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  1. Content type: Review

    Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation...

    Authors: Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong and Wenqi Wu

    Citation: Cancer Cell International 2019 19:221

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  2. Content type: Primary research

    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and human papillomavirus (HPV) has been increasingly recognized as a pathogenic factor for the initiation and development...

    Authors: Yu Jin, Yuexiu Li, Xin Wang and Ya Yang

    Citation: Cancer Cell International 2019 19:220

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  3. Content type: Primary research

    Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relap...

    Authors: Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu and He Huang

    Citation: Cancer Cell International 2019 19:218

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  4. Content type: Primary research

    Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a no...

    Authors: Fei Ding, Jindong Lai, Yang Gao, Genhui Wang, Jingwen Shang, Daojun Zhang and Shumao Zheng

    Citation: Cancer Cell International 2019 19:217

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  5. Content type: Primary research

    The long non-coding RNA H19 plays critical roles in cancer occurrence, development, and progression. The present study is for the first time to evaluate the association of genetic variations in the H19 promoter r...

    Authors: Wenyan Qin, Xiaodong Wang, Yilin Wang, Yalun Li, Qiuchen Chen, Xiaoyun Hu, Zhikun Wu, Pengfei Zhao, Shanqiong Li, Haishan Zhao, Weifan Yao, Jian Ding, Minjie Wei and Huizhe Wu

    Citation: Cancer Cell International 2019 19:215

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  6. Content type: Primary research

    Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic a...

    Authors: Sacnite del Mar Díaz-González, Eduardo Daniel Rodríguez-Aguilar, Angélica Meneses-Acosta, Viviana Valadez-Graham, Jessica Deas, Claudia Gómez-Cerón, Carlos Alberto Tavira-Montalván, Alitzel Arizmendi-Heras, Julián Ramírez-Bello, Mario Enrique Zurita-Ortega, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez, Gloria Fernández-Tilapa, Víctor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes…

    Citation: Cancer Cell International 2019 19:214

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  7. Content type: Primary research

    Gastric cancer (GC) is one of the most common malignant tumours with high mortality and metastasis rates. E2F3, miR-125a and DKK3 have been reported to be involved in various cancer types, but their detailed r...

    Authors: Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao, Bozhen Xie and Xin Zhang

    Citation: Cancer Cell International 2019 19:212

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  8. Content type: Primary research

    CircRNA myosin light chain kinase (circRNA MYLK) has been shown to promote the progression of various tumor diseases. The purpose of this study was to explore the potential molecular mechanism of circMYLK in h...

    Authors: Zhiqin Li, Yushu Hu, Qinglei Zeng, Hongyan Wang, Jingya Yan, Hua Li and Zujiang Yu

    Citation: Cancer Cell International 2019 19:211

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  9. Content type: Primary research

    Long non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We ...

    Authors: Sheng Huang, Yayun Chi, Weiru Chi, Rong Guo, Yonghui Su, Jingyan Xue, Shaoqiang Zhou, Jiankui Wang, Zhuangqing Yang, Jianyun Nie, Zhimin Shao, Dedian Chen and Jiong Wu

    Citation: Cancer Cell International 2019 19:210

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  10. Content type: Minireview

    The recent advent of immunomodulatory therapies into the clinic has demanded the identification of innovative predictive biomarkers to identify patients most likely to respond to immunotherapy and support the ...

    Authors: Francesca Galuppini, Carlo Alberto Dal Pozzo, Jutta Deckert, Fotios Loupakis, Matteo Fassan and Raffaele Baffa

    Citation: Cancer Cell International 2019 19:209

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  11. Content type: Primary research

    Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients.

    Authors: Wen Jiang, Qing Guo, Chenghe Wang and Yu Zhu

    Citation: Cancer Cell International 2019 19:208

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  12. Content type: Review

    Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy i...

    Authors: Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes and Floriano Paes Silva-Jr

    Citation: Cancer Cell International 2019 19:207

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  13. Content type: Primary research

    Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.

