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  1. Content type: Primary research

    Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with target...

    Authors: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat and John Lunec

    Citation: Cancer Cell International 2019 19:53

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  2. Content type: Primary research

    Aberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by integrative bioinformat...

    Authors: Tong Lu, Di Chen, Yuanyong Wang, Xiao Sun, Shicheng Li, Shuncheng Miao, Yang Wo, Yanting Dong, Xiaoliang Leng, Wenxing Du and Wenjie Jiao

    Citation: Cancer Cell International 2019 19:52

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  3. Content type: Primary research

    Methylation plays a key role in the aetiology and pathogenesis of prostate cancer (PCa). This study aimed to identify aberrantly methylated differentially expressed genes (DEGs) and pathways in PCa and explore...

    Authors: Kai Wu, Xiaotao Yin, Yipeng Jin, Fangfang Liu and Jiangping Gao

    Citation: Cancer Cell International 2019 19:51

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  4. Content type: Primary research

    Prostate cancer (PCa) is a malignancy cause of cancer deaths and frequently diagnosed in male. This study aimed to identify tumor suppressor genes, hub genes and their pathways by combined bioinformatics analy...

    Authors: Yanqiu Tong, Yang Song and Shixiong Deng

    Citation: Cancer Cell International 2019 19:50

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  5. Content type: Primary research

    Hepatocyte nuclear factor 4α (HNF4α) is a tissue-specific transcription factor that regulates the expression of numerous genes in hepatocytes and pancreatic β cells. HNF4α has been reported to affect cell prol...

    Authors: Qiqing Sun, Wenyan Xu, Shunrong Ji, Yi Qin, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu and Xiaowu Xu

    Citation: Cancer Cell International 2019 19:49

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  6. Content type: Primary research

    Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin,...

    Authors: Pei-Ying Jin, Zi-Hui Zheng, Hong-Jie Lu, Jing Yan, Gui-Hong Zheng, Yuan-Lin Zheng, Dong-Mei Wu and Jun Lu

    Citation: Cancer Cell International 2019 19:48

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  7. Content type: Primary research

    Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense R...

    Authors: Dawei Jiang, Liu Xu, Jianqi Ni, Jie Zhang, Min Cai and Lan Shen

    Citation: Cancer Cell International 2019 19:47

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  8. Content type: Primary research

    Among breast cancer (BC) patients the outcomes of anticancer therapy vary dramatically due to the highly heterogeneous molecular characteristics of BC. Therefore, an extended panel of BC cell lines are require...

    Authors: Anna A. Nushtaeva, Anastasia A. Karpushina, Mikhail S. Ermakov, Ludmila F. Gulyaeva, Alexey V. Gerasimov, Sergey V. Sidorov, Tatyana A. Gayner, Anastasia Y. Yunusova, Anastasia V. Tkachenko, Vladimir A. Richter and Olga A. Koval

    Citation: Cancer Cell International 2019 19:46

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  9. Content type: Primary research

    The study purpose was to make investigation into the influence of XIST on cervical cancer progression and what’s more its potential mechanism.

    Authors: Xing Chen, Dongsheng Xiong, Liya Ye, Kai Wang, Lingfei Huang, Shuangshuang Mei, Jinhong Wu, Shanshan Chen, Xiaoli Lai, Lingzhi Zheng and Meifen Wang

    Citation: Cancer Cell International 2019 19:45

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  10. Content type: Primary research

    FOXD3 is aberrantly regulated in several tumors, but its underlying mechanisms in ovarian cancer (OC) remains largely unknown. The present study aimed to explore the role and associated mechanisms of FOXD3 in OC.

    Authors: Gui-fang Luo, Chang-ye Chen, Juan Wang, Hai-yan Yue, Yong Tian, Ping Yang, Yu-kun Li and Yan Li

    Citation: Cancer Cell International 2019 19:44

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  11. Content type: Primary research

    Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in man...

    Authors: Dongdong Wu, Zhengguo Liu, Jianmei Li, Qianqian Zhang, Peiyu Zhong, Tieshan Teng, Mingliang Chen, Zhongwen Xie, Ailing Ji and Yanzhang Li

    Citation: Cancer Cell International 2019 19:43

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  12. Content type: Primary research

    Human bladder cancer is one of the common malignant tumors, and it mainly occurs in men. miR-182-5p, a member of miR-183 family, acts as tumor suppressor or oncogene in various kinds of tumors. In this study, ...

