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  1. ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializati...

    Authors: Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen, Chien-Ming Lo, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai and Chang-Han Chen
    Citation: Cancer Cell International 2018 18:219
    Content type: Primary research Published on:

  2. Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it’s essential to...

    Authors: Jun Shang, Qian Song, Zuyi Yang, Xiaoyan Sun, Meijuan Xue, Wenjie Chen, Jingcheng Yang and Sihua Wang
    Citation: Cancer Cell International 2018 18:218
    Content type: Primary research Published on:

  3. Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scr...

    Authors: William Torén, Daniel Ansari and Roland Andersson
    Citation: Cancer Cell International 2018 18:217
    Content type: Review Published on:

  4. Metastatic cancer to bone is well-known to produce extreme pain. It has been suggested that the magnitude of this perceived pain is associated with disease progression and poor prognosis. These data suggest a ...

    Authors: Silvia Gutierrez and M. Danilo Boada
    Citation: Cancer Cell International 2018 18:216
    Content type: Primary research Published on:

  5. Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecula...

    Authors: Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou and Jian Li
    Citation: Cancer Cell International 2018 18:215
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:14

  6. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism und...

    Authors: Zongfu Pan, Lu Li, Qilu Fang, Yiwen Zhang, Xiaoping Hu, Yangyang Qian and Ping Huang
    Citation: Cancer Cell International 2018 18:214
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:230

  7. Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to ...

    Authors: Sumei Yao, Xinming Chen, Jinliang Chen, Yangbo Guan, Yifei Liu, Jianrong Chen and Xuedong Lv
    Citation: Cancer Cell International 2018 18:213
    Content type: Primary research Published on:

  8. CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as a tumor prognosis marker has not been systematically assessed. The current meta-a...

    Authors: Huiqian Fan, Weijun Wang, Jingjing Yan, Li Xiao and Ling Yang
    Citation: Cancer Cell International 2018 18:212
    Content type: Primary research Published on:

  9. Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tu...

    Authors: Gábor Petővári, Zoltán Hujber, Ildikó Krencz, Titanilla Dankó, Noémi Nagy, Fanni Tóth, Regina Raffay, Katalin Mészáros, Hajnalka Rajnai, Enikő Vetlényi, Krisztina Takács-Vellai, András Jeney and Anna Sebestyén
    Citation: Cancer Cell International 2018 18:211
    Content type: Primary research Published on:

  11. It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein,...

    Authors: Li-Juan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jia-Yan Zhang, Nan Yao, Mao-Hua Huang, Xiao-Bo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jia-Xu Chen, Wen-Cai Ye and Dong-Mei Zhang
    Citation: Cancer Cell International 2018 18:209
    Content type: Primary research Published on:

  12. TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism a...

    Authors: Jianning Yao, Xuexiu Zhang, Jiaheng Li, Dongyao Zhao, Bing Gao, Haining Zhou, Shilin Gao and Lianfeng Zhang
    Citation: Cancer Cell International 2018 18:208
    Content type: Primary research Published on:

  13. To investigate the potential prognostic role of pre-treatment prognostic nutritional index (PNI) in urinary cancers.

    Authors: Feng Qi, Xiang Zhou, Yi Wang, Yamin Wang, Yichun Wang, Qijie Zhang, Rong Cong, Jie Yang and Ninghong Song
    Citation: Cancer Cell International 2018 18:207
    Content type: Primary research Published on:

  14. Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear cell renal cell carcinoma (nccRCC), which accounting for 4–5% of renal cell carcinoma (RCC). However, there is no effective bi...

    Authors: Xiaomao Yin, Jianfeng Wang and Jin Zhang
    Citation: Cancer Cell International 2018 18:206
    Content type: Primary research Published on:

  15. The origin of cancer cells is the most fundamental yet unresolved problem in cancer research. Cancer cells are thought to be transformed from the normal cells. However, recent studies reveal that the primary c...

    Authors: Qing-lin Dong and Xiang-ying Xing
    Citation: Cancer Cell International 2018 18:205
    Content type: Hypothesis Published on:

  16. Homeobox C6 (HOXC6) plays a part in malignant progression of some tumors. However, the expression of HOXC6 and its clinical significance remains unclear in cervical carcinoma (CC). The purpose of this study is...

    Authors: Feng Zhang, Chen-Chen Ren, Ling Liu, Yan-Nan Chen, Li Yang and Xiao-An Zhang
    Citation: Cancer Cell International 2018 18:204
    Content type: Primary research Published on:

  18. Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the pathogenesis of various cancers. This stud...

