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  2. Authors: Radmehr Shafiee, Javad Javanbakh, Nahid Atyabi, Pegah Kheradmand, Danial Kheradmand, Alimohammad Bahrami, Hasti Daraei and Farshid Khadivar
    Citation: Cancer Cell International 2016 16:83
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2013 13:469

  3. Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and ...

    Authors: Diana Corallo, Simona Candiani, Michela Ori, Sanja Aveic and Gian Paolo Tonini
    Citation: Cancer Cell International 2016 16:82
    Content type: Review Published on:

  4. Many long non coding RNAs have been identified as key modulators in cancer development. A lncRNA, DBCCR1-003, derived from the locus of tumor suppressor gene DBCCR1 (deleted in bladder cancer chromosome region...

    Authors: Defeng Qi, Jinhui Li, Biao Que, Jialin Su, Mengxi Li, Chaofeng Zhang, Mei Yang, Guoren Zhou and Weidong Ji
    Citation: Cancer Cell International 2016 16:81
    Content type: Primary research Published on:

  6. The molecular mechanisms underlying the development and progression of gastric carcinoma remain poorly understood. The main objective of this study was to investigate the expression level of targeting protein ...

    Authors: Cuijie Shao, Changsheng Duan, Jiani Wang, Shunlian Luan, Yong Gao, Dan Jin, Deqiang Wang, Yuming Li and Lihua Xu
    Citation: Cancer Cell International 2016 16:79
    Content type: Primary Research Published on:

  7. Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from b...

    Authors: Hao Chen, Robert Klein, Stacy Arnold, Setsuko Chambers and Wenxin Zheng
    Citation: Cancer Cell International 2016 16:78
    Content type: Primary research Published on:

  8. Molecular profiling of colorectal cancer (CRC) based on global gene expression has revealed multiple dysregulated signalling pathways associated with drug resistance and poor prognosis. However, the role of BM...

    Authors: Radhakrishnan Vishnubalaji, Shijun Yue, Musaad Alfayez, Moustapha Kassem, Fei-Fei Liu, Abdullah Aldahmash and Nehad M. Alajez
    Citation: Cancer Cell International 2016 16:77
    Content type: Primary research Published on:

  9. To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function.

    Authors: Jian-jun Li, Jie Luo, Jing-ning Lu, Xiao-na Liang, Yi-huan Luo, Yong-ru Liu, Jie Yang, Hua Ding, Gui-hui Qin, Li-hua Yang, Yi-wu Dang, Hong Yang and Gang Chen
    Citation: Cancer Cell International 2016 16:76
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:60

  10. A trend of stage-by-stage increase in tumorsphere (TS) formation from glioma samples has been reported. Despite this trend, not all surgical specimens give rise to TSs, even World Health Organization (WHO) gra...

    Authors: Kyoung Su Sung, Jin-Kyoung Shim, Ji-Hyun Lee, Se Hoon Kim, Sohee Park, Tae-Hoon Roh, Ju Hyung Moon, Eui-Hyun Kim, Sun Ho Kim, Su Jae Lee, Yong Min Huh, Seok-Gu Kang and Jong Hee Chang
    Citation: Cancer Cell International 2016 16:75
    Content type: Primary research Published on:

  11. Ovarian cancer is a common type of gynecological malignancies, and is the fifth leading cause of cancer-related death in women in the United States. MiR-429 and KIAA0101 have been found to be involved in sever...

    Authors: Hong Chen, Bairong Xia, Tianbo Liu, Mei Lin and Ge Lou
    Citation: Cancer Cell International 2016 16:74
    Content type: Primary research Published on:

  12. Osteosarcoma is the most common malignancy of bone. Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of aggressive phenotype. ANRIL has been shown to be a long nonc...

    Authors: Xiaokang Wei, Chuanshun Wang, Chunhui Ma, Wei Sun, Haoqing Li and Zhendong Cai
    Citation: Cancer Cell International 2016 16:73
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2017 17:60

  13. Membrane depolarization is associated with breast cancer. Depolarization-activated voltage-gated ion channels are directly implicated in the initiation, proliferation, and metastasis of breast cancer.

    Authors: Seher Berzingi, Mackenzie Newman and Han-Gang Yu
    Citation: Cancer Cell International 2016 16:72
    Content type: Primary research Published on:

  14. The transmembrane receptor family Roundabout (Robo) was described to have an essential role in the developing nervous system. Recent studies demonstrated that Robo3 shows an altered expression in rheumatoid ar...