    Authors: Fei Wang, Dinglan Wu, Zhanping Xu, Jianxiang Chen, Jiye Zhang, Xiaojuan Li, Shiliang Chen, Fengrong He, Jianbing Xu, Liangju Su, Defan Luo, Shufang Zhang and Weifu Wang

    Citation: Cancer Cell International 2019 19:42

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  13. Content type: Primary research

    Angiogenic factor with G-patch and FHA domain 1 (AGGF1), as a newly identified human angiogenic factor, is overexpressed in some types of malignant tumors and closely associated with patient’s prognosis. Howev...

    Authors: Han-Hui Yao, Ya-Jun Zhao, Yi-Fu He, Da-Bing Huang and Wei Wang

    Citation: Cancer Cell International 2019 19:41

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  14. Content type: Primary research

    The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs ...

    Authors: Qingmei Wang, Rongzhang He, Tan Tan, Jia Li, Zheng Hu, Weihao Luo, Lili Duan, Wenna Luo and Dixian Luo

    Citation: Cancer Cell International 2019 19:40

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  15. Content type: Primary research

    Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the expression pattern of Linc00959 in BC and to evaluate its bio...

    Authors: Weiru Chi, Sheng Huang, Bingqiu Xiu, Qi Zhang, Zhiming Shao, Jiong Wu and Yayun Chi

    Citation: Cancer Cell International 2019 19:39

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  16. Content type: Primary research

    The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need...

    Authors: Yang Chen, Zhong Chen, Ying Su, Donghong Lin, Min Chen, Shangyuan Feng and Changyan Zou

    Citation: Cancer Cell International 2019 19:37

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  17. Content type: Primary research

    Radiation therapy remains an important therapeutic modality, especially for those patients who are not candidates for radical resection. Many strategies have been developed to increase the radiosensitivity of ...

    Authors: Wen-Xiu Ding, Shu Liu, Jian-Xin Ma, Juan Pu, Hai-Jing Wang, Shu Zhang and Xin-chen Sun

    Citation: Cancer Cell International 2019 19:36

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  18. Content type: Primary research

    Voltage-gated sodium (NaV) channels are heteromeric proteins consisting of a single pore forming α-subunit associated with one or two auxiliary β-subunits. These channels are classically known for being responsib...

    Authors: Ana Laura Sanchez-Sandoval and Juan Carlos Gomora

    Citation: Cancer Cell International 2019 19:35

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  19. Content type: Primary research

    SLC25A22, a member of mitochondrial carrier system (MCS) family encoding a mitochondrial glutamate transporter, has been reported to have vital roles in promoting proliferation and migration in cancer. Gallbla...

    Authors: Pengcheng Du, Haibin Liang, Xiaowei Fu, Peng Wu, Chao Wang, Haimin Chen, Bingbing Zheng, Jun Zhang, Shuanghui Hu, Rengui Zeng, Bo Liang and Lu Fang

    Citation: Cancer Cell International 2019 19:33

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  20. Content type: Primary research

    Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a f...

    Authors: Yalu Liu, Xiaogan Wang, Lijuan Deng, Lingyan Ping, Yunfei Shi, Wen Zheng, Ningjing Lin, Xiaopei Wang, Meifeng Tu, Yan Xie, Weiping Liu, Zhitao Ying, Chen Zhang, Zhengying Pan, Xi Wang, Ning Ding…

    Citation: Cancer Cell International 2019 19:32

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  21. Content type: Primary research

    This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem ...

    Authors: Shuai Cao, Liangde Jiang, Lulu Shen and Zhizheng Xiong

    Citation: Cancer Cell International 2019 19:31

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  22. Content type: Correction

    Following publication of the original article [1], the authors notified us of an error in the spelling of second author’s name. The correct name spelling is Suad A. Telity.

    Authors: Abdel-Moneim M. Osman, Suad A. Telity, Zoheir A. Damanhouri, Sameer E. Al-Harthy, Huda M. Al-Kreathy, Wafaa S. Ramadan, Mohamed F. Elshal, Lateef M. Khan and Fatemah Kamel

    Citation: Cancer Cell International 2019 19:30

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    The original article was published in Cancer Cell International 2015 15:6

  23. Content type: Correction

    Following publication of the original article [1], the authors would like to make an amendment to the Acknowledgements section.

