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  1. Gene knockout technologies involving programmable nucleases have been used to create knockouts in several applications. Gene editing using Zinc-finger nucleases (ZFNs), Transcription activator like effectors (...

    Authors: Sumitra Shankar, Ahalya Sreekumar, Deepti Prasad, Ani V. Das and M. Radhakrishna Pillai
    Citation: Cancer Cell International 2018 18:169
    Content type: Primary research Published on:

  2. Drug resistance prevents the effective treatment of cancers. DNA methylation has been found to participate in the development of cancer drug resistance.

    Authors: Dabing Huang, Yong Wang, Yifu He, Gang Wang, Wei Wang, Xinghua Han, Yubei Sun, Lin Lin, Benjie Shan, Guodong Shen, Min Cheng, Geng Bian, Xiang Fang, Shilian Hu and Yueyin Pan
    Citation: Cancer Cell International 2018 18:168
    Content type: Primary research Published on:

  3. Inflammation is a major player in breast cancer (BC) progression. Allograft-inflammatory factor-1 (AIF1) is a crucial mediator in the inflammatory response. AIF1 reportedly plays a role in BC, but the mechanis...

    Authors: Ferial Amira Slim, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Simon Jacob, Caroline Diorio and Francine Durocher
    Citation: Cancer Cell International 2018 18:167
    Content type: Primary research Published on:

  5. Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial fragmentation and then inv...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke
    Citation: Cancer Cell International 2018 18:165
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2019 19:286

  6. Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of the long noncoding RNA (lncRNA) urothelial car...

    Authors: Ying-nan Yang, Rui Zhang, Jing-wen Du, Heng-heng Yuan, Yan-jing Li, Xiao-li Wei, Xiao-xue Du, Shu-lin Jiang and Yu Han
    Citation: Cancer Cell International 2018 18:164
    Content type: Primary research Published on:

  8. Follistatin (FST), an activin-binding protein, inhibits activin action by interfering with activin binding to its receptor. The prognostic value of FST has been studied in various cancers. However, these studi...

    Authors: Pengyu Zhang, Yingxin Ruan, Jun Xiao, Fangfang Chen and Xuejun Zhang
    Citation: Cancer Cell International 2018 18:162
    Content type: Primary research Published on:

  9. Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or micro...

    Authors: Zhonghao Wang, Bei Lu, Lixin Sun, Xi Yan and Jinzhi Xu
    Citation: Cancer Cell International 2018 18:161
    Content type: Primary research Published on:

  10. In an earlier study, we investigated the expression of tight junction protein claudins (CLDNs) in human osteosarcoma (OS) cells, and the CLDN2 was found to be down-regulated in primary tumor cells compared wit...

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li and Tao Li
    Citation: Cancer Cell International 2018 18:160
    Content type: Primary research Published on:

  11. While the somatic mutation profiles of renal cell carcinoma (RCC) have been revealed by several studies worldwide, the overwhelming majority of those were not derived from Chinese patients. The landscape of so...

    Authors: Jie Wang, Zhijun Xi, Jianzhong Xi, Hanshuo Zhang, Juan Li, Yuchao Xia and Yuanxue Yi
    Citation: Cancer Cell International 2018 18:159
    Content type: Primary research Published on:

  12. Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs)...

    Authors: Babak Otoukesh, Bahram Boddouhi, Mehdi Moghtadaei, Peyman Kaghazian and Maria Kaghazian
    Citation: Cancer Cell International 2018 18:158
    Content type: Review Published on:

  13. Increasing evidence suggests a critical role for long noncoding RNAs (LncRNAs) and pseudogenes in cancer. Renal cell carcinoma (RCC), the most common primary renal neoplasm, is highly aggressive and difficult ...

    Authors: Binghai Chen, Chengyue Wang, Jin Zhang, Yang Zhou, Wei Hu and Tao Guo
    Citation: Cancer Cell International 2018 18:157
    Content type: Primary research Published on:

  14. As newly identified Wnt enhancer, R-spondin gene family members have been linked to various cancers; however, their role in isocitrate dehydrogenase-wildtype subtype of human glioblastoma (GBM) cells remains u...

