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  1. Increasing evidence has proven that the γ-secretase complex plays significant roles in the carcinogenesis of malignancies. However, the independent effect of nicastrin (NCSTN), the largest constituent of the γ...

    Authors: Xicheng Wang, Xining Wang, Yunxiuxiu Xu, Maolin Yan, Wenxin Li, Jie Chen and Tao Chen

    Citation: Cancer Cell International 2020 20:91

    Content type: Primary research

    Published on:

  2. Breast cancer is the leading cause of cancer-related mortality in women worldwide. Long non-coding RNAs (lncRNAs) are of critical importance in tumor drug resistance. Herein, this study aims to determine the r...

    Authors: Jin Gao, Yuan Yuan, Lili Zhang, Shaorong Yu, Jianwei Lu, Jifeng Feng and Sainan Hu

    Citation: Cancer Cell International 2020 20:90

    Content type: Primary research

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  3. Extensive studies revealed that long non-coding RNAs (lncRNAs) could act as a regulator in tumors, including lung adenocarcinoma (LUAD). LncRNA FTX transcript, XIST regulator (FTX) has been reported to regulat...

    Authors: Xiaodong Huo, Huixing Wang, Bin Huo, Lei Wang, Kuo Yang, Jinhuan Wang, Lili Wang and Haitao Wang

    Citation: Cancer Cell International 2020 20:89

    Content type: Primary research

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  4. Gastric cancer (GC) is the fifth most frequently diagnosed cancer and the third leading cause of cancer-related mortality. Lack of prognostic indicators for patient survival hinders GC treatment and survival.

    Authors: Chunmei Li, Ya Zheng, Ke Pu, Da Zhao, Yuping Wang, Quanlin Guan and Yongning Zhou

    Citation: Cancer Cell International 2020 20:88

    Content type: Primary research

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  5. LncRNA NEAT1 has been identified as a tumour driver in many human cancers. However, the underlying mechanism of lncRNA NEAT1 in diffuse large B-cell lymphoma (DLBCL) progression is unclear.

    Authors: Chong-Sheng Qian, Ling-Jie Li, Hai-Wen Huang, Hai-Fei Yang and De-Pei Wu

    Citation: Cancer Cell International 2020 20:87

    Content type: Primary research

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  6. Papillary carcinoma is an uncommon type of breast cancer. Additionally, patients with huge breast papillary carcinoma are extremely rare in clinical practice. To improve therapeutic effect on such patients, it...

    Authors: Xuelu Li, Bo Pan, Xiaoqing Song, Ning Li, Dongyi Zhao, Man Li and Zuowei Zhao

    Citation: Cancer Cell International 2020 20:86

    Content type: Primary research

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  7. Currently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.

    Authors: Chang Li, Yuan Tian, Yun Liang and Qingchun Li

    Citation: Cancer Cell International 2020 20:84

    Content type: Primary research

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  8. Osteosarcoma is a highly aggressive bone tumor that most commonly affects children and adolescents. Treatment and outcomes for osteosarcoma have remained unchanged over the past 30 years. The relationship betw...

    Authors: Weifeng Hong, Hong Yuan, Yujun Gu, Mouyuan Liu, Yayun Ji, Zifang Huang, Junlin Yang and Liheng Ma

    Citation: Cancer Cell International 2020 20:83

    Content type: Primary research

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  9. Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies, including gastric cancer (GC). Researches concerning cancers have revealed that aberrant expression of circRNAs play a ...

    Authors: Yan Ma, Xiliang Cong, Yiyun Zhang, Xin Yin, Ziyu Zhu and Yingwei Xue

    Citation: Cancer Cell International 2020 20:81

    Content type: Primary research

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  10. Numerous circular RNAs (circRNAs) have been recognized as vital modulators of human malignancies, including glioma. Whereas, the functional role of circRNA Pituitary Homeo Box 1 (circPITX1) in the radioresista...

    Authors: Yongchang Guan, Zhi Cao, Jinghua Du, Tao Liu and Tingzhong Wang

    Citation: Cancer Cell International 2020 20:80

    Content type: Primary research

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  11. Astrocyte-elevated gene-1 (AEG-1) is over-expressed in many cancer cells and has multiple key functions in tumor initiation and progression. Currently, targeted-AEG-1 siRNA is one of the most common techniques to...

    Authors: Min Long, Fang Lin, Xi Wang, Xi Chen, Li Liu, Huizhong Zhang and Ke Dong

    Citation: Cancer Cell International 2020 20:79

    Content type: Primary research

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  12. Non-small-cell lung cancer (NSCLC) is one of the common cancers in the world. Circular RNA 0072083 (circ_0072083, circZFR) has been reported to be associated with the progression of NSCLC. In this study, we in...