    Authors: Anke Ruedel, Mandy Schott, Thomas Schubert and Anja Katrin Bosserhoff
    Citation: Cancer Cell International 2016 16:71
    Content type: Primary research Published on:

  15. The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and M...

    Authors: Elena de Blas, María Cristina Estañ, María del Carmen Gómez de Frutos, Javier Ramos, María del Carmen Boyano-Adánez and Patricio Aller
    Citation: Cancer Cell International 2016 16:70
    Content type: Primary research Published on:

  16. The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigate...

    Authors: Ruo Chen, Shi-Jie Wang, Yang Zhang, Rong Hou, Jian-Li Jiang and Hong-Yong Cui
    Citation: Cancer Cell International 2016 16:69
    Content type: Primary research Published on:

  17. Recent studies indicated that histone deacetylase inhibitors (HDACi), a class of anticancer agents, are in addition to their ability of apoptosis induction also capable of provoking autophagy. Promoted by the ...

    Authors: Leopold F. Fröhlich, Maria Mrakovcic, Claudia Smole and Kurt Zatloukal
    Citation: Cancer Cell International 2016 16:68
    Content type: Primary research Published on:

  18. To investigate the role of total cellular microRNA (miRNA) in regulating epithelial-to-mesenchymal transition (EMT) during human endometrial endometrioid adenocarcinoma (EEC).

    Authors: Ping Liu, Chao Wang, Chengbin Ma, Qiongwei Wu, Wenying Zhang and Guoying Lao
    Citation: Cancer Cell International 2016 16:67
    Content type: Primary research Published on:

  19. Lung cancer causes the most cancer deaths worldwide, thus there is a urgent need to develop new treatment options. Concurrent chemoradiotherapy has become a common strategy for the treatment of non-resectable ...

    Authors: Patrick Dorn, Colin Charles Tièche, Ren-Wang Peng, Laurène Froment, Ralph Alexander Schmid and Thomas Michael Marti
    Citation: Cancer Cell International 2016 16:66
    Content type: Primary research Published on:

  20. Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is t...

    Authors: Hao Wang, Cheng Hang, Xi-Long Ou, Jin-Shan Nie, Yi-Tao Ding, Shi-Gui Xue, Hua Gao and Jian-Xin Zhu
    Citation: Cancer Cell International 2016 16:65
    Content type: Primary research Published on:

  21. Chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS), resulting in only an approximately 20 % survival rate in patients with metastatic disease at diagnosis. Identifying the mechanisms res...

    Authors: Youguang Pu, Qiyi Yi, Fangfang Zhao, Haiyan Wang, Wenjing Cai and Shanbao Cai
    Citation: Cancer Cell International 2016 16:64
    Content type: Primary research Published on:

  22. Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Many microRNAs (miRNAs), small non-coding RNAs, are involved in regulating cancer cell proliferation, metastasis, migrat...

    Authors: Yue-Bin Zeng, Xing-Hua Liang, Guang-Xian Zhang, Nan Jiang, Tong Zhang, Jian-Ying Huang, Lei Zhang and Xian-Cheng Zeng
    Citation: Cancer Cell International 2016 16:63
    Content type: Primary research Published on:

  23. A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in the transformation of malignant cells. Constitutive and abnormal activation of RTKs may occur in tumors eit...

    Authors: Sanja Aveic and Gian Paolo Tonini
    Citation: Cancer Cell International 2016 16:62
    Content type: Review Published on:

  24. Peptidylarginine deiminase (PAD) post-translationally converts arginine residues to citrulline residues. Recent studies have suggested that PADI2 (PAD isoform 2), a member of the PAD family, is involved in the...

    Authors: Huifeng Wang, Bing Xu, Xiaoqian Zhang, Yabing Zheng, Yan Zhao and Xiaotian Chang
    Citation: Cancer Cell International 2016 16:61
    Content type: Primary research Published on:

  26. Enhancer of Zeste Drosophila Homologue 2 (EZH2) is a key regulator of transcription as a member of polycomb repressive complex 2 (PRC2) which exerts repression of downstream genes and is correlated to invasivenes...

    Authors: Maria Ramaglia, Velia D’Angelo, Adriana Iannotta, Daniela Di Pinto, Elvira Pota, Maria Carmen Affinita, Vittoria Donofrio, Maria Elena Errico, Angela Lombardi, Cristiana Indolfi, Fiorina Casale and Michele Caraglia
    Citation: Cancer Cell International 2016 16:59
    Content type: Primary research Published on:

  27. Glioblastoma stem cells (GSC) have been extensively recognized as a plausible cause of glioblastoma resistance to therapy and recurrence resulting in high glioblastoma mortality. Abnormalities in the DNA repai...

