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  1. Patient-derived organoids (PDO) have been proposed as a novel in vitro method of drug screening for different types of cancer. However, to date, extrahepatic biliary tract carcinoma (eBTC) PDOs have not yet be...

    Authors: Zhiwei Wang, Yinghao Guo, Yun Jin, Xiaoxiao Zhang, Hao Geng, Guangyuan Xie, Dan Ye, Yuanquan Yu, Daren Liu, Donger Zhou, Baizhou Li, Yan Luo, Shuyou Peng and Jiangtao Li

    Citation: Cancer Cell International 2021 21:519

    Content type: Primary research

    Published on:

  2. There is a lack of effective treatments for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). Furthermore, the response rate of NPC patients to programmed death 1 (PD-1) inhibitors is approximately 20...

    Authors: Ao Zhang, Guanqing Zhong, Luocan Wang, Rongzeng Cai, Runkun Han, Caixia Xu, Shulin Chen, Peng Sun and Hao Chen

    Citation: Cancer Cell International 2021 21:518

    Content type: Primary research

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  3. The gamma-glutamyl transferase (GGT) to alanine aminotransferase (ALT) ratio has been reported as an effective predictor of the severity of hepatitis and HCC. The purpose of this study was to determine the rol...

    Authors: Zhifeng Zhao, Yiming Zhu, Xiaochun Ni, Jiayun Lin, Hongjie Li, Lei Zheng, Chihao Zhang, Xiaoliang Qi, Haizhong Huo, Xiaolou Lou, Qiang Fan, Yongyang Bao and Meng Luo

    Citation: Cancer Cell International 2021 21:517

    Content type: Primary research

    Published on:

  4. The WNT gene family plays an important role in the occurrence and development of malignant tumors, but its involvement has not been systematically analyzed in uterine corpus endometrial carcinoma (UCEC). This ...

    Authors: Yuexin Hu, Mingjun Zheng, Dandan Zhang, Rui Gou, Ouxuan Liu, Shuang Wang and Bei Lin

    Citation: Cancer Cell International 2021 21:516

    Content type: Primary research

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  5. DNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting. In mammals, DNA methylation is achieved by DNA methyltransferases (DNMT...

    Authors: Ramesh Elango, Radhakrishnan Vishnubalaji, Hibah Shaath and Nehad M. Alajez

    Citation: Cancer Cell International 2021 21:515

    Content type: Primary research

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  6. ALDOA is a glycolytic enzyme found mainly in developing embryos, adult muscle and various malignant tumours, including pancreatic tumours. Our previous study revealed that ALDOA, an oncogene, can promote the p...

    Authors: Haidi Chen, Zeng Ye, Xiaowu Xu, Yi Qin, Changfeng Song, Guixiong Fan, Haifeng Hu, Yuheng Hu, Xianjun Yu, Wensheng Liu, Shunrong Ji and Wenyan Xu

    Citation: Cancer Cell International 2021 21:514

    Content type: Primary research

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  7. Unilateral breast cancer (UBC) patients with germline pathogenic BRCA1/2 variants have a higher risk of developing contralateral breast cancer (CBC) and need contralateral risk-reducing local treatments, includin...

    Authors: Ziqi Jia, Jiaxin Li, Yuelun Zhang, Xin Wang, Jiahua Xing, Zeyu Xing, Xin Huang, Gang Liu, Menglu Zhang, Kexin Feng, Jiang Wu, Wenyan Wang, Jie Wang, Jiaqi Liu and Xiang Wang

    Citation: Cancer Cell International 2021 21:512

    Content type: Review

    Published on:

  8. The development of multiple myeloma (MM) is considered to involve a multistep transformation process, but the role of cytogenetic abnormalities and molecular alterations in determining the cell fate of multipl...

    Authors: Zhiyong Zeng, Junfang Lin, Kejie Zhang, Xizhe Guo, Xiaoqiang Zheng, Apeng Yang and Junmin Chen

    Citation: Cancer Cell International 2021 21:511

    Content type: Primary research

    Published on:

  9. Chordomas are rare, slow-growing and locally aggressive bone sarcomas. At present, chordomas are difficult to manage due to their high recurrence rate, metastasis tendency and poor prognosis. The underlying me...

