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  1. The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complem...

    Authors: Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao and Yupei Zhao
    Citation: Cancer Cell International 2019 19:300
    Content type: Review Published on:

  2. Photoimmunotherapy (PIT) employing antibody-photosensitizer conjugates is a promising treatment for cancer. However, the fixed antigen specificity severely limits the efficacy and the applicability. Here we de...

    Authors: Naoto Shirasu, Hirotomo Shibaguchi, Hiromi Yamada, Masahide Kuroki and Shin’ichiro Yasunaga
    Citation: Cancer Cell International 2019 19:299
    Content type: Primary research Published on:

  3. Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family of proteins and its deregulation has been implicated in the malignancy of several cancer types. Dlg5 ...

    Authors: Dongping Wang, Qi Zhang, Fenfen Li, Chan Wang, Changming Yang and Hong Yu
    Citation: Cancer Cell International 2019 19:298
    Content type: Primary research Published on:

  4. Transcription factors (TFs) are responsible for the regulation of various activities related to cancer like cell proliferation, invasion, and migration. It is thought that, the measurement of TFs levels could ...

    Authors: Boxin Zhang, Haihui Wang, Ziyan Guo and Xinhai Zhang
    Citation: Cancer Cell International 2019 19:297
    Content type: Primary research Published on:

  5. Endometrial cancer (EC) is one of the three major gynecological malignancies. Numerous biomarkers that may be associated with survival and prognosis have been identified through database mining in previous stu...

    Authors: Zi-Hao Wang, Yun-Zheng Zhang, Yu-Shan Wang and Xiao-Xin Ma
    Citation: Cancer Cell International 2019 19:296
    Content type: Primary research Published on:

  6. The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is formed by one of t...

    Authors: Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu and Xun Qi
    Citation: Cancer Cell International 2019 19:295
    Content type: Review Published on:

  7. Glioma is considered one of the most common tumors and has a poor prognosis. Recently, microRNAs (miRNAs) have been reported to be strongly linked to various human tumors including glioma. In this study, we in...

    Authors: Yangyang Li, Jia Xu, Jiale Zhang, Jie Zhang, Jian Zhang and Xiaoming Lu
    Citation: Cancer Cell International 2019 19:294
    Content type: Primary research Published on:

  8. Although leukemic blast cells of Pro-B cell acute lymphoblastic leukemia (ALL) are arrested at the same stage of B cell differentiation, the immature B cell subtype is still biologically heterogeneous and is a...

    Authors: Chao Gao, Shu-Guang Liu, Zhi-Xia Yue, Yi Liu, Jing Liang, Jun Li, Yuan-Yuan Zhang, Jiao-Le Yu, Ying Wu, Wei Lin, Hu-Yong Zheng and Rui-Dong Zhang
    Citation: Cancer Cell International 2019 19:293
    Content type: Primary research Published on:

  9. During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokin...

    Authors: Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz and Kinga A. Kocemba-Pilarczyk
    Citation: Cancer Cell International 2019 19:292
    Content type: Hypothesis Published on:

  10. Previous genome-wide transcriptome profiling found circ_ZNF124 was highly expressed in lung adenocarcinoma, however, the role of circ_ZNF124 in non-small cell lung cancer (NSCLC) is still unknown. The purpose ...

    Authors: Qianping Li, Qin Huang, Shaofei Cheng, Song Wu, Hongyang Sang and Junyi Hou
    Citation: Cancer Cell International 2019 19:291
    Content type: Primary research Published on:

  11. Hepatocellular carcinoma (HCC) is a serious threat to public health due to its poor prognosis. The current study aimed to develop and validate a prognostic nomogram to predict the overall survival of HCC patie...

    Authors: Zhiqiao Zhang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Qingbo Liu, Peng Wang and Jianqiang Ding
    Citation: Cancer Cell International 2019 19:290
    Content type: Primary research Published on:

  12. SNAI2, a member of the snail zinc finger protein family, plays an important role in the metastasis of several types of carcinoma.

    Authors: Jie Ding, Yu Xia, Zhaoyan Yu, Jing Wen, Zhuxue Zhang, Zhongmin Zhang, Zhenhua Liu, Zhuan Jiang, Hang Liu and Guoqing Liao
    Citation: Cancer Cell International 2019 19:289
    Content type: Primary research Published on:

  13. The study aimed to explore the associations between the interactions of serum vitamin B2 or B12 levels, aberrant DNA methylation of p16 or p53 and MTHFR C677T polymorphism and the risks of esophageal squamous cel...