    Authors: Huiping Li, Fangfang Liu and Wenjing Qin

    Citation: Cancer Cell International 2020 20:78

    Content type: Primary research

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  13. This study aimed to comprehensively assess the diagnostic value of fibrinogen to prealbumin ratio (FPR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) as single markers or in combination in patients...

    Authors: Li Huang, Zhuning Mo, Zuojian Hu, Linyan Zhang, Shanzi Qin, Xue Qin and Shan Li

    Citation: Cancer Cell International 2020 20:77

    Content type: Primary research

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  14. Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRN...

    Authors: Erdong Shen, Xin Wang, Xin Liu, Mingyue Lv, Liang Zhang, Guolian Zhu and Zhe Sun

    Citation: Cancer Cell International 2020 20:76

    Content type: Primary research

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  15. Long non-coding RNA (lncRNA) is a class of endogenous RNA with a length of more than 200 nucleotides, which is emerging as a pivotal player in cancer development and progression. However, the functional roles ...

    Authors: Jiahui Du, Guangzhao Zhang, Hongli Qiu, Haifeng Yu and Wuying Yuan

    Citation: Cancer Cell International 2020 20:75

    Content type: Primary research

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  16. Circular RNA (circRNA) is increasingly attracting attention in gastric cancer (GC). Hsa_circ_0032821 (circ_0032821) has been declared to be upregulated in human GC tissues. However, the biological role of circ...

    Authors: Yuanyuan Jiang, Yan Zhang, Feifei Chu, Lidong Xu and Huili Wu

    Citation: Cancer Cell International 2020 20:74

    Content type: Primary research

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  17. Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm resulting from BCR–ABL-transformed hematopoietic stem cells. Previous research has implicated multifunctional proinflammatory cytokine...

    Authors: Lei Wang, Mingming Wang, Hongju Dou, Wenjie Lin and Lifang Zou

    Citation: Cancer Cell International 2020 20:73

    Content type: Primary research

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  18. Family with sequence similarity 83 member H antisense RNA 1 (FAM83H-AS1) is a novel long non-coding RNA. Increasing studies have reported that FAM83H-AS1 is abnormally expressed in a variety of tumors and is a...

    Authors: Qin Yang, Jie Wang, Pingyong Zhong, Tinggang Mou, Hao Hua, Pan Liu and Fei Xie

    Citation: Cancer Cell International 2020 20:72

    Content type: Review

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  19. Gliomas represent the largest class of primary central nervous system neoplasms, many subtypes of which exhibit poor prognoses. Surgery followed by radiotherapy and chemotherapy has been used as a standard str...

    Authors: Juan Wu, Hong-kai Su, Zhi-hui Yu, Shao-yan Xi, Cheng-cheng Guo, Zhe-yu Hu, Yue Qu, Hai-ping Cai, Yi-ying Zhao, Hua-fu Zhao, Fu-rong Chen, Yu-fan Huang, Shing-shun Tony To, Bing-hong Feng, Ke Sai, Zhong-ping Chen…

    Citation: Cancer Cell International 2020 20:71

    Content type: Primary research

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  20. Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen f...

    Authors: Aarifa Nazmeen, Guangping Chen, Tamal Kanti Ghosh and Smarajit Maiti

    Citation: Cancer Cell International 2020 20:70

    Content type: Primary research

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  21. Glucose metabolic reprogramming is a significant hallmark of malignant tumors including GBM. Previous studies suggest that microRNAs play key roles in modulating this process in GBM cells. miR-181b acts as a t...

    Authors: JianXing Yin, ZhuMei Shi, WenJin Wei, Chenfei Lu, Yutian Wei, Wei Yan, Rui Li, JunXia Zhang, YongPing You and XieFeng Wang

    Citation: Cancer Cell International 2020 20:69

    Content type: Primary research

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  22. Long noncoding RNAs (lncRNAs) have been shown to participate in multiple biological processes and confer drug resistance. However, it remains unclear whether lncRNAs are involved in conferring cetuximab resist...

    Authors: Xiaoqian Zhang, Long Wen, Shanwen Chen, Junling Zhang, Yongchen Ma, Jianwen Hu, Taohua Yue, Jingui Wang, Jing Zhu, Dingfang Bu and Xin Wang

    Citation: Cancer Cell International 2020 20:68

    Content type: Primary research

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  23. Circular RNAs (circRNAs) have been shown to play a crucial role in tumorigenesis. In this study, we investigated the function of hsa_circ_0137008 and its underlying molecular mechanism in colorectal cancer (CRC).

    Authors: Zhanfeng Yang, Jingjing Zhang, Danghui Lu, Yan Sun, Xinyong Zhao, Xiaoqiong Wang, Wen Zhou, Qunli He and Zhi Jiang

    Citation: Cancer Cell International 2020 20:67

    Content type: Primary research

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  24. Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those...

