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  1. Several studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression. Nevertheless, the potential effects of m6A modifications in the tumor ...

    Authors: Hao Xu, Lu Yin, Qianhui Xu, Jingjing Xiang and Rujun Xu
    Citation: Cancer Cell International 2022 22:199
  2. Non-small cell lung cancer (NSCLC), the most primary lung cancer subtype, threatens human health globally. Long non-coding RNAs (lncRNAs) have been uncovered to affect multiple cancers progression. Nevertheles...

    Authors: Shangxiao Huang, Shixiong Liang, Jianfeng Huang, Penghui Luo, Dunchang Mo and Hanlei Wang
    Citation: Cancer Cell International 2022 22:198
  3. This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2...

    Authors: Jia-fu Feng, Jun Wang, Gang Xie, Yao-dong Wang, Xiao-han Li, Wen-yu Yang, Yu-wei Yang and Bin Zhang
    Citation: Cancer Cell International 2022 22:197
  4. Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (...

    Authors: Masoumeh Sharifi-Azad, Marziyeh Fathi, William C. Cho, Abolfazl Barzegari, Hamed Dadashi, Mehdi Dadashpour and Rana Jahanban-Esfahlan
    Citation: Cancer Cell International 2022 22:196
  5. Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes. Diffe...

    Authors: Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao and Hua Zhong
    Citation: Cancer Cell International 2022 22:195
  6. DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes e...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:194
  7. To screen and verify differential genes affecting the prognosis of breast cancer.

    Authors: Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu and Wencui Li
    Citation: Cancer Cell International 2022 22:193
  8. In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA ex...

    Authors: Nicole Huge, Thea Reinkens, Reena Buurman, Maria Sandbothe, Anke Bergmann, Hannah Wallaschek, Beate Vajen, Amelie Stalke, Melanie Decker, Marlies Eilers, Vera Schäffer, Oliver Dittrich-Breiholz, Engin Gürlevik, Florian Kühnel, Brigitte Schlegelberger, Thomas Illig…
    Citation: Cancer Cell International 2022 22:192
  9. Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal di...

    Authors: Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang and Yuxia Fan
    Citation: Cancer Cell International 2022 22:191
  10. Extracellular vesicles secreted by tumor microenvironment (TME) cells are vital players in tumor progression through transferring nucleic acids and proteins. Macrophages are the main immune cells in TME and tu...

    Authors: Wen-Xiu Xu, Dan-Dan Wang, Zhi-Qiang Zhao, He-Da Zhang, Su-Jin Yang, Qian Zhang, Lei Li and Jian Zhang
    Citation: Cancer Cell International 2022 22:190
  11. Inositol Polyphosphate-5-Phosphatase B (INPP5B), a inositol 5-phosphatase, plays an important role in many biological processes through phosphorylating PI(4,5)P2 and/or PI(3,4,5)P3 at the 5-position. Nevertheless...

    Authors: Jun Deng, Xu Lin, Qi Li, Xiao-yu Cai, Lin-wen Wu, Wei Wang, Bo Zhang, Yang-ling Li, Jian Hu and Neng-ming Lin
    Citation: Cancer Cell International 2022 22:189
  12. Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. Although previous studies have shown that ANLN is related to carcinogenesis, no pan-...

    Authors: Yanlong Shi, Xinyu Ma, Menglu Wang, Sheng Lan, Haokun Jian, Yue Wang, Qian Wei and Fei Zhong
    Citation: Cancer Cell International 2022 22:188
  13. The interaction between tumor cells and tumor microenvironment (TME) has an important impact on progression and prognosis of multiple myeloma (MM), and has been proven to be promising therapeutic targets. This...

    Authors: Huizhong Wang, Ruonan Shao, Wenjian Liu, Shumei Peng, Shenrui Bai, Bibo Fu, Congling Zhao and Yue Lu
    Citation: Cancer Cell International 2022 22:187
  14. Immune checkpoint inhibitors (ICIs) have made important breakthrough in anti-tumor therapy, however, no single biomarker can accurately predict their efficacy. Studies have found that tumor microenvironment is...

