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  1. Cisplatin is one of the first-line drugs for urothelial bladder cancer (UBC) treatment. However, its considerable side effects and the emergence of drug resistance are becoming major limitations for its applic...

    Authors: Xiao-Zhong Liao, Lan-Ting Tao, Jia-Hui Liu, Yue-Yu Gu, Jun Xie, Yuling Chen, Mei-Gui Lin, Tao-Li Liu, Dong-Mei Wang, Hai-Yan Guo and Sui-Lin Mo
    Citation: Cancer Cell International 2017 17:124
    Content type: Primary Research Published on:

  2. Different cells and mediators in the tumor microenvironment play important roles in the progression of breast cancer. The aim of this study was to determine the composition of the microenvironment during tumor...

    Authors: Rahil Eftekhari, Rezvan Esmaeili, Reza Mirzaei, Katayoon Bidad, Stacy de Lima, Maryam Ajami, Hedayatollah Shirzad, Jamshid Hadjati and Keivan Majidzadeh-A
    Citation: Cancer Cell International 2017 17:123
    Content type: Primary Research Published on:

  3. Patient-derived xenografts (PDX) have a biologically stable in tumor architecture, drug responsiveness, mutational status and global gene-expression patterns. Numerous PDX models have been established to date,...

    Authors: Xiaoqian Ji, Siyu Chen, Yanwu Guo, Wende Li, Xiaolong Qi, Han Yang, Sa Xiao, Guang Fang, Jinfang Hu, Chuangyu Wen, Huanliang Liu, Zhen Han, Guangxu Deng, Qingbin Yang, Xiangling Yang, Yuting Xu…
    Citation: Cancer Cell International 2017 17:122
    Content type: Primary Research Published on:

  4. Forty years ago the actin cytoskeleton was determined to be disrupted in fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear connection between the cytoskeleton and DNA r...

    Authors: Nicolette M. Clark, Carlos A. Garcia Galindo, Vandan K. Patel, Michele L. Parry, Rebecca J. Stoll, John M. Yavorski, Elizabeth P. Pinkason, Edna M. Johnson, Chelsea M. Walker, Joseph Johnson, Wade J. Sexton, Domenico Coppola and George Blanck
    Citation: Cancer Cell International 2017 17:121
    Content type: Primary Research Published on:

  5. Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated ...

    Authors: Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi and Masatoshi Tagawa
    Citation: Cancer Cell International 2017 17:120
    Content type: Primary Research Published on:

  6. Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who re...

    Authors: Shuo Miao, Su-Mei Wang, Xue Cheng, Yao-Feng Li, Qing-Song Zhang, Gang Li, Song-Qing He, Xiao-Ping Chen and Ping Wu
    Citation: Cancer Cell International 2017 17:119
    Content type: Primary Research Published on:

  7. Hepatocellular carcinoma (HCC) remains one of the most lethal cancers. MicroRNA-155 (miR-155) and collagen triple helix repeat containing 1 (CTHRC1) were found to be involved in hepatocarcinogenesis, but thei...

    Authors: Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo and Li Li
    Citation: Cancer Cell International 2017 17:118
    Content type: Primary Research Published on:

  8. Chemoresistance of glioblastoma (GBM) is a feature of this devastating disease. This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ...

    Authors: Ke Wang, Dongjiang Chen, Zhouqi Qian, Daming Cui, Liang Gao and Meiqing Lou
    Citation: Cancer Cell International 2017 17:117
    Content type: Primary Research Published on:

  9. Herein, for the first time, we report aberrant expression of membrane-associated RING-CH8 (MARCH8) in human esophageal squamous cell carcinoma. MARCH8 is a member of the recently discovered MARCH family of rea...

    Authors: Shivam Singh, Anoop Saraya, Prasenjit Das and Rinu Sharma
    Citation: Cancer Cell International 2017 17:116
    Content type: Primary Research Published on:

  10. We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesi...

    Authors: Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang and Hai-Jun Yu
    Citation: Cancer Cell International 2017 17:115
    Content type: Primary Research Published on:

  11. T lymphocytes play an indispensably important role in clearing virus and tumor antigen. There is little knowledge about impacts of inhibitory molecules with cytokine on tumor-infiltrating CD4+ T-cells in the pres...

    Authors: Long Yuan, Benling Xu, Peng Yuan, Jinxue Zhou, Peng Qin, Lu Han, Guangyu Chen, Zhenlei Wang, Zengci Run, Peng Zhao and Quanli Gao
    Citation: Cancer Cell International 2017 17:114
    Content type: Primary Research Published on:

  12. Human chemokine like factor (CKLF)-like MAL and related proteins for vesicle trafficking transmembrane, domain-containing member 5 (CMTM5) has been shown to involved and may function as a tumour suppressor in ...

