Articles

Contribution of nuclear BCL10 expression to tumor progression and poor prognosis of advanced and/or metastatic pancreatic ductal adenocarcinoma by activating NF-κB-related signaling

We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-κB in breast cancer and lymphoma cell lines. In this study, we assessed whether nuclear BCL10 translocation is ...

Authors: Sung-Hsin Kuo, Shih-Hung Yang, Ming-Feng Wei, Hsiao-Wei Lee, Yu-Wen Tien, Ann-Lii Cheng and Kun-Huei Yeh

Pseudogene HSPA7 is a poor prognostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) and correlated with immune infiltrates

Pseudogenes played important roles in tumorigenesis, while there are nearly no reports about the expression and roles of HSPA7 in the cancer.

Authors: Chunjin Ding, Rundong He, Jinghan Zhang, Zhan Dong and Jun Wu

Ovarian cancer: epigenetics, drug resistance, and progression

Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and the activation of abnormal cell signa...

Authors: Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang and Xipeng Wang

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway

Encouraged by the goal of developing an effective treatment strategy for prostate cancer, this study explored the mechanism involved in metformin-mediated inhibition of AR-negative prostate cancer.

Authors: Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang and Jianquan Hou

LncRNA CTD-3252C9.4 modulates pancreatic cancer cell survival and apoptosis through regulating IFI6 transcription

Pancreatic cancer (PC) is one of the most lethal cancer types with high degree of malignancy and poor prognosis. Recent studies have shown that long non-coding RNAs (lncRNAs) were associated with the initiatio...

Authors: Xin Yin, Jingyan Yang, Jintian Chen, Ruiqi Ni, Yanhao Zhou, Hao Song, Liang Jin, Tingting Tang and Yi Pan

Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs

Gastric cancer (GC) is a globally prevalent cancer, ranking fifth for incidence and fourth for mortality worldwide. The N6-methyladenosine (m⁶A) related long noncoding RNAs (lncRNAs) were widely investigated in r...

Authors: Tenghui Han, Dong Xu, Jun Zhu, Jipeng Li, Lei Liu and Yanchun Deng

Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19

Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SAR...

Authors: Sepehr Shafiee, Luca Cegolon, Mostafa Khafaei, Nasrin Gholami, Shi Zhao, Nasrin Khalesi, Hamidreza Moosavian, Saeid Fathi, Morteza Izadi, Alireza Ghadian, Mohammad Javanbakht, Amin Javanbakht and Reza Akhavan-Sigari

DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling

DDX52 is a type of DEAD/H box RNA helicase that was identified as a novel prostate cancer (PCa) genetic locus and possible causal gene in a European large-scale transcriptome-wide association study. However, t...

Authors: Wandong Yu, Hangbin Ma, Junhong Li, Jinchao Ge, Pengyu Wang, Yinghao Zhou, Jun Zhang and Guowei Shi

LINC01410 leads the migration, invasion and EMT of bladder cancer cells by modulating miR-4319 / Snail1

Several previous studies have implied the significance of lncRNA1410 (LINC01410) in gastric cancer, rectal cancer, and cervical cancer. Nevertheless, the potential of LINC01410 in bladder cancer (BC) developme...

Authors: Wei Guo, Qimei Gai, Yue Ma, Zhengfei Shan and Jitao Wu

Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations will inevitably develop drug resistance after being treated with the third-generation EGFR-tyrosine kinase inh...

Authors: Xinying Li, Cen Chen, Zimu Wang, Jiaxin Liu, Wei Sun, Kaikai Shen, Yanling Lv, Suhua Zhu, Ping Zhan, Tangfeng Lv and Yong Song

Molecular mechanism underlying the apoptotic modulation by ethanol extract of Pseudolarix kaempferi in mucoepidermoid carcinoma of the salivary glands

Pseudolarix kaempferi is a traditional Chinese natural product that possesses the potential cytotoxic effects against cancer. However, the precise molecular mechanism underlying its cytotoxic effects has not yet ...

Authors: Su-Jung Choi, Chi-Hyun Ahn, Kyoung-Ok Hong, Ji-Hoon Kim, Seong-Doo Hong, Ji-Ae Shin and Sung-Dae Cho

Nivolumab monotherapy or combination therapy with ipilimumab for lung cancer: a systemic review and meta-analysis

The high incidence and mortality of lung cancer have seriously affected human life and health. Nivolumab is a monoclonal antibody that can inhibit programmed death 1 (PD-1) and Ipilimumab is a monoclonal antib...

