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  1. lncRNAs have been proved to play crucial parts in various human cytopathology and cell physiology, including tumorigenesis. Down-regulated lncRNAs SNHG6 have shown great cell proliferation inhibitory effects i...

    Authors: Xin Zhu, Guangling Yang, Jisheng Xu and Chuanlin Zhang

    Citation: Cancer Cell International 2019 19:82

    Content type: Primary research

    Published on:

  2. Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used i...

    Authors: Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu and Yan Li

    Citation: Cancer Cell International 2019 19:81

    Content type: Primary research

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  3. Invasion and metastasis are determinant events in the prognosis of Colorectal cancer (CRC), a common neoplasm worldwide. An important factor for metastasis is the acquired capacity of the cell to proliferate a...

    Authors: Jossimar Coronel-Hernández, Eduardo López-Urrutia, Carlos Contreras-Romero, Izamary Delgado-Waldo, Gabriela Figueroa-González, Alma D. Campos-Parra, Rebeca Salgado-García, Antonio Martínez-Gutierrez, Miguel Rodríguez-Morales, Nadia Jacobo-Herrera, Luis Ignacio Terrazas, Abraham Silva-Carmona, César López-Camarillo and Carlos Pérez-Plasencia

    Citation: Cancer Cell International 2019 19:80

    Content type: Primary research

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  4. The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple hum...

    Authors: Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu and Ninghong Song

    Citation: Cancer Cell International 2019 19:79

    Content type: Primary research

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  5. Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in various kinds of cancers. Here, we aimed to determine whether the expressi...

    Authors: Ziping Wu, Lei Zhang, Shuguang Xu, Yanping Lin, Wenjin Yin, Jinglu Lu, Rui Sha, Xiaonan Sheng, Liheng Zhou and Jinsong Lu

    Citation: Cancer Cell International 2019 19:78

    Content type: Primary research

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  6. The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pa...

    Authors: Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage and Konrad Steinestel

    Citation: Cancer Cell International 2019 19:77

    Content type: Primary research

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  7. It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such ...

    Authors: Shanli Li, Feng Xue, Yi Zheng, Pengtao Yang, Shuai Lin, Yujiao Deng, Peng Xu, Linghui Zhou, Qian Hao, Zhen Zhai, Ying Wu, Zhijun Dai and Shu Chen

    Citation: Cancer Cell International 2019 19:76

    Content type: Primary research

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  8. The role of TMED3 involved in cancers has been seldom described, let alone in breast cancer. To explore the clinicopathological significance of TMED3 expression and the biological roles involved in breast canc...

    Authors: Jing Pei, Jing Zhang, Xiaowei Yang, Zhengsheng Wu, Chenyun Sun, Zhaorui Wang and Benzhong Wang

    Citation: Cancer Cell International 2019 19:75

    Content type: Primary research

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  9. Gastric cardia adenocarcinoma (GCA) is an aggressive subtype of gastric cancer with a high metastatic rate. However, the metastatic biomarker of GCA has not been established.

    Authors: Jing Wei, Lincui Wang, Jun Zhu, Aiqin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Genbao Shao, Wannian Yang and Qiong Lin

    Citation: Cancer Cell International 2019 19:74

    Content type: Primary research

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  10. Pediatric cancer survival rates overall have been improving, but neuroblastoma (NBL) and acute lymphoblastic leukemia (ALL), two of the more prevalent pediatric cancers, remain particularly challenging. One is...

    Authors: Andrea Diviney, Boris I. Chobrutskiy, Saif Zaman and George Blanck

    Citation: Cancer Cell International 2019 19:73

    Content type: Primary research

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  11. Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal cancer (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon cancer remains largely...

    Authors: Shurui Ouyang, Xin Zhou, Zhengquan Chen, Maijian Wang, Xinbin Zheng and Ming Xie

    Citation: Cancer Cell International 2019 19:72

    Content type: Primary research

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  12. Oxaliplatin-based chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Recent studies suggested that therapeutic resistance of tumors was affected by tumor microenvironment (TME). As a major co...