    Authors: Da Pan, Ming Su, Guiling Huang, Pengfei Luo, Ting Zhang, Lingmeng Fu, Jie Wei, Shaokang Wang and Guiju Sun
    Citation: Cancer Cell International 2019 19:288
    Content type: Primary research Published on:

  15. The authors have retracted this article [1] because Figure 4a has been duplicated from Figure 5d in a previously published article [2]. In addition, the article contains sections that substantially overlap wit...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke
    Citation: Cancer Cell International 2019 19:286
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2018 18:165

  16. Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na+/H+ exchanger NHE1 plays a significant part in human melanoma ...

    Authors: Dennis Keurhorst, Ivan Liashkovich, Fabian Frontzek, Svenja Nitzlaff, Verena Hofschröer, Rita Dreier and Christian Stock
    Citation: Cancer Cell International 2019 19:285
    Content type: Primary research Published on:

  17. Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in certain human tumors. However, the detailed biological function of TRIM11 in ch...

    Authors: Bin Wang, Gang Wang, Qingfeng Wang, Ziqiang Zhu, Yunqing Wang, Kangwu Chen and Huilin Yang
    Citation: Cancer Cell International 2019 19:284
    Content type: Primary research Published on:

  18. Tripartite motif‑containing 27 (TRIM27) belongs to the TRIM protein family, which is closely related to the progression of some certain human cancers. Nevertheless, the biological function of TRIM27 in esophag...

    Authors: Liang Ma, Ninghua Yao, Ping Chen and Zhixiang Zhuang
    Citation: Cancer Cell International 2019 19:283
    Content type: Primary research Published on:

  19. Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly maligna...

    Authors: Jian-Xian Lin, Xiong-Feng Weng, Xin-Sheng Xie, Ning-Zi Lian, Sheng-Liang Qiu, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Si-Jia Liu, Min Hu, Yi-Ke Lin, Chang-Ming Huang…
    Citation: Cancer Cell International 2019 19:282
    Content type: Primary research Published on:

  20. Recently, the impact of microRNAs (miRNAs) and exosome on ovarian cancer has been assessed in many studies. We aim to explore the mechanism of exosomes transferring miR-205 in ovarian cancer, and confirm its d...

    Authors: Lijun Wang, Fei Zhao, Zhongqing Xiao and Liang Yao
    Citation: Cancer Cell International 2019 19:281
    Content type: Primary research Published on:

  21. Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.

    Authors: Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao and Feng Zhi
    Citation: Cancer Cell International 2019 19:280
    Content type: Primary research Published on:

  22. Radiation sensitive 52 (RAD52) is an important protein that mediates DNA repair in tumors. However, little is known about the impact of RAD52 on hepatocellular carcinoma (HCC). We investigated the expression o...

    Authors: Ping Li, YanZhen Xu, Qinle Zhang, Yu Li, Wenxian Jia, Xiao Wang, Zhibin Xie, Jiayi Liu, Dong Zhao, Mengnan Shao, Suixia Chen, Nanfang Mo, Zhiwen Jiang, Liuyan Li, Run Liu, Wanying Huang…
    Citation: Cancer Cell International 2019 19:279
    Content type: Primary research Published on:

  23. Long noncoding RNAs (lncRNAs) are involved in different pathogenesis pathways including cancer pathogenesis. The adenoma-carcinoma pathway in colorectal cancer may involve the aberrant and variable gene expres...

    Authors: Milad Shademan, Azam Naseri Salanghuch, Khadijeh Zare, Morteza Zahedi, Mohammad Ali Foroughi, Kambiz Akhavan Rezayat, Hooman Mosannen Mozaffari, Kamran Ghaffarzadegan, Ladan Goshayeshi and Hesam Dehghani
    Citation: Cancer Cell International 2019 19:278
    Content type: Primary research Published on:

  24. CKS1 is highly expressed in colon cancer tissues, and is essential for cancer cell proliferation. The downstream molecular mechanism of CKS1 has been fully studied, but the upstream regulatory mechanism of it ...

    Authors: Zhengbin Chai, Li Wang, Yabing Zheng, Na Liang, Xiwei Wang, Yingying Zheng, Zhiwei Zhang, Chuanxi Zhao, Tingting Zhu and Chunyan Liu
    Citation: Cancer Cell International 2019 19:277
    Content type: Primary research Published on:

  26. The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) is involved in various cancers and often functions through microRNAs. The pro-survival protein PTP1B is known to play important roles i...

    Authors: Yi Li, Qingan Zeng, Jiliang Qiu, Ting Pang, Jianzhong Xian and Xuexia Zhang
    Citation: Cancer Cell International 2019 19:275
    Content type: Primary research Published on:

  27. Daily experience tells us that breast cancer can be controlled using standard protocols up to the advent of a relapse. Now new frontiers in precision medicine like liquid biopsy of cell free DNA (cfDNA) give u...

