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  1. Cisplatin (CIS) is a potent antineoplastic agent with high therapeutic efficacy against many kinds of tumors. Its use is limited by its nephrotoxicity. The aim of this work was to minimize cisplatin effective ...

    Authors: Abdel-Moneim M. Osman, Ali A. Alqahtani, Zoheir A. Damanhouri, Sameer E. Al-Harthy, Mohamed F. ElShal, Wafaa S. Ramadan, Fatemah Kamel, Mohamed A. M. Osman and Lateef M. Khan
    Citation: Cancer Cell International 2015 15:104
    Content type: Primary research Published on:

  2. The incidence of tumors with life-threatening effects has increased gradually over time; however, the mechanisms involved in tumor development have not been fully elucidated. Recent studies have shown that mic...

    Authors: Juanjuan Zhao, Yijing Tao, Ya Zhou, Nalin Qin, Chao Chen, Dan Tian and Lin Xu
    Citation: Cancer Cell International 2015 15:103
    Content type: Review Published on:

  3. The central nervous system (CNS) is protected by several barriers, including the blood–brain (BBB) and blood-cerebrospinal fluid (BCSFB) barriers. Understanding how cancer cells circumvent these protective bar...

    Authors: Elodie Vandenhaute, Carolin Stump-Guthier, María Lasierra Losada, Tobias Tenenbaum, Henriette Rudolph, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Matthias Dürken, Martin März and Michael Karremann
    Citation: Cancer Cell International 2015 15:102
    Content type: Primary research Published on:

  4. Celastrol has anti-cancer effects by increase of apoptosis of gastric cancer cells. However, its role in gastric cancer cell cycle is still unclear. The aim of this study was to investigate the effect and mec...

    Authors: Min Sha, Jun Ye, Zheng-yun Luan, Ting Guo, Bian Wang and Jun-xing Huang
    Citation: Cancer Cell International 2015 15:101
    Content type: Primary research Published on:

  5. Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicro...

    Authors: Seok Fang Oon, Meenakshii Nallappan, Thiam Tsui Tee, Shamarina Shohaimi, Nur Kartinee Kassim, Mohd Shazrul Fazry Sa’ariwijaya and Yew Hoong Cheah
    Citation: Cancer Cell International 2015 15:100
    Content type: Review Published on:

  6. LIN28B is a conserved RNA-binding protein critically involved in development, cellular metabolism and tumorigenesis. It is frequently overexpressed in human cancers and correlates with tumor aggressiveness as ...

    Authors: Dongmiao Wang, Yuming Zhu, Yanling Wang, Zhongwu Li, Chunping Yuan, Wei Zhang, Hua Yuan, Jinhai Ye, Jianrong Yang, Hongbing Jiang and Jie Cheng
    Citation: Cancer Cell International 2015 15:99
    Content type: Primary research Published on:

  7. Changes in DNA methylation are associated with changes in somatic cell fate without the alteration of coding sequences. In addition to its use as a traceable biomarker, reversible DNA methylation could also se...

    Authors: Chih-Cheng Chen, Kuan-Der Lee, Mei-Yu Pai, Pei-Yi Chu, Chia-Chen Hsu, Chia-Chen Chiu, Li-Tzong Chen, Jang-Yang Chang, Shu-Huei Hsiao and Yu-Wei Leu
    Citation: Cancer Cell International 2015 15:98
    Content type: Primary research Published on:

  8. The indirubin derivative 7-bromoindirubin-3′-oxime (7BIO) has already shown anticancer properties by causing cell death in some tumour cell lines and may be a new therapeutic option for treatment-resistant tum...

    Authors: Martina Broecker-Preuss, Nina Becher-Boveleth, Susanne Gall, Katrin Rehmann, Susann Schenke and Klaus Mann
    Citation: Cancer Cell International 2015 15:97
    Content type: Primary research Published on:

  9. Colorectal cancer is one of the commonest cancers in the world and it is also a common cause of cancer-related death worldwide. Despite advanced treatment strategies, the disease is rarely cured completely due...