    Authors: Xiu-Tao Fu, Kang Song, Jian Zhou, Ying-Hong Shi, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Zhen-Bin Ding and Jia Fan

    Citation: Cancer Cell International 2019 19:71

    Content type: Primary research

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  13. Pretreatment inflammatory factors, including neutrophil, lymphocyte, platelet and monocyte counts as well as the ratios between them such as neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) a...

    Authors: Hao Peng and Xiaogang Luo

    Citation: Cancer Cell International 2019 19:70

    Content type: Primary research

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  14. Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we aimed to investigate whether lycopene cou...

    Authors: Xiufeng Jiang, Hui Wu, Wei Zhao, Xiao Ding, Qian You, Feng Zhu, Meifang Qian and Ping Yu

    Citation: Cancer Cell International 2019 19:68

    Content type: Primary research

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  15. Low molecular weight protein tyrosine phosphatase (LMW-PTP) is overexpressed in different cancer types and its expression is related to more aggressive disease, reduced survival rate and drug resistance. Morin...

    Authors: Nagaja Capitani, Giulia Lori, Paolo Paoli, Laura Patrussi, Arianna Troilo, Cosima T. Baldari, Giovanni Raugei and Mario Milco D’Elios

    Citation: Cancer Cell International 2019 19:67

    Content type: Primary research

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  16. The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...

    Authors: Jinghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang and Li Wang

    Citation: Cancer Cell International 2019 19:66

    Content type: Primary research

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  17. Xinjiang is one of the areas with the highest incidence of cervical cancer in China. Genetic variation in Human papillomavirus type 16 (HPV16) may increase the ability of the virus to mediate carcinogenesis an...

    Authors: Xiangyi Zhe, Huizhen Xin, Zhenzhen Pan, Fuyuan Jin, Weinan Zheng, Hongtao Li, Dongmei Li, Dongdong Cao, Ying Li, Chunhe Zhang, Shaowei Fu, Renfu Shao and Zemin Pan

    Citation: Cancer Cell International 2019 19:65

    Content type: Primary research

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  18. Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful comp...

    Authors: Jia-Jie Tan, Lu Wang, Ting-Ting Mo, Jie Wang, Mei-Gui Wang and Xiang-Ping Li

    Citation: Cancer Cell International 2019 19:64

    Content type: Primary research

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  19. Mitogen-activated protein kinase phosphatases-4 (MKP-4) is reported to exert a prognostic merit in hepatocarcinogenesis. However, the underlying molecular mechanisms have not been clearly defined.

    Authors: Zhongyi Shen, Chengliang Zhang, Lishuai Qu, Cuihua Lu, Mingbing Xiao, Runzhou Ni and Jinxia Liu

    Citation: Cancer Cell International 2019 19:61

    Content type: Primary research

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  20. Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib is a first-line drug for the treatment of HCC. However, the clinical benefit of sorafenib is often impaired ...

    Authors: Jie Song, Wei Zhao, Chang Lu and Xue Shao

    Citation: Cancer Cell International 2019 19:60

    Content type: Primary research

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  21. Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) de...

    Authors: Qinghe Zhao, Wuliang Wang and Jinquan Cui

    Citation: Cancer Cell International 2019 19:58

    Content type: Primary research

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  22. The tripartite motif (TRIM) family proteins are implicated in the pathogenesis of various human malignancies. The up-regulation and oncogenic roles of TRIM52 have been reported in hepatocellular carcinoma. In ...

    Authors: Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru and Xianju Qin

    Citation: Cancer Cell International 2019 19:57

    Content type: Primary research

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  23. T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors with poor outcomes. WP1130 has shown potent activity against a variety...

    Authors: Hao Luo, Bo Jing, Yu Xia, Yugen Zhang, Meng Hu, Haiyan Cai, Yin Tong, Li Zhou, Li Yang, Junmei Yang, Hu Lei, Hanzhang Xu, Chuanxu Liu and Yingli Wu

    Citation: Cancer Cell International 2019 19:56

    Content type: Primary research

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  24. Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a member of microfilament-related formins and mediates cell motility in breast cancer (BrCa). However, the genetic mutation status of DAAM1 mRNA and ...