    Authors: Erkang Jiang, Lianping Wei, Fang Tao, Mei Yu, Shu Wang, Xiuhong Zhou, Daxiang Li and Zhongwen Xie

    Citation: Cancer Cell International 2019 19:206

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  14. Content type: Primary research

    Kinesin family member 26B (KIF26B) is unveiled acted as important role in many solid tumors, however, the function of KIF26B in hepatocellular carcinoma (HCC) is unclear.

    Authors: Hua Li, Shen Shen, Xiaolong Chen, Zhigang Ren, Zhiqin Li and Zujiang Yu

    Citation: Cancer Cell International 2019 19:205

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  15. Content type: Primary research

    Although the most thyroid carcinoma patients have good prognosis, around 20% of papillary thyroid carcinoma (PTC) patients have a high rate of metastasis and recurrence after routine treatment, which causes hi...

    Authors: Longyan Yang, Rongxin Sun, Yan Wang, Ying Fu, Yuanyuan Zhang, Zhaohui Zheng, Zhili Ji and Dong Zhao

    Citation: Cancer Cell International 2019 19:204

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  16. Content type: Primary research

    Thioredoxin reductase 1 (TXNRD1) is an antioxidant enzyme reportedly overexpressed in hepatocellular carcinoma (HCC); however, the detailed function and mechanisms of TXNRD1 in HCC remain obscure. In this study, ...

    Authors: Shengni Hua, Yingyao Quan, Meixiao Zhan, Huaxin Liao, Yong Li and Ligong Lu

    Citation: Cancer Cell International 2019 19:203

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  17. Content type: Primary research

    Long noncoding RNA (lncRNA) has been implicated in numerous tumors, including pancreatic cancer (PC). However, the precise cellular roles and molecular mechanisms of lncRNA DIO3OS on PC development remains to ...

    Authors: Kang Cui, Shuiling Jin, Yabing Du, Junlin Yu, Han Feng, Qingxia Fan and Wang Ma

    Citation: Cancer Cell International 2019 19:202

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  18. Content type: Primary research

    To explore the role of lysophosphatidic acid receptor 1 (LPAR1) and its correlation with the PI3K/AKT pathway in the development of intratumoral heterogeneity (ITH) in human ovarian serous cystadenocarcinoma (...

    Authors: Ran Cui, Guangming Cao, Huimin Bai and Zhenyu Zhang

    Citation: Cancer Cell International 2019 19:201

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  19. Content type: Primary research

    miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 ...

    Authors: Fangxuan Li, Jinchao Huang, Juntian Liu, Wengui Xu and Zhiyong Yuan

    Citation: Cancer Cell International 2019 19:200

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  20. Content type: Primary research

    Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated with chemotherapy resistance. The previous study confirmed that the ovarian cancer patients w...

    Authors: Jing Tang, Jiang Zhu, Yuguang Ye, Yu Liu, Yan He, Lei Zhang, Dai Tang, Cong Qiao, Xinxin Feng, Junyi Li, Yanni Kan, Xiaobo Li, Xiaoming Jin and Dan Kong

    Citation: Cancer Cell International 2019 19:199

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  21. Content type: Primary research

    MicroRNAs (miRNAs) play a pivotal role in hepatocellular carcinoma (HCC) progression and have been confirmed to participate in the carcinogenesis and development of HCC. However, the relationship between miR-4...

    Authors: Yixi Zhang, Zebin Zhu, Shanzhou Huang, Qiang Zhao, Changjun Huang, Yunhua Tang, Chengjun Sun, Zhiheng Zhang, Linhe Wang, Huadi Chen, Maogen Chen, Weiqiang Ju and Xiaoshun He

    Citation: Cancer Cell International 2019 19:198

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  22. Content type: Primary research

    Mitofusin 2 (Mfn2) is outer membrane protein, as the inhibitor of Ras protein. This study aimed to investigate the effect of Mfn2 on cell proliferation, and cell-cycle in Hela cervical carcinoma cell lines.