    Authors: Thamil Selvee Ramasamy, Ain Zubaidah Ayob, Hsu Hsu Lynn Myint, Sharmanee Thiagarajah and Farahnaz Amini
    Citation: Cancer Cell International 2015 15:96
    Content type: Review Published on:

  10. Cancer stem cells (CSCs) constitute 1–2 % of cancer tissue and are a major cause of tumor metastasis and recurrence. The culture environment is important in maintaining CSCs in vitro. Sphere formation is one m...

    Authors: Seon Ok Min, Sang Woo Lee, Seon Young Bak and Kyung Sik Kim
    Citation: Cancer Cell International 2015 15:95
    Content type: Primary research Published on:

  11. The article to which this update relates has been retracted. Please see the retraction notice for more detail: http://dx.doi.org/10.1186/s12935-015-0226-9

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Jay Gopal Ray, Sukumar Maity, Indranil kulavi and Mahitosh Mandal
    Citation: Cancer Cell International 2015 15:94
    Content type: Erratum Published on:

    The original article was published in Cancer Cell International 2015 15:74

  12. Previous study showed that downregulated BCL11B expression in T cell acute lymphoblastic leukemia (T-ALL) cell line Molt-4 inhibited cell proliferation and induce apoptosis, which may be related to PHTF1 gene ove...

    Authors: Xin Huang, Suxia Geng, Jianyu Weng, Zesheng Lu, Lingji Zeng, Minming Li, Chengxin Deng, Xiuli Wu, Yangqiu Li and Xin Du
    Citation: Cancer Cell International 2015 15:93
    Content type: Primary research Published on:

  14. AKT plays a pivotal role in the signal transduction of cancer cells. MK2206, an AKT inhibitor, has been shown to be an effective anti-cancer drug to a variety of cancer cell lines. However, some cancer cells a...

    Authors: Lei Qi, Hidemi Toyoda, Dong-qing Xu, Ye Zhou, Naoto Sakurai, Keishirou Amano, Kentaro Kihira, Hiroki Hori, Eiichi Azuma and Yoshihiro Komada
    Citation: Cancer Cell International 2015 15:91
    Content type: Primary research Published on:

    The Erratum to this article has been published in Cancer Cell International 2015 15:108

  15. Conjugated linolenic acids (CLN) refer to the positional and geometric isomers of octadecatrienoic acids with three conjugated double bonds (C18:3). Previous researches have demonstrated that CLN can inhibit t...

    Authors: Wai Nam Liu and Kwok Nam Leung
    Citation: Cancer Cell International 2015 15:90
    Content type: Primary research Published on:

  16. Cyclin D3, which induces progression through the G1 phase of the cell cycle, is a regulator of Cyclin-dependent kinases 4 and 6. Previous studies revealed that abnormal expression of Cyclin D3 was found in man...

    Authors: Yayun Chi, Sheng Huang, Mengying Liu, Liang Guo, Xuxia Shen and Jiong Wu
    Citation: Cancer Cell International 2015 15:89
    Content type: Primary research Published on:

  17. We studied a primary culture developed from a biopsy of a clear cell carcinoma of the ovary (O-CCC) by (a) assessing its capacity to retain in vitro pathological features of the tumor of origin; (b) characteri...

    Authors: Alicia A. Goyeneche, Michael Koch, Maria C. Bell and Carlos M. Telleria
    Citation: Cancer Cell International 2015 15:88
    Content type: Primary research Published on:

  18. Dysregulated miRNAs play an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In this study, we ...

    Authors: Qiang Sun, Shuai Chen, Xue Zhao, Ming Yan, Zheng Fang, Haibin Wang, Junfang Zhao, Minglei Sun, Xinguang Han, Wantao Chen and Xinming Li
    Citation: Cancer Cell International 2015 15:87
    Content type: Primary research Published on:

  19. MicroRNAs (miRNAs) play key roles in cancer development and progression. The purpose of the present study was to determine the expression levels of miR-133a and miR-539 in osteosarcoma patients and to further ...

