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  1. Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying me...

    Authors: Lin Yang, Hailong Si, Meng Ma, Yu Fang, Yina Jiang, Jintao Wang, Cheng Zhang and Haijuan Xiao

    Citation: Cancer Cell International 2021 21:202

    Content type: Primary research

    Published on:

  2. VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis. VEGF-VEGF...

    Authors: Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand and Leila Farahmand

    Citation: Cancer Cell International 2021 21:200

    Content type: Review

    Published on:

  3. Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improved, the prognosis of BC patients in advanced stages remains unsatisfac...

    Authors: Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li and Shaohua Wang

    Citation: Cancer Cell International 2021 21:199

    Content type: Primary research

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  4. Acute myeloid leukaemia (AML) is an aggressive blood cancer. In approximately 30% of the cases, driver mutations in the FLT3 gene are identified. FLT3 inhibitors are used in treatment of such patients together...

    Authors: Jingmei Yang, H. Jonathan G. Lindström and Ran Friedman

    Citation: Cancer Cell International 2021 21:198

    Content type: Primary research

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  5. Osteosarcoma is an aggressive malignant tumor which has attracted worldwide attention. MEX3A may be associated with tumors while has not yet seen its coverage on osteosarcoma. Herein, this study was to investi...

    Authors: Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen and Yi Shen

    Citation: Cancer Cell International 2021 21:197

    Content type: Primary research

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  6. High tumor mutation burden (TMB) has gradually become a sensitive biomarker for predicting the response to immunotherapy in many cancers, including lung, bladder and head and neck cancers. However, whether hig...

    Authors: Rong Tang, Xiaomeng Liu, Wei Wang, Jie Hua, Jin Xu, Chen Liang, Qingcai Meng, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi

    Citation: Cancer Cell International 2021 21:196

    Content type: Primary research

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  7. Non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB-DLBCL) has worse clinical outcome than GCB-DLBCL, and some relapsed/refractory non-GCB-DLBCL (R/R non-GCB-DLBCL) are even resistant to CD2...

    Authors: Xin Xu, Ting Wei, Weijie Zhong, Rosalind Ang, Ye Lei, Hui Zhang and Qingshan Li

    Citation: Cancer Cell International 2021 21:195

    Content type: Primary research

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  8. Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiot...

    Authors: Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima jafarpor, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mostafa Manian and Reza Nedaeinia

    Citation: Cancer Cell International 2021 21:194

    Content type: Review

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  9. Ovarian epithelial cancer is one of the leading malignant tumors in gynecology and lacks effective diagnostic and prognostic markers. Our study aims to screen and verify ovarian epithelial cancer biomarkers.

    Authors: Xiaoying Chang, Dan Li, Chang Liu, Zhe Zhang and Tao Wang

    Citation: Cancer Cell International 2021 21:193

    Content type: Primary research

    Published on:

  10. Osteosarcoma (OS) is the most common primary malignant bone tumor in young people. Tumor-associated macrophages (TAMs) have been reported to play an important role in the development of osteosarcoma. However, ...

    Authors: Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou and Wei Guo

    Citation: Cancer Cell International 2021 21:192

    Content type: Primary research

    Published on:

  11. Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa an...

    Authors: Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu and Mingzhi Zhang

    Citation: Cancer Cell International 2021 21:191

    Content type: Primary research

    Published on:

  12. Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which might act an important factor in tumorig...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Nanjun Li, Ruiqi Mu, Zhixuan Qi, Yunuo Shen, Zijie Wang, Jingchao Wen, Jiaxin Zhao, Di Weng and Wen Huang

    Citation: Cancer Cell International 2021 21:190

    Content type: Primary research

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    The Correction to this article has been published in Cancer Cell International 2021 21:448

  13. Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with ...

    Authors: Zeeshan Javed, Haleema Sadia, Muhammad Javed Iqbal, Shazia Shamas, Kausar Malik, Rais Ahmed, Shahid Raza, Monica Butnariu, Natalia Cruz-Martins and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:189

    Content type: Review

    Published on:

  14. Cancers are serious life-threatening diseases which annually are responsible for millions of deaths across the world. Despite many developments in therapeutic approaches for affected individuals, the rate of m...

    Authors: Saeed Mehrzadi, Mohammad Hossein Pourhanifeh, Alireza Mirzaei, Farid Moradian and Azam Hosseinzadeh

    Citation: Cancer Cell International 2021 21:188

    Content type: Review

    Published on:

  15. Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated ...

    Authors: Zheyu Wu, Yufeng Zhang, Zhiqiang Yang, Yufan Zhu, Yuanlong Xie, Fuling Zhou and Lin Cai

    Citation: Cancer Cell International 2021 21:187

    Content type: Primary research

    Published on:

  16. To our knowledge, LncRNA SNHG15 exerted its tumor-promoting effects to facilitate the development of breast cancer (BC), but there still needed more data to elucidate the potential underlying mechanisms.

