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  1. In humans, riboflavin must be obtained through intestinal absorption because it cannot be synthesized by the body. SLC52A2 encodes a membrane protein belonging to the riboflavin transporter protein family and ...

    Authors: Lilong Zhang, Man Li, Zhoujun Cui, Dongqi Chai, Yongjun Guan, Chen Chen and Weixing Wang
    Citation: Cancer Cell International 2022 22:8
  2. Bladder cancer (BLCA) is one of the most common malignancies worldwide. One of the main reasons for the unsatisfactory management of BLCA is the complex molecular biological mechanism. Annexin A1 (ANXA1), a Ca2+-...

    Authors: Piao Li, Lingling Li, Zhou Li, Shennan Wang, Ruichao Li, Weiheng Zhao, Yanqi Feng, Shanshan Huang, Lu Li, Hong Qiu and Shu Xia
    Citation: Cancer Cell International 2022 22:7
  3. Ovarian cancer is the most aggressive gynecological malignancy. Transcriptional regulators impact the tumor phenotype and, consequently, clinical progression and response to therapy. PHD finger protein 20-like...

    Authors: Dulce Rosario Alberto-Aguilar, Verónica Ivonne Hernández-Ramírez, Juan Carlos Osorio-Trujillo, Dolores Gallardo-Rincón, Alfredo Toledo-Leyva and Patricia Talamás-Rohana
    Citation: Cancer Cell International 2022 22:6
  4. Alternative splicing (AS) plays important roles in transcriptome and proteome diversity. Its dysregulation has a close affiliation with oncogenic processes. This study aimed to evaluate AS-based biomarkers by ...

    Authors: Boxue He, Cong Wei, Qidong Cai, Pengfei Zhang, Shuai Shi, Xiong Peng, Zhenyu Zhao, Wei Yin, Guangxu Tu, Weilin Peng, Yongguang Tao and Xiang Wang
    Citation: Cancer Cell International 2022 22:5
  5. Serine/threonine protein kinase 25 (STK25) plays an important role in regulating glucose and insulin homeostasis and in ectopic lipid accumulation. It directly affects the progression and prognosis of nonalcoh...

    Authors: Yichao Zhang, Junhui Xu, Zhendong Qiu, Yongjun Guan, XiaoYi Zhang, Xin Zhang, Dongqi Chai, Chen Chen, Qinyong Hu and Weixing Wang
    Citation: Cancer Cell International 2022 22:4
  6. Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects. Though, tumor inherent or acquir...

    Authors: Somayeh Vafaei, Angelina O. Zekiy, Ramadhan Ado Khanamir, Burhan Abdullah Zaman, Arman Ghayourvahdat, Hannaneh Azimizonuzi and Majid Zamani
    Citation: Cancer Cell International 2022 22:2
  7. Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma (HCC). Ferritin heavy chain (FTH) is a major iron storing n...

    Authors: Wanye Hu, Chaoting Zhou, Qiangan Jing, Yancun Li, Jing Yang, Chen Yang, Luyang Wang, Jiayu Hu, Huanjuan Li, Hairui Wang, Chen Yuan, Yi Zhou, Xueying Ren, Xiangmin Tong, Jing Du and Ying Wang
    Citation: Cancer Cell International 2021 21:709
  8. Distance metastasis is the leading cause of death for breast cancer patients, and circulating tumor cells (CTCs) play a key role in cancer metastasis. There have been few studies on CTCs at the molecular level...

    Authors: Xuan Li, Hefen Sun, Qiqi Liu, Yang Liu, Yifeng Hou and Wei Jin
    Citation: Cancer Cell International 2021 21:708
  9. Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis. Hence, effecti...

    Authors: Hong-Bo Li, Jun-Kai Chen, Ze-Xin Su, Qing-Lin Jin, Li-Wen Deng, Gang Huang and Jing-Nan Shen
    Citation: Cancer Cell International 2021 21:706
  10. Cancer can be considered as a communication disease between and within cells; nevertheless, there is no effective therapy for the condition, and this disease is typically identified at its late stage. Chemothe...