    Authors: Alireza Mirghasemi, Afshin Taheriazam, Seyyed Hasan Karbasy, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi and Aram Mokarizadeh
    Citation: Cancer Cell International 2015 15:86
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:84

  20. Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15–20 %, with a m...

    Authors: Shanshan Chen, Ping Li, Rui Yang, Ruirui Cheng, Furui Zhang, Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Yuwen Du, Guoqiang Zhao and Guojun Zhang
    Citation: Cancer Cell International 2015 15:85
    Content type: Primary research Published on:

  21. Lung cancer, predominantly non-small-cell lung cancer (NSCLC), is the leading cause of cancer deaths worldwide. There is a great need to identify critical effectors involved in metastasis of NSCLC that will fa...

    Authors: Qinchuan Li, Yang Han, Chunhong Wang, Shan Shan, Yuanyuan Wang, Jingang Zhang and Tao Ren
    Citation: Cancer Cell International 2015 15:84
    Content type: Primary research Published on:

  22. Prolactin (PRL) has been implicated in the development of different types of cancer. However, signaling pathways might be activated depending on various forms of prolactin receptor (PRLR). JAK/STAT is an impor...

    Authors: Adrián Ramírez de Arellano, Edgar I. Lopez-Pulido, Priscila A. Martínez-Neri, Ciro Estrada Chávez, Renee González Lucano, Mary Fafutis-Morris, A. Aguilar-Lemarroy, José. F. Muñoz-Valle and Ana Laura Pereira-Suárez
    Citation: Cancer Cell International 2015 15:83
    Content type: Primary research Published on:

  23. The purpose of this study was to assess the antitumoral effect of the methanol extract (MeOH) from Nitraria retusa leaves and to investigate its immunomodulatory activity that mediated the prevention of tumor pro...

    Authors: Jihed Boubaker, Fadwa Chaabane, Ahmed Bedoui, Rihab Aloui, Besma Ben Ahmed, Kamel Ghedira and Leila Chekir-Ghedira
    Citation: Cancer Cell International 2015 15:82
    Content type: Primary research Published on:

  24. Rhodiola algida var. tangutica is a traditional Tibetan herb. Its root and rhizome have been successfully used as an effective clinical remedy for the prevention and treatment of cance...

    Authors: Yu-juan Qi, Sen Cui, Dian-xiang Lu, Ying-zhong Yang, Yushuang Luo, Lan Ma, Yan Ma, Tana Wuren, Rong Chang, Lei Qi, Ba-ji Ben, Jun Han and Ri-Li Ge
    Citation: Cancer Cell International 2015 15:81
    Content type: Primary research Published on:

  25. Aberrant expression of miR-193a-3p and astrocyte elevated gene-1 (AEG-1) have been revealed to be related to the tumorigenesis of various cancers, including non-small cell lung cancer (NSCLC). However, the sig...

    Authors: Fanghui Ren, Hua Ding, Suning Huang, Hanlin Wang, Mei Wu, Dianzhong Luo, Yiwu Dang, Lihua Yang and Gang Chen
    Citation: Cancer Cell International 2015 15:80
    Content type: Primary research Published on:

  26. Etoposide has been used clinically in cancer treatment, as well as in numerous research studies, for many years. However, there is incomplete information about its exact mechanism of action in induction of cel...

    Authors: Sarwat Jamil, Irene Lam, Maryam Majd, Shu-Huei Tsai and Vincent Duronio
    Citation: Cancer Cell International 2015 15:79
    Content type: Primary research Published on:

  27. Pachymic acid (PA), a lanostane-type triterpenoid from Poria cocos, has been reported to possess anti-emetic, anti-inflammatory, and anti-cancer properties. Nonetheless, the anti-tumor effect of PA in lung cancer...