    Authors: Jie Mei, Ting Yan, Yifu Huang, Tiansong Xia, Fei Chang, Shuning Shen, Leiyu Hao, Yin Chen, Zhongyuan Wang, Xiaozheng Jiang, Bujie Xu and Yichao Zhu

    Citation: Cancer Cell International 2019 19:55

    Content type: Primary research

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  25. Current chemotherapy for castration-resistant prostate cancer is established on taxane-based compounds like docetaxel. However, eventually, the development of toxic side effects and resistance limits the thera...

    Authors: Belén G. Sánchez, Alicia Bort, Pedro A. Mateos-Gómez, Nieves Rodríguez-Henche and Inés Díaz-Laviada

    Citation: Cancer Cell International 2019 19:54

    Content type: Primary research

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  26. Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with target...

    Authors: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat and John Lunec

    Citation: Cancer Cell International 2019 19:53

    Content type: Primary research

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  27. Aberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by integrative bioinformat...

    Authors: Tong Lu, Di Chen, Yuanyong Wang, Xiao Sun, Shicheng Li, Shuncheng Miao, Yang Wo, Yanting Dong, Xiaoliang Leng, Wenxing Du and Wenjie Jiao

    Citation: Cancer Cell International 2019 19:52

    Content type: Primary research

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  28. Methylation plays a key role in the aetiology and pathogenesis of prostate cancer (PCa). This study aimed to identify aberrantly methylated differentially expressed genes (DEGs) and pathways in PCa and explore...

    Authors: Kai Wu, Xiaotao Yin, Yipeng Jin, Fangfang Liu and Jiangping Gao

    Citation: Cancer Cell International 2019 19:51

    Content type: Primary research

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  29. Prostate cancer (PCa) is a malignancy cause of cancer deaths and frequently diagnosed in male. This study aimed to identify tumor suppressor genes, hub genes and their pathways by combined bioinformatics analy...

    Authors: Yanqiu Tong, Yang Song and Shixiong Deng

    Citation: Cancer Cell International 2019 19:50

    Content type: Primary research

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  30. Hepatocyte nuclear factor 4α (HNF4α) is a tissue-specific transcription factor that regulates the expression of numerous genes in hepatocytes and pancreatic β cells. HNF4α has been reported to affect cell prol...

    Authors: Qiqing Sun, Wenyan Xu, Shunrong Ji, Yi Qin, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu and Xiaowu Xu

    Citation: Cancer Cell International 2019 19:49

    Content type: Primary research

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  31. Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin,...

    Authors: Pei-Ying Jin, Zi-Hui Zheng, Hong-Jie Lu, Jing Yan, Gui-Hong Zheng, Yuan-Lin Zheng, Dong-Mei Wu and Jun Lu

    Citation: Cancer Cell International 2019 19:48

    Content type: Primary research

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  32. Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense R...

    Authors: Dawei Jiang, Liu Xu, Jianqi Ni, Jie Zhang, Min Cai and Lan Shen

    Citation: Cancer Cell International 2019 19:47

    Content type: Primary research

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  33. Among breast cancer (BC) patients the outcomes of anticancer therapy vary dramatically due to the highly heterogeneous molecular characteristics of BC. Therefore, an extended panel of BC cell lines are require...

    Authors: Anna A. Nushtaeva, Anastasia A. Karpushina, Mikhail S. Ermakov, Ludmila F. Gulyaeva, Alexey V. Gerasimov, Sergey V. Sidorov, Tatyana A. Gayner, Anastasia Y. Yunusova, Anastasia V. Tkachenko, Vladimir A. Richter and Olga A. Koval

    Citation: Cancer Cell International 2019 19:46

    Content type: Primary research

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  34. The study purpose was to make investigation into the influence of XIST on cervical cancer progression and what’s more its potential mechanism.