    Authors: Wanqiong Yuan, Feng Wei, Hanqiang Ouyang, Xiaoqing Ren, Jing Hang, Xiaoning Mo and Zhongjun Liu

    Citation: Cancer Cell International 2021 21:510

    Content type: Primary research

    Published on:

  10. Our previous bioinformatics-based study found that midkine (MDK) was associated with poor prognosis of glioblastoma (GBM). However, the mechanism of MDK in GBM remains elusive.

    Authors: Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei and Donghua Zou

    Citation: Cancer Cell International 2021 21:509

    Content type: Primary research

    Published on:

  11. Glioblastomas (GBMs) are grade IV central nervous system tumors characterized by a poor prognosis and a short median overall survival. Effective induction of GBM cell death is difficult because the GBM cell po...

    Authors: Tingzheng Pan, Xuetao Li, Yanyan Li, Zhennan Tao, Hui Yao, Yue Wu, Guangliang Chen, Kai Zhang, Youxin Zhou and Yulun Huang

    Citation: Cancer Cell International 2021 21:508

    Content type: Primary research

    Published on:

  12. The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. H...

    Authors: R. Daniel Bonfil, Wei Chen, Semir Vranic, Anjum Sohail, Dongping Shi, Hyejeong Jang, Hyeong-Reh Kim, Marco Prunotto and Rafael Fridman

    Citation: Cancer Cell International 2021 21:507

    Content type: Primary research

    Published on:

  13. O6-methylguanine-DNA methyltransferase (MGMT) is a pivotal enzyme for repairing DNA alkylation damage. Epigenetic modification of MGMT has been well known as a promising prognostic biomarker for glioma. However, ...

    Authors: Liming Huang, Wenshen Xu, Danfang Yan, Xi Shi, Xin You, Jiaqi Xu, Pingping You, Yuanyuan Ke and Lian Dai

    Citation: Cancer Cell International 2021 21:506

    Content type: Primary research

    Published on:

  14. Colorectal cancer (CC) is one of the major contributors to tumor-related death worldwide, and its main cause of death is distant metastasis. Dysregulation of long non-coding RNA (lncRNA) LINC01605 has been imp...

    Authors: Meng Yue, Tao Liu, Guoqiang Yan, Xiaofan Luo and Lei Wang

    Citation: Cancer Cell International 2021 21:504

    Content type: Primary research

    Published on:

  15. Exosomes are a promising tool in disease detection because they are noninvasive, cost-effective, sensitive and stable in body fluids. MicroRNAs (miRNAs) are the main exosomal component and participate in tumor...

    Authors: Yeye Guo, Xu Zhang, Linconghua Wang, Min Li, Minxue Shen, Zhe Zhou, Susi Zhu, Keke Li, Zhiqin Fang, Bei Yan, Shuang Zhao, Juan Su, Xiang Chen and Cong Peng

    Citation: Cancer Cell International 2021 21:487

    Content type: Primary research

    Published on:

  16. The benefit of targeted therapy for renal cell carcinoma (RCC) is largely crippled by drug resistance. Rapid disease progression and poor prognosis occur in patients with drug resistance. New treatments demand...

    Authors: Xiu-wu Pan, Da Xu, Wen-jin Chen, Jia-xin Chen, Wei-jie Chen, Jian-qing Ye, Si-shun Gan, Wang Zhou, Xu Song, Lei Shi and Xin-gang Cui

    Citation: Cancer Cell International 2021 21:486

    Content type: Primary research

    Published on:

  17. Lenvatinib and lenvatinib-based combination treatments are widely used in patients with unresectable hepatocellular carcinoma (uHCC) in clinical practice, but their curative effect and safety need further stud...

    Authors: Yun Zhu, Penghui Sun, Kunyuan Wang, Shuzhe Xiao, Yanling Cheng, Xiangzhao Li, Biao Wang, Jiancong Li, Wenxuan Yu and Yang Cheng

    Citation: Cancer Cell International 2021 21:503

    Content type: Primary research

    Published on:

  18. Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs (tRNA-derived stress-induced RNA), an emerging category of regulatory RNA molecules derived from transfer RNAs (tRNAs)...

    Authors: Yongqiang Zhou, Jinjing Hu, Lu Liu, Mengchao Yan, Qiyu Zhang, Xiaojing Song, Yan Lin, Dan Zhu, Yongjian Wei, Zongli Fu, Liming Hu, Yue Chen and Xun Li

    Citation: Cancer Cell International 2021 21:502

    Content type: Primary research

    Published on:

  19. Recent reports suggest that the long non-coding RNA LBX2 antisense RNA 1 (LBX2-AS1) acts as an important regulator in cancer progression, but its significance in colorectal cancer (CRC) remains undetermined.