    Authors: Jun Ma, Jun Liu, Chunwei Lu and Dingfang Cai
    Citation: Cancer Cell International 2015 15:78
    Content type: Primary research Published on:

  28. Colon carcinoma is one of the commonly tumors that threaten human beings as its highly morbidity and mortality. Recent evidences suggested that microRNA-21 (miR-21) played an important role in the development ...

    Authors: Yi-Jing Tao, Yong-ju Li, Wen Zheng, Juan-juan Zhao, Meng-meng Guo, Ya Zhou, Na-lin Qin, Jing Zheng and Lin Xu
    Citation: Cancer Cell International 2015 15:77
    Content type: Primary research Published on:

  29. Neuroblastoma is a neural crest-derived tumor and is the most common cancer in children less than 1 year of age. We hypothesized that aberrations in genes that control the cell cycle could play an important ro...

    Authors: Ali Rihani, Jo Vandesompele, Frank Speleman and Tom Van Maerken
    Citation: Cancer Cell International 2015 15:76
    Content type: Primary research Published on:

  30. Rhabdomyosarcoma is a rare malignant skeletal muscle tumor. It mainly occurs in children and young adults and has an unsatisfactory prognosis. Prior studies showed a direct myotoxic effect of bupivacaine on di...

    Authors: Thomas Metterlein, Petra Hoffmann, Ruth Späth, Michael Gruber, Bernhard M Graf and Wolfgang Zink
    Citation: Cancer Cell International 2015 15:75
    Content type: Primary research Published on:

  31. Squamous cell carcinoma of the oral cavity (SCCOC) is the dominant origin of cancer associated mortality. Previous findings by our study reported that acquisition of anoikis resistance has a significant role i...

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Joygopal Roy, Sukumar Maity, Indranil kulavi and Mahitosh Mandal
    Citation: Cancer Cell International 2015 15:74
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2021 21:82

    The Erratum to this article has been published in Cancer Cell International 2015 15:94

  32. A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis. A20 is frequently inactivated by deletions and/or mut...

    Authors: Yi Xu, Junyan Hu, Xu Wang, Li Xuan, Jing Lai, Ling Xu, Shaohua Chen, Lijian Yang, Gengxin Luo, Kanger Zhu, Xiuli Wu and Yangqiu Li
    Citation: Cancer Cell International 2015 15:73
    Content type: Primary research Published on:

  33. Interleukin (IL)-18 gene polymorphisms have been found to play multiple roles in various diseases. However, studies focused on its involvement in hepatocellular carcinoma (HCC) remains...

    Authors: Jingui Bao, Yu Lu, Yan Deng, Chengzhi Rong, Yanqiong Liu, Xiuli Huang, Liuying Song, Shan Li and Xue Qin
    Citation: Cancer Cell International 2015 15:72
    Content type: Primary Research Published on:

  34. Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemothera...

    Authors: Khalid O Alfarouk, Christian-Martin Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H H Bashir, Osama Y Mohammed, Gamal O Elhassan, Salvador Harguindey, Stephan J Reshkin, Muntaser E Ibrahim and Cyril Rauch
    Citation: Cancer Cell International 2015 15:71
    Content type: Review Published on:

  35. Glycogen synthase kinase-3β (GSK3β) expression and activity are upregulated in pancreatic cancer tissues. In our previous study, we found that stromal cell-derived factor-1/ chemokine receptor C-X-C motif chem...

    Authors: Xu Ying, Li Jing, Shijie Ma, Qianjun Li, Xiaoling Luo, Zhenguo Pan, Yanling Feng and Pan Feng
    Citation: Cancer Cell International 2015 15:70
    Content type: Primary research Published on:

  36. Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with carcinogenesis, which is suspected to promote angiogenesis and tissue...

    Authors: Liyan Qu and Bing Liu
    Citation: Cancer Cell International 2015 15:69
    Content type: Review Published on:

  37. Variants in the axis inhibition 2 (AXIN2) gene might alter the protein’s structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual’s susceptibil...

