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  1. Metastasis and disease refractoriness remain as major challenges for non-small cell lung cancer (NSCLC) treatment and understanding the underlying molecular mechanisms is of scientific and clinical value. Ther...

    Authors: Wenshu Chen, Guanying Zheng, Jianyuan Huang, Lihuan Zhu, Wujin Li, Tianxing Guo, Yangyun Huang and Xiaojie Pan

    Citation: Cancer Cell International 2021 21:111

    Content type: Primary research

    Published on:

  2. PR55α plays important roles in oncogenesis and progression of numerous malignancies. However, its role in hepatocellular carcinoma (HCC) is unclear. This study aims to characterize the functions of PR55α in HCC.

    Authors: JiangSheng Zhao, GuoFeng Chen, Jingqi Li, Shiqi Liu, Quan Jin, ZhengWei Zhang, Fuzhen Qi, JianHuai Zhang and JianBo Xu

    Citation: Cancer Cell International 2021 21:107

    Content type: Primary research

    Published on:

  3. SLC7A7 (solute carrier family 7, amino acid transporter light chain, y + L system, member 7) is a critical gene in the regulation of cationic amino acid transport. However, the relationships between SLC7A7 and...

    Authors: Wumin Dai, Jianguo Feng, Xiao Hu, Yongyi Chen, Qing Gu, Wangang Gong, Tingting Feng and Jie Wu

    Citation: Cancer Cell International 2021 21:106

    Content type: Primary research

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  4. Long intergenic non-protein coding RNA 00342 (LINC00342) has been identified as a novel oncogene. However, the functional role of LINC00342 in colorectal cancer (CRC) remains unclear.

    Authors: Peng Shen, Lili Qu, Jingjing Wang, Quchen Ding, Chuanwen Zhou, Rui Xie, Honggang Wang and Guozhong Ji

    Citation: Cancer Cell International 2021 21:105

    Content type: Primary research

    Published on:

  5. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s12935-021-01798-y

    Authors: Shaoqiang Cheng, Bingshu Xia, Hongbin Li, Yuying Li, Xinxin Lv, Yue Zhang and Yuanxi Huang

    Citation: Cancer Cell International 2021 21:104

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2020 20:321

  6. Glioma is the most prevalent malignant form of brain tumors, with a dismal prognosis. Currently, cancer immunotherapy has emerged as a revolutionary treatment for patients with advanced highly aggressive thera...

    Authors: Houshi Xu, Qingwei Zhu, Lan Tang, Junkun Jiang, Huiwen Yuan, Anke Zhang and Meiqing Lou

    Citation: Cancer Cell International 2021 21:103

    Content type: Primary research

    Published on:

  7. Glioblastoma is the most common primary malignant brain tumor. Because of the limited understanding of its pathogenesis, the prognosis of glioblastoma remains poor. This study was conducted to explore potentia...

    Authors: Kai Yu, Huan Yang, Qiao-li Lv, Li-chong Wang, Zi-long Tan, Zhe Zhang, Yu-long Ji, Qian-xia Lin, Jun-jun Chen, Wei He, Zhen Chen and Xiao-li Shen

    Citation: Cancer Cell International 2021 21:102

    Content type: Primary research

    Published on:

  8. The overall survival of metastatic colon adenocarcinoma (COAD) remains poor, so it is important to explore the mechanisms of metastasis and invasion. This study aimed to identify invasion-related genetic marke...

    Authors: Jiahua Liu, Chunhui Jiang, Chunjie Xu, Dongyang Wang, Yuguang Shen, Ye Liu and Lei Gu

    Citation: Cancer Cell International 2021 21:101

    Content type: Primary research

    Published on:

  9. The expansion and metastasis of colorectal cancers are closely associated with the dynamic growth of cancer stem cells (CSCs). This study aimed to explore the possible effect of LXR (a regulator of glycolysis ...

    Authors: Hassan Dianat-Moghadam, Mostafa Khalili, Mohsen Keshavarz, Mehdi Azizi, Hamed Hamishehkar, Reza Rahbarghazi and Mohammad Nouri

    Citation: Cancer Cell International 2021 21:100

    Content type: Primary research

    Published on:

  10. Hepatocellular carcinoma (HCC) is one of the most prevalent and inflammation-associated cancers. The tumor microenvironment (TME) plays an essential role in HCC development and metastasis, leading to poor pro...

    Authors: Yanan Peng, Chang Liu, Mengting Li, Wenjie Li, Mengna Zhang, Xiang Jiang, Ying Chang, Lan Liu, Fan Wang and Qiu Zhao

    Citation: Cancer Cell International 2021 21:98

    Content type: Primary research

    Published on:

  11. It has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans w...

    Authors: Yan Mei, Mingdian Wang, Guanming Lu, Jiangchao Li, Lixia Peng, Yanhong Lang, Mingming Yang, Lingbi Jiang, Changzhi Li, Lisheng Zheng, Zhijie Liu, Dehuan Xie, Lingling Guo, Bijun Huang, Musheng Zeng, Yanxia Shi…

    Citation: Cancer Cell International 2021 21:97

    Content type: Primary research

    Published on:

  12. Choroidal melanoma is the most common primary intraocular malignancy that occurs in adults. Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta. In thi...

    Authors: Qiuqiu Zhang, Qianwei Zhang, Huiyuan Li, Xiaofei Zhao and Han Zhang

    Citation: Cancer Cell International 2021 21:96

    Content type: Primary research

    Published on:

  13. Increasing evidence has shown that cytolytic activity (CYT) is a new immunotherapy biomarker that characterises the antitumour immune activity of cytotoxic T cells and macrophages. In this study, we establishe...

    Authors: Xiaoye Jiang, Zhongxiang Jiang, Lichun Xiang, Xuenuo Chen, Jiao Wu and Zheng Jiang

    Citation: Cancer Cell International 2021 21:95

    Content type: Primary research

    Published on:

  14. Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with stem cell property. Increased evidence suggest that CSCs could be responsible for chemoresistance and recurrence in colorectal can...

    Authors: Zhao-liang Yu, Yu-feng Chen, Bin Zheng, Ze-rong Cai, Yi-feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao-jian

    Citation: Cancer Cell International 2021 21:94

    Content type: Primary research

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  15. Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma,...

    Authors: Yin Luo, Yitong Liu, Chengkun Wang and Runliang Gan

    Citation: Cancer Cell International 2021 21:93

    Content type: Review

    Published on:

  16. For patients with hepatocellular carcinoma (HCC) with microvascular invasion (MVI) after curative resection, the effects of various postoperative adjuvant therapies are not summarized in detail, and the compar...

    Authors: Jiarui Yang, Hao Liang, Kunpeng Hu, Zhiyong Xiong, Mingbo Cao, Zhaozhong Zhong, Zhicheng Yao and Meihai Deng

    Citation: Cancer Cell International 2021 21:92

    Content type: Review

    Published on:

  17. Exosomes are known to transmit microRNAs (miRNAs) to affect cancer progression, while the role of M2 macrophages-derived exosomes (M2 exosomes) conveying miR-501-3p in lung cancer (LC) remains unknown. We aim ...

    Authors: Jie Lei, Peng Chen, Feng Zhang, Na Zhang, Jianfei Zhu, Xiaoping Wang and Tao Jiang

    Citation: Cancer Cell International 2021 21:91

    Content type: Primary research

    Published on:

  18. Osteosarcoma is one of the most prevalent primary bone tumours in adolescents. Accumulating evidence shows that aberrant expression of the long non-coding RNA (lncRNA) NEAT1 and microRNA-483 (miR-483) contribu...