    Authors: Wenqin Feng, Anqi Lin, Le Sun, Ting Wei, Haoxuan Ying, Jian Zhang, Peng Luo and Weiliang Zhu
    Citation: Cancer Cell International 2022 22:186
  15. Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study focused on identifying targets that affect the multifocality of PTC. In a pr...

    Authors: Ga Hyun Kim, Hye Jin Heo, Ji Wan Kang, Eun-Kyung Kim, Seung Eun Baek, Keunyoung Kim, In Joo Kim, Sunghwan Suh, Byung-Joo Lee, Yun Hak Kim and Kyoungjune Pak
    Citation: Cancer Cell International 2022 22:185
  16. Breast cancer (BC) is one of the most prevalent malignancies among women globally. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are associated with BC carcinogenesis. In the current study, w...

    Authors: Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li and Ying Wang
    Citation: Cancer Cell International 2022 22:184
  17. Tetraspanins are members of the 4-transmembrane protein superfamily (TM4SF) that function by recruiting many cell surface receptors and signaling proteins into tetraspanin-enriched microdomains (TEMs) that pla...

    Authors: Shijie Shao, Lianhua Piao, Liwei Guo, Jiangsong Wang, Luhui Wang, Jiawen Wang, Lei Tong, Xiaofeng Yuan, Junke Zhu, Sheng Fang and Yimin Wang
    Citation: Cancer Cell International 2022 22:183
  18. Long noncoding RNAs (lncRNAs) are emerging as master regulators for gene expression and thus play a vital role in human tumorigenesis and progression. But the involvement of novel lncRNAs in non-small cell lun...

    Authors: Wei Gong, Yinyan Li, Jianfeng Xian, Lei Yang, Yuanyuan Wang, Xin Zhang, Yifeng Zhou, Xinhua Wang, Guibin Qiao, Cuiyi Chen, Soham Datta, Xincheng Gao, Jiachun Lu and Fuman Qiu
    Citation: Cancer Cell International 2022 22:181
  19. Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. However, the link between immunodeficiency and prostate cancer progressi...

    Authors: Chia-Yang Li, Shu-Pin Huang, Yei-Tsung Chen, Hsin-En Wu, Wei-Chung Cheng, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Jiun-Hung Geng, Te-Ling Lu and Bo-Ying Bao
    Citation: Cancer Cell International 2022 22:180
  20. Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family of transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on the type and genetic...

    Authors: Junqiang Liu, Zhiyuan Chou, Chun Li, Kai Huang, Xuejian Wang, Xiunan Li, Chuanchun Han, Abdullah Al-Danakh, Xiaodong Li and Xishuang Song
    Citation: Cancer Cell International 2022 22:179
  21. Breast cancer is notorious for its increasing incidence for decades. Ascending evidence has demonstrated that translocase of inner mitochondrial membrane (TIMM) proteins play vital roles in progression of seve...

    Authors: Zhonglin Wang, Shuqin Li, Feng Xu, Jingyue Fu, Jie Sun, XinLi Gan, Chuang Yang and Zhongqi Mao
    Citation: Cancer Cell International 2022 22:177
  22. Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis. Other important etiologies ...

    Authors: Faezeh Malakoti, Niloufar Targhazeh, Erfan Abadifard, Reza Zarezadeh, Sahar Samemaleki, Zatollah Asemi, Simin Younesi, Reza Mohammadnejad, Seyed Hadi Hossini, Ansar Karimian, Forough Alemi and Bahman Yousefi
    Citation: Cancer Cell International 2022 22:176
  23. Epithelial ovarian cancer (EOC) is an aggressive and lethal malignancy and novel EOC cell lines with detailed characterization are needed, to provide researchers with diverse helpful resources to study EOC bio...

    Authors: Fernanda Silva, Filipa Coelho, Ana Peixoto, Pedro Pinto, Carmo Martins, Ann-Sophie Frombach, Vítor E. Santo, Catarina Brito, António Guimarães and Ana Félix
    Citation: Cancer Cell International 2022 22:175
  24. FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived ped...