    Authors: Wenhao Luo, Gang Yang, Wentao Luo, Zhe Cao, Yueze Liu, Jiangdong Qiu, Guangyu Chen, Lei You, Fangyu Zhao, Lianfang Zheng and Taiping Zhang

    Citation: Cancer Cell International 2020 20:66

    Content type: Review

    Published on:

  25. Glioma is one of the most malignant brain tumors and accounts for the majority of brain cancer related death. Despite progress on mechanistic studies, current understandings of the initiation and progression o...

    Authors: Tengfei Li, Wanchun Yang, Mao Li, Shuxin Zhang, Xingwang Zhou, Mingrong Zuo, Qiuyun Yuan, Mina Chen and Yanhui Liu

    Citation: Cancer Cell International 2020 20:65

    Content type: Primary research

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  26. Pancreatic ductal adenocarcinoma (PDA) is one of the most serious causes of death in the world due to its high mortality and inefficacy treatments. MEX3A was first identified in nematodes and was associated wi...

    Authors: Xing Wang, Yu-Qiang Shan, Qing-Quan Tan, Chun-Lu Tan, Hao Zhang, Jin-Heng Liu, Neng-Wen Ke, Yong-Hua Chen and Xu-Bao Liu

    Citation: Cancer Cell International 2020 20:63

    Content type: Primary research

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  27. microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferat...

    Authors: Haithm Mousa, Menglang Yuan, Xinsheng Zhang, Xiaomeng Li, Abdullah Shopit, Marwan Almoiliqy, Mohammed Alshwmi, Aisha Al-Dherasi, Yue Xu and Yunfei Zuo

    Citation: Cancer Cell International 2020 20:62

    Content type: Primary research

    Published on:

  28. Long non-coding RNAs (lncRNAs) are implicated in many pathophysiological processes, including cancers. In particular, lncRNA DANCR is regarded as a cancer-associated lncRNA exerting various regulatory mechanis...

    Authors: Wanjia Tian, Ningjing Lei, Ruixia Guo, Zhongfu Yuan and Lei Chang

    Citation: Cancer Cell International 2020 20:61

    Content type: Primary research

    Published on:

  29. Following the publication of the original article [1], the authors reported that they had supplied the incorrect figure 6 for publication. The correct figure 6 is given in this correction article. The results ...

    Authors: Jian-jun Li, Jie Luo, Jing-ning Lu, Xiao-na Liang, Yi-huan Luo, Yong-ru Liu, Jie Yang, Hua Ding, Gui-hui Qin, Li-hua Yang, Yi-wu Dang, Hong Yang and Gang Chen

    Citation: Cancer Cell International 2020 20:60

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2016 16:76

  30. Endometrial cancer (EC) is one kind of women cancers. Bioinformatic technology could screen out relative genes which made targeted therapy becoming conventionalized.

    Authors: JinHui Liu, Mingming Feng, SiYue Li, Sipei Nie, Hui Wang, Shan Wu, Jiangnan Qiu, Jie Zhang and WenJun Cheng

    Citation: Cancer Cell International 2020 20:59

    Content type: Primary research

    Published on:

  31. Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of soft-tissue sarcoma, derived from a peripheral branch or the sheath of the sciatic nerve, brachial plexus, or sacral plexus. The clinical...

    Authors: Rieko Oyama, Fusako Kito, Mami Takahashi, Emi Hattori, Rei Noguchi, Yoko Takai, Marimu Sakumoto, Zhiwei Qiao, Shunichi Toki, Masato Sugawara, Yoshikazu Tanzawa, Eisuke Kobayashi, Fumihiko Nakatani, Shintaro Iwata, Akihiko Yoshida, Akira Kawai…

    Citation: Cancer Cell International 2020 20:58

    Content type: Primary research

    Published on:

  32. Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and...

    Authors: Jingyu Wang, Weize Lv, Zhidong Lin, Xiao Wang, Juyuan Bu and Yonghui Su

    Citation: Cancer Cell International 2020 20:57

    Content type: Primary research

    Published on:

  33. Accumulating evidence has demonstrated that microRNA-200s (miR-200a, miR-200b and miR-200c) could serve as promising molecular biomarkers for cancer prognosis. Nevertheless, the associations between miR-200s e...

    Authors: Qiliang Peng, Ming Cheng, Ting Li, Xiangying Chen, Yi Shen, Yaqun Zhu and Bo Xu

    Citation: Cancer Cell International 2020 20:56

    Content type: Primary research

    Published on:

  34. The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, and are essential for cell survival and also are promising anticancer target...