    Authors: Gang Xu and Chengxue Dang
    Citation: Cancer Cell International 2017 17:113
    Content type: Primary Research Published on:

  14. RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents...

    Authors: María Fernanda Rubio, María Cecilia Lira, Francisco Damián Rosa, Adrían Dario Sambresqui, María Cecilia Salazar Güemes and Mónica Alejandra Costas
    Citation: Cancer Cell International 2017 17:111
    Content type: Primary Research Published on:

  15. Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy (“self-eating”) plays important roles in multiple diseases and acts as a tumor suppressor in ca...

    Authors: Eun Jung Sohn and Hwan Tae Park
    Citation: Cancer Cell International 2017 17:110
    Content type: Review Published on:

  16. Recent studies showed that long non-coding RNA (lncRNA) plays an important role in many life activities. RPPH1 is one of the lncRNA genes that are expressed differently between breast cancer and normal tissues by...

    Authors: Yi Zhang and Lili Tang
    Citation: Cancer Cell International 2017 17:109
    Content type: Primary Research Published on:

  17. Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In...

    Authors: Hongshuang Tong, Yue Wang, Yue Li, Shujuan Liu, Chunjie Chi, Desheng Liu, Lei Guo, Enyou Li and Changsong Wang
    Citation: Cancer Cell International 2017 17:108
    Content type: Primary Research Published on:

  18. Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought t...

    Authors: Qiong Wang, Zhongwu Li, Yaping Wu, Rong Huang, Yumin Zhu, Wei Zhang, Yanling Wang and Jie Cheng
    Citation: Cancer Cell International 2017 17:107
    Content type: Primary Research Published on:

  19. Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly different...

    Authors: Sen Yang and Li-Juan Guo
    Citation: Cancer Cell International 2017 17:106
    Content type: Primary Research Published on:

  20. MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cyt...

    Authors: Laura Boldrini, Mirella Giordano, Cristina Niccoli, Franca Melfi, Marco Lucchi, Alfredo Mussi and Gabriella Fontanini
    Citation: Cancer Cell International 2017 17:105
    Content type: Primary Research Published on:

  21. Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 sub...

    Authors: Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim and Chul-Kee Park
    Citation: Cancer Cell International 2017 17:104
    Content type: Primary Research Published on:

  22. Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem ...

    Authors: Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen
    Citation: Cancer Cell International 2017 17:103
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:73

  23. MicroRNAs are considered as potential regulators in various biological pathways and contribute to the diagnosis and prognosis of cancers. MicroRNA-214-3p (miR-214-3p) was proved to be correlated with various c...

    Authors: Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang
    Citation: Cancer Cell International 2017 17:102
    Content type: Primary Research Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:55

  24. Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential...

    Authors: Hu Lei, Huizhuang Shan and Yingli Wu
    Citation: Cancer Cell International 2017 17:101
    Content type: Review Published on:

  25. As one of the hallmarks of cancer, chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS). MicroRNAs (miRNAs) act as key regulators of gene expression in diverse biological processes includi...

    Authors: Fangfang Zhao, Youguang Pu, Mingda Cui, Haiyan Wang and Shanbao Cai
    Citation: Cancer Cell International 2017 17:100
    Content type: Primary Research Published on:

  26. Upon publication of the original article [1], it was noticed that corresponding author status has been erroneously attributed to José Antonio Fagundes Assumpção. The corresponding author of this manuscript should...

    Authors: José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa
    Citation: Cancer Cell International 2017 17:99
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2017 17:82

  27. More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a nat...

    Authors: Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo and Hua-Qiao Wang
    Citation: Cancer Cell International 2017 17:98
    Content type: Primary Research Published on:

  28. Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-re...

    Authors: Lisa Repsold, Roger Pool, Mohammed Karodia, Gregory Tintinger and Annie Margaretha Joubert
    Citation: Cancer Cell International 2017 17:89
    Content type: Review Published on:

  29. miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC), a series of miRNAs have been proven to involve into CRC carcinogenesis, invasion and metastasis. Aberrant miR-42...

    Authors: Wen-Ting Wei, Xin-Xin Nian, Shu-Yang Wang, Hong-Li Jiao, Yong-Xia Wang, Zhi-Yuan Xiao, Run-Wei Yang, Yan-Qing Ding, Ya-Ping Ye and Wen-Ting Liao
    Citation: Cancer Cell International 2017 17:91
    Content type: Primary Research Published on:

  30. The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of ce...

    Authors: Huiru Tang, Yan Wang, Bing Zhang, Shiqiu Xiong, Liangshuai Liu, Wei Chen, Guosheng Tan and Heping Li
    Citation: Cancer Cell International 2017 17:97
    Content type: Primary Research Published on:

  31. Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used ...

