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  1. Content type: Primary research

    Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically as...

    Authors: Jing Wen, Qian Xu and Yuan Yuan

    Citation: Cancer Cell International 2018 18:155

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  2. Content type: Review

    BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis. Although, there are different opinions on the level of gene expression and function of BORIS in normal and cancer tissues, the results...

    Authors: Sara Soltanian and Hesam Dehghani

    Citation: Cancer Cell International 2018 18:154

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  3. Content type: Primary research

    Chronic inflammation is deemed to play a significant effect on initiation and progression of esophageal squamous cell carcinoma (ESCC). In current study, we investigated the prognostic and predictive role of a...

    Authors: Qiu-Fang Gao, Jia-Cong Qiu, Xiao-Hong Huang, Yan-Mei Xu, Shu-Qi Li, Fan Sun, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Yu-Huan Jiang, Qing-Gen Chen, Lei Zhang, Xiao-Zhong Wang and Hou-Qun Ying

    Citation: Cancer Cell International 2018 18:153

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  4. Content type: Review

    Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefo...

    Authors: Xiaoli Hu, Hailing Liu, Miaomiao Ye and Xueqiong Zhu

    Citation: Cancer Cell International 2018 18:152

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  5. Content type: Primary research

    Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a distinct clinicopathological entity and EBV-associated disease that is highly aggressive. Many patients had failed to respond to conventional chemotherapy ...

    Authors: Xudong Zhang, Xiaorui Fu, Meng Dong, Zhenzhen Yang, Shaoxuan Wu, Mijing Ma, Zhaoming Li, Xinhua Wang, Ling Li, Xin Li, Zhenchang Sun, Yu Chang, Feifei Nan, Jiaqin Yan, Yun Mao, Mingzhi Zhang…

    Citation: Cancer Cell International 2018 18:150

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  6. Content type: Primary research

    Marsdenia tenacissima is an herb medicine which has been utilized to treat malignant diseases for decades. The M. tenacissima extract (MTE) shows significant anti-proliferation activity against non-small cell lun...

    Authors: Yan-Na Jiao, Li-Na Wu, Dong Xue, Xi-Juan Liu, Zhi-Hua Tian, Shan-Tong Jiang, Shu-Yan Han and Ping-Ping Li

    Citation: Cancer Cell International 2018 18:149

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  7. Content type: Primary research

    Arterialized vein flap is a kind of unphysiological flap. Unphysiological reconstruction of blood circulation leads to higher load than that supported by physiological flap and is the culprit of flap swelling,...

    Authors: Zheng Li, Zhen-wei Zhang, Shao-xiao Yu, Jia-chuan Zhuang, Yu-hai Ke, Yi Xiong, Hui-xin Lin and Wen-feng Chen

    Citation: Cancer Cell International 2018 18:148

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  8. Content type: Primary research

    Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characte...

    Authors: Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder and Angelo De Milito

    Citation: Cancer Cell International 2018 18:147

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  9. Content type: Primary research

    The molecular mechanism of Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) remains elusive. A collection of molecular regulators including transcription factor and noncoding RNA (ncRNAs) may affect...

    Authors: Jing-jing Jing, Ze-yang Wang, Hao Li, Li-ping Sun and Yuan Yuan

    Citation: Cancer Cell International 2018 18:146

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  10. Content type: Primary research

    Ovarian cancer is the fifth leading cause of cancer deaths in women worldwide. LncRNACCAT1 was reported to play a critical role in cell metastasis of ovarian cancer. However, little is known about the detailed me...

    Authors: Yang Mu, Na Li and Yu-Lan Cui

    Citation: Cancer Cell International 2018 18:145

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  11. Content type: Primary research

    Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...

    Authors: Lujun Chen, Jun Feng, Shaoxian Wu, Bin Xu, You Zhou, Changping Wu and Jingting Jiang

    Citation: Cancer Cell International 2018 18:144

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  12. Content type: Primary research

    Long non-coding RNA (lncRNA) SNHG5 has been found to play an important role in tumors. Nevertheless, the function and mechanism of lncRNA SNHG5 in osteosarcoma (OS) remains unclear. The purpose of this study w...

