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  1. CD44 is highly expressed in most cancer cells and its cross-linking pattern is closely related to tumor migration and invasion. However, the underlying molecular mechanism regarding CD44 cross-linking during c...

    Authors: Song Hu, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang and Feng Gao

    Citation: Cancer Cell International 2020 20:563

    Content type: Primary research

    Published on:

  2. Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought to identify poten...

    Authors: Qin Xie, Ying-sheng Xiao, Shi-cheng Jia, Jie-xuan Zheng, Zhen-chao Du, Yi-chun Chen, Mu-tong Chen, Yuan-ke Liang, Hao-yu Lin and De Zeng

    Citation: Cancer Cell International 2020 20:562

    Content type: Primary research

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  3. EGFR tyrosine kinase inhibitors (TKIs) have been developed for the treatment of EGFR mutated NSCLC. Parthenolide, a natural product of parthenolide, which belongs to the sesquiterpene lactone family and has a ...

    Authors: Xiaoling Li, Riming Huang, Mingyue Li, Zheng Zhu, Zhiyan Chen, Liao Cui, Hui Luo and Lianxiang Luo

    Citation: Cancer Cell International 2020 20:561

    Content type: Primary research

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  4. Bladder cancer (BC) is a leading cause of death among urothelial malignancies that more commonly affect male population. Poor prognosis and resistance to chemotherapy are the two most important characteristics...

    Authors: Khushbukhat Khan, Cristina Quispe, Zeeshan Javed, Muhammad Javed Iqbal, Haleema Sadia, Shahid Raza, Asma Irshad, Bahare Salehi, Željko Reiner and Javad Sharifi-Rad

    Citation: Cancer Cell International 2020 20:560

    Content type: Review

    Published on:

  5. Beast cancer is the most common women cancer worldwide, while two third of them are ER alpha positive breast cancer. Among the ER alpha positive breast cancer, about 80% are P53 wild type, indicating the poten...

    Authors: Xinxing Wang, Yujie Zhang, Xinhong Pei, Guangcheng Guo, Bingjian Xue, Xin Duan and Dongwei Dou

    Citation: Cancer Cell International 2020 20:559

    Content type: Primary research

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  6. Extracellular vesicles (EVs) secreted by tumours, including exosomes, are important factors that regulate cell–cell interactions in oncogenesis. Although EV studies are ongoing, the biological understanding of...

    Authors: Seung Ah Choi, Eun Jung Koh, Ryong Nam Kim, Jung Woo Byun, Ji Hoon Phi, Jeyul Yang, Kyu-Chang Wang, Ae Kyung Park, Do Won Hwang, Ji Yeoun Lee and Seung-Ki Kim

    Citation: Cancer Cell International 2020 20:558

    Content type: Primary research

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  7. Colorectal cancer (CRC) is a common malignant tumor with unsatisfactory overall prognosis. CircRNAs could be promising prognostic biomarkers in cancers, and play important role in the process of tumorigenesis ...

    Authors: Linlin Xing, Mengyan Xia, Xin Jiao and Ling Fan

    Citation: Cancer Cell International 2020 20:557

    Content type: Primary research

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  8. There is evidence that circSMYD4 is differentially expressed in hepatocellular carcinoma (HCC), but its mechanism of action remains unclear. Therefore, this study aimed to explore the role of circSMYD4 in the ...

    Authors: Yanhe Zhang, Hui Wang, Chao Li, Linlin Gao, Yayun Zheng, Wenjuan Chang, Chao Lu and Xiaoguang Zhao

    Citation: Cancer Cell International 2020 20:556

    Content type: Primary research

    Published on:

  9. To establish and validate a multi-parametric prognostic model based on clinical features and serological markers to estimate the overall survival (OS) in non-small cell lung cancer (NSCLC) patients with chroni...

    Authors: Shulin Chen, Hanqing Huang, Yijun Liu, Changchun Lai, Songguo Peng, Lei Zhou, Hao Chen, Yiwei Xu and Xia He

    Citation: Cancer Cell International 2020 20:555

    Content type: Primary research

    Published on:

  10. Circular RNAs (circRNAs) play crucial roles in the development and progression of human cancers, including non-small cell lung cancer (NSCLC). However, most of these circRNAs, such as hsa_circ_0014235, are not...

    Authors: Xueliang Xu, Rong Tao, Liying Sun and Xia Ji

    Citation: Cancer Cell International 2020 20:552

    Content type: Primary research

    Published on:

  11. It has been known that ovarian cancer (OC) is a leading cause for women mortality globally. We aimed to analyze the underlying mechanism supporting that enhancer of zeste homolog 2 (EZH2) affected the developm...