    Authors: Feng Jiao, Ting Han, Cuncun Yuan, Yiyi Liang, Jiujie Cui, Meng Zhuo and Liwei Wang

    Citation: Cancer Cell International 2020 20:55

    Content type: Primary research

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  35. Rhophilin Rho GTPase binding protein 1 antisense RNA 1 (RHPN1-AS1) is a newly discovered oncogene in several diseases, such as breast cancer, non-small cell lung cancer and uveal melanoma. Nevertheless, its mo...

    Authors: Wei Zheng, Hui Li, Hui Zhang, Chao Zhang, Zhonglin Zhu, Hong Liang and Yifeng Zhou

    Citation: Cancer Cell International 2020 20:54

    Content type: Primary research

    Published on:

  36. Glioma is the most common and aggressive primary brain tumor with high mortality rate around the world. LncRNAs have been identified to play key roles in tumorigenesis in various cancers, including glioma. How...

    Authors: Lei Feng, Tao Lin, Haijiang Che and Xiaoming Wang

    Citation: Cancer Cell International 2020 20:53

    Content type: Primary research

    Published on:

  37. Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 t...

    Authors: Hannah Maria Baumert, Eric Metzger, Matthias Fahrner, Julie George, Roman K. Thomas, Oliver Schilling and Roland Schüle

    Citation: Cancer Cell International 2020 20:52

    Content type: Primary research

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  38. The urgent problem in the treatment of breast cancer is the recurrence induced by breast cancer stem cells (CSCs). Understanding the role and molecular mechanism of specific molecules in breast cancer stem cel...

    Authors: Xiaohui Zhao, Chao Jiang, Rui Xu, Qingnan Liu, Guanglin Liu and Yan Zhang

    Citation: Cancer Cell International 2020 20:51

    Content type: Primary research

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  39. Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the dev...

    Authors: Zhiyuan Xiao, Zhigang Wei, Danling Deng, Zhe Zheng, Yali Zhao, Shenglu Jiang, Dan Zhang, Ling-Jie Zhang, Mingmei Fan, Siqi Chen, ShuYang Wang, Yanqing Ding, Yaping Ye and Hongli Jiao

    Citation: Cancer Cell International 2020 20:50

    Content type: Primary research

    Published on:

  40. Osteosarcoma (OS) is a common primary malignant bone tumour. Growing evidence suggests that circular RNAs (circRNAs) are closely related to the development of tumours. However, the function of circRNAs in OS r...

    Authors: Yu Qiu, Chao Pu, Yanchao Li and Baochuang Qi

    Citation: Cancer Cell International 2020 20:48

    Content type: Primary research

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  41. This study aimed to investigate the clinical characteristics of miR-450b-3p in the patients of gastric cancer (GC), and further explore whether miR-450b-3p could inhibit the proliferation of GC cells via regul...

    Authors: Juan Yao, Hao Zhang, Cheng Liu, Shuangshuang Chen, Rongyu Qian and Kun Zhao

    Citation: Cancer Cell International 2020 20:47

    Content type: Primary research

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  42. This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).

    Authors: Dandan Zhao, Jing Wu, Yinjuan Zhao, Wei Shao, Qi Cheng, Xiaoyan Shao, Xianwen Yuan, Juan Ye, Jianpu Gao, Meiling Jin, Chaojun Li, Xiaolin Chen, Yue Zhao and Bin Xue

    Citation: Cancer Cell International 2020 20:46

    Content type: Primary research

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  43. Aberrant expression of ubiquitin-specific peptide 22 (USP22) has been detected in various cancers. This study aimed to investigate the role of USP22 and the underlying mechanism in human gastric cancer.

    Authors: ChitChoon Lim, Jia-Cheng Xu, Tian-Yin Chen, Jia-Xin Xu, Wei-Feng Chen, Jian-Wei Hu, Quan-Lin Li and Yi-Qun Zhang

    Citation: Cancer Cell International 2020 20:45

    Content type: Primary research

    Published on:

  44. The Ecotropic viral integration site 5 (Evi5) is recognized as a potential oncogene and a cell cycle regulator. Evi5 regulates the abundance of Emi1, an inhibitor of the anaphase-promoting complex/cyclosome, t...

    Authors: Cheng-Gang Mao, Xiao-Chun Zhou, Yi-Dao Jiang, Li-Jia Wan, Ze-Zhang Tao and Jun Guo

    Citation: Cancer Cell International 2020 20:44

    Content type: Primary research

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  45. Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal c...

    Authors: Yage Luo, Lili Wang, Wenwen Ran, Guangqi Li, Yujing Xiao, Xiaonan Wang, Han Zhao and Xiaoming Xing

    Citation: Cancer Cell International 2020 20:43

    Content type: Primary research

    Published on:

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