    Authors: Cheng Ju, Ruihao Zhou, Jun Sun, Feifei Zhang, Xiaofeng Tang, Kaddie Kwok Chen, Junliang Zhao, Xiaoyong Lan, Shifan Lin, Zhiping Zhang and Xiao-Bin Lv

    Citation: Cancer Cell International 2018 18:141

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  13. Content type: Primary research

    Pancreatic cancer, one of the most aggressive malignancies, ranks the fourth cause of cancer-related death worldwide. Aberrantly expressed long non-coding RNAs (lncRNAs) functioned as oncogenes or tumor suppre...

    Authors: Yong An, Xue-min Chen, Yong Yang, Feng Mo, Yong Jiang, Dong-lin Sun and Hui-hua Cai

    Citation: Cancer Cell International 2018 18:143

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  14. Content type: Primary research

    Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to imp...

    Authors: LingLi Hou, Jiancheng Tu, Fangxiong Cheng, Hongwei Yang, Fei Yu, Minghua Wang, Jiubo Liu, Jinbo Fan and Guojun Zhou

    Citation: Cancer Cell International 2018 18:142

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  15. Content type: Primary research

    Aberrant methylation of DNA is a key driver of hepatocellular carcinoma (HCC). In this study, we sought to integrate four cohorts profile datasets to identify such abnormally methylated genes and pathways asso...

    Authors: Guorun Fan, Yaqin Tu, Cai Chen, Haiying Sun, Chidan Wan and Xiong Cai

    Citation: Cancer Cell International 2018 18:140

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  16. Content type: Primary research

    Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are associated with abnormal production of plasma cells, although their pathological mechanism of each disease is different. The main character...

    Authors: Ruonan Xu, Ying Fang, Chunmei Hou, Bing Zhai, Zhenyu Jiang, Ning Ma, Liang Wang, Gencheng Han and Renxi Wang

    Citation: Cancer Cell International 2018 18:138

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  17. Content type: Review

    High prevalence of hepatocellular carcinoma (HCC) and typically poor prognosis of this disease that lead to late stage diagnosis when potentially curative therapies are least effective; therefore, development ...

    Authors: Faezeh Hosseinzadeh, Javad Verdi, Jafar Ai, Saieh Hajighasemlou, Iman Seyhoun, Frzad Parvizpour, Fatemeh Hosseinzadeh, Abolfazl Iranikhah and Sadegh Shirian

    Citation: Cancer Cell International 2018 18:133

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  18. Content type: Primary research

    Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early...

    Authors: Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2018 18:135

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  19. Content type: Primary research

    Glioblastoma multiforme (GBM) is a highly aggressive brain tumor in which cancer cells with stem cell-like features, called cancer stem cells (CSCs), were identified. Two CSC populations have been previously i...

    Authors: Bianca Maria Scicchitano, Silvia Sorrentino, Gabriella Proietti, Gina Lama, Gabriella Dobrowolny, Angela Catizone, Elena Binda, Luigi Maria Larocca and Gigliola Sica

    Citation: Cancer Cell International 2018 18:136

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  20. Content type: Correction

    Following publication of the original article [1], the authors reported a typing mistake in the title. In this Correction the incorrect and correct titles are shown.

    Authors: Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu and Jingting Jiang

    Citation: Cancer Cell International 2018 18:134

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    The original article was published in Cancer Cell International 2018 18:126

  21. Content type: Primary research

    Non-small cell lung cancer (NSCLC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown...

    Authors: Shaoqiang Wang, Yingying Zheng, Zhiwei He, Wolong Zhou, Yuanda Cheng and Chunfang Zhang

    Citation: Cancer Cell International 2018 18:132

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  22. Content type: Review

    Colorectal cancer (CRC) is one of the most common cancers diagnosed and among the commonest causes of cancer-related mortality globally. Despite the various available treatment options, millions of people stil...

    Authors: Adewale Oluwaseun Fadaka, Babajide A. Ojo, Olusola Bolaji Adewale, Temitope Esho and Ashley Pretorius

    Citation: Cancer Cell International 2018 18:130

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  23. Content type: Primary research

    No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).

    Authors: Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli…

    Citation: Cancer Cell International 2018 18:131

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  24. Content type: Primary research

    SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism e...

    Authors: Marie Saghaeian Jazi, Nader Mansour Samaei, Seyed Javad Mowla, Babak Arefnezhad and Morteza Kouhsar

    Citation: Cancer Cell International 2018 18:129

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  25. Content type: Primary research

    Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transpor...