    Authors: Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2019 19:29

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    The original article was published in Cancer Cell International 2018 18:135

  24. Content type: Primary research

    Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain. Several studies have also suggested tha...

    Authors: Elie Akoury, Pouyan Ahangar, Antone Nour, Jacques Lapointe, Karl-Philippe Guérard, Lisbet Haglund, Derek H. Rosenzweig and Michael H. Weber

    Citation: Cancer Cell International 2019 19:28

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  25. Content type: Primary research

    Currently, cancer-related competing endogenous RNA (ceRNA) networks are attracting significant interest. As long noncoding RNA ZEB1-AS1 has been reported to function as an oncogene due to sponging microRNAs (m...

    Authors: Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang and Dong-Qiu Dai

    Citation: Cancer Cell International 2019 19:27

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    The Correction to this article has been published in Cancer Cell International 2019 19:95

  26. Content type: Primary research

    Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and int...

    Authors: Alexander H. Chung, Tina M. Leisner, Gabrielle J. Dardis, Marissa M. Bivins, Alana L. Keller and Leslie V. Parise

    Citation: Cancer Cell International 2019 19:26

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  27. Content type: Primary research

    Increasing studies indicated that circRNAs play critical roles in tumor progression. However, the roles and underlying mechanisms of circRNAs in gastric cancer (GC) remain largely unclear.

    Authors: Minghui Xue, Guangyan Li, Xiangjie Fang, Lili Wang, Yuhong Jin and Qinglan Zhou

    Citation: Cancer Cell International 2019 19:25

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  28. Content type: Primary research

    Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux and subsequent chronic inflammation are key causal facto...

    Authors: Ting Yuan, Zhen Ni, Chuan Han, Yali Min, Nina Sun, Caifang Liu, Miao Shi, Wenquan Lu, Na Wang, Feng Du, Qiong Wu, Ning Xie and Yongquan Shi

    Citation: Cancer Cell International 2019 19:24

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  29. Content type: Review

    Inflammatory breast cancer (IBC) is an infrequent but aggressive manifestation of breast cancer, which accounts for 2–4% of all breast cancer cases but responsible for 7–10% of breast cancer-related deaths, an...

    Authors: Yihang Qi, Xiangyu Wang, Xiangyi Kong, Jie Zhai, Yi Fang, Xiaoxiang Guan and Jing Wang

    Citation: Cancer Cell International 2019 19:23

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  30. Content type: Primary research

    Circulating tumor cells (CTCs) have been described as a population of cells that may seed metastasis, which is a reliable target for the prevention of metastases in lung cancer patients at the early stage. The...

    Authors: Zujun Que, Bin Luo, Zhiyi Zhou, Changsheng Dong, Yi Jiang, Lin Wang, Qihui Shi and Jianhui Tian

    Citation: Cancer Cell International 2019 19:21

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  31. Content type: Primary research

    Increasingly evidences suggest that long noncoding RNAs (lncRNAs) play important roles in various cancers. LncRNA PXN-AS1-L is recently revealed to act as on oncogene in liver cancer. However, the expression, ...

    Authors: Zhifa Zhang, Zhaohui Peng, Junying Cao, Jiaqi Wang, Yongyu Hao, Kai Song, Yan Wang, Wei Hu and Xuesong Zhang

    Citation: Cancer Cell International 2019 19:20

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  32. Content type: Primary research

    Incidence of endometrial cancer are rising both in the United States and worldwide. As endometrial cancer becomes more prominent, the need to develop and characterize biomarkers for early stage diagnosis and t...

    Authors: Michelle H. Townsend, Zac E. Ence, Abigail M. Felsted, Alyssa C. Parker, Stephen R. Piccolo, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2019 19:19

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  33. Content type: Primary research

    The mechanism of pancreatic cancer metastasis remains poorly understood. Recently, lncRNA CASC2 has been demonstrated to be a tumor suppressor in various types of cancer. This study aimed to explore the mechan...

    Authors: Hui Zhang, Xielin Feng, Mingyi Zhang, Aixiang Liu, Lang Tian, Wentao Bo, Haiqing Wang and Yong Hu

    Citation: Cancer Cell International 2019 19:18

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  34. Content type: Primary research

    In our previous study, we demonstrated that Sirtuin 6 (SIRT6) is upregulated and associated with papillary thyroid cancer (PTC) progression (Qu et al. in Int J Oncol 50(5):1683–92, 2017). This study examined whet...

