Authors: Chen Yang, Yi-Yuan Jin, Jie Mei, Die Hu, Xiaoyu Jiao, Hui-Lian Che, Chun-Lei Tang, Yan Zhang and Guo-Sheng Wu
    Citation: Cancer Cell International 2022 22:202
  42. Phosphoglucomutase 1 (PGM1) is known for its involvement in cancer pathogenesis. However, its biological role in colorectal cancer (CRC) has remained unknown. Here, we studied the functions and mechanisms of P...

    Authors: Zhewen Zheng, Xue Zhang, Jian Bai, Long Long, Di Liu and Yunfeng Zhou
    Citation: Cancer Cell International 2022 22:201
  43. Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger h...

    Authors: Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh and Vahideh Tarhriz
    Citation: Cancer Cell International 2022 22:200

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