    Authors: Zhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Lilei Zhuang and Shenbao Wu
    Citation: Cancer Cell International 2018 18:202
    Content type: Primary research Published on:

  19. There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been...

    Authors: Yiming Mao, Donglai Chen, Shanzhou Duan, Yuhuan Zhao, Changjiang Wu, Feng Zhu, Chang Chen and Yongbing Chen
    Citation: Cancer Cell International 2018 18:201
    Content type: Review Published on:

  20. Apoptosis and autophagy are known to play important roles in cancer development. It has been reported that HVJ-E induces apoptosis in cancer cells, thereby inhibiting the development of tumors. To define the m...

    Authors: Tao Wang, Ning Yu, Miao Qian, Jie Feng, Shuyang Cao, Jun Yin and Quan Zhang
    Citation: Cancer Cell International 2018 18:200
    Content type: Primary research Published on:

  23. To get insight into the molecular mechanisms underlying the anti-tumor activity of S-adenosyl-l-methionine (AdoMet), we analyzed AdoMet-induced modulation of microRNAs (miRNAs) expression profile in MCF-7 breast ...

    Authors: Concetta Paola Ilisso, Donatella Delle Cave, Laura Mosca, Martina Pagano, Alessandra Coppola, Luigi Mele, Michele Caraglia, Giovanna Cacciapuoti and Marina Porcelli
    Citation: Cancer Cell International 2018 18:197
    Content type: Primary research Published on:

  24. RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been ...

    Authors: Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng and Huimin Hu
    Citation: Cancer Cell International 2018 18:196
    Content type: Primary research Published on:

  25. MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resis...

    Authors: Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu and Ling-yu Zhao
    Citation: Cancer Cell International 2018 18:195
    Content type: Primary research Published on:

  26. As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase in morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to lung ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu and Changgang Sun
    Citation: Cancer Cell International 2018 18:194
    Content type: Primary research Published on:

  27. Anoikis resistance has been demonstrated to facilitate distant metastases of cancers. MicroRNA-133b (miR-133b) is found to be down-regulated in various tumors, including esophageal squamous cell carcinoma (ESC...

    Authors: Jin-Feng Zhu, Yi Liu, He Huang, Li Shan, Zhi-Gang Han, Jun-Yuan Liu, Ying-Long Li, Xiang Dong and Wei Zeng
    Citation: Cancer Cell International 2018 18:193
    Content type: Primary research Published on:

  28. The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that ...

    Authors: Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard and Kelly R. Hume
    Citation: Cancer Cell International 2018 18:192
    Content type: Primary research Published on:

  29. Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...

    Authors: Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu and Shukui Wang
    Citation: Cancer Cell International 2018 18:191
    Content type: Primary research Published on:

  30. Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years old, which often invade kidney (KRTs) and Center Nervous System, named Atypical teratoid/rhabdoid tumors (AT/RTs...

    Authors: Yanming Ren, Chuanyuan Tao, Xiliang Wang and Yan Ju
    Citation: Cancer Cell International 2018 18:190
    Content type: Primary research Published on:

  32. 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical applicatio...

    Authors: Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert and Iman van den Bout
    Citation: Cancer Cell International 2018 18:188
    Content type: Primary research Published on:

  33. Accumulating evidence have indicated that regulatory T cells (Tregs) play an essential role in T cell-mediated immune response and development of multiple myeloma (MM). CD4+FoxP3+ T cells are composed of three ph...

    Authors: Ji-nuo Wang, Xin-xin Cao, Ai-lin Zhao, Hao Cai, Xuan Wang and Jian Li
    Citation: Cancer Cell International 2018 18:187
    Content type: Primary research Published on:

  34. MiRNAs was recognized as vital regulators involved in cancer development. Radioresistance remains a major obstacle for effective treatment of cancers. The mechanisms on the miRNA-mediated radioresistance of ca...

    Authors: Chunbao Zang, Fangfang Zhao, Lei Hua and Youguang Pu
    Citation: Cancer Cell International 2018 18:186
    Content type: Primary research Published on:

  35. Lung cancer is the leading cause of cancer deaths in the world. The major histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum-based therapy is the standard of care for pati...

    Authors: Heather E. Kapperman, Alicia A. Goyeneche and Carlos M. Telleria
    Citation: Cancer Cell International 2018 18:185
    Content type: Primary research Published on:

  36. miRNA clusters are widely expressed across species, accumulating evidence has illustrated that miRNA cluster functioned more efficiently than single miRNA in cancer oncogenesis. It is likely that miRNA cluster...