    Authors: Flora Cimmino, Annalaura Montella, Matilde Tirelli, Marianna Avitabile, Vito Alessandro Lasorsa, Feliciano Visconte, Sueva Cantalupo, Teresa Maiorino, Biagio De Angelis, Martina Morini, Aurora Castellano, Franco Locatelli, Mario Capasso and Achille Iolascon
    Citation: Cancer Cell International 2022 22:174
  25. The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. ...

    Authors: Anqi Lin, Ningning Zhou, Weiliang Zhu, Jiexia Zhang, Ting Wei, Linlang Guo, Peng Luo and Jian Zhang
    Citation: Cancer Cell International 2022 22:173
  26. Ovarian cancer is a female malignancy with high fatality-to-case ratio, which is due to late detection of cancer. Understanding the molecular mechanisms participating in these processes would facilitate design...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Majid Samsami
    Citation: Cancer Cell International 2022 22:172
  27. G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations. Predicted G-quadrup...

    Authors: Soudeh Ghafouri-Fard, Atefe Abak, Aria Baniahmad, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali and Marcel E. Dinger
    Citation: Cancer Cell International 2022 22:171
  28. Gliomas are the most common primary malignant tumours of the central nervous system (CNS). To improve the prognosis of glioma, it is necessary to identify molecular markers that may be useful for glioma therap...

    Authors: Hui Huang, Zhengyuan Huo, Jiantong Jiao, Wei Ji, Jin Huang, Zheng Bian, Bin Xu, Junfei Shao and Jun Sun
    Citation: Cancer Cell International 2022 22:170
  29. Chondrogenesis is the formation of chondrocytes and cartilage tissues and starts with mesenchymal stem cell (MSC) recruitment and migration, condensation of progenitors, chondrocyte differentiation, and matura...

    Authors: Xiaohui Yang, Shifeng Tian, Linlin Fan, Rui Niu, Man Yan, Shuo Chen, Minying Zheng and Shiwu Zhang
    Citation: Cancer Cell International 2022 22:169
  30. Chimeric antigen receptor (CAR) T-cell therapy is a promising and rapidly expanding therapeutic option for a wide range of human malignancies. Despite the ongoing progress of CAR T-cell therapy in hematologic ...

    Authors: Amirhossein Mardi, Anastasia V. Shirokova, Rebar N. Mohammed, Ali Keshavarz, Angelina O. Zekiy, Lakshmi Thangavelu, Talar Ahmad Merza Mohamad, Faroogh Marofi, Navid Shomali, Amir Zamani and Morteza Akbari
    Citation: Cancer Cell International 2022 22:168
  31. Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of metabolism and angiogenesis,...

    Authors: Bing Feng, Jianzhong Wu, Bo Shen, Feng Jiang and Jifeng Feng
    Citation: Cancer Cell International 2022 22:166
  32. Novel strategies are required since the hypoxic tumor microenvironment is one of the important impediments for conventional cancer therapy. High mobility group box 1 (HMGB1) protein can block aerobic respirati...

    Authors: Sara Shayan, Arash Arashkia, Golnaz Bahramali, Asghar Abdoli, Mohammad Sadegh Shams Nosrati and Kayhan Azadmanesh
    Citation: Cancer Cell International 2022 22:164
  33. Delayed cancer diagnosis and inefficient cancer prognosis determination are problems faced in cancer diagnosis and treatment. MicroRNAs (miRs), especially miR-212, have shown a promise in cancer diagnosis and ...

    Authors: Sara Raji, Mehrdad Sahranavard, Mahdi Mottaghi and Amirhossein Sahebkar
    Citation: Cancer Cell International 2022 22:163
  34. Piezo1 has been revealed to play a regulatory role in vascular development and progression of variety tumors. However, whether and how the progression of hepatocellular carcinoma (HCC) regulated by Piezo1 rema...

    Authors: Yi-ming Li, Cong Xu, Bo Sun, Fang-jing Zhong, Momo Cao and Lian-yue Yang
    Citation: Cancer Cell International 2022 22:162
  35. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type worldwide. Deregulation of mRNA translation is a frequent feature of cancer. Eukaryotic translation initiation factor 3 subuni...