    Authors: Si Liu, Kin Pong U, Jieting Zhang, Lai Ling Tsang, Jiawei Huang, Shui Ping Tu and Xiaohua Jiang
    Citation: Cancer Cell International 2018 18:156
    Content type: Primary research Published on:

  15. Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically as...

    Authors: Jing Wen, Qian Xu and Yuan Yuan
    Citation: Cancer Cell International 2018 18:155
    Content type: Primary research Published on:

  16. BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis. Although, there are different opinions on the level of gene expression and function of BORIS in normal and cancer tissues, the results...

    Authors: Sara Soltanian and Hesam Dehghani
    Citation: Cancer Cell International 2018 18:154
    Content type: Review Published on:

  17. Chronic inflammation is deemed to play a significant effect on initiation and progression of esophageal squamous cell carcinoma (ESCC). In current study, we investigated the prognostic and predictive role of a...

    Authors: Qiu-Fang Gao, Jia-Cong Qiu, Xiao-Hong Huang, Yan-Mei Xu, Shu-Qi Li, Fan Sun, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Yu-Huan Jiang, Qing-Gen Chen, Lei Zhang, Xiao-Zhong Wang and Hou-Qun Ying
    Citation: Cancer Cell International 2018 18:153
    Content type: Primary research Published on:

  18. Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefo...

    Authors: Xiaoli Hu, Hailing Liu, Miaomiao Ye and Xueqiong Zhu
    Citation: Cancer Cell International 2018 18:152
    Content type: Review Published on:

  20. Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a distinct clinicopathological entity and EBV-associated disease that is highly aggressive. Many patients had failed to respond to conventional chemotherapy ...

    Authors: Xudong Zhang, Xiaorui Fu, Meng Dong, Zhenzhen Yang, Shaoxuan Wu, Mijing Ma, Zhaoming Li, Xinhua Wang, Ling Li, Xin Li, Zhenchang Sun, Yu Chang, Feifei Nan, Jiaqin Yan, Yun Mao, Mingzhi Zhang…
    Citation: Cancer Cell International 2018 18:150
    Content type: Primary research Published on:

  21. Marsdenia tenacissima is an herb medicine which has been utilized to treat malignant diseases for decades. The M. tenacissima extract (MTE) shows significant anti-proliferation activity against non-small cell lun...

    Authors: Yan-Na Jiao, Li-Na Wu, Dong Xue, Xi-Juan Liu, Zhi-Hua Tian, Shan-Tong Jiang, Shu-Yan Han and Ping-Ping Li
    Citation: Cancer Cell International 2018 18:149
    Content type: Primary research Published on:

  22. Arterialized vein flap is a kind of unphysiological flap. Unphysiological reconstruction of blood circulation leads to higher load than that supported by physiological flap and is the culprit of flap swelling,...

    Authors: Zheng Li, Zhen-wei Zhang, Shao-xiao Yu, Jia-chuan Zhuang, Yu-hai Ke, Yi Xiong, Hui-xin Lin and Wen-feng Chen
    Citation: Cancer Cell International 2018 18:148
    Content type: Primary research Published on:

  23. Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characte...

    Authors: Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder and Angelo De Milito
    Citation: Cancer Cell International 2018 18:147
    Content type: Primary research Published on:

  24. The molecular mechanism of Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) remains elusive. A collection of molecular regulators including transcription factor and noncoding RNA (ncRNAs) may affect...

    Authors: Jing-jing Jing, Ze-yang Wang, Hao Li, Li-ping Sun and Yuan Yuan
    Citation: Cancer Cell International 2018 18:146
    Content type: Primary research Published on:

  25. Ovarian cancer is the fifth leading cause of cancer deaths in women worldwide. LncRNACCAT1 was reported to play a critical role in cell metastasis of ovarian cancer. However, little is known about the detailed me...

    Authors: Yang Mu, Na Li and Yu-Lan Cui
    Citation: Cancer Cell International 2018 18:145
    Content type: Primary research Published on:

  26. Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...