    Authors: Maria Palmieri, Margherita Baldassarri, Francesca Fava, Alessandra Fabbiani, Giuseppe Maria Campennì, Maria Antonietta Mencarelli, Rossella Tita, Stefania Marsili, Alessandra Renieri and Elisa Frullanti
    Citation: Cancer Cell International 2019 19:274
    Content type: Commentary Published on:

  28. This study is performed to investigate the effects of adenovirus-mediated X-linked inhibitor of apoptosis protein (XIAP) overexpressed bone marrow mesenchymal stem cells (BMSCs) on brain injury in rats with ce...

    Authors: Wenjing Deng, Chenghe Fan, Yanbo Fang, Yanan Zhao, Yamin Wei, Meng Li and Junfang Teng
    Citation: Cancer Cell International 2019 19:273
    Content type: Primary research Published on:

  29. To investigate the value of dynamic monitoring peripheral blood lymphocyte-to-monocyte (LMR) ratio in evaluating the treatment response and prognosis of patients with extranodal NK/T cell lymphoma (ENKTL).

    Authors: Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song and Qingsong Yin
    Citation: Cancer Cell International 2019 19:272
    Content type: Review Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:21

  30. Prostate cancer (PCa) is a common disease that often occurs among older men and a frequent cause of malignancy associated death in this group. microRNA (miR)-129-5p has been identified as an essential regulato...

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu and Dong Chen
    Citation: Cancer Cell International 2019 19:271
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:237

  31. LncRNAs may exert a regulatory effect in tumorigenesis. Although the expression of lncRNA HOTAIR has been confirmed to be notably elevated in the tissues of CSCC, its biological mechanism in CSCC is still unknown...

    Authors: Guo-Jun Yu, Yong Sun, Da-Wei Zhang and Peng Zhang
    Citation: Cancer Cell International 2019 19:270
    Content type: Primary research Published on:

  32. Malignant glioma is one of the essentially incurable tumors with chemoresistance and tumor recurrence. As a histone methyltransferase, SUV39H2 can trimethylate H3K9. SUV39H2 is highly expressed in many types o...

    Authors: Ran Wang, Lilin Cheng, Xi Yang, Xin Chen, Yifeng Miao, Yongming Qiu and Zhiyi Zhou
    Citation: Cancer Cell International 2019 19:269
    Content type: Primary research Published on:

  33. Circular RNAs (circRNAs) are involved in regulating tumor pathogenesis. The mechanism of circRNAs in gastric cancer (GC) is still unknown. Our study aimed to identify differentially expressed circRNAs and asse...

    Authors: Jianming Wei, Jinmiao Wang, Xibo Gao and Feng Qi
    Citation: Cancer Cell International 2019 19:268
    Content type: Primary research Published on:

  34. Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal...

    Authors: Rongrong Zhong, Zhuozhi Chen, Ting Mo, Zimo Li and Peng Zhang
    Citation: Cancer Cell International 2019 19:267
    Content type: Primary research Published on:

  35. Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The inhibition of epidermal growth factor receptor (EGFR) signaling by tyrosine kinase inhibitors or monoclonal antibo...

    Authors: Jing Wang, Peiyuan Sun, Qi Wang, Pan Zhang, Yuna Wang, Chengting Zi, Xuanjun Wang and Jun Sheng
    Citation: Cancer Cell International 2019 19:266
    Content type: Primary research Published on:

  36. Tumor-infiltrating immune cells (TIICs) are highly relevant to clinical outcome of glioma. However, previous studies cannot account for the diverse functions that make up the immune response in malignant trans...

    Authors: Jiacheng Lu, Hailin Li, Zhengxin Chen, Ligang Fan, Shuang Feng, Xiaomin Cai and Huibo Wang
    Citation: Cancer Cell International 2019 19:265
    Content type: Primary research Published on:

  37. Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell proliferation and metastasis in several cancers. The role of CENPF in breast cancer (BC) bone metastasis rema...

    Authors: Jingbo Sun, Jingzhan Huang, Jin Lan, Kun Zhou, Yuan Gao, Zhigao Song, Yunyao Deng, Lixin Liu, Ying Dong and Xiaolong Liu
    Citation: Cancer Cell International 2019 19:264
    Content type: Primary research Published on:

  38. Triple-negative breast carcinoma (TNBC) patients do not benefit from hormone- or human epidermal growth factor receptor 2- (HER2-) targeted therapies. Accurate testing is pivotal for these patients.

    Authors: Jose De Jesus and Marilin Rosa
    Citation: Cancer Cell International 2019 19:263
    Content type: Primary research Published on:

  39. Pancreatic cancer is a malignancy with a very poor prognosis. The emergence of liquid biopsy is expected to achieve accurate early diagnosis through detection of tumor-derived secreted proteins in the blood. E...