    Authors: Chengzhi Xu, Yupeng Shen, Yong Shi, Ming Zhang and Liang Zhou
    Citation: Cancer Cell International 2022 22:161
  36. Several nervous and nerve-related biomarkers have been detected in colorectal cancer (CRC) and can contribute to the progression of CRC. However, the role of leucine-rich repeat neuronal 4 (LRRN4), a recently ...

    Authors: Cheng Xu, Yulin Chen, Feiwu Long, Junman Ye, Xue Li, Qiaorong Huang, Dejiao Yao, Xiaoli Wang, Jin Zhao, Wentong Meng, Xianming Mo, Ran Lu, Chuanwen Fan and Tao Zhang
    Citation: Cancer Cell International 2022 22:158
  37. Tumour angiogenesis is an independent risk factor for bladder urothelial carcinoma (BUC) progression, but viable and promising antiangiogenic targets are understudied. Emerging evidence suggests that long non-...

    Authors: Xinyuan Li, Chunlin Zhang, Xiang Peng, Yang Li, Guo Chen, Xin Gou, Xiang Zhou and Chao Ma
    Citation: Cancer Cell International 2022 22:157
  38. The glycoprotein alpha-1-antichymotrypsin (AACT), a serine protease inhibitor, is mainly synthesized in the liver and then secreted into the blood and is involved in the acute phase response, inflammation, and...

    Authors: Yanxia Jin, Weidong Wang, Qiyun Wang, Yueyang Zhang, Kashif Rafiq Zahid, Umar Raza and Yongsheng Gong
    Citation: Cancer Cell International 2022 22:156
  39. The tumor microenvironment contributes to tumor initiation, growth, invasion, and metastasis. The tumor microenvironment is heterogeneous in cellular and acellular components, particularly structural features ...

    Authors: Hailan Yan, Jinghua Shi, Yi Dai, Xiaoyan Li, Yushi Wu, Jing Zhang, Zhiyue Gu, Chenyu Zhang and Jinhua Leng
    Citation: Cancer Cell International 2022 22:155
  40. Gastritis is a superficial and prevalent inflammatory lesion that is considered a public health concern once can cause gastric ulcers and gastric cancer, especially when associated with Helicobacter pylori infect...

    Authors: Ana Maria Oliveira Ferreira da Mata, Marcia Fernanda Correia Jardim Paz, Ag-Anne Pereira Melo de Menezes, Antonielly Campinho dos Reis, Bruna da Silva Souza, Carlos Dimas de Carvalho Sousa, Sônia Alves Machado, Thiago Soares Gondim Medeiros, Chandan Sarkar, Muhammad Torequl Islam, Javad Sharifi-Rad, Sevgi Durna Daştan, Mohammed M. Alshehri, João Marcelo de Castro e Sousa and Ana Amélia de Carvalho Melo Cavalcante
    Citation: Cancer Cell International 2022 22:154
  41. Growing evidence has indicated that tumor-associated macrophages (TAMs) promote tumor angiogenesis. However, the mechanisms underlying the pro-angiogenic switch of TAMs remains unclear. Here, we examined how e...

    Authors: Yuwei Shou, Xiaoqian Wang, Chao Chen, Yinghao Liang, Chenbo Yang, Qiankun Xiao, Hui Li, Shuaiyuan Wang, Jiao Shu, Xiangyu Tian and Kuisheng Chen
    Citation: Cancer Cell International 2022 22:153
  42. Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. MicroRNAs (miRNAs) negatively regulate gene expression post-transcriptionally by binding to the 3'–untrans...

    Authors: Huihui Wang, Shubing Zhang, Tao Li, Lianzi Wang, Wei Lv, Shanshan Wang, Dongyue Ma, Yan Zang, Xinyue Zhu, Yuanhong Xu, Lan Zheng, Jilong Shen and Wei Wei
    Citation: Cancer Cell International 2022 22:149
  43. Ovarian cancer is a common gynecological disease and seriously endangers women's health. Currently, there is still a lack of effective molecular markers for the diagnosis and treatment of ovarian cancer. The p...

    Authors: Wang Xiaowei, Lu Tong, Qu Yanjun and Fan Lili
    Citation: Cancer Cell International 2022 22:148

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