    Authors: Saša Kenig, Valentina Faoro, Evgenia Bourkoula, Neža Podergajs, Tamara Ius, Marco Vindigni, Miran Skrap, Tamara Lah, Daniela Cesselli, Paola Storici and Alessandro Vindigni
    Citation: Cancer Cell International 2016 16:58
    Content type: Primary research Published on:

  28. Oridonin (ORI) can inhibit proliferation and migration in various types of cancer cell lines. However, the exact mechanism remains unclear. We investigated the migration inhibitory effect of ORI on human pancr...

    Authors: Qian-Qian Liu, Ke Chen, Qiao Ye, Xiao-Hua Jiang and Yun-Wei Sun
    Citation: Cancer Cell International 2016 16:57
    Content type: Primary research Published on:

  29. The introduction of effective novel biomarkers of invasion and metastasis is integral for the advancement of breast cancer management. The present study focused on the identification and evaluation of calretic...

    Authors: Mohammadreza Zamanian, Lama Abdel Qader Hamadneh, Abhi Veerakumarasivam, Sabariah Abdul Rahman, Shamarina Shohaimi and Rozita Rosli
    Citation: Cancer Cell International 2016 16:56
    Content type: Primary research Published on:

  31. This retrospective study aimed to investigate the prognostic significance of pretreatment lymphocyte-to-monocyte ratio (LMR) in locally advanced cervical cancer and its effect on overall survival.

    Authors: Si-wei Li, Wenxin Yuan, Bo Zhao, Zhuo-kai He, Xiang Guo, Wei-xiong Xia and Li-hua Xu
    Citation: Cancer Cell International 2016 16:54
    Content type: Primary research Published on:

  32. Poly(ADP-ribose) polymerase (PARP) inhibitors have entered the clinics for their promising anticancer effect as adjuvant in chemo- and radiotherapy and as single agent on BRCA-mutated tumours. Poly(ADP-ribose)...

    Authors: Aurélia Noll, Giuditta Illuzzi, Jean-Christophe Amé, Françoise Dantzer and Valérie Schreiber
    Citation: Cancer Cell International 2016 16:53
    Content type: Primary research Published on:

  33. The conventional radical resection of proximal gastric cancer is even more risky when performed laparoscopically, though this technique is widely used in gastrointestinal surgery and is accepted as the superio...

    Authors: Liansheng Zheng, Ce Zhang, Da Wang, Qi Xue, Xiaoping Liu, Ke-Jian Zhou, Hao Liu and Guoxin Li
    Citation: Cancer Cell International 2016 16:52
    Content type: Primary research Published on:

  34. Euglena tuba, a microalga, is known for its excellent antioxidant and iron-chelation activities; however its anticancer efficacies have not been reported yet. This study investigates t...

    Authors: Sourav Panja, Nikhil Baban Ghate and Nripendranath Mandal
    Citation: Cancer Cell International 2016 16:51
    Content type: Primary research Published on:

  35. Human chorionic gonadotropin (hCG) can play a crucial role in angiogenesis. In the present study, we focused on hCG to gain insight into its potential effects on vasculogenic mimicry (VM) in ovarian cancer cells.

    Authors: Min Su, Xiangxiang Xu, Weiwei Wei, Sainan Gao, Xiaoying Wang, Caoyi Chen and Yuquan Zhang
    Citation: Cancer Cell International 2016 16:50
    Content type: Primary research Published on:

  36. Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique prot...

    Authors: Himani Garg, Prerna Suri, Jagdish C. Gupta, G. P. Talwar and Shweta Dubey
    Citation: Cancer Cell International 2016 16:49
    Content type: Review Published on:

  37. Epithelial to mesenchymal transition (EMT) has been shown to be a crucial enhancing mechanism in the process of cancer metastasis, as it increases cancer cell capabilities to migrate, invade and survive in cir...

    Authors: Chuanpit Ninsontia, Preeyaporn Plaimee Phiboonchaiyanan and Pithi Chanvorachote
    Citation: Cancer Cell International 2016 16:48
    Content type: Primary research Published on:

  39. Glioblastoma (GBM) is the most common primary brain tumor presenting self-renewing cancer stem cells. The role of these cells on the development of the tumors has been proposed to recapitulate programs from em...