    Authors: Yan Chen, Jun Li, Jia-Kun Xiao, Lei Xiao, Bin-Wu Xu and Chen Li

    Citation: Cancer Cell International 2021 21:90

    Content type: Primary research

    Published on:

  19. MicroRNAs are a class of non-coding RNAs that regulate gene expression through binding to mRNAs and preventing their translation. One family of microRNAs known as the miR-200 family is an important regulator o...

    Authors: K. Simpson, G. Conquer-van Heumen, K. L. Watson, M. Roth, C. J. Martin and R. A. Moorehead

    Citation: Cancer Cell International 2021 21:89

    Content type: Primary research

    Published on:

  20. Utrophin (UTRN), as a tumor suppressor gene, is involved in various cancer progression. The function of UTRN in the melanoma process and the related molecular mechanisms are still unclear. Herein, we studied the ...

    Authors: Sitong Zhou, Wen Ouyang, Xi Zhang, Lexi Liao, Xiaobing Pi, Ronghua Yang, Baiqiang Mei, Huaiyuan Xu, Shijian Xiang and Jiehua Li

    Citation: Cancer Cell International 2021 21:88

    Content type: Primary research

    Published on:

  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen

    Citation: Cancer Cell International 2021 21:86

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:72

  22. Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel th...

    Authors: Ke-Tao Jin, Bo Chen, Yu-Yao Liu, H uan-Rong Lan and Jie-Ping Yan

    Citation: Cancer Cell International 2021 21:83

    Content type: Review

    Published on:

  23. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01786-2

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Joygopal Roy, Sukumar Maity, Indranil Kulavi and Mahitosh Mandal

    Citation: Cancer Cell International 2021 21:82

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2015 15:74

  24. Liver cancer (LC) is one of the most fatal cancers throughout the world. More efficient and sensitive gene signatures that could accurately predict survival in LC patients are vitally needed to promote a bette...

    Authors: Wenjing Zhu, Qiliang Zhang, Min Liu, Meixing Yan, Xiao Chu and Yongchun Li

    Citation: Cancer Cell International 2021 21:81

    Content type: Primary research

    Published on:

  25. UCEC is the most common gynecological malignancy in many countries, and its mechanism of occurrence and development is related to tumor mutation burden (TMB) and immune cell infiltration. Therefore, it is nece...

    Authors: Ling Zhao, Xueshu Fu, Xiling Han, Yanjun Yu, Yaping Ye and Jun Gao

    Citation: Cancer Cell International 2021 21:80

    Content type: Primary research

    Published on:

  26. Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs...

    Authors: Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Muhammad Naeem Shahwani, Asma Irshad, Shahid Raza, Bahare Salehi, Javad Sharifi-Rad, Hafiz A. R. Suleria, Natália Cruz-Martins and Cristina Quispe

    Citation: Cancer Cell International 2021 21:77

    Content type: Review

    Published on:

  27. Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months. The current standard treatm...

    Authors: Xin Xu, Wenli Chen, Wenjun Zhu, Jing Chen, Bin Ma, Jianxia Ding, Zaichuan Wang, Yifei Li, Yeming Wang and Xiaochun Zhang

    Citation: Cancer Cell International 2021 21:76

    Content type: Review

    Published on:

  28. The regulator of cullins-1 (ROC1) is an essential subunit in the cullin-RING ligase (CRL) protein complex and has been shown to be critical in bladder cancer cell survival and progression. This study aimed to ...

    Authors: W. Wang, J. Qiu, P. Qu, H. Chen, J. Lan, H. Chen, L. Li and M. Gu

    Citation: Cancer Cell International 2021 21:75

    Content type: Primary research

    Published on:

  29. Lung cancer is one of the important health threats worldwide, of which 5-year survival rate is less than 15%. Non-small-cell lung cancer (NSCLC) accounts for about 80% of all lung cancer with high metastasis a...