    Authors: Shao-hsuan Wen, Shey-chiang Su, Bo-huang Liou, Cheng-hao Lin and Kuan-rong Lee

    Citation: Cancer Cell International 2018 18:128

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  26. Content type: Primary research

    MicroRNAs are small RNAs (~ 22 nt) that modulate the expression of thousands of genes in tumors and play important roles in the formation of multidrug resistance. In this study, we firstly investigated that miR-4...

    Authors: Fan Feng, Xiaolan Zhu, Chunyan Wang, Liang Chen, Weiping Cao, Yueqin Liu, Qi Chen and Wenlin Xu

    Citation: Cancer Cell International 2018 18:127

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  27. Content type: Primary research

    Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...

    Authors: Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu and Jingting Jiang

    Citation: Cancer Cell International 2018 18:126

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    The Correction to this article has been published in Cancer Cell International 2018 18:134

  28. Content type: Review

    Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involv...

    Authors: Dan Dong, Zhongyi Mu, Chenghai Zhao and Mingli Sun

    Citation: Cancer Cell International 2018 18:125

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  29. Content type: Primary research

    Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role ...

    Authors: Yong-Xia Wang, Hui-Fang Zhu, Zhe-Ying Zhang, Feng Ren and Yu-Han Hu

    Citation: Cancer Cell International 2018 18:124

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  30. Content type: Primary research

    To investigate the efficacy and safety of concurrent chemoradiotherapy with capecitabine or oxaliplatin in locally advanced (T3-4/N + M0) rectal cancer.

    Authors: Wanghua Chen, Wenling Wang, Yuxin Li, Hongmin Dong, Gang Wang and Xiaokai Li

    Citation: Cancer Cell International 2018 18:123

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  31. Content type: Primary research

    LncRNAs can regulate miRNAs and mRNAs by sequestering and binding them. Indeed, many researchers have reported lncRNA mediated-competing endogenous RNAs (ceRNAs) could regulate the progression of solid tumors....

    Authors: Xuejiao Yin, Sui Huang, Ruiqi Zhu, Fengjuan Fan, Chunyan Sun and Yu Hu

    Citation: Cancer Cell International 2018 18:122

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  32. Content type: Primary research

    Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated macrophages (M2 TAMs) that promote cancer progression. However, communicative mechanisms between M2 TAMs and canc...

    Authors: Li She, Yuexiang Qin, Juncheng Wang, Chao Liu, Gangcai Zhu, Guo Li, Ming Wei, Changhan Chen, Guancheng Liu, Diekuo Zhang, Xiyu Chen, Yunyun Wang, Yuanzheng Qiu, Yongquan Tian, Xin Zhang, Yong Liu…

    Citation: Cancer Cell International 2018 18:120

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  33. Content type: Primary research

    Local or distant metastasis remains the main course of death in head and neck squamous cell carcinoma (HNSCC) patients. MicroRNAs (miRNAs) have been implicated in metastasis of HNSCC, but the mechanisms of the...

    Authors: Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu and Xiaomeng Song

    Citation: Cancer Cell International 2018 18:121

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  34. Content type: Primary research

    The neutrophil-to-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Here we cond...

    Authors: Shidai Mu, Lisha Ai, Fengjuan Fan, You Qin, Chunyan Sun and Yu Hu

    Citation: Cancer Cell International 2018 18:119

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  35. Content type: Primary research

    Basal/human epidermal growth factor receptor (HER)2-positive (HER2+) breast cancer is resistant to monoclonal antibody (herceptin) treatment. There are currently only three basal/HER2+ breast cancer cell lines...

    Authors: Fei Zhou, Yanhua Zhang, Xiufang Xu, Jingfeng Luo, Fang Yang, Linbo Wang, Shuduo Xie, Jihong Sun and Xiaoming Yang

    Citation: Cancer Cell International 2018 18:118

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  36. Content type: Primary research

    Cytokine-based cancer therapies have attracted a great deal of attention in recent years. Unfortunately, resistance to treatment limits the efficacy of these therapeutics. Therefore, the aim of our study was t...

    Authors: Kaihua Ji, Kaili Lin, Yan Wang, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Yang Liu and Qiang Liu

    Citation: Cancer Cell International 2018 18:117

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  37. Content type: Primary research

    The aim of the study was to investigate the effect associated with the protein expression of VEGF, JAK2 and STAT3 on the clinicopathologic characteristics and prognosis in the development and progression of na...