    Authors: Yu-Nan Ma, Yong-Gang Hong, Guan-Yu Yu, Si-yuan Jiang, Bo-lun Zhao, An Guo, Yao Wang, Xiao-ming Cui, Li-Qiang Hao and Hao Zheng

    Citation: Cancer Cell International 2021 21:501

    Content type: Primary research

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  20. The prognosis of hepatocellular carcinoma (HCC) is not optimistic. Our study focused on present inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), gam...

    Authors: Wenlong Wu, Quancheng Wang, Dandan Han, Jianhui Li, Ye Nie, Dongnan Guo, Long Yang, Kaishan Tao, Xuan Zhang and Kefeng Dou

    Citation: Cancer Cell International 2021 21:500

    Content type: Primary research

    Published on:

  21. Cancers are regarded as one of the main causes of death and result in high health burden worldwide. The management of cancer include chemotherapy, surgery and radiotherapy. The chemotherapy, which involves the...

    Authors: Ahmed Olatunde, Manisha Nigam, Rahul Kunwar Singh, Abhaya Shikhar Panwar, Abdulwahab Lasisi, Fahad A. Alhumaydhi, Vijay Jyoti kumar, Abhay Prakash Mishra and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:499

    Content type: Review

    Published on:

  22. Primary breast double-hit lymphoma (PB-DHL) is a rare, highly aggressive malignancy that poses challenges regarding accurate diagnosis and selecting optimal treatment regimens.

    Authors: Tingting Zhang, Yuanfeng Zhang, Hairong Fei, Xue Shi, Liang Wang, Peijun Wang, Jie Yu, Yuyan Shen and Sizhou Feng

    Citation: Cancer Cell International 2021 21:498

    Content type: Primary research

    Published on:

  23. Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnost...

    Authors: Mandana Ameli-Mojarad, Melika Ameli-Mojarad, Mahrooyeh Hadizadeh, Chris Young, Hosna Babini, Ehsan Nazemalhosseini-Mojarad and Maziar Ashrafian Bonab

    Citation: Cancer Cell International 2021 21:496

    Content type: Review

    Published on:

  24. Increasing studies focused on the regulatory roles of circular RNAs (circRNAs) in diverse cancers. This study was to evaluate the function and mechanism of circRNA Scm-like with four malignant brain tumor doma...

    Authors: Zhiwei Chang, Yang Fu, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao and Yanru Qin

    Citation: Cancer Cell International 2021 21:495

    Content type: Primary research

    Published on:

  25. Papillary thyroid carcinoma (PTC), with a rapidly increasing incidence, is the most prevalent malignant cancer of the thyroid. However, its pathogenesis is unclear and its specific clinical indicators have not...

    Authors: Yonglian Huang, Hengwei Zhang, Lidong Wang, Chenxi Liu, Mingyue Guo, Hao Tan and Zhen Liu

    Citation: Cancer Cell International 2021 21:494

    Content type: Primary research

    Published on:

  26. Gastric cancer (GC) is one of the most common and fatal cancers worldwide. Effective biomarkers to aid the early diagnosis of GC, as well as predict the course of disease, are urgently needed. Hence, we explor...

    Authors: Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin and Weihua Fu

    Citation: Cancer Cell International 2021 21:493

    Content type: Primary research

    Published on:

  27. Toosendanin (TSN) is a triterpenoid compound mainly used as an ascaris repellant. Recent studies have shown that it possesses antitumor effects in many types of tumor cells. However, the effects of TSN on glio...

    Authors: Chaochao Zhang, Haijun Gao, Ziqiang Liu, Jiacheng Lai, Zhixin Zhan, Yong Chen and Haiyan Huang

    Citation: Cancer Cell International 2021 21:492

    Content type: Primary research

    Published on:

  28. T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therap...

    Authors: Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng and Yangqiu Li

    Citation: Cancer Cell International 2021 21:490

    Content type: Primary research

    Published on:

  29. As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory drugs. As a genetic drug carrier, exosomes are beneficial to improve t...

    Authors: Wen Zhou, Mingming Xu, Zhipeng Wang and Mingjun Yang

    Citation: Cancer Cell International 2021 21:485

    Content type: Primary research

    Published on:

  30. Colorectal cancer (CRC) is one of the most malignant cancer types, characterized by elevated mortality rate and treatment resistance. Despite the progress achieved in the explanation of the molecular basis of ...

    Authors: Faezeh Vakhshiteh, Shokoufeh Hassani, Navid Momenifar and Fatemeh Pakdaman

    Citation: Cancer Cell International 2021 21:483

    Content type: Minireview

    Published on:

  31. DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs), whose function in hepatocellular carcinoma has...

    Authors: Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan and Sha-Sha Fan

    Citation: Cancer Cell International 2021 21:482

    Content type: Primary research

    Published on:

  32. Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop n...

    Authors: Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei and Lin Chen

    Citation: Cancer Cell International 2021 21:481

    Content type: Primary research

    Published on:

  33. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditi...

    Authors: Xiao Li, Hongming Zhu, Weixuan Sun, Xingru Yang, Qing Nie and Xuedong Fang

    Citation: Cancer Cell International 2021 21:479

    Content type: Review

    Published on:

  34. The long noncoding RNA gastric cancer associated transcript 3 (GACAT3) has been demonstrated to be implicated in the carcinogenesis and progression of many malignancies. However, GACAT3’s levels and role in es...

    Authors: Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang and Yuhang Xiao

    Citation: Cancer Cell International 2021 21:478

    Content type: Primary research

    Published on:

  35. Long noncoding RNAs (lncRNAs) have been elucidated to participate in the development and progression of various cancers. In this study, we aimed to explore the underlying functions and mechanisms of LINC00958 ...

    Authors: Hong Liang, Qiuyan Zhao, Zhonglin Zhu, Chao Zhang and Hui Zhang

    Citation: Cancer Cell International 2021 21:477

    Content type: Primary research

    Published on:

  36. Muscle-invasive bladder cancer (MIBC) is one of the most important type of bladder cancer, with a high morbidity and mortality rate. Studies have found that long non-coding RNA (lncRNA) plays a key role in mai...

    Authors: Yingchun Liang, Fangdie Ye, Zhang Cheng, Yuxi Ou, Lujia Zou, Yun Hu, Jimeng Hu and Haowen Jiang

    Citation: Cancer Cell International 2021 21:476

    Content type: Primary research

    Published on:

  37. Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system. However, the prognostic value of XDH...

    Authors: Zhen Lin, Yi-Zhao Xie, Ming-Chun Zhao, Pin-Pin Hou, Juan Tang and Guang-Liang Chen

    Citation: Cancer Cell International 2021 21:475

    Content type: Primary research

    Published on:

  38. Breast cancer is the most common cancer in women, and its high mortality has become one of the biggest health problems globally. Several studies have reported an association between breast cancer and ATM gene ...

    Authors: Masoumeh Moslemi, Maryam Vafaei, Pouria Khani, Marzieh Soheili, Reza Nedaeinia, Mostafa Manian, Yousef Moradi and Ehsan Sohrabi

    Citation: Cancer Cell International 2021 21:474

    Content type: Review

    Published on:

  39. Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. However, major limitations are the ava...

    Authors: Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan and Priya Ramanathan

    Citation: Cancer Cell International 2021 21:473

    Content type: Primary research

    Published on:

  40. CD9 is implicated in cancer progression and metastasis by its role in suppressing cancer cell proliferation and survival. However, the prognostic and clinicopathological significance of CD9 expression is contr...

    Authors: Hyun Min Koh, Bo Gun Jang, Dong Hui Lee and Chang Lim Hyun

    Citation: Cancer Cell International 2021 21:472

    Content type: Review

    Published on:

  41. Prostate cancer (PCa) is still a serious male malignant disease across the world. However, no exact pathogenesis had been explained. Although adenylosuccinate lyase (ADSL) gene was identified to be important i...

    Authors: Jinling Liao, Qiong Song, Jie Li, Kechen Du, Yang Chen, Chunlin Zou and Zengnan Mo

    Citation: Cancer Cell International 2021 21:467

    Content type: Primary research

    Published on:

  42. To evaluate the clinical effectiveness of a novel CellDetect staining technique, compared with fluorescent in situ hybridization (FISH), and urine cytology, in the diagnosis of urothelial carcinoma (UC).

    Authors: Donghao Shang, Yuting Liu, Xiuhong Xu, Zhenghao Chen and Daye Wang

    Citation: Cancer Cell International 2021 21:465

    Content type: Primary research

    Published on:

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