    Authors: Dongbo Wu, Fanglan Wu, Birong Li, Wei Huang and Donglian Wang

    Citation: Cancer Cell International 2020 20:551

    Content type: Primary research

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  12. A systematic review and meta-analysis was performed to compare the clinicopathological features and survival outcomes between sarcomatoid variant (SV)-urothelial carcinoma of the bladder (UCB) and conventional...

    Authors: Liangyou Gu, Qing Ai, Qiang Cheng, Xin Ma, Baojun Wang, Qingbo Huang, Xintao Li, Peng Zhang, Kan Liu, Xupeng Zhao, Hongzhao Li and Xu Zhang

    Citation: Cancer Cell International 2020 20:550

    Content type: Review

    Published on:

  13. Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRN...

    Authors: Tianqi Zhang, Kunpeng Zhang, Kaiyue Ji, Cuiping Zhang, Yueping Jiang, Qi Zhang, Zibin Tian, Xinyu Wang, Mengyuan Zhang and Xiaoyu Li

    Citation: Cancer Cell International 2020 20:549

    Content type: Primary research

    Published on:

  14. To explore the effects of combinations of antiangiogenic agents and chemotherapy agents on non-small cell lung cancer (NSCLC) patients and indirectly compare the therapeutic effect of Endostar combined with ch...

    Authors: Yimin Li, Yonglin Yi, Anqi Lin, Peng Luo and Jian Zhang

    Citation: Cancer Cell International 2020 20:548

    Content type: Review

    Published on:

  15. RAS association domain family protein 1A (RASSF1A) promoter hypermethylation is suggested to be linked to hepatocellular carcinoma (HCC), but the results remained controversial.

    Authors: Gang Xu, Xiaoxiang Zhou, Jiali Xing, Yao Xiao, Bao Jin, Lejia Sun, Huayu Yang, Shunda Du, Haifeng Xu and Yilei Mao

    Citation: Cancer Cell International 2020 20:547

    Content type: Primary research

    Published on:

  16. Pathogenesis of colorectal cancer (CRC) is connected to deregulation of apoptosis while the effect of lncRNAs, as critical regulatory molecules, on this pathway is not clear well. The present study aimed to id...

    Authors: Fatemeh Akbari, Maryam Peymani, Ali Salehzadeh and Kamran Ghaedi

    Citation: Cancer Cell International 2020 20:546

    Content type: Primary research

    Published on:

  17. Docetaxel resistance affects prognosis in advanced prostate cancer (PCa). The precise mechanisms remain unclear. Transcription factor Forkhead box M1 (FOXM1), which participates in cell proliferation and cell ...

    Authors: Hongbo Yu, Zheng Xu, Maomao Guo, Weiwan Wang, Weican Zhang, Sudong Liang, Zhibin Xu, Jun Ye, Gangyi Zhu, Chenyang Zhang and Jianzhong Lin

    Citation: Cancer Cell International 2020 20:545

    Content type: Primary research

    Published on:

  18. The HER2 + tumor immune microenvironment is composed of macrophages, natural killer cells, and tumor infiltrating lymphocytes, which produce pro-inflammatory cytokines. Determining the effect of T-cells on HER...

    Authors: Patrick N. Song, Ameer Mansur, Kari J. Dugger, Tessa R. Davis, Grant Howard, Thomas E. Yankeelov and Anna G. Sorace

    Citation: Cancer Cell International 2020 20:544

    Content type: Primary research

    Published on:

  19. Long noncoding RNAs (lncRNAs) are important functional regulators of many biological processes of cancers. However, the mechanisms by which lncRNAs modulate androgen-independent prostate cancer (AIPC) developm...

    Authors: Weiyuan Li, Ganggang Yang, Dengke Yang, Dong Li and Qian Sun

    Citation: Cancer Cell International 2020 20:543

    Content type: Primary research

    Published on:

  20. ZBTB protein is an important member of the C2H2 zinc finger protein family. As a transcription factor, it is widely involved in the transcriptional regulation of genes, cell proliferation, differentiation, and...

    Authors: Rong Geng, Yuhua Zheng, Donghua zhou, Qingdong Li, Ruiman Li and Xiaoling Guo

    Citation: Cancer Cell International 2020 20:542

    Content type: Primary research

    Published on:

  21. Uterine corpus endometrial carcinoma (UCEC) is a frequent gynecological malignancy with a poor prognosis particularly at an advanced stage. Herein, this study aims to construct prognostic markers of UCEC based...