    Authors: Jin-Zhang Cheng, Jun-Jun Chen, Kai Xue, Zong-Gui Wang and Dan Yu

    Citation: Cancer Cell International 2018 18:110

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  38. Content type: Primary research

    Glioblastoma (GBM) is a tumor of the central nervous system. After surgical removal and standard therapy, recurrence of tumors is observed within 6–9 months because of the high migratory behavior and the infil...

    Authors: Henry Oppermann, Johannes Dietterle, Katharina Purcz, Markus Morawski, Christian Eisenlöffel, Wolf Müller, Jürgen Meixensberger and Frank Gaunitz

    Citation: Cancer Cell International 2018 18:111

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  39. Content type: Primary research

    Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to its aggressive, metastatic behavior, and a lack of a targeted therapy. Trivalent arsenic derivatives ...

    Authors: Bo Yuan, Mingjiang Yao, Xiao Wang, Ai Sato, Ayane Okazaki, Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano and Norio Takagi

    Citation: Cancer Cell International 2018 18:113

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  40. Content type: Review

    Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternal...

    Authors: Tian Xie, Shan Pan, Hang Zheng, Zilv Luo, Kingsley M. Tembo, Muhammad Jamal, Zhongyang Yu, Yao Yu, Jing Xia, Qian Yin, Meng Wang, Wen Yuan, Qiuping Zhang and Jie Xiong

    Citation: Cancer Cell International 2018 18:112

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  41. Content type: Primary research

    Increasing numbers of studies have examined the correlation between specific miRNAs and tumours to enable their diagnosis and treatment. However, there are few reports regarding the concrete role and mechanism...

    Authors: Ming Zhuang, Xubin Qiu, Dong Cheng, Chenlei Zhu and Liang Chen

    Citation: Cancer Cell International 2018 18:114

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  42. Content type: Primary research

    Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance ...

    Authors: Ling Wang, Fu-biao Kang, Guo-chuan Zhang, Juan Wang, Ming-fang Xie and Ying-ze Zhang

    Citation: Cancer Cell International 2018 18:115

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  43. Content type: Primary research

    Accumulating data indicated that circRNA plays important roles in regulating many biological processes of the tumor, the present study is designated for exploring roles of the circ-ZEB1.33-miR-200a-3p-CDK6 reg...

    Authors: Yuhua Gong, Jinzhong Mao, Di Wu, Xuemei Wang, Long Li, Liang Zhu and Rong Song

    Citation: Cancer Cell International 2018 18:116

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  44. Content type: Primary research

    The aberrant regulation of MALAT1 has been indicated to be involved in various carcinogenic pathways contributing to the tumourigenesis and progression of cancers. The current meta-analysis summarized the rese...

    Authors: Juan Li, Zhigang Cui, Hang Li, Xiaoting Lv, Min Gao, Zitai Yang, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou and Zhihua Yin

    Citation: Cancer Cell International 2018 18:109

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  45. Content type: Review

    The prognostic significance of galectin-1 (Gal-1) expression in cancerous patients has been assessed for several years while the results remain controversial. Thus, we performed the first comprehensive meta-an...

    Authors: Rongzu Wu, Tingchun Wu, Kai Wang, Shicheng Luo, Zhen Chen, Min Fan, Dong Xue, Hao Lu, Qianfeng Zhuang and Xianlin Xu

    Citation: Cancer Cell International 2018 18:108

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  46. Content type: Primary research

    Increasing evidence has shown that long non-coding RNAs (lncRNAs) are important prognostic biomarkers and epigenetic regulators with critical roles in cancer initiation and progression. However, the expression...

    Authors: Fan Wu, Zheng Zhao, Ruichao Chai, Yuqing Liu, Kuanyu Wang, Zhiliang Wang, Guanzhang Li, Ruoyu Huang, Haoyu Jiang and Kenan Zhang

    Citation: Cancer Cell International 2018 18:107

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  47. Content type: Primary research

    MicroRNAs (miRNAs) have been reported to play crucial roles in multiple cancers including non-small cell lung cancer (NSCLC). Here, we investigated the role of miR-145 and miR-497 in TGF-β-induced epithelial–m...

    Authors: Qi Yin, Yang Han, Dongyi Zhu, Zhanxia Li, Shan Shan, Wenjing Jin, Qingchun Lu and Tao Ren

    Citation: Cancer Cell International 2018 18:105

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