    Authors: Zhikui Gao, Peng Zhang, Ming Xie, Han Gao, Lihong Yin and Ran Liu
    Citation: Cancer Cell International 2018 18:184
    Content type: Primary research Published on:

  37. Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved i...

    Authors: Rong Hu, Ming-qing Wang, Wen-bo Niu, Yan-jing Wang, Yang-yang Liu, Ling-yu Liu, Ming Wang, Juan Zhong, Hai-yan You, Xiao-hui Wu, Ning Deng, Lu Lu and Lian-bo Wei
    Citation: Cancer Cell International 2018 18:183
    Content type: Primary research Published on:

  39. Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a c...

    Authors: Xiaojun Zhou, Zhili Shan, Hengying Yang, Jingjing Xu, Wenjing Li and Feng Guo
    Citation: Cancer Cell International 2018 18:181
    Content type: Primary research Published on:

  40. With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. The main goal of this study is to identify the potential outcome of WPS on human brea...

    Authors: Khaled W. Sadek, Mahmoud Y. Haik, Anas A. Ashour, Tahira Baloch, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Asad Zeidan and Ala-Eddin Al Moustafa
    Citation: Cancer Cell International 2018 18:180
    Content type: Primary research Published on:

  41. Some progresses have been made in research of long non-coding RNA (hereunder referred to as LncRNA) related to breast cancer. Lots of data about LncRNA transcription concerning breast cancer have been obtained...

    Authors: Xu Bin, Yang Hongjian, Zhang Xiping, Chen Bo, Yang Shifeng and Tang Binbin
    Citation: Cancer Cell International 2018 18:179
    Content type: Review Published on:

  42. Deregulated Hippo signaling has been uncovered to be intricately involved in tumorigenesis. Transcriptional factor TEADs serve as key mediators of Hippo signaling and have been increasingly appreciated as puta...

    Authors: Wei Zhang, Jin Li, Yaping Wu, Han Ge, Yue Song, Dongmiao Wang, Hua Yuan, Hongbing Jiang, Yanling Wang and Jie Cheng
    Citation: Cancer Cell International 2018 18:178
    Content type: Primary research Published on:

  44. Sorafenib is the standard targeted drug used to treat hepatocellular carcinoma (HCC), but the therapeutic response between individuals varies markedly. Recently, cytokine-based immunotherapy has been a topic o...

    Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen
    Citation: Cancer Cell International 2018 18:176
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2019 19:358

  45. Gao-Min Liu and Yao-Ming Zhang recently published a review entitled «Targeting FBPase is an emerging novel approach for cancer therapy» (Liu and Zhang in Cancer Cell Int 18:36, 2018). In this paper, the authors h...

    Authors: Philippe Icard, Ludovic Fournel, Antoine Coquerel, Joseph Gligorov, Marco Alifano and Hubert Lincet
    Citation: Cancer Cell International 2018 18:175
    Content type: Commentary Published on:

  46. Pancreatic cancer is characterized by its unsatisfying early detection rate, rapid disease progression and poor prognosis. Further studies on molecular mechanism and novel predictive biomarkers for pancreatic ...

    Authors: Defeng Sun, Haoyi Jin, Jun Zhang and Xiaodong Tan
    Citation: Cancer Cell International 2018 18:174
    Content type: Primary research Published on:

  47. Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

    Authors: Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu and Bingyuan Zhang
    Citation: Cancer Cell International 2018 18:173
    Content type: Primary research Published on:

  48. Galectin-3 as a β-galactoside-binding protein, has been found to be involved in tumor cell growth, anti-apoptosis, adhesion, angiogenesis, invasion, and distant metastases, indicating that it may play a pivota...

    Authors: Yi Wang, Shiwei Liu, Ye Tian, Yamin Wang, Qijie Zhang, Xiang Zhou, Xianghu Meng and Ninghong Song
    Citation: Cancer Cell International 2018 18:172
    Content type: Primary research Published on:

  49. Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions...

    Authors: Xin-Xing Wang, Guang-Cheng Guo, Xue-Ke Qian, Dong-Wei Dou, Zhe Zhang, Xiao-Dong Xu, Xin Duan and Xin-Hong Pei
    Citation: Cancer Cell International 2018 18:171
    Content type: Primary research Published on:

  50. Cancer metastasis is the major reason for cancer related deaths, and the mechanism of cancer metastasis still unclear. RPLP1, a member of a group of proteins known as ribosomal proteins, is associated with tum...

    Authors: Zhixian He, Qian Xu, Xi Wang, Jun Wang, Xiangming Mu, Yunhui Cai, Yangyang Qian, Weiwei Shao and Zhimin Shao
    Citation: Cancer Cell International 2018 18:170
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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