    Authors: Xing Chen, Dongsheng Xiong, Liya Ye, Kai Wang, Lingfei Huang, Shuangshuang Mei, Jinhong Wu, Shanshan Chen, Xiaoli Lai, Lingzhi Zheng and Meifen Wang

    Citation: Cancer Cell International 2019 19:45

    Content type: Primary research

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  35. FOXD3 is aberrantly regulated in several tumors, but its underlying mechanisms in ovarian cancer (OC) remains largely unknown. The present study aimed to explore the role and associated mechanisms of FOXD3 in OC.

    Authors: Gui-fang Luo, Chang-ye Chen, Juan Wang, Hai-yan Yue, Yong Tian, Ping Yang, Yu-kun Li and Yan Li

    Citation: Cancer Cell International 2019 19:44

    Content type: Primary research

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  36. Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in man...

    Authors: Dongdong Wu, Zhengguo Liu, Jianmei Li, Qianqian Zhang, Peiyu Zhong, Tieshan Teng, Mingliang Chen, Zhongwen Xie, Ailing Ji and Yanzhang Li

    Citation: Cancer Cell International 2019 19:43

    Content type: Primary research

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  37. Human bladder cancer is one of the common malignant tumors, and it mainly occurs in men. miR-182-5p, a member of miR-183 family, acts as tumor suppressor or oncogene in various kinds of tumors. In this study, ...

    Authors: Fei Wang, Dinglan Wu, Zhanping Xu, Jianxiang Chen, Jiye Zhang, Xiaojuan Li, Shiliang Chen, Fengrong He, Jianbing Xu, Liangju Su, Defan Luo, Shufang Zhang and Weifu Wang

    Citation: Cancer Cell International 2019 19:42

    Content type: Primary research

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  38. Angiogenic factor with G-patch and FHA domain 1 (AGGF1), as a newly identified human angiogenic factor, is overexpressed in some types of malignant tumors and closely associated with patient’s prognosis. Howev...

    Authors: Han-Hui Yao, Ya-Jun Zhao, Yi-Fu He, Da-Bing Huang and Wei Wang

    Citation: Cancer Cell International 2019 19:41

    Content type: Primary research

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  39. The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs ...

    Authors: Qingmei Wang, Rongzhang He, Tan Tan, Jia Li, Zheng Hu, Weihao Luo, Lili Duan, Wenna Luo and Dixian Luo

    Citation: Cancer Cell International 2019 19:40

    Content type: Primary research

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  40. Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the expression pattern of Linc00959 in BC and to evaluate its bio...

    Authors: Weiru Chi, Sheng Huang, Bingqiu Xiu, Qi Zhang, Zhiming Shao, Jiong Wu and Yayun Chi

    Citation: Cancer Cell International 2019 19:39

    Content type: Primary research

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  41. The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need...

    Authors: Yang Chen, Zhong Chen, Ying Su, Donghong Lin, Min Chen, Shangyuan Feng and Changyan Zou

    Citation: Cancer Cell International 2019 19:37

    Content type: Primary research

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  42. Radiation therapy remains an important therapeutic modality, especially for those patients who are not candidates for radical resection. Many strategies have been developed to increase the radiosensitivity of ...

    Authors: Wen-Xiu Ding, Shu Liu, Jian-Xin Ma, Juan Pu, Hai-Jing Wang, Shu Zhang and Xin-chen Sun

    Citation: Cancer Cell International 2019 19:36

    Content type: Primary research

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  43. Voltage-gated sodium (NaV) channels are heteromeric proteins consisting of a single pore forming α-subunit associated with one or two auxiliary β-subunits. These channels are classically known for being responsib...

    Authors: Ana Laura Sanchez-Sandoval and Juan Carlos Gomora

    Citation: Cancer Cell International 2019 19:35

    Content type: Primary research

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  44. SLC25A22, a member of mitochondrial carrier system (MCS) family encoding a mitochondrial glutamate transporter, has been reported to have vital roles in promoting proliferation and migration in cancer. Gallbla...

    Authors: Pengcheng Du, Haibin Liang, Xiaowei Fu, Peng Wu, Chao Wang, Haimin Chen, Bingbing Zheng, Jun Zhang, Shuanghui Hu, Rengui Zeng, Bo Liang and Lu Fang

    Citation: Cancer Cell International 2019 19:33

    Content type: Primary research

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