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  1. Pluripotent mouse embryonic stem (ES) cells can be induced in vitro to become neural progenitors. Upon transplantation, neural progenitors migrate toward areas of damage and inflammation in the CNS. We tested whe...

    Authors: Peter Serfozo, Maggie S Schlarman, Chris Pierret, Bernard L Maria and Mark D Kirk
    Citation: Cancer Cell International 2006 6:1
    Content type: Primary research Published on:

  2. Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. Alterations in...

    Authors: Himani Sharma, Archna Singh, Chandresh Sharma, Sunesh Kumar Jain and Neeta Singh
    Citation: Cancer Cell International 2005 5:34
    Content type: Primary research Published on:

  3. Clinicians will argue that cancer can only really receive the treatment that is needed through thorough understanding of medicine. However, even empirical approaches to therapy result in experimental analysis ...

    Authors: Denys N Wheatley Editor-in-Chief, Cancer Cell International
    Citation: Cancer Cell International 2005 5:33
    Content type: Editorial Published on:

  4. Considering the width and importance of using Multicellular Tumor Spheroids (MTS) in oncology research, size determination of MTSs by an accurate and fast method is essential. In the present study an effective...

    Authors: Azita Monazzam, Pasha Razifar, Örjan Lindhe, Raymond Josephsson, Bengt Långström and Mats Bergström
    Citation: Cancer Cell International 2005 5:32
    Content type: Primary research Published on:

  5. It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of auror...

    Authors: Ash-shafie Abdullah, Charlene Foong and Maki Murata-Hori
    Citation: Cancer Cell International 2005 5:31
    Content type: Primary research Published on:

  7. The p23.2 region of human chromosome 8 is frequently deleted in several types of epithelial cancer and those deletions appear to be associated with poor prognosis. Cub and Sushi Multiple Domains 1 (CSMD1) was pos...

    Authors: Toni M Richter, Benton D Tong and Steven B Scholnick
    Citation: Cancer Cell International 2005 5:29
    Content type: Primary research Published on:

  8. Many anticancer agents and carcinogens are DNA damaging chemicals and exposure to such chemicals results in the deregulation of cell cycle progression. The molecular mechanisms of DNA damage-induced cell cycle...

    Authors: Huijun Zhu, Catherine Smith, Charles Ansah and Nigel J Gooderham
    Citation: Cancer Cell International 2005 5:28
    Content type: Primary research Published on:

  9. p53 is important in the development of hepatocellular carcinoma (HCC) and in therapeutic approaches, but the mechanism whereby it inhibits HCC growth is still unclear. The aim of the present study was to estab...

    Authors: Tian-Yi Chi, George G Chen, Lok-Kee Ho and Paul BS Lai
    Citation: Cancer Cell International 2005 5:27
    Content type: Primary research Published on:

  10. Sodium weighted images can indicate sodium signal intensities from different features in the tumor before and 24 hours following administration of Taxotere.

    Authors: Rakesh Sharma, Richard P Kline, Ed X Wu and Jose K Katz
    Citation: Cancer Cell International 2005 5:26
    Content type: Primary research Published on:

  12. This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation. Cross talk between p53 and beta-catenin p...

    Authors: Nalini Chandar, Rasleen Saluja, Peter C Lamar, Kevin Kolman and Walter C Prozialeck
    Citation: Cancer Cell International 2005 5:24
    Content type: Primary research Published on:

  13. The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human...

    Authors: Ivan L Cameron, Lu-Zhe Sun, Nicholas Short, W Elaine Hardman and C Douglas Williams
    Citation: Cancer Cell International 2005 5:23
    Content type: Primary research Published on:

  14. Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet,...

    Authors: Ilhan Akan, Selma Akan, Hakan Akca, Burhan Savas and Tomris Ozben
    Citation: Cancer Cell International 2005 5:22
    Content type: Primary research Published on:

  15. A secreted peptide Pep27 initiates the cell death program in S. pneumoniae through signal transduction. This study was undertaken to evaluate the relation between the structure and cytotoxic activity of Pep27 and...

    Authors: Dong Gun Lee, Kyung-Soo Hahm, Yoonkyung Park, Hai-Young Kim, Weontae Lee, Sung-Chul Lim, Youn-Kyung Seo and Cheol-Hee Choi
    Citation: Cancer Cell International 2005 5:21
    Content type: Primary research Published on:

  16. Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular sphe...

    Authors: Ponce de León Valeria and Barrera-Rodríguez Raúl
    Citation: Cancer Cell International 2005 5:20
    Content type: Primary research Published on:

  17. Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis. Targeted therapeu...

    Authors: Ekwere T Ifon, Alan LY Pang, Warren Johnson, Kathleen Cashman, Sharon Zimmerman, Sumitra Muralidhar, Wai-Yee Chan, John Casey and Leonard Jason Rosenthal
    Citation: Cancer Cell International 2005 5:19
    Content type: Primary research Published on:

  19. A neoplastic tumor cannot grow beyond a millimeter or so in diameter without recruitment of endothelial cells and new blood vessels to supply nutrition and oxygen for tumor cell survival. This study was design...

    Authors: Ivan L Cameron, Nicholas Short, LuZhe Sun and W Elaine Hardman
    Citation: Cancer Cell International 2005 5:17
    Content type: Primary research Published on:

  20. Combined effect of vanadium and beta-carotene on rat liver DNA-chain break and Proton induced X-ray emission (PIXE) analysis was studied during a necrogenic dose (200 mg/kg of body weight) of Diethyl Nitrosami...