    Authors: Negar Noorbakhsh, Bentolhoda Hayatmoghadam, Marzieh Jamali, Maryam Golmohammadi and Maria Kavianpour
    Citation: Cancer Cell International 2021 21:705
  11. Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransf...

    Authors: Ruiyang Zhao, Bo Cao, Hanghang Li, Tian Li, Xingming Xu, Hao Cui, Huan Deng and Bo Wei
    Citation: Cancer Cell International 2021 21:704
  12. The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malign...

    Authors: Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano and Carlo Cenciarelli
    Citation: Cancer Cell International 2021 21:703
  13. Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge in tumor treatment. A high dose of PTX was used for cell lines to analyze the changes in molecular expression. The miR-378d was ...

    Authors: Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li…
    Citation: Cancer Cell International 2021 21:702
  14. Epigenetic alterations contribute greatly to metastasis and dissemination in hepatocellular carcinoma (HCC). SMARCC1, as a SWI/SNF chromatin remodeling factor, has been reported to play important roles in many...

    Authors: Xiaopeng Cai, Jiaming Zhou, Jingwen Deng and Zhi Chen
    Citation: Cancer Cell International 2021 21:701
  15. Nowadays, acute leukemia (AL) among children has favorable outcome, yet some of them get refractory or relapse mainly due to drug resistance. High-mobility group box 1 (HMGB1) has been proven to have a importa...

    Authors: Weixin Lai, Xinyu Li, Qian Kong, Han Chen, Yunyao Li, Lu-Hong Xu and Jianpei Fang
    Citation: Cancer Cell International 2021 21:700
  16. Cholangiocarcinoma (CCA) is one of the deadliest cancers of the digestive tract. The prognosis of CCA is poor and the 5-year survival rate is low. Bioinformatic analysis showed that early mitotic inhibitor 2 (...

    Authors: Shuai Zhou, Kang Lin Qu, Jin Ang Li, Shi Lei Chen, Yi Gang Zhang, Chao Zhu, Hao Jin, Yong Wang, Qing Pang and Hui Chun Liu
    Citation: Cancer Cell International 2021 21:699
  17. Pancreatic cancer is one of the most common malignancies worldwide. In recent years, specific metabolic activities, which involves the development of tumor, caused wide public concern. In this study, we wish t...

    Authors: Weiyang Cai, Wenming Bao, Shengwei Chen, Yan Yang and Yanyan Li
    Citation: Cancer Cell International 2021 21:698
  18. Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-act...

    Authors: YingYing He, Zhicheng He, Xiaoyu Zhang and Shubai Liu
    Citation: Cancer Cell International 2021 21:697
  19. Head and neck squamous cell carcinoma (HNSCC) are one of the most common types of head and neck cancer, and it is urgent to find effective treatment for advanced patients. Exploring developing and progressing ...

    Authors: You Fu, Guocai Tian, Zhiyuan Zhang and Xiao Yang
    Citation: Cancer Cell International 2021 21:696
  20. Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of grea...

    Authors: Xiaoyu Zhu, Xiaoping Wang, Yifei Gong and Junlin Deng
    Citation: Cancer Cell International 2021 21:695
  21. Skin cutaneous melanoma (SKCM) is the most common skin tumor with high mortality. The unfavorable outcome of SKCM urges the discovery of prognostic biomarkers for accurate therapy. The present study aimed to e...

    Authors: Hanwen Wang, Xiaoxia Xie, Junyou Zhu, Shaohai Qi and Julin Xie
    Citation: Cancer Cell International 2021 21:694
  22. Researches indicated the process of Endothelial-Mesenchymal-Transition (EndMT) of vascular endothelial cells (ECs) was critically involved in the progression of tumor. ECs demonstrated functional and phenotypi...

    Authors: Jingyuan Chen, Shengbo Han, Jinhuang Chen, Ping Hu, Zhu Zeng, Yuhang Hu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Fengyu Xu and Gang Zhao
    Citation: Cancer Cell International 2021 21:692
  23. Patients with small-cell lung cancer (SCLC) are burdened by limited treatment options and the disease’s dismal prognosis. Long non-coding RNAs (lncRNAs) are essential regulators of genetic alteration and are a...