    Authors: Cankun Zhou, Chaomei Li, Fangli Yan and Yuhua Zheng

    Citation: Cancer Cell International 2020 20:541

    Content type: Primary research

    Published on:

  22. Yangyin Fuzheng Jiedu Prescription (YFJP) is a traditional Chinese medicine (TCM) indicated for the treatment of hepatocellular carcinoma (HCC). Its potential targets and molecular mechanisms are not clear. Th...

    Authors: Fengna Yan, Miaomiao Feng, Xinhui Wang, Peng Wang, Yuqing Xie, Xiaoli Liu, Weihong Li and Zhiyun Yang

    Citation: Cancer Cell International 2020 20:540

    Content type: Primary research

    Published on:

  23. Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polya...

    Authors: Jiajing Li, Yan Meng, Xiaolin Wu and Yuxin Sun

    Citation: Cancer Cell International 2020 20:539

    Content type: Review

    Published on:

  24. Bladder cancer (BC) is a commonly diagnosed malignant tumor in the urinary system, with a high morbidity and a high recurrence rate. Current studies indicated that metabolism-associated genes (MAGs) having cri...

    Authors: Chengquan Shen, Jing Liu, Liping Wang, Zhijuan Liang, Haitao Niu and Yonghua Wang

    Citation: Cancer Cell International 2020 20:538

    Content type: Primary research

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  25. Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variet...

    Authors: Milad Ashrafizadeh, Zahra Ahmadi, Tahereh Farkhondeh and Saeed Samarghandian

    Citation: Cancer Cell International 2020 20:537

    Content type: Review

    Published on:

  26. Long noncoding RNAs (lncRNAs) are composed of > 200 nucleotides; they lack the ability to encode proteins but play important roles in a variety of human tumors. A large number of studies have shown that dysreg...

    Authors: Bin Xu, Jie Mei, Wei Ji, Zheng Bian, Jiantong Jiao, Jun Sun and Junfei Shao

    Citation: Cancer Cell International 2020 20:536

    Content type: Review

    Published on:

  27. Growing evidence has indicated the vital parts of long non-coding RNAs (lncRNAs) in modulating the progression of assorted human cancers, including cervical cancer (CC). Nevertheless, the role and mechanism of...

    Authors: Yihong Chen, Qiumei Wu, Jing Lin and Juanbing Wei

    Citation: Cancer Cell International 2020 20:535

    Content type: Primary research

    Published on:

  28. Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by ...

    Authors: Xiaotang Yu, Xinchen Zhang, Guang Wang, Bo Wang, Yanfang Ding, Jinyao Zhao, Hanlin Liu and Shiying Cui

    Citation: Cancer Cell International 2020 20:534

    Content type: Primary research

    Published on:

  29. Viruses are obligate parasites that depend on host cells to provide the energy and molecular precursors necessary for successful infection. The main component of virus-induced metabolic reprogramming is the ac...

    Authors: Jing Cai, Wenbo Zhu, Yuan Lin, Jun Hu, Xincheng Liu, Wencang Xu, Ying Liu, Cheng Hu, Songmin He, Shoufang Gong, Guangmei Yan and Jiankai Liang

    Citation: Cancer Cell International 2020 20:532

    Content type: Primary research

    Published on:

  30. Long noncoding RNAs (lncRNAs) have been proved to be an important regulator in gene expression. In almost all kinds of cancers, lncRNAs participated in the process of pathogenesis, invasion, and metastasis. Me...

    Authors: Shengyang Ge, Yuanyuan Mi, Xiaojun Zhao, Qingfeng Hu, Yijun Guo, Fan Zhong, Yang Zhang, Guowei Xia and Chuanyu Sun

    Citation: Cancer Cell International 2020 20:531

    Content type: Primary research

    Published on:

  31. The effect of the geriatric nutritional risk index (GNRI) on the prognosis of patients with gastrointestinal malignancy remains unclear. The aim of our study was to systematically explore the value of the GNRI...

    Authors: Hailun Xie, Shuangyi Tang, Lishuang Wei and Jialiang Gan

    Citation: Cancer Cell International 2020 20:530

    Content type: Review

    Published on:

  32. Abnormal proliferation, metastasis and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are direct factors of posterior capsular opacification (PCO). Nuclear enriched abundant transc...

    Authors: Huajun Wang and Guangying Zheng

    Citation: Cancer Cell International 2020 20:529

    Content type: Primary research

    Published on:

  33. Protein regulator of cytokinesis 1 (PRC1) has been reported to play important role in the pathogenesis of various cancers. However, its role in colon cancer has not been studied. Here, we aimed to investigate ...