    Authors: Jiang Du, Hong Zhong and Binlin Ma

    Citation: Cancer Cell International 2021 21:186

    Content type: Primary research

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  17. Early diagnosis of nasopharyngeal carcinoma (NPC) is vital to improve the prognosis of these patients. However, early diagnosis of NPC is typically challenging. Therefore, we explored the pathogenetic roles an...

    Authors: Wei Zheng, Wangzhong Ye, Zijie Wu, Xinyi Huang, Yuanji Xu, Qinyan Chen, Zhizhong Lin, Yanyu Chen, Penggang Bai and Chuanben Chen

    Citation: Cancer Cell International 2021 21:185

    Content type: Primary research

    Published on:

  18. Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which repres...

    Authors: Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang and Xin-hua Liang

    Citation: Cancer Cell International 2021 21:184

    Content type: Review

    Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu

    Citation: Cancer Cell International 2021 21:183

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:136

  20. Previous studies have found that the microenvironment of cervical cancer (CESC) affects the progression and treatment of this disease. Thus, we constructed a multigene model to assess the survival of patients ...

    Authors: Qian Chen, Bingqing Qiu, Xiaoyun Zeng, Lang Hu, Dongping Huang, Kaihua Chen and Xiaoqiang Qiu

    Citation: Cancer Cell International 2021 21:182

    Content type: Primary research

    Published on:

  21. Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. However, the molecular mechanism of LUAD tumorigenesis and development remains unclear. The purpose of this study was to comprehensi...

    Authors: Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang and Qun Wang

    Citation: Cancer Cell International 2021 21:181

    Content type: Primary research

    Published on:

  22. Long noncoding RNAs (lncRNAs) have recently identified as essential gene modulators in numerous cancers. Previous studies have confirmed the oncogenic role of long intergenic nonprotein-coding RNA 00514 (LINC0...

    Authors: Xiao Luo and Hui Wang

    Citation: Cancer Cell International 2021 21:180

    Content type: Primary research

    Published on:

  23. Studies have discussed long noncoding RNA DDX11-AS1 (DDX11-AS1)-mediated downstream mechanism in hepatocellular carcinoma (HCC). The goal of this study was to investigate the regulatory mechanism of DDX11-AS1-...

    Authors: Gangqiang Ding, Yanli Zeng, Dongqiang Yang, Can Zhang, Chongshan Mao, Erhui Xiao, Yi Kang and Jia Shang

    Citation: Cancer Cell International 2021 21:179

    Content type: Primary research

    Published on:

  24. Aberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric cancer still remains as a challenging problem.

    Authors: Narjes Jafari, Saeid Abediankenari and Hadi Hossein-Nataj

    Citation: Cancer Cell International 2021 21:178

    Content type: Primary research

    Published on:

  25. Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), pla...

    Authors: Yuanyuan Li and Ling Gu

    Citation: Cancer Cell International 2021 21:177

    Content type: Primary research

    Published on:

  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhao‑liang Yu, Yu‑feng Chen, Bin Zheng, Ze-rong Cai, Yi‑feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao‑jian Wu

    Citation: Cancer Cell International 2021 21:176

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:94

  27. Transcription factors (TFs) may be engaged in reciprocal regulatory circuits with certain miRNAs to maintain cellular homeostasis. Disequilibrium of the reciprocities by certain tumor-related stimuli may give ...

    Authors: Wenjing Zhang, Haitao Yang, Zhongqiu Wang, Yanting Wu, Jingzhai Wang, Guihua Duan, Qiang Guo and Yu Zhang

    Citation: Cancer Cell International 2021 21:175

    Content type: Primary research

    Published on:

  28. The incidence and mortality rates of hepatocellular carcinoma are among the highest of all cancers all over the world. However the survival rates are relatively low due to lack of effective treatments. Efforts...

    Authors: Fan Zhang, Mengjuan Xue, Xin Jiang, Huiyuan Yu, Yixuan Qiu, Jiaming Yu, Fan Yang and Zhijun Bao

    Citation: Cancer Cell International 2021 21:174

    Content type: Primary research

    Published on:

  29. Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was...

    Authors: Ning Wei, Mengyue Zhou, Siyu Lei, Zhiheng Zhong and Ruihua Shi

    Citation: Cancer Cell International 2021 21:173

    Content type: Review

    Published on:

  30. As a tissue-specific proangiogenic or antiangiogenic agent, angiopoietin-like 4 (ANGPTL4) has recently gained attention in many diseases, such as metabolic syndrome, cardiovascular disease and cancer. However,...