    Authors: Yuxin Qi, Wenping Yang, Shuang Liu, Fanjie Han, Haibin Wang, Yonghong Zhao, Yufa Zhou and Daijun Zhou

    Citation: Cancer Cell International 2021 21:74

    Content type: Primary research

    Published on:

  30. Non-small cell lung cancer (NSCLC) is a threat to human health. Circular RNAs (circRNAs) have been proved to function in NSCLC development. In this study, the role of circRNA hsa_circ_0010235 in NSCLC progress...

    Authors: Furui Zhang, Ruirui Cheng, Ping Li, Chunya Lu and Guojun Zhang

    Citation: Cancer Cell International 2021 21:73

    Content type: Primary research

    Published on:

  31. The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mech...

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen

    Citation: Cancer Cell International 2021 21:72

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:86

  32. Recent studies have established the roles of microRNAs (miRNAs) in cancer progression. The aberrant expression of miR-335-5p has been reported in many cancers, including gastric cancer (GC). In this study, the...

    Authors: Yi Gao, Yanfeng Wang, Xiaofei Wang, Changan Zhao, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yun Feng, Dan Li, Jing Yan, Yan Yao, Weihong Hu, Ruxin Ding, Mengjie Zhang, Lumin Wang…

    Citation: Cancer Cell International 2021 21:71

    Content type: Primary research

    Published on:

  33. Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.

    Authors: Baocheng Zhu, Hengguan Cui and Weiqiang Xu

    Citation: Cancer Cell International 2021 21:70

    Content type: Primary research

    Published on:

  34. Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1...

    Authors: Annie Cristhine Moraes Sousa-Squiavinato, Renata Ivo Vasconcelos, Adriana Sartorio Gehren, Priscila Valverde Fernandes, Ivanir Martins de Oliveira, Mariana Boroni and Jose Andrés Morgado-Díaz

    Citation: Cancer Cell International 2021 21:69

    Content type: Primary research

    Published on:

  35. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) could interact with each other to play a vital role in the pathogenesis of cancers. We aimed to examine the expression profile, clinical significance and r...

    Authors: Jingjing Jing, Xu Zhao, Jiannan Wang and Tan Li

    Citation: Cancer Cell International 2021 21:68

    Content type: Primary research

    Published on:

  36. Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleol...

    Authors: Rui Feng, Zhongxing Li, Xing Wang, Guangcheng Ge, Yuejun Jia, Dan Wu, Yali Ji and Chenghao Wang

    Citation: Cancer Cell International 2021 21:67

    Content type: Primary research

    Published on:

  37. Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increa...

    Authors: Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian

    Citation: Cancer Cell International 2021 21:66

    Content type: Review

    Published on:

  38. Lung cancer is the most common malignant tumor. Identification of novel diagnostic and prognostic biomarkers for lung cancer is a key research imperative. The role of centromere protein K (CENPK) in cancer is ...

    Authors: Jiayu Ma, Xiaochuan Chen, Mingqiang Lin, Zhiping Wang, Yahua Wu and Jiancheng Li

    Citation: Cancer Cell International 2021 21:65

    Content type: Primary research

    Published on:

  39. Hedgehog (Hh) signaling pathway, which is essential for cell proliferation and differentiation, is noted to be aberrantly activated in tumor from increasing studies in recent years. MicroRNAs (miRNAs) as an im...

    Authors: Jiong Ma, Chunxia Zhou and Xuejun Chen

    Citation: Cancer Cell International 2021 21:64

    Content type: Primary research

    Published on:

  40. Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels suppl...

    Authors: Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi and Mostafa Manian

    Citation: Cancer Cell International 2021 21:62

    Content type: Review

    Published on:

  41. Studies have shown the value of subtypes and distribution of gastric intestinal metaplasia (GIM) for prediction of gastric cancer. We aim to combine GIM subtypes and distribution to form a new scoring system f...

    Authors: Ning Wei, Zhiheng Zhong and Ruihua Shi

    Citation: Cancer Cell International 2021 21:61

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:132

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