    Authors: Tianxiang Xu, Xiaoxia Wang, Xiangdong Jia, Weishi Gao, Junhua Li, Fengying Gao, Ping Zhan and Wu Ji

    Citation: Cancer Cell International 2020 20:528

    Content type: Primary research

    Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mohsen Keshavarz, Ailar Sabbaghi, Seyed Mohammad Miri, Abolhasan Rezaeyan, Yaser Arjeini and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:527

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2020 20:131

  35. Circular RNAs (circRNAs) have been discovered to participate in the carcinogenesis of multiple cancers. However, the role of circRNAs in esophageal squamous cell carcinoma (ESCC) progression is yet to be prope...

    Authors: Xiaoyong Li, Laichun Song, Bo Wang, Chao Tao, Lei Shi and Ming Xu

    Citation: Cancer Cell International 2020 20:526

    Content type: Primary research

    Published on:

  36. Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves t...

    Authors: Khatereh Khorsandi, Reza Hosseinzadeh and Elham Chamani

    Citation: Cancer Cell International 2020 20:525

    Content type: Primary research

    Published on:

  37. Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of fo...

    Authors: Xun Chen, Shangwu Chen and Dongsheng Yu

    Citation: Cancer Cell International 2020 20:523

    Content type: Review

    Published on:

  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Seyed Mohammad Miri, Mir Saeed Ebrahimzadeh, Elahe Abdolalipour, Mahsa Yazdi, Hassan Hosseini Ravandi and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:522

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2020 20:380

  39. Novel chemotherapeutic drugs with good anti-tumor activity are of pressing need for bladder cancer treatment. In this study, plumbagin (PL), a natural plant-derived drug extracted from Chinese herbals, was ide...

    Authors: Renjie Zhang, Zijian Wang, Wenjie You, Fengfang Zhou, Zicheng Guo, Kaiyu Qian, Yu Xiao and Xinghuan Wang

    Citation: Cancer Cell International 2020 20:520

    Content type: Primary research

    Published on:

  40. Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application in clear cell renal cell c...

    Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu and Yanxiang Cheng

    Citation: Cancer Cell International 2020 20:519

    Content type: Primary research

    Published on:

  41. Glioma is the most frequent and lethal primary brain malignancy. Amounting evidence has highlighted the importance of exosomal microRNAs (miRNAs or miRs) in this malignancy. This study aimed to investigate the...

    Authors: Meng Wang, Yi Zhao, Zhi-Yun Yu, Ren-De Zhang, Shu-Ang Li, Peng Zhang, Ti-Kun Shan, Xue-You Liu, Ze-Ming Wang, Pei-Chao Zhao and Hong-Wei Sun

    Citation: Cancer Cell International 2020 20:518

    Content type: Primary research

    Published on:

  42. Ovarian cancer (OC) is a common gynecological cancer and characterized by high metastatic potential. MicroRNAs (miRNAs, miRs) have the promise to be harnessed as prognostic and therapeutic biomarkers for OC. H...

    Authors: Yang Gu and Shulan Zhang

    Citation: Cancer Cell International 2020 20:517

    Content type: Primary research

    Published on:

  43. The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) rema...

    Authors: Yuqi Xiang, Liyu Liu, Ying Wang, Bo Li, Jinwu Peng and Deyun Feng

    Citation: Cancer Cell International 2020 20:516

    Content type: Primary research

    Published on:

  44. CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied.

    Authors: Ben-Shun Hu, Tian Tang, Jun-Li Jia, Bi-Chen Xie, Tie-Long Wu, Ying-Yue Sheng, Yu-Zheng Xue and Hua-Min Tang

    Citation: Cancer Cell International 2020 20:513

    Content type: Primary research

    Published on:

  45. Prostate cancer (PCa) is a kind of malignancy occurring in the prostate gland. Substantial researches have proved the major role of long noncoding RNAs (lncRNAs) in PCa. However, the role of long intergenic no...

    Authors: Enhui Ma, Qianqian Wang, Jinhua Li, Xinqi Zhang, Zhenjia Guo and Xiaofeng Yang

    Citation: Cancer Cell International 2020 20:515

    Content type: Primary research

    Published on:

  46. Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present ...

    Authors: Zhiyan Ruan, Hongling Deng, Minhua Liang, Zhe Xu, Manxiang Lai, Hong Ren, Xiangliang Deng and Xinguo Su

    Citation: Cancer Cell International 2020 20:511

    Content type: Primary research

    Published on:

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