    Authors: Xiaowen Liu, Jun Sun, Ping Yuan, Kangquan Shou, Yuanhong Zhou, Wenqi Gao, Jin She, Jun Hu, Jun Yang and Jian Yang

    Citation: Cancer Cell International 2019 19:197

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  23. Content type: Primary research

    Accumulating evidence shows that circular RNAs (circRNAs) plays vital roles in tumor progression. However, the biological functions of circRNAs in laryngeal squamous cell carcinoma (LSCC) metastasis is still u...

    Authors: Jian-Xing Wang, Yan Liu, Xin-Ju Jia, Shu-Xia Liu, Jin-Hui Dong, Xiu-Min Ren, Ou Xu, Hai-Zhong Zhang, Hui-Jun Duan and Chun-Guang Shan

    Citation: Cancer Cell International 2019 19:196

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  24. Content type: Primary research

    AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin ha...

    Authors: Jian Zhu, Hanhui Zou, Wei Yu, Yuluan Huang, Bing Liu, Tao Li, Chengzhen Liang and Huimin Tao

    Citation: Cancer Cell International 2019 19:195

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  25. Content type: Primary research

    Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for ...

    Authors: Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang and Yi-chong Chen

    Citation: Cancer Cell International 2019 19:193

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  26. Content type: Primary research

    Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs durin...

    Authors: Rongsheng Zhang, Fan Qi, Shengli Shao, Geng Li and Yongdong Feng

    Citation: Cancer Cell International 2019 19:192

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  27. Content type: Primary research

    Doxorubicin (DOX) is one of the most important anticancer agents used in treating breast cancer. However, chronic cardiotoxicity and multidrug resistance limit the chemotherapeutic use of DOX.

    Authors: Hamdan S. Al-malky, Abdel-Moneim M. Osman, Zoheir A. Damanhouri, Huda M. Alkreathy, Jumana Y. Al Aama, Wafaa S. Ramadan, Ali A. Al Qahtani and Hadiah B. Al Mahdi

    Citation: Cancer Cell International 2019 19:191

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  28. Content type: Primary research

    Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects.

    Authors: Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti and Mokenge P. Malafa

    Citation: Cancer Cell International 2019 19:189

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  29. Content type: Primary research

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors ...

    Authors: Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang and Elaine Lai-Han Leung

    Citation: Cancer Cell International 2019 19:188

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  30. Content type: Primary research

    MicroRNAs (miRNAs) play crucial roles in varieties of cancers, particularly in tumorigenesis, progression, and migration. Dysregulation of miR-28 was reported to occur in various types of human malignancies. I...

    Authors: Yan Lv, Huijun Yang, Xingkai Ma and Geping Wu

    Citation: Cancer Cell International 2019 19:187

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  31. Content type: Primary research

    Mounting evidences have demonstrated that HCC patients with or without cirrhosis possess different clinical characteristics, tumor development and prognosis. However, few studies directly investigated the unde...

    Authors: Bisha Ding, Weiyang Lou, Jingxing Liu, Ruohan Li, Jing Chen and Weimin Fan

    Citation: Cancer Cell International 2019 19:186

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  32. Content type: Primary research

    Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene express...

    Authors: Wenbiao Chen, Jia Zhuang, Peizhong Peter Wang, Jingjing Jiang, Chenhong Lin, Ping Zeng, Yan Liang, Xujun Zhang, Yong Dai and Hongyan Diao

    Citation: Cancer Cell International 2019 19:185

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  33. Content type: Primary research

    Pleckstrin Homology Like Domain Family Member 2 (PHLDB2) is an important protein with a PH-domain for interaction with partners to regulate cell migration. However, the role of PHLDB2 in human cancer metastasi...

    Authors: Geng Chen, Tong Zhou, Tantan Ma, Tingting Cao and Zhenxiang Yu

    Citation: Cancer Cell International 2019 19:184

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  34. Content type: Primary research

    Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs in gastric cancer (GC) are still unknown. Here,...

    Authors: Yong-jun Guan, Jian-ying Ma and Wei Song

    Citation: Cancer Cell International 2019 19:183

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  35. Content type: Primary research

    Metastasis is an important factor in the poor prognosis of breast cancer. As an important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to tumorigenesis. However, the molecular me...