    Authors: Lujun Chen, Jun Feng, Shaoxian Wu, Bin Xu, You Zhou, Changping Wu and Jingting Jiang
    Citation: Cancer Cell International 2018 18:144
    Content type: Primary research Published on:

  27. Pancreatic cancer, one of the most aggressive malignancies, ranks the fourth cause of cancer-related death worldwide. Aberrantly expressed long non-coding RNAs (lncRNAs) functioned as oncogenes or tumor suppre...

    Authors: Yong An, Xue-min Chen, Yong Yang, Feng Mo, Yong Jiang, Dong-lin Sun and Hui-hua Cai
    Citation: Cancer Cell International 2018 18:143
    Content type: Primary research Published on:

  28. Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to imp...

    Authors: LingLi Hou, Jiancheng Tu, Fangxiong Cheng, Hongwei Yang, Fei Yu, Minghua Wang, Jiubo Liu, Jinbo Fan and Guojun Zhou
    Citation: Cancer Cell International 2018 18:142
    Content type: Primary research Published on:

  29. Long non-coding RNA (lncRNA) SNHG5 has been found to play an important role in tumors. Nevertheless, the function and mechanism of lncRNA SNHG5 in osteosarcoma (OS) remains unclear. The purpose of this study w...

    Authors: Cheng Ju, Ruihao Zhou, Jun Sun, Feifei Zhang, Xiaofeng Tang, Kaddie Kwok Chen, Junliang Zhao, Xiaoyong Lan, Shifan Lin, Zhiping Zhang and Xiao-Bin Lv
    Citation: Cancer Cell International 2018 18:141
    Content type: Primary research Published on:

  30. Aberrant methylation of DNA is a key driver of hepatocellular carcinoma (HCC). In this study, we sought to integrate four cohorts profile datasets to identify such abnormally methylated genes and pathways asso...

    Authors: Guorun Fan, Yaqin Tu, Cai Chen, Haiying Sun, Chidan Wan and Xiong Cai
    Citation: Cancer Cell International 2018 18:140
    Content type: Primary research Published on:

  32. Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are associated with abnormal production of plasma cells, although their pathological mechanism of each disease is different. The main character...

    Authors: Ruonan Xu, Ying Fang, Chunmei Hou, Bing Zhai, Zhenyu Jiang, Ning Ma, Liang Wang, Gencheng Han and Renxi Wang
    Citation: Cancer Cell International 2018 18:138
    Content type: Primary research Published on:

  34. Glioblastoma multiforme (GBM) is a highly aggressive brain tumor in which cancer cells with stem cell-like features, called cancer stem cells (CSCs), were identified. Two CSC populations have been previously i...

    Authors: Bianca Maria Scicchitano, Silvia Sorrentino, Gabriella Proietti, Gina Lama, Gabriella Dobrowolny, Angela Catizone, Elena Binda, Luigi Maria Larocca and Gigliola Sica
    Citation: Cancer Cell International 2018 18:136
    Content type: Primary research Published on:

  35. Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early...

    Authors: Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison and Kim L. O’Neill
    Citation: Cancer Cell International 2018 18:135
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:29

  36. Following publication of the original article [1], the authors reported a typing mistake in the title. In this Correction the incorrect and correct titles are shown.

    Authors: Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu and Jingting Jiang
    Citation: Cancer Cell International 2018 18:134
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2018 18:126

  37. High prevalence of hepatocellular carcinoma (HCC) and typically poor prognosis of this disease that lead to late stage diagnosis when potentially curative therapies are least effective; therefore, development ...

    Authors: Faezeh Hosseinzadeh, Javad Verdi, Jafar Ai, Saieh Hajighasemlou, Iman Seyhoun, Frzad Parvizpour, Fatemeh Hosseinzadeh, Abolfazl Iranikhah and Sadegh Shirian
    Citation: Cancer Cell International 2018 18:133
    Content type: Review Published on:

  38. Non-small cell lung cancer (NSCLC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown...

    Authors: Shaoqiang Wang, Yingying Zheng, Zhiwei He, Wolong Zhou, Yuanda Cheng and Chunfang Zhang
    Citation: Cancer Cell International 2018 18:132
    Content type: Primary research Published on:

  39. No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).

    Authors: Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli…
    Citation: Cancer Cell International 2018 18:131
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:244

  40. Colorectal cancer (CRC) is one of the most common cancers diagnosed and among the commonest causes of cancer-related mortality globally. Despite the various available treatment options, millions of people stil...