    Authors: Zhitong Wu, Yifan Sun, Shifu Tang, Chunming Liu, Shengbo Zhu, Lili Wei and Hong Xu
    Citation: Cancer Cell International 2015 15:68
    Content type: Primary research Published on:

  40. Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on cell proliferatio...

    Authors: Chuntuan Li, Pengliang Xin, Huifang Xiao, Yan Zheng, Yuanling Huang and Xiongpeng Zhu
    Citation: Cancer Cell International 2015 15:65
    Content type: Primary research Published on:

  41. The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis.

    Authors: Nives Pećina-Šlaus and Marko Pećina
    Citation: Cancer Cell International 2015 15:64
    Content type: Review Published on:

  42. Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays...

    Authors: Jun Zeng, Rong Shi, Cui-xia Cai, Xin-rui Liu, Yan-bin Song, Min Wei and Wen-li Ma
    Citation: Cancer Cell International 2015 15:63
    Content type: Primary research Published on:

  43. Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the...

    Authors: Yongru Liu, Fanghui Ren, Minhua Rong, Yihuan Luo, Yiwu Dang and Gang Chen
    Citation: Cancer Cell International 2015 15:62
    Content type: Primary research Published on:

  44. Increasing evidence indicates that dysregulation of microRNAs is involved in tumor progression and development. The aim of this study was to investigate the expression of microRNA-24 (miR-24) and its function ...

    Authors: Li Xu, Zhifeng Chen, Fei Xue, Wei Chen, Ruina Ma, Shiyin Cheng and Pengcheng Cui
    Citation: Cancer Cell International 2015 15:61
    Content type: Primary research Published on:

  45. This study is to explore the pathological features of transplanted tumor established by CD133 positive TJ905 glioblastoma stem-like cells.

    Authors: Feng Jin, Ran Zhang, Song Feng, Chuan-Tao Yuan, Ren-Ya Zhang, Guang-Kui Han, Gen-Hua Li, Xi-Zhen Yu, Yang Liu, Ling-Sheng Kong, Shu-Ling Zhang and Lei Zhao
    Citation: Cancer Cell International 2015 15:60
    Content type: Primary research Published on:

  46. This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells.

    Authors: Yongchao Ma, Fazhang Zou, Junping Xiong, Wei Wan, Li Yin, Xianjia Li, Zhanyu Bei, Lei Yuan, Song Meng, Jianguo Wang and Guohua Song
    Citation: Cancer Cell International 2015 15:59
    Content type: Primary research Published on:

  47. Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-...

    Authors: Mario Orozco-Morales, Francisco Javier Sánchez-García, Irene Golán-Cancela, Norma Hernández-Pedro, Jose A. Costoya, Verónica Pérez de la Cruz, Sergio Moreno-Jiménez, Julio Sotelo and Benjamín Pineda
    Citation: Cancer Cell International 2015 15:57
    Content type: Primary research Published on:

  48. Radiotherapy is an important therapeutic method for lung cancer. However, in clinical situations, cellular resistance to radiotherapy is a significant component of tumor treatment failure. Thus, clarification ...

    Authors: Chen Liao, Wei Xiao, Nuo Zhu, Zhiyuan Liu, Jiu Yang, Yanhu Wang and Mei Hong
    Citation: Cancer Cell International 2015 15:56
    Content type: Primary research Published on:

  49. Recently, we have reported the induction of apoptosis by 2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-NC) in HepG2, T47D and HCT116 cells with low nano molar IC50 values. In this study, anti...

    Authors: Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand and Shima Hallaj Neishabouri
    Citation: Cancer Cell International 2015 15:55
    Content type: Primary research Published on:

  50. Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome re...

    Authors: Siaw Shi Boon and Sai-Peng Sim
    Citation: Cancer Cell International 2015 15:54
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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