Authors: Huihui Jiang, Aiqun Xu, Wanli Xia, Xingyuan Xia, Pulin Li, Binbin Zhang, Ke Zhu, Sijing Zhou and Ran Wang

LncRNA OGFRP1 acts as an oncogene in NSCLC via miR-4640-5p/eIF5A axis

Long noncoding RNAs (lncRNAs) OGFRP1 is up-regulated in endometrial cancer and cervical carcinoma, and OGFRP1 suppression inhibits the malignant behavior of cancer cells. Here, we evaluated the expression patt...

Authors: Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen and Xuewei Zhuang

Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression

Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in the clinic are lacking. Bufalin is effective in treating various tu...

Authors: Yao Li, Yan Zhang, Xufang Wang, Qian Yang, Xuanxuan Zhou, Junsheng Wu, Xu Yang, Yani Zhao, Rui Lin, Yanhua Xie, Jiani Yuan, Xiaohui Zheng and Siwang Wang

Ultrastructural analysis of breast cancer patient-derived organoids

Breast cancer Patient Derived Organoids (PDO) have been demonstrated to be a reliable model to study cancer that promised to replace and reduce the use of animals in pre-clinical research. They displayed conco...

Authors: Lorena Signati, Raffaele Allevi, Francesca Piccotti, Sara Albasini, Laura Villani, Marta Sevieri, Arianna Bonizzi, Fabio Corsi and Serena Mazzucchelli

Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway

Epithelial–mesenchymal transition (EMT) promotes migration, invasion, and metastasis of hepatocellular carcinoma (HCC) cells. The molecular mechanisms behind EMT and metastasis in HCC remain unclear.

Authors: Hong-Lin Luo, Tao Luo, Jun-Jie Liu, Fei-Xiang Wu, Tao Bai, Chao Ou, Jie Chen, Le-Qun Li and Jian-Hong Zhong

Recent advances of m⁶A methylation modification in esophageal squamous cell carcinoma

In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N⁶-methyladenosine (m⁶A) has gradually become a research hotspot in the f...

Authors: Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Manli Cui, Mingxin Zhang and Lingmin Zhang

[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

The underlying mechanism behind the tumorigenesis and progression of pancreatic cancer is not clear, and treatment failure is generally caused by early metastasis, recurrence, drug resistance and vascular inva...

Authors: Xueyi Jiang, Jie Wang, Peng Chen, Zhiwei He, Jian Xu, Yankun Chen, Xinyuan Liu and Jianxin Jiang

Triple-negative breast cancer: understanding Wnt signaling in drug resistance

Triple-negative breast cancer (TNBC) is not as prevalent as hormone receptor or HER2-positive breast cancers and all receptor tests come back negative. More importantly, the heterogeneity and complexity of the...

Authors: Parnaz Merikhian, Mohammad Reza Eisavand and Leila Farahmand

WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer

WD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain protein family. Its biological function is largely unclear, particularly in colorectal cancer (CRC).

Authors: Zijian Li, Min Feng, Jie Zhang, Xingzhou Wang, En Xu, Chao Wang, Fengcen Lin, Zhi Yang, Heng Yu, Wenxian Guan and Hao Wang

Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of hu...

Authors: Qian Lu, Jun Lou, Ruyun Cai, Weidong Han and Hongming Pan

Retraction Note to: Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis

Authors: Chang Li, Yuan Tian, Yun Liang and Qingchun Li

TACR2 is associated with the immune microenvironment and inhibits migration and proliferation via the Wnt/β-catenin signaling pathway in prostate cancer

The tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene. Recent microarray analysis for prostate cancer suggests that TACR2 expression is associated with clinical phenotype and...

Authors: Wang Jianfeng, Wang Yutao and Bi Jianbin

A novel signature constructed by ferroptosis-associated genes (FAGs) for the prediction of prognosis in bladder urothelial carcinoma (BLCA) and associated with immune infiltration

Ferroptosis, a novel form of regulated cell death, has been implicated in the pathogenesis of cancers. Nevertheless, the potential function and prognostic values of ferroptosis in bladder urothelial carcinoma ...

Authors: Jiao-chen Luan, Teng-yue Zeng, Qi-jