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  1. Autophagy is an evolutionarily conserved process through which cells degrade and recycle cytoplasm. The relation among autophagy, apoptosis and tumor is highly controversial until now and the molecular mechani...

    Authors: Jing Liu, Shuaiyu Long, Huanan Wang, Nannan Liu, Chuchu Zhang, Lingling Zhang and Yingjie Zhang

    Citation: Cancer Cell International 2019 19:336

    Content type: Primary research

    Published on:

  2. The high prevalence of alternative splicing among genes implies the importance of genomic complexity in regulating normal physiological processes and diseases such as gastric cancer (GC). The standard form of ...

    Authors: Wei-zhao Peng, Ji-xi Liu, Chao-feng Li, Ren Ma and Jian-zheng Jie

    Citation: Cancer Cell International 2019 19:335

    Content type: Primary research

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  3. Endometrial carcinoma (EC) accounts for 5.8% of all cancers in Saudi females. Although most ECs are sporadic, 2–5% tend to be familial, being associated with Lynch syndrome and Cowden syndrome. In this study, ...

    Authors: Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rong Bu, Kaleem Iqbal, Sarah Siraj, Tariq Masoodi, Rica Micaela Concepcion, Laila Omar Ghazwani, Ismail AlBadawi, Fouad Al-Dayel and Khawla S. Al-Kuraya

    Citation: Cancer Cell International 2019 19:334

    Content type: Primary research

    Published on:

  4. Abiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined.

    Authors: Jingli Han, Junhua Zhang, Wei Zhang, Dalei Zhang, Ying Li, Jinsong Zhang, Yaqun Zhang, Tongxiang Diao, Luwei Cui, Wenqing Li, Fei Xiao, Ming Liu and Lihui Zou

    Citation: Cancer Cell International 2019 19:332

    Content type: Primary research

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  5. Abnormal activation of the classic Wnt signaling pathway is closely related to the occurrence of epithelial cancers. B-cell lymphoma 9 (BCL9), a transcription factor, is a novel oncogene discovered in the clas...

    Authors: Jing Wang, Mingjun Zheng, Liancheng Zhu, Lu Deng, Xiao Li, Linging Gao, Caixia Wang, Huimin Wang, Juanjuan Liu and Bei Lin

    Citation: Cancer Cell International 2019 19:330

    Content type: Primary research

    Published on:

  6. Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver disease worldwide. Molecular changes in HCC collectively contribute to Wnt/β-catenin, as a tumor proliferative signaling pathway, to...

    Authors: Jafar Ai, Neda Ketabchi, Javad Verdi, Nematollah Gheibi, Hossein Khadem Haghighian and Maria Kavianpour

    Citation: Cancer Cell International 2019 19:329

    Content type: Review

    Published on:

  7. Circular RNA Itchy E3 ubiquitin protein ligase (Circ-ITCH) is significantly down-regulated in various kinds of tumors, however, the mechanisms of action and functions of circITCH gene in prostate cancer (PC) a...

    Authors: Xuegang Wang, Rong Wang, Zhun Wu and Peide Bai

    Citation: Cancer Cell International 2019 19:328

    Content type: Primary research

    Published on:

  8. The aim of this study was to investigate the regulatory network of lncRNAs as competing endogenous RNAs (ceRNA) in bladder urothelial carcinoma (BUC) based on gene expression data derived from The Cancer Genom...

    Authors: Jiawu Wang, Chengyao Zhang, Yan Wu, Weiyang He and Xin Gou

    Citation: Cancer Cell International 2019 19:327

    Content type: Primary research

    Published on:

  9. Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135...

    Authors: Zilong Zhao, Xiafei Lin, Yunhui Tong and Wenxia Li

    Citation: Cancer Cell International 2019 19:326

    Content type: Primary research

    Published on:

  10. The large involvement of long non-coding RNAs (LncRNAs) in the biological progression of numerous cancers has been reported. The function of lncRNA KCNQ1OT1 in bladder cancer (BC) remains largely unknown. This...

    Authors: Jingyu Wang, Hao Zhang, Jie Situ, Mingzhao Li and Hua Sun

    Citation: Cancer Cell International 2019 19:325

    Content type: Primary research

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  11. Spindle and kinetochore associated protein 1 (SKA1) is a protein involved in chromosome congression and mitosis. It has been found to be upregulated and oncogenic in several human cancers. Herein, we investiga...

    Authors: Xizhao Wang, Yu Zeng, Mingfeng Zhou, Xian Zhang, Anqi Xu, Jie Lin, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Zhengming Zhan, Hao Long and Ye Song

    Citation: Cancer Cell International 2019 19:324

    Content type: Primary research

    Published on:

  12. There is growing evidence of the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). The objective was to discuss whether exosomal lncRNA HNF1A-AS1 impacted drug resistance in CC via binding to mic...

    Authors: Xiaoqiong Luo, Jingxi Wei, Feng-lian Yang, Xiao-xia Pang, Feng Shi, Yu-xia Wei, Bi-yun Liao and Jun-li Wang

    Citation: Cancer Cell International 2019 19:323

    Content type: Primary research

    Published on:

  13. Autologous tumor-infiltrating lymphocytes (Tils) immunotherapy is a promising treatment in patients with advanced hepatocellular cancer. Although Tils treatment has shown great promise, their persistence and t...

    Authors: Benling Xu, Long Yuan, Guangyu Chen, Tiepeng Li, Jinxue Zhou, Chengjuan Zhang, Peng Qin, Musleh M. Muthana, Shengdian Wang, Xuexiang Du and Quanli Gao

    Citation: Cancer Cell International 2019 19:322

    Content type: Primary research

    Published on:

  14. Since FTO was recognized as the first m6A demethylase, the understanding of its biological function has been widely expanded. However, the role of FTO in cervical cancer tumorigenesis remains unclear.

    Authors: Dongling Zou, Lei Dong, Chenying Li, Zhe Yin, Shuan Rao and Qi Zhou

    Citation: Cancer Cell International 2019 19:321

    Content type: Primary research

    Published on:

  15. Pancreatic cancer (PC) is one of the deadliest cancers about the digestive system. Recent researches have validated that long non-coding RNAs (lncRNAs) play vital roles in various cancers, while the function o...

    Authors: Luyang Zhang, Yunjian Wang, Ling Zhang, Guohua You, Congyu Li, Bo Meng, Minghe Zhou and Min Zhang

    Citation: Cancer Cell International 2019 19:320

    Content type: Primary research

    Published on:

  16. Osteosarcoma is the most common bone tumors which consisted of malignant mesenchymal cells generating osteoid and immature bone. It has been showed that osteosarcoma is common in children and adolescents and s...

    Authors: Hadis Fathizadeh, Hamed Mirzaei and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:319

    Content type: Review

    Published on:

  17. This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients.

    Authors: Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang, Wenting Jiang, Han Wang, Lili Chen, Jiping Luo, Yanyang Chen, Kejing Tang, Chengzhi Zhou and Zunfu Ke

    Citation: Cancer Cell International 2019 19:318

    Content type: Primary research

    Published on:

  18. Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival ra...

    Authors: Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid and Thomas M. Marti

    Citation: Cancer Cell International 2019 19:317

    Content type: Primary research

    Published on:

  19. Glioma is a lethal malignant brain tumor, which affects the brain functions and is life-threatening. LncRNA UCA1 was identified as a pivotal regulator for tumorigenesis of glioma. MiR-206 was discovered to pro...

    Authors: Zhi Huang, Xuya Zhao, Xiaowen Wu, Lei Xiang, Yingnan Yuan, Shi Zhou and Wenfeng Yu

    Citation: Cancer Cell International 2019 19:316

    Content type: Primary research

    Published on:

  20. The prognostic value of pre-treatment platelet-to-lymphocyte ratio (PLR) in patients with urothelial carcinoma (UC) remains controversial. Therefore, this meta-analysis aimed to identify the prognostic impact ...

    Authors: Yuhai Bao, Yin Wang, Xiaodong Li, Mingjun Pan, Hongze Zhang, Zegen Cheng and Xueyi Wang

    Citation: Cancer Cell International 2019 19:315

    Content type: Primary research

    Published on:

  21. The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the ...

    Authors: Shuai Wu, Chen Luo, Fengjiao Li, N. U. Farrukh Hameed, Qiuyan Jin and Jie Zhang

    Citation: Cancer Cell International 2019 19:314

    Content type: Primary research

    Published on:

  22. Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed t...

    Authors: Huan-yu Zhang, Mao-qing Xing, Jing Guo, Jin-chuan Zhao, Xin Chen, Zhong Jiang, Hong Zhang and Qian Dong

    Citation: Cancer Cell International 2019 19:313

    Content type: Primary research

    Published on:

  23. Bladder cancer is the most common human urological malignancies with poor prognosis, and the pathophysiology of bladder cancer involves multi-linkages of regulatory networks in the bladder cancer cells. Recent...

    Authors: Jinan Guo, Zhixin Chen, Hongtao Jiang, Zhou Yu, Junming Peng, Jing Xie, ZaiShang Li, Weiqing Wu, Zhiqiang Cheng and Kefeng Xiao

    Citation: Cancer Cell International 2019 19:312

    Content type: Primary research

    Published on:

  24. Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma subtype with a poor prognosis. LncRNA-LET is a long non-coding RNA (lncRNA) that is down-regulated in ccRCC tissues. However, its...

    Authors: Zhuo Ye, Jiachen Duan, Lihui Wang, Yanli Ji and Baoping Qiao

    Citation: Cancer Cell International 2019 19:311

    Content type: Primary research

    Published on:

  25. Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. This study characterized the clinicopathologic and survival analysis of this tumor, fur...

    Authors: Dan Huang, Fei Ren, Shujuan Ni, Cong Tan, Weiwei Weng, Meng Zhang, Midie Xu, Lei Wang, Qinghua Xu and Weiqi Sheng

    Citation: Cancer Cell International 2019 19:310

    Content type: Primary research

    Published on:

  26. Galectins constitute a family of β-galactoside-binding proteins, which influence various hallmarks of pancreatic cancer, including cell proliferation, invasion and migration; immune escape; and angiogenesis. A...

    Authors: Qiqing Sun, Yiyin Zhang, Mengqi Liu, Zeng Ye, Xianjun Yu, Xiaowu Xu and Yi Qin

    Citation: Cancer Cell International 2019 19:309

    Content type: Review

    Published on:

  27. MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer ...

    Authors: Wen-Li Liu, Hu-xia Wang, Cheng-xin Shi, Fei-yu Shi, Ling-yu Zhao, Wei Zhao and Guang-hui Wang

    Citation: Cancer Cell International 2019 19:308

    Content type: Primary research

    Published on:

  28. Lymph node metastasis is one of the most important factors affecting the prognosis of tongue cancer, and the molecular mechanism regulating lymph node metastasis of tongue cancer is poorly known.

    Authors: Fang Xiao, Yinhua Dai, Yujiao Hu, Mengmeng Lu and Qun Dai

    Citation: Cancer Cell International 2019 19:307

    Content type: Primary research

    Published on:

  29. Increased cell mobility is a signature when tumor cells undergo epithelial-to-mesenchymal transition. TGF-β is a key stimulating factor to promote the transcription of a variety of downstream genes to accelera...

    Authors: Jing Huang, Siyuan Chang, Yabin Lu, Jing Wang, Yang Si, Lijian Zhang, Shan Cheng and Wen G. Jiang

    Citation: Cancer Cell International 2019 19:306

    Content type: Primary research

    Published on:

  30. Switch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors. However, the mechanis...

    Authors: Lin Shi, Huize Liu, Yifeng Wang, Yulong Chong, Jie Wang, Guanzheng Liu, Xu Zhang, Xiangyu Chen, Huan Li, Mingshan Niu, Jun Liang, Rutong Yu and Xuejiao Liu

    Citation: Cancer Cell International 2019 19:305

    Content type: Primary research

    Published on:

  31. Cervical cancer (CC) is the fourth leading cause of cancer-associated death in women worldwide. Recently, long noncoding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) has been demonstrated to ...

    Authors: Qian Zhang, Jindan Zheng and Lili Liu

    Citation: Cancer Cell International 2019 19:304

    Content type: Primary research

    Published on:

  32. Ovarian cancer is the third most common cause of death among gynecologic malignancies worldwide. Understanding the biology and molecular pathogenesis of ovarian epithelial tumors is key to developing improved ...

    Authors: Amata Amy Soriano, Tiziana de Cristofaro, Tina Di Palma, Serena Dotolo, Priyanka Gokulnath, Antonella Izzo, Gaetano Calì, Angelo Facchiano and Mariastella Zannini

    Citation: Cancer Cell International 2019 19:303

    Content type: Primary research

    Published on:

  33. Tongue squamous cell carcinoma (TSCC) is a most invasive cancer with high mortality and poor prognosis. It is reported that lncRNA DANCR has implications in multiple types of cancers. However, its biological r...

    Authors: Ying Zheng, Bowen Zheng, Xue Meng, Yuwen Yan, Jia He and Yi Liu

    Citation: Cancer Cell International 2019 19:302

    Content type: Primary research

    Published on:

  34. The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complem...

    Authors: Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao and Yupei Zhao

    Citation: Cancer Cell International 2019 19:300

    Content type: Review

    Published on:

  35. Photoimmunotherapy (PIT) employing antibody-photosensitizer conjugates is a promising treatment for cancer. However, the fixed antigen specificity severely limits the efficacy and the applicability. Here we de...

    Authors: Naoto Shirasu, Hirotomo Shibaguchi, Hiromi Yamada, Masahide Kuroki and Shin’ichiro Yasunaga

    Citation: Cancer Cell International 2019 19:299

    Content type: Primary research

    Published on:

  36. Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family of proteins and its deregulation has been implicated in the malignancy of several cancer types. Dlg5 ...

    Authors: Dongping Wang, Qi Zhang, Fenfen Li, Chan Wang, Changming Yang and Hong Yu

    Citation: Cancer Cell International 2019 19:298

    Content type: Primary research

    Published on:

  37. Transcription factors (TFs) are responsible for the regulation of various activities related to cancer like cell proliferation, invasion, and migration. It is thought that, the measurement of TFs levels could ...

    Authors: Boxin Zhang, Haihui Wang, Ziyan Guo and Xinhai Zhang

    Citation: Cancer Cell International 2019 19:297

    Content type: Primary research

    Published on:

  38. Endometrial cancer (EC) is one of the three major gynecological malignancies. Numerous biomarkers that may be associated with survival and prognosis have been identified through database mining in previous stu...

    Authors: Zi-Hao Wang, Yun-Zheng Zhang, Yu-Shan Wang and Xiao-Xin Ma

    Citation: Cancer Cell International 2019 19:296

    Content type: Primary research

    Published on:

  39. The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is formed by one of t...

    Authors: Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu and Xun Qi

    Citation: Cancer Cell International 2019 19:295

    Content type: Review

    Published on:

  40. Glioma is considered one of the most common tumors and has a poor prognosis. Recently, microRNAs (miRNAs) have been reported to be strongly linked to various human tumors including glioma. In this study, we in...

    Authors: Yangyang Li, Jia Xu, Jiale Zhang, Jie Zhang, Jian Zhang and Xiaoming Lu

    Citation: Cancer Cell International 2019 19:294

    Content type: Primary research

    Published on:

  41. Although leukemic blast cells of Pro-B cell acute lymphoblastic leukemia (ALL) are arrested at the same stage of B cell differentiation, the immature B cell subtype is still biologically heterogeneous and is a...

    Authors: Chao Gao, Shu-Guang Liu, Zhi-Xia Yue, Yi Liu, Jing Liang, Jun Li, Yuan-Yuan Zhang, Jiao-Le Yu, Ying Wu, Wei Lin, Hu-Yong Zheng and Rui-Dong Zhang

    Citation: Cancer Cell International 2019 19:293

    Content type: Primary research

    Published on:

  42. During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokin...

    Authors: Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz and Kinga A. Kocemba-Pilarczyk

    Citation: Cancer Cell International 2019 19:292

    Content type: Hypothesis

    Published on:

  43. Previous genome-wide transcriptome profiling found circ_ZNF124 was highly expressed in lung adenocarcinoma, however, the role of circ_ZNF124 in non-small cell lung cancer (NSCLC) is still unknown. The purpose ...

    Authors: Qianping Li, Qin Huang, Shaofei Cheng, Song Wu, Hongyang Sang and Junyi Hou

    Citation: Cancer Cell International 2019 19:291

    Content type: Primary research

    Published on:

  44. Hepatocellular carcinoma (HCC) is a serious threat to public health due to its poor prognosis. The current study aimed to develop and validate a prognostic nomogram to predict the overall survival of HCC patie...

    Authors: Zhiqiao Zhang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Qingbo Liu, Peng Wang and Jianqiang Ding

    Citation: Cancer Cell International 2019 19:290

    Content type: Primary research

    Published on:

  45. SNAI2, a member of the snail zinc finger protein family, plays an important role in the metastasis of several types of carcinoma.

    Authors: Jie Ding, Yu Xia, Zhaoyan Yu, Jing Wen, Zhuxue Zhang, Zhongmin Zhang, Zhenhua Liu, Zhuan Jiang, Hang Liu and Guoqing Liao

    Citation: Cancer Cell International 2019 19:289

    Content type: Primary research

    Published on:

  46. The authors have retracted this article [1] because Figure 4a has been duplicated from Figure 5d in a previously published article [2]. In addition, the article contains sections that substantially overlap wit...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke

    Citation: Cancer Cell International 2019 19:286

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2018 18:165

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