    Authors: Mitali Basu Chattopadhyay, Sutapa Mukherjee, Indira Kulkarni, V Vijayan, Manika Doloi, NB Kanjilal and Malay Chatterjee
    Citation: Cancer Cell International 2005 5:16
    Content type: Primary research Published on:

  21. Multidrug resistance (MDR) phenotype of malignant cells is the major problem in the chemotherapy of neoplasia. The treatment of leukemia with retinoids is aimed on the induction of leukemic cells differentiati...

    Authors: Tatjana P Stromskaya, Ekaterina Y Rybalkina, Tatjana N Zabotina, Alexander A Shishkin and Alla A Stavrovskaya
    Citation: Cancer Cell International 2005 5:15
    Content type: Primary research Published on:

  23. A human malignant continuous cell line, named NG97, was recently established in our laboratory. This cell line has been serially subcultured over 100 times in standard culture media presenting no sign of cell ...

    Authors: Camila ML Machado, André Schenka, José Vassallo, Wirla MSC Tamashiro, Estela M Gonçalves, Selma C Genari and Liana Verinaud
    Citation: Cancer Cell International 2005 5:13
    Content type: Primary research Published on:

  24. The effects of an omega-3 (n-3) fatty acid enriched diet alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human MDA-MB231 breast cancer xenograft were tested. The cancer cell...

    Authors: W Elaine Hardman, LuZhe Sun, Nicholas Short and Ivan L Cameron
    Citation: Cancer Cell International 2005 5:12
    Content type: Primary research Published on:

  25. Inflammatory breast cancer (IBC) is the most lethal form of locally invasive breast cancer known. However, very little information is available on the cellular mechanisms responsible for manifestation of the I...

    Authors: Michaela R Hoffmeyer, Kristin M Wall and Suranganie F Dharmawardhane
    Citation: Cancer Cell International 2005 5:11
    Content type: Primary research Published on:

  27. The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes...

    Authors: Richmond T Prehn
    Citation: Cancer Cell International 2005 5:9
    Content type: Hypothesis Published on:

  28. Androgens and androgen receptors (AR) regulate normal prostate development and growth. They also are involved in pathological development of prostatic diseases, including benign prostatic hyperplasia (BPH) and...

    Authors: Qing Yang, Kar-Ming Fung, Wanda V Day, Bradley P Kropp and Hsueh-Kung Lin
    Citation: Cancer Cell International 2005 5:8
    Content type: Primary research Published on:

  29. Calcineurin (CaN) is an important serine-threonine phosphatase (PP2B), which plays a crucial role in calcium-calmodulin mediated signal transduction events. Calcineurin has been implicated in pathogenesis of v...

    Authors: S Padma, A Pavani Sowjanya, Usha Rani Poli, Meenakshi Jain, BN Rao and Gayatri Ramakrishna
    Citation: Cancer Cell International 2005 5:7
    Content type: Primary research Published on:

  30. A full-term pregnancy has been associated with reduced risk for developing breast cancer. In rodent models, the protective effect of pregnancy can be mimicked with a defined regimen of estrogen and progesteron...

    Authors: Jiahui Zhang, Yifan Tu and Sallie Smith-Schneider
    Citation: Cancer Cell International 2005 5:6
    Content type: Primary research Published on:

  31. The necessary and sufficient capabilities of cancer cell have been identified. Strikingly, this list does not include one that would seem to be a key property, namely the ability of cancer cells to kill their ...

    Authors: Anatoly V Lichtenstein
    Citation: Cancer Cell International 2005 5:5
    Content type: Hypothesis Published on:

  33. Melanoma inhibitory activity (MIA) is a small secreted protein that interacts with extracellular matrix proteins. Its over-expression promotes the metastatic behavior of malignant melanoma, thus making it a po...

    Authors: Jamael El Fitori, Jörg Kleeff, Nathalia A Giese, Ahmed Guweidhi, Anja K Bosserhoff, Markus W Büchler and Helmut Friess
    Citation: Cancer Cell International 2005 5:3
    Content type: Primary research Published on:

  34. Most cancer cells are characterized by mobile lipids visible on proton NMR (1H-NMR), these being comprised mainly of methyl and methylene signals from lipid acyl chains. Erythroleukemia K562 cells show narrow sig...

    Authors: Aurélie Mannechez, Paiboon Reungpatthanaphong, Jacques D de Certaines, Geneviève Leray and Laurence Le Moyec
    Citation: Cancer Cell International 2005 5:2
    Content type: Primary research Published on:

  35. Breast cancer cells frequently metastasize to the skeleton and induce extensive bone destruction. Cancer cells produce proteinases, including matrix metalloproteinases (MMPs) and the plasminogen activator syst...

    Authors: Hayley Morgan and Peter A Hill
    Citation: Cancer Cell International 2005 5:1
    Content type: Primary research Published on:

  36. Tumor microenvironment, which is largely affected by inflammatory cells, is a crucial participant in the neoplastic process through promotion of cell proliferation, survival and migration. We measured the effe...

    Authors: Inga Zelvyte, Tim Stevens, Ulla Westin and Sabina Janciauskiene
    Citation: Cancer Cell International 2004 4:7
    Content type: Primary research Published on:

  37. Heptaplatin is a new platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines (Cancer Chemother Pharmacol 1995; 35: 441).

    Authors: Cheol-Hee Choi, Yoon-Jung Cha, Chun-San An, Kyung-Jong Kim, Kweon-Cheon Kim, Sung-Pyo Moon, Zang Hee Lee and Young-Don Min
    Citation: Cancer Cell International 2004 4:6
    Content type: Primary research Published on:

  38. Prostate cancer is the second leading cause of male death in the United States. The incidence increases most rapidly with age, and multiple genetic and epigenetic factors have been implicated in the initiation...

    Authors: James Kumi-Diaka, Simone Saddler-Shawnette, Alex Aller and Jayann Brown
    Citation: Cancer Cell International 2004 4:5
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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