    Authors: Zhihui Zhang, Yuejun Luo, Chaoqi Zhang, Peng Wu, Guochao Zhang, Qingpeg Zeng, Lide Wang, Liyan Xue, Zhaoyang Yang, Hua Zeng, Bo Zheng, Fengwei Tan, Qi Xue, Shugeng Gao, Nan Sun and Jie He
    Citation: Cancer Cell International 2021 21:691
  24. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and...

    Authors: Sigrid Nakken, Øystein Eikrem, Hans-Peter Marti, Christian Beisland, Leif Bostad, Andreas Scherer, Arnar Flatberg, Vidar Beisvag, Eleni Skandalou, Jessica Furriol and Philipp Strauss
    Citation: Cancer Cell International 2021 21:690
  25. Osteosarcoma is the third most common cancer in adolescence and the first common primary malignant tumor of bone. The long-term prognosis of osteosarcoma still remains unsatisfactory in the past decades. There...

    Authors: Minchao Lv, Qingxin Xu, Bei Zhang, Zhiqiang Yang, Jun Xie, Jinku Guo, Feixiong He and Wei Wang
    Citation: Cancer Cell International 2021 21:689
  26. The neutrophil-to-lymphocyte ratio (NLR) as an inflammatory marker may represent changes between inflammation and host immunity that affect the prognosis of peripheral T-cell lymphoma (PTCL). To comprehensivel...

    Authors: Jia Liu, Shengnan Zhang, Ruihua Mi, Lin Chen and Qingsong Yin
    Citation: Cancer Cell International 2021 21:688
  27. Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively increasing incidence rate has been observed in recent years, with 95% of thyroid cancer represented by differentiated thyroi...

    Authors: Guo Huang, Juan Chen, Jun Zhou, Shuai Xiao, Weihong Zeng, Jiliang Xia and Xi Zeng
    Citation: Cancer Cell International 2021 21:687
  28. Accumulating studies indicated that dysregulated long non-coding RNA human histocompatibility leukocyte antigen (HLA) Complex P5 (HCP5) may functions as an potential prognostic predictor in multiple cancers. T...

    Authors: Shao-pu Hu, Meng-xue Ge, Lei Gao, Min Jiang and Kai-wen Hu
    Citation: Cancer Cell International 2021 21:686
  29. Classical von Hippel Lindau (VHL) disease/syndrome includes CNS hemangioblastoma, renal or pancreatic cysts, pheochromocytoma, renal carcinoma and exodermic cystadenoma. The syndrome is caused by mutation of V...

    Authors: Dali Tong, Yao Zhang, Jun Jiang and Gang Bi
    Citation: Cancer Cell International 2021 21:685
  30. Angiogenesis provides essential nutrients and oxygen for tumor growth and has become the main mechanism of tumor invasion and metastasis. Exosomes are nanoscale membrane vesicles containing proteins, lipids, m...

    Authors: Xuewu You, Wenxiong Sun, Ying Wang, Xiaoli Liu, Aihong Wang, Lu Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Cancer Cell International 2021 21:684
  31. Multiple myeloma (MM) is the most common malignant hematological disease in the people worldwide. Glaucocalyxin A (GLA) is a bioactive ent-kauranoid diterpenoid, that is derived from Rabdosia japonica var. GLA ha...

    Authors: Mei Li, Cailong Chen, Qian Wang, Xiaolu Jiang, Lanlan Tan, Ying Huang, Yan Zhang and Zubin Zhang
    Citation: Cancer Cell International 2021 21:683
  32. One of the obstacles in treating different cancers, especially solid tumors, is cancer stem cells (CSCs) with their ability in resistance to chemo/radio therapy. The efforts for finding advanced treatments to ...

    Authors: Alireza Shokouhifar, Javad Firouzi, Masoumeh Nouri, Gholamreza Anani Sarab and Marzieh Ebrahimi
    Citation: Cancer Cell International 2021 21:682
  33. Several treatments are available for treatment of early and very early-stage Hepatocellular Carcinoma, also known as small Hepatocellular Carcinoma (SHCC). However, there is no consensus with regards to the ef...