    Authors: Jehad Zweiri and Stephen E. Christmas
    Citation: Cancer Cell International 2017 17:96
    Content type: Primary Research Published on:

  32. The tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure.

    Authors: Gang Chen, Mingfeng He, Yin Yin, Ting Yan, Wenfang Cheng, Zebo Huang, Lan Zhang, Huo Zhang, Ping Liu, Wei Zhu and Yichao Zhu
    Citation: Cancer Cell International 2017 17:95
    Content type: Primary Research Published on:

  33. The relationship between specific genome alterations and hepatocellular carcinoma (HCC) cancer stem cells (CSCs) remains unclear. In this study, we evaluated the relationship between somatic mutations and epit...

    Authors: Takehiro Hayashi, Taro Yamashita, Hikari Okada, Kouki Nio, Yasumasa Hara, Yoshimoto Nomura, Tomoyuki Hayashi, Yoshiro Asahina, Mariko Yoshida, Naoki Oishi, Hajime Sunagozaka, Hajime Takatori, Masao Honda and Shuichi Kaneko
    Citation: Cancer Cell International 2017 17:94
    Content type: Primary Research Published on:

  35. Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). However, the mechanisms underlying gastric carcinogenesis and the dys-regulation of NUD...

    Authors: Jingjing Duan, Haiyang Zhang, Shuang Li, Xinyi Wang, Haiou Yang, Shunchang Jiao and Yi Ba
    Citation: Cancer Cell International 2017 17:92
    Content type: Primary Research Published on:

  36. Cancers are caused by the acquisition of somatic mutations. Numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely ...

    Authors: Aijun Liang, Bin Zhou and Wei Sun
    Citation: Cancer Cell International 2017 17:90
    Content type: Primary Research Published on:

  37. Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. Howev...

    Authors: Weinan Zheng, Zhimin Zhao, Xinan Yi, Qiangqiang Zuo, Hongtao Li, Xiaoqing Guo, Dongmei Li, Hongchang He, Zemin Pan, Peiwen Fan, Feng Li, Yanhong Liao and Renfu Shao
    Citation: Cancer Cell International 2017 17:88
    Content type: Primary Research Published on:

  38. Glioblastoma is the most common and aggressive brain tumor associated with a poor prognosis. Plant homeodomain finger protein 20 (PHF20) is highly expressed in primary human gliomas and its expression is assoc...

    Authors: Tianlong Liu, Tiejun Zhang, Feng Zhou, Jitao Wang, Xiaohu Zhai, Nan Mu, Jongsun Park, Minna Liu, Wenxing Liu, Peijin Shang, Yi Ding, Aidong Wen and Yuwen Li
    Citation: Cancer Cell International 2017 17:87
    Content type: Primary Research Published on:

  39. BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V...

    Authors: Tiziana Notarangelo, Lorenza Sisinni, Valentina Condelli and Matteo Landriscina
    Citation: Cancer Cell International 2017 17:86
    Content type: Primary Research Published on:

  40. Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma a...

    Authors: Phaijit Sritananuwat, Natthaporn Sueangoen, Parichut Thummarati, Kittiya Islam and Tuangporn Suthiphongchai
    Citation: Cancer Cell International 2017 17:85
    Content type: Primary Research Published on:

  41. Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemothe...

    Authors: Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen and Shi-Bing Su
    Citation: Cancer Cell International 2017 17:84
    Content type: Primary Research Published on:

  42. Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (B...

    Authors: Chao-hua Mo, Li Gao, Xiao-fei Zhu, Kang-lai Wei, Jing-jing Zeng, Gang Chen and Zhen-bo Feng
    Citation: Cancer Cell International 2017 17:83
    Content type: Primary Research Published on:

  43. In cancer cells, autophagy can act as both tumor suppressor, when autophagic event eliminates cellular contends which exceeds the cellular capacity of regenerate promoting cell death, and as a pro-survival age...

    Authors: José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa
    Citation: Cancer Cell International 2017 17:82
    Content type: Primary Research Published on:

    The Correction to this article has been published in Cancer Cell International 2017 17:99

  44. ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focuse...

    Authors: Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu and Hong Shen
    Citation: Cancer Cell International 2017 17:81
    Content type: Primary Research Published on:

  45. Epithelial–mesenchymal transition (EMT), TP53, and Podoplanin have been implicated in the tumorigenesis and metastasis of human cancers. Nevertheless, the clinical significance of these markers in cancer patie...

    Authors: Jiaying Lin, Jiaqi Lu, Chao Wang and Xiaohong Xue
    Citation: Cancer Cell International 2017 17:80
    Content type: Primary Research Published on:

  46. Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether int...

    Authors: Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu and Tingyan Liu
    Citation: Cancer Cell International 2017 17:79
    Content type: Primary Research Published on:

  50. Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) and pathways in CRC by ...

    Authors: Jingwei Liu, Hao Li, Liping Sun, Zhenning Wang, Chengzhong Xing and Yuan Yuan
    Citation: Cancer Cell International 2017 17:75
    Content type: Primary Research Published on:
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Cancer Cell International

ISSN: 1475-2867

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