    Authors: Zhou Yang, Weiping Yu, Renhong Huang, Min Ye and Zhijun Min

    Citation: Cancer Cell International 2019 19:17

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  35. Content type: Primary research

    Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment in clinically relevant in vitro tumor models is e...

    Authors: Styliani Melissaridou, Emilia Wiechec, Mustafa Magan, Mayur Vilas Jain, Man Ki Chung, Lovisa Farnebo and Karin Roberg

    Citation: Cancer Cell International 2019 19:16

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  36. Content type: Primary research

    Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mec...

    Authors: Junsheng Gu, Xiaorui Liu, Juan Li and Yuting He

    Citation: Cancer Cell International 2019 19:15

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  37. Content type: Correction

    Following publication of the original article [1], we have been notified that the data in Fig. 1 was wrongly presented. The correct Fig. 1 is presented below.

    Authors: Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou and Jian Li

    Citation: Cancer Cell International 2019 19:14

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    The original article was published in Cancer Cell International 2018 18:215

  38. Content type: Primary research

    Rosiglitazone metformin adduct (RZM) is a novel compound, synthesized from rosiglitazone (Ros) and metformin (Met) combined at a molar mass ratio of 1:1. Met and Ros are widely used together for treating type ...

    Authors: Yuyang Liu, Xiangnan Hu, Xuefeng Shan, Ke Chen and Hua Tang

    Citation: Cancer Cell International 2019 19:13

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  39. Content type: Review

    Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology essential for understanding gene function. CRISPR/Cas9 is a targeted genome-editing platform derived from ba...

    Authors: Debarati Ghosh, Prabhadevi Venkataramani, Saikat Nandi and Sonali Bhattacharjee

    Citation: Cancer Cell International 2019 19:12

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  40. Content type: Primary research

    Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case–control study aims to assess ...

    Authors: Zhijun Dai, Tian Tian, Meng Wang, Tielin Yang, Hongtao Li, Shuai Lin, Qian Hao, Peng Xu, Yujiao Deng, Linghui Zhou, Na Li and Yan Diao

    Citation: Cancer Cell International 2019 19:11

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  41. Content type: Primary research

    Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that t...

    Authors: Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Hannah Kim, Sylvia Bamford, Clara Salamanca, Gabriel DiMattia, Trevor Shepherd, Mattia Cremona, Bryan Hennessy, Shawn Anderson, Stanislav Volik, Colin C. Collins, David G. Huntsman and Mark S. Carey

    Citation: Cancer Cell International 2019 19:10

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  42. Content type: Primary research

    T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiolog...

    Authors: Yanfei Jia, Yan Qi, Yunshan Wang, Xiaoli Ma, Yihui Xu, Jun Wang, Xiaoqian Zhang, Meihua Gao, Beibei Cong and Shuyi Han

    Citation: Cancer Cell International 2019 19:9

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  43. Content type: Primary research

    Cervical carcinoma is a major gynecological cancer and causes cancer-related deaths in worldwide, the latent pathogenesis and progress of cervical cancer is still under research. ClC-3 may be an important prom...

    Authors: Yu-tao Guan, Yong Xie, Hui Zhou, Hai-yan Shi, Yu-yuan Zhu, Xiao-lu Zhang, Yi Luan, Xi-ming Shen, Yang-ping Chen, Li-jiang Xu, Zhong-qiu Lin and Gang Wang

    Citation: Cancer Cell International 2019 19:8

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  44. Content type: Primary research

    Gambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic ...

    Authors: Hongcheng Wang, Zhi Zhao, Shizhou Lei, Shaoli Li, Zhen Xiang, Xiaoyu Wang, Xiuyan Huang, Guanggai Xia and Xinyu Huang

    Citation: Cancer Cell International 2019 19:7

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  45. Content type: Primary research

    Many studies have aimed to clarify the relationship between Notch1 signaling and papillary thyroid carcinoma (PTC), but the results have been inconsistent to date. In the present study, a systematic review and...

    Authors: Libing Yuan, Lei Ma, Haibo Xue and Shoujun Song

    Citation: Cancer Cell International 2019 19:5

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  46. Content type: Primary research

    The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-med...

    Authors: Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu and Bin Liu

    Citation: Cancer Cell International 2019 19:4

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