    Authors: Maria Cecília Oliveira-Nunes, Suzana Assad Kahn, Ana Luiza de Oliveira Barbeitas, Tania Cristina Leite de Sampaio e Spohr, Luiz Gustavo Feijó Dubois, Grasiella Maria Ventura Matioszek, William Querido, Loraine Campanati, José Marques de Brito Neto, Flavia Regina Souza Lima, Vivaldo Moura-Neto and Katia Carneiro
    Citation: Cancer Cell International 2016 16:46
    Content type: Primary Research Published on:

  40. Since cytotoxic T cell (CTL) response is the major cellular type in attacking tumor cells, most immunotherapy targets to manipulate the CTL response. Immunotherapies targeting melanoma-specific antigens (MAGEs...

    Authors: Wang Junwei, Zhan Xiumin, Ye Jing, Yang Shoujing and Li Zengshan
    Citation: Cancer Cell International 2016 16:45
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2017 17:10

  41. Spheroid based culture methods are gaining prominence to elucidate the role of the microenvironment in liver carcinogenesis. Additionally, the phenomenon of epithelial-mesenchymal transition also plays an impo...

    Authors: Joseph M. Pomo, Robert M. Taylor and Rama R. Gullapalli
    Citation: Cancer Cell International 2016 16:44
    Content type: Primary research Published on:

  42. With the continuing development of new anti-cancer drugs comes a need for preclinical experimental models capable of predicting the clinical activity of these novel agents in cancer patients. However existing ...

    Authors: Kyung-Min Kim, Jin-Kyoung Shim, Jong Hee Chang, Ji-Hyun Lee, Se-Hoon Kim, Junjeong Choi, Junseong Park, Eui-Hyun Kim, Sun Ho Kim, Yong-Min Huh, Su-Jae Lee, Jae-Ho Cheong and Seok-Gu Kang
    Citation: Cancer Cell International 2016 16:43
    Content type: Primary research Published on:

  43. Deregulation of miRNA-210 is a common event in several types of cancer. However, increased expression levels in the cancer tissue have been associated with both poor and good prognosis of patients. Similarly, ...

    Authors: Katrin E. Tagscherer, Anne Fassl, Tabea Sinkovic, Jutta Richter, Sabrina Schecher, Stephan Macher-Goeppinger and Wilfried Roth
    Citation: Cancer Cell International 2016 16:42
    Content type: Primary research Published on:

  44. Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patien...

    Authors: Phyllis F. Y. Cheung, Chi Wai Yip, Linda W. C. Ng, Kwok Wai Lo, Chit Chow, Kui Fat Chan, Tan To Cheung and Siu Tim Cheung
    Citation: Cancer Cell International 2016 16:41
    Content type: Primary research Published on:

  46. Marine algae consumption is linked to law cancer incidences in countries that traditionally consume marine products. Hence, Phytochemicals are considered as potential chemo-preventive and chemotherapeutic agen...

    Authors: Hossam Murad, Mohammad Hawat, Adnan Ekhtiar, Abdulmunim AlJapawe, Assef Abbas, Hussein Darwish, Oula Sbenati and Ahmed Ghannam
    Citation: Cancer Cell International 2016 16:39
    Content type: Primary research Published on:

  48. Lyn, an import member of Src family kinases (SFKs), is supposed to be implicated in acute myeloid leukemia (AML) pathogenesis and development by participation in AML differentiation, yet the details still rema...

    Authors: Noriyoshi Iriyama, Bo Yuan, Yoshihiro Hatta, Norio Takagi and Masami Takei
    Citation: Cancer Cell International 2016 16:37
    Content type: Primary research Published on:

  49. Temozolomide (TMZ) is a first-line drug for the treatment of glioblastoma. Long-term TMZ-treated tumour cells acquire TMZ resistance by profound reprogramming of the transcriptome, proteome, kinome, metabolism...

    Authors: Aleksei A. Stepanenko, Svitlana V. Andreieva, Kateryna V. Korets, Dmytro O. Mykytenko, Vladimir P. Baklaushev, Nataliya L. Huleyuk, Oksana A. Kovalova, Kateryna V. Kotsarenko, Vladimir P. Chekhonin, Yegor S. Vassetzky, Stanislav S. Avdieiev and Vladimir V. Dmitrenko
    Citation: Cancer Cell International 2016 16:36
    Content type: Primary research Published on:

  50. Malignant Mesothelioma (MM) is a highly aggressive tumor with poor prognosis. Multimodal treatments and novel molecular targeted therapies against MM are in high demand in order treat this disease effectively....

    Authors: Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto and Taketo Yamada
    Citation: Cancer Cell International 2016 16:35
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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