    Authors: Sha Yang, Huapeng Lin and Jianning Song
    Citation: Cancer Cell International 2021 21:681
  34. Eukaryotic initiation factor 3a (EIF3A), a “reader” protein for RNA methylation, has been found to be involved in promoting tumorigenesis in a variety of cancers. The impact of EIF3A in clear cell renal cell c...

    Authors: Yi Zhang, Xiaoliang Hua, Haoqiang Shi, Li Zhang, Haibing Xiao and Chaozhao Liang
    Citation: Cancer Cell International 2021 21:680
  35. Growing evidence has shown that the prognosis for colon cancer depends on changes in microenvironment. The purpose of this study was to elucidate the prognostic value of long noncoding RNAs (lncRNAs) related t...

    Authors: Yilin Lin, Xiaoxian Pan, Zhihua Chen, Suyong Lin, Zhanlong Shen and Shaoqin Chen
    Citation: Cancer Cell International 2021 21:679
  36. Cervical cancer (CC) is the second most common cancer among women with high morbidity and mortality. TKTL1 is a key protein in glucose metabolism in cancer cells and controls the pentose phosphate pathway (PPP...

    Authors: Yingping Zhu, Yu Qiu and Xueqin Zhang
    Citation: Cancer Cell International 2021 21:678
  37. M2 macrophages are associated with a poor prognosis in a variety of malignancies. There are, however, few relevant investigations in clear cell renal cell carcinoma (ccRCC).

    Authors: Yingwei Xie, Zhiliang Chen, Qiyu Zhong, Zaosong Zheng, Yuqing Chen, Wentai Shangguan, Yishan Zhang, Jingying Yang, Dingjun Zhu and Wenlian Xie
    Citation: Cancer Cell International 2021 21:677
  38. Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic ...

    Authors: Shankun Zhao, Peng Li, Weizhou Wu, Qinzhang Wang, Biao Qian, Xin Li and Maolei Shen
    Citation: Cancer Cell International 2021 21:676
  39. Liquid biopsy (LB) has boosted a remarkable change in the management of cancer patients by contributing to tumour genomic profiling. Plasma circulating cell-free tumour DNA (ctDNA) is the most widely searched ...

    Authors: Maria Gabriela O. Fernandes, Natália Cruz-Martins, José Carlos Machado, José Luís Costa and Venceslau Hespanhol
    Citation: Cancer Cell International 2021 21:675
  40. Pancreatic cancer (PCa) is a fatal malignancy with poor prognosis, high recurrence and mortality. Substantial reports have suggested long non-coding RNAs (lncRNAs) are implicated in development of numerous mal...

    Authors: Jin Xu, Weixue Xu, Xuan Yang, Zhen Liu, Yiya Zhao and Qinyun Sun
    Citation: Cancer Cell International 2021 21:674
  41. Owing to the lack of effective treatment options, early metastasis remains the major cause of pancreatic ductal adenocarcinoma (PDAC) recurrence and mortality. However, the molecular mechanism of early metasta...

    Authors: Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng and Zhou Luan
    Citation: Cancer Cell International 2021 21:670
  42. Increasing evidence has indicated that pyroptosis could regulate the tumor immune microenvironment (TIME) to affect the tumor development. As a highly immunogenic tumor, clear cell renal cell carcinoma (ccRCC)...

    Authors: Yan Zhang, Xianwu Chen, Qinghe Fu, Feifan Wang, Xuejian Zhou, Jiayong Xiang, Ning He, Zhenghui Hu and Xiaodong Jin
    Citation: Cancer Cell International 2021 21:667
  43. C1QTNF6 (CTRP6), a member of the CTRP family, has recently been implied to play a role in the tumorigenesis of for a variety of cancer types. However, the role of C1QTNF6 in oral squamous cell carcinoma (OSCC)...

    Authors: Xiaobin Song, Longjie Li, Liang Shi, Xinyu Liu, Xun Qu, Fengcai Wei and Ketao Wang
    Citation: Cancer Cell International 2021 21:666

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