    Authors: Adewale Oluwaseun Fadaka, Babajide A. Ojo, Olusola Bolaji Adewale, Temitope Esho and Ashley Pretorius
    Citation: Cancer Cell International 2018 18:130
    Content type: Review Published on:

  41. SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism e...

    Authors: Marie Saghaeian Jazi, Nader Mansour Samaei, Seyed Javad Mowla, Babak Arefnezhad and Morteza Kouhsar
    Citation: Cancer Cell International 2018 18:129
    Content type: Primary research Published on:

  42. Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transpor...

    Authors: Shao-hsuan Wen, Shey-chiang Su, Bo-huang Liou, Cheng-hao Lin and Kuan-rong Lee
    Citation: Cancer Cell International 2018 18:128
    Content type: Primary research Published on:

  43. MicroRNAs are small RNAs (~ 22 nt) that modulate the expression of thousands of genes in tumors and play important roles in the formation of multidrug resistance. In this study, we firstly investigated that miR-4...

    Authors: Fan Feng, Xiaolan Zhu, Chunyan Wang, Liang Chen, Weiping Cao, Yueqin Liu, Qi Chen and Wenlin Xu
    Citation: Cancer Cell International 2018 18:127
    Content type: Primary research Published on:

  44. Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...

    Authors: Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu and Jingting Jiang
    Citation: Cancer Cell International 2018 18:126
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:134

  45. Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involv...

    Authors: Dan Dong, Zhongyi Mu, Chenghai Zhao and Mingli Sun
    Citation: Cancer Cell International 2018 18:125
    Content type: Review Published on:

  46. Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role ...

    Authors: Yong-Xia Wang, Hui-Fang Zhu, Zhe-Ying Zhang, Feng Ren and Yu-Han Hu
    Citation: Cancer Cell International 2018 18:124
    Content type: Primary research Published on:

  47. To investigate the efficacy and safety of concurrent chemoradiotherapy with capecitabine or oxaliplatin in locally advanced (T3-4/N + M0) rectal cancer.

    Authors: Wanghua Chen, Wenling Wang, Yuxin Li, Hongmin Dong, Gang Wang and Xiaokai Li
    Citation: Cancer Cell International 2018 18:123
    Content type: Primary research Published on:

  48. LncRNAs can regulate miRNAs and mRNAs by sequestering and binding them. Indeed, many researchers have reported lncRNA mediated-competing endogenous RNAs (ceRNAs) could regulate the progression of solid tumors....

    Authors: Xuejiao Yin, Sui Huang, Ruiqi Zhu, Fengjuan Fan, Chunyan Sun and Yu Hu
    Citation: Cancer Cell International 2018 18:122
    Content type: Primary research Published on:

  49. Local or distant metastasis remains the main course of death in head and neck squamous cell carcinoma (HNSCC) patients. MicroRNAs (miRNAs) have been implicated in metastasis of HNSCC, but the mechanisms of the...

    Authors: Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu and Xiaomeng Song
    Citation: Cancer Cell International 2018 18:121
    Content type: Primary research Published on:

  50. Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated macrophages (M2 TAMs) that promote cancer progression. However, communicative mechanisms between M2 TAMs and canc...

    Authors: Li She, Yuexiang Qin, Juncheng Wang, Chao Liu, Gangcai Zhu, Guo Li, Ming Wei, Changhan Chen, Guancheng Liu, Diekuo Zhang, Xiyu Chen, Yunyun Wang, Yuanzheng Qiu, Yongquan Tian, Xin Zhang, Yong Liu…
    Citation: Cancer Cell International 2018 18:120
    Content type: Primary research Published on:
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Cancer Cell International

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