    Authors: Peng Liu, Lingming Kong, Haoyi Jin, Yunhao Wu, Xiaodong Tan and Bing Song
    Citation: Cancer Cell International 2019 19:262
    Content type: Primary research Published on:

  40. Cancer has been a worldwide health problem with a high risk of morbidity and mortality, however ideal biomarkers for effective screening and diagnosis of cancer patients are still lacking. Small nucleolar RNA ...

    Authors: Chenghao Zhang, Xiaolei Ren, Jieyu He, Wanchun Wang, Chao Tu and Zhihong Li
    Citation: Cancer Cell International 2019 19:261
    Content type: Primary research Published on:

  41. The glial cells of the primary olfactory nervous system, olfactory ensheathing cells (OECs), are unusual in that they rarely form tumors. Only 11 cases, all of which were benign, have been reported to date. In...

    Authors: Mariyam Murtaza, Anu Chacko, Ali Delbaz, Ronak Reshamwala, Andrew Rayfield, Brent McMonagle, James A. St John and Jenny A. K. Ekberg
    Citation: Cancer Cell International 2019 19:260
    Content type: Review Published on:

  42. Serum/plasma YKL-40 can be a useful index that is associated with tumor development. However, the prognostic value of serum/plasma YKL-40 in patients with solid tumors is still unclear. We aimed to utilize the...

    Authors: Bingxian Bian, Li Li, Junyao Yang, Yi Liu, Guohua Xie, Yingxia Zheng, Liang Zeng, Junxiang Zeng and Lisong Shen
    Citation: Cancer Cell International 2019 19:259
    Content type: Primary research Published on:

  43. This study is conducted to investigate the effect of lncRNA PIK3CD-AS1 on the growth and metastasis of hepatocellular carcinoma (HCC) and its potential mechanism.

    Authors: Wei Song, Jingjing Zhang, Jianbo Zhang, Miaomiao Sun and Qingxin Xia
    Citation: Cancer Cell International 2019 19:150
    Content type: Primary research Published on:

  44. Non-small-cell lung cancer (lung cancer) has become one of the leading causes worldwide and the underlying mechanism is not fully understood. The transcriptional factor Kruppel like factor 8 (KLF8) is involved...

    Authors: Dongjie Ma, Hongsheng Liu, Yingzhi Qin, Zhenhuan Tian, Shanqing Li and Naixin Liang
    Citation: Cancer Cell International 2019 19:258
    Content type: Primary research Published on:

  45. miRNAs, a major class of small noncoding RNAs approximately 18–25 nucleotides in length, function by repressing the expression of target genes through binding to complementary sequences in the 3′-UTRs of targe...

    Authors: Yue Yu and Xu-Chen Cao
    Citation: Cancer Cell International 2019 19:257
    Content type: Review Published on:

  46. A hallmark of acute promyelocytic leukemia (APL) is the expression of PML/RARα fusion protein. Treatment with all-trans retinoic acid (ATRA) results in the terminal differentiation of neutrophil granulocytes. ...

    Authors: Xinrui Wang, Huiyong Fan, Congling Xu, Guojuan Jiang, Haiwei Wang and Ji Zhang
    Citation: Cancer Cell International 2019 19:256
    Content type: Primary research Published on:

  47. Hepatocellular carcinoma (HCC), the most common primary cancer of the liver, is one of the most common malignancies and the leading cause of cancer-related death worldwide. Leucine-rich repeat and sterile alph...

    Authors: Lili Pian, Xiaofeng Huang, Min Zhao, Yaolin Zhang, Cheng Qin, Jiyan Zhang, Jun Zhang and Qingyang Wang
    Citation: Cancer Cell International 2019 19:255
    Content type: Primary research Published on:

  48. Extracellular ATP (eATP) was shown to induce epithelial–mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact inducti...

    Authors: Yanyang Cao, Xuan Wang, Yunsheng Li, Maria Evers, Haiyun Zhang and Xiaozhuo Chen
    Citation: Cancer Cell International 2019 19:254
    Content type: Primary research Published on:

  49. Phosphoglucomutase (PGM), a key enzyme in the metabolism of glucose-1-phosphate and glucose-6-phosphate, has been found to be associated with proliferation, invasion, and metastasis of cancer. However, the exp...

    Authors: Yifan Sun, Haihua Long, Lin Sun, Xiujuan Sun, Liping Pang, Jianlin Chen, Qingqun Yi, Tianwei Liang and Yongqi Shen
    Citation: Cancer Cell International 2019 19:253
    Content type: Primary research Published on:

  50. Exosomal nucleic acid (exoNA) is a feasible target to improve the sensitivity of EGFR mutation testing in non-small cell lung cancer patients with limited cell-free DNA (cfDNA) mutant copies. However, the type an...

    Authors: Yoonjung Kim, Saeam Shin, Boyeon Kim and Kyung-A Lee
    Citation: Cancer Cell International 2019 19:251
    Content type: Primary research Published on:
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Cancer Cell International

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