    Authors: Jian Wang, Shujing Li, Xiahui Li, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Miao Wang and Huijian Wu

    Citation: Cancer Cell International 2019 19:182

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  36. Content type: Primary research

    Emerging evidence has revealed miR-29 family as promising biomarkers for colorectal cancer (CRC), but their biomarker potential and molecular mechanisms remain poorly understood.

    Authors: Qiliang Peng, Zhengyang Feng, Yi Shen, Jiahao Zhu, Li Zou, Yuntian Shen and Yaqun Zhu

    Citation: Cancer Cell International 2019 19:181

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  37. Content type: Review

    Colorectal cancer (CRC) is the third most common cancer and one of the main causes of cancer death entire the world. Environmental, dietary, and lifestyle factors including red meat consumption, cigarette smok...

    Authors: Mohadese Honari, Rana Shafabakhsh, Russel J. Reiter, Hamed Mirzaei and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:180

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  38. Content type: Primary research

    Multi-drug resistance is the major cause of chemotherapy failure in hepatocellular carcinoma (HCC). YAP, a critical effector of the Hippo pathway, has been shown to contribute to the progression, metastasis an...

    Authors: Yuan Zhou, Yubo Wang, Wuhua Zhou, Tianchi Chen, Qinchuan Wu, Vikram Kumar Chutturghoon, Bingyi Lin, Lei Geng, Zhe Yang, Lin Zhou and Shusen Zheng

    Citation: Cancer Cell International 2019 19:179

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  39. Content type: Primary research

    MicroRNA-29c (miR-29c) is abnormally expressed in several cancers and serves as an important predictor of tumor prognosis. Herein, we investigate the effects of abnormal miR-29c expression and analyze its clin...

    Authors: Li-juan Tang, Guo-kang Sun, Ting-juan Zhang, De-hong Wu, Jing-dong Zhou, Bei-bei Ma, Zi-jun Xu, Xiang-mei Wen, Qin Chen, Dong-ming Yao, Jun Qian, Ji-chun Ma and Jiang Lin

    Citation: Cancer Cell International 2019 19:177

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  40. Content type: Primary research

    Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-smal...

    Authors: Chao Liu, Bin Xu, Qian Li, Aijie Li, Lan Li, Jinbo Yue, Qinyong Hu and Jinming Yu

    Citation: Cancer Cell International 2019 19:176

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  41. Content type: Primary research

    Accumulated evidences have demonstrated that long non-coding RNAs (lncRNAs) are correlated with prognosis of patients with hepatocellular carcinoma. The current study aimed to develop and validate a prognostic...

    Authors: Zhiqiao Zhang, Yanling Ouyang, Yiyan Huang, Peng Wang, Jing Li, Tingshan He and Qingbo Liu

    Citation: Cancer Cell International 2019 19:174

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  42. Content type: Review

    Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, m...

    Authors: Elsa N. Garza Treviño, Paulina Delgado González, Carlos I. Valencia Salgado and Alejandra Martinez Garza

    Citation: Cancer Cell International 2019 19:173

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  43. Content type: Primary research

    Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets. We aimed to explore some novel gene...

    Authors: Xuemei Lv, Miao He, Yanyun Zhao, Liwen Zhang, Wenjing Zhu, Longyang Jiang, Yuanyuan Yan, Yue Fan, Hongliang Zhao, Shuqi Zhou, Heyao Ma, Yezhi Sun, Xiang Li, Hong Xu and Minjie Wei

    Citation: Cancer Cell International 2019 19:172

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  44. Content type: Review

    Mounting evidence has shown that long noncoding RNAs (lncRNAs) can play a substantial role in gallbladder cancer (GBC) development as tumor promotors or suppressors, and their abnormal expression is relevant t...

    Authors: Yuan Zhong, Xiaochao Wu, Quanpeng Li, Xianxiu Ge, Fei Wang, Peiyao Wu, Xueting Deng and Lin Miao

    Citation: Cancer Cell International 2019 19:169

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