    Authors: Yuxian Wu, Jinghai Gao and Xiaojun Liu

    Citation: Cancer Cell International 2021 21:171

    Content type: Primary research

    Published on:

  31. Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased e...

    Authors: Simon Keane, Tommy Martinsson, Per Kogner and Katarina Ejeskär

    Citation: Cancer Cell International 2021 21:170

    Content type: Primary research

    Published on:

  32. Nowadays, colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors worldwide, the incidence rate of which is still increasing year by year. Herein, the objective of this study is to inves...

    Authors: Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi and Wei Pei

    Citation: Cancer Cell International 2021 21:169

    Content type: Primary research

    Published on:

  33. Long non-coding RNA (lncRNA) has been confirmed to exert a critical effect on the progression of tumors, including prostate cancer. Previous literature has demonstrated LINC01116 involves in activities of mult...

    Authors: Shengjie Yu, Huihong Yu, Yuanfeng Zhang, Chuan Liu, Weili Zhang and Yunyun Zhang

    Citation: Cancer Cell International 2021 21:168

    Content type: Primary research

    Published on:

  34. Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide with poor prognosis. The pathogenesis of human papillomavirus (HPV)-positive and HPV-negative HNSCCs differs. However, few studies have...

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang

    Citation: Cancer Cell International 2021 21:167

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:248

  35. Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC. The ...

    Authors: Gongmin Zhu, Hongwei Xia, Qiulin Tang and Feng Bi

    Citation: Cancer Cell International 2021 21:166

    Content type: Primary research

    Published on:

  36. Radiotherapy is a major treatment for esophageal squamous cell carcinoma (ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC. The function of SOCS6, which has been shown to be ...

    Authors: Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng and Xiaozhi Zhang

    Citation: Cancer Cell International 2021 21:165

    Content type: Primary research

    Published on:

  37. Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. Thi...

    Authors: Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu and Xiaowen Zhang

    Citation: Cancer Cell International 2021 21:164

    Content type: Review

    Published on:

  38. Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells. In this study, the positive effe...

    Authors: Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng and Nan Cui

    Citation: Cancer Cell International 2021 21:163

    Content type: Primary research

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  39. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM p...

    Authors: Jiayue Yang, Cheng Yang, Hong Shen, Wenjun Wu, Zhen Tian, Qinghua Xu, Cuiping Cao, Shugao Ye, Le Ban, Xin Tong and Jie Mei

    Citation: Cancer Cell International 2021 21:162

    Content type: Primary research

    Published on:

  40. Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the pote...

    Authors: Xin Pan, Gang Wang and Baoming Wang

    Citation: Cancer Cell International 2021 21:161

    Content type: Primary research

    Published on:

  41. CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspect...

    Authors: Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat and Kazem Mousavizadeh

    Citation: Cancer Cell International 2021 21:160

    Content type: Review

    Published on:

  42. Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to eval...

    Authors: Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou and Guihai Zhang

    Citation: Cancer Cell International 2021 21:159

    Content type: Primary research

    Published on:

  43. A crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate ...

    Authors: Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev and Majid Ahmadi

    Citation: Cancer Cell International 2021 21:158

    Content type: Review

    Published on:

  44. Uterine leiomyosarcoma (ULMS) is a malignant tumor found in the smooth muscle lining the walls of the uterus. Cancer stem cells (CSCs) are responsible for metastasis, drug resistance, and relapse of cancer, re...

    Authors: Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang and Jingting Cai

    Citation: Cancer Cell International 2021 21:157

    Content type: Primary research

    Published on:

  45. Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in gastrointestinal system. MicroRNAs (miRNAs) have been reported to be implicated in cancer development. However, the role of miR-...

    Authors: Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui and Qiang Wang

    Citation: Cancer Cell International 2021 21:155

    Content type: Primary research

    Published on:

  46. Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs have been experimentally validated and functionally described. In this research, we aime...

    Authors: Lanlan Xi, Quanlin Liu, Wei Zhang, Linshan Luo, Jingfeng Song, Ruitao Liu, Shue Wei and Yong Wang

    Citation: Cancer Cell International 2021 21:153

    Content type: Primary research

    Published on:

  47. CircRNAs with tissue-specific expression and stable structure may be good tumor prognostic markers. However, the expression of circRNAs in esophageal squamous cell carcinoma (ESCC) remain unknown. We aim to id...

    Authors: Weiwei Wang, Di Zhu, Zhihua Zhao, Miaomiao Sun, Feng Wang, Wencai Li, Jianying Zhang and Guozhong Jiang

    Citation: Cancer Cell International 2021 21:151

    Content type: Primary research

    Published on:

  48. Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several huma...

    Authors: Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu and Jiansong Ji

    Citation: Cancer Cell International 2021 21:150

    Content type: Primary research

    Published on:

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