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  1. Primary Research

    Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

    Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma a...

    Phaijit Sritananuwat, Natthaporn Sueangoen, Parichut Thummarati, Kittiya Islam and Tuangporn Suthiphongchai

    Cancer Cell International 2017 17:85

    Published on: 26 September 2017

  2. Primary Research

    The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data

    Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (B...

    Chao-hua Mo, Li Gao, Xiao-fei Zhu, Kang-lai Wei, Jing-jing Zeng, Gang Chen and Zhen-bo Feng

    Cancer Cell International 2017 17:83

    Published on: 25 September 2017

  3. Primary Research

    The role of pparγ and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation

    In cancer cells, autophagy can act as both tumor suppressor, when autophagic event eliminates cellular contends which exceeds the cellular capacity of regenerate promoting cell death, and as a pro-survival age...

    José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Cancer Cell International 2017 17:82

    Published on: 15 September 2017

    The Correction to this article has been published in Cancer Cell International 2017 17:99

  4. Primary Research

    SNP rs3202538 in 3′UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population

    ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focuse...

    Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu and Hong Shen

    Cancer Cell International 2017 17:81

    Published on: 13 September 2017

  5. Primary Research

    Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway

    Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether int...

    Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu and Tingyan Liu

    Cancer Cell International 2017 17:79

    Published on: 5 September 2017

  6. Primary Research

    The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

    Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1....

    Nur Sabrina Kamarulzaman, Hemaniswarri Dewi Dewadas, Chiuan Yee Leow, Nik Soriani Yaacob and Noor Fatmawati Mokhtar

    Cancer Cell International 2017 17:74

    Published on: 1 August 2017

  7. Research

    Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

    Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors reoccur and currently predictive cancer stem cell...

    Ishaq Khan, Saleh Baeesa, Mohammed Bangash, Hans-Juergen Schulten, Fahad Alghamdi, Hanadi Qashqari, Nawal Madkhali, Angel Carracedo, Mohamad Saka, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed AlQahtani, Saleh Al-Karim, Ghazi Damanhouri, Kulvinder Saini, Adeel Chaudhary…

    Cancer Cell International 2017 17:72

    Published on: 21 July 2017

  8. Primary Research

    EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP

    Rituximab combined with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) is used as standard frontline regimen for diffuse large B-cell lymphoma (DLBCL). The landscape of somatic mutations in D...

    Jiao Li, Ning Ding, Xiaogan Wang, Lan Mi, Lingyan Ping, Xuan Jin, Yalu Liu, Zhitao Ying, Yan Xie, Weiping Liu, Yuqin Song and Jun Zhu

    Cancer Cell International 2017 17:70

    Published on: 14 July 2017

  9. Review

    Chemotherapy and tumor microenvironment of pancreatic cancer

    Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and ...

    Qiaofei Liu, Quan Liao and Yupei Zhao

    Cancer Cell International 2017 17:68

    Published on: 5 July 2017

  10. Primary Research

    Induction of apoptosis and proliferation inhibition of hepatocellular carcinoma by 6-chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA): in vitro and vivo studies

    6-Chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA), a novel sponge-derived compound, has been reported to elicit a cytotoxic effect by inhibiting cell proliferation.

    Yun Huang, Guohua Liu, Feng Yang, Xiaowei Xing, Ying Li, Zhijun Huang and Hong Yuan

    Cancer Cell International 2017 17:66

    Published on: 3 July 2017

  11. Review

    HOTAIR: a key regulator in gynecologic cancers

    Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can inter...

    Jing Li, Jing Wang, Yan Zhong, Ruixia Guo, Danxia Chu, Haifeng Qiu and Zhongfu Yuan

    Cancer Cell International 2017 17:65

    Published on: 21 June 2017

  12. Primary Research

    Overexpression of lncRNA HOXA11-AS promotes cell epithelial–mesenchymal transition by repressing miR-200b in non-small cell lung cancer

    Recent studies have verified that long noncoding RNAs (lncRNAs) involved in many biological functions and play crucial roles in human cancers progression, the study aimed to detect the association between long...

    Jian-Hui Chen, Li-Yang Zhou, Suo Xu, Yu-Long Zheng, Yu-Feng Wan and Cheng-Ping Hu

    Cancer Cell International 2017 17:64

    Published on: 12 June 2017

  13. Primary Research

    Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA

    To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes.

    Quanfeng Wu, Xiaoli Wu, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu and Xipeng Wang

    Cancer Cell International 2017 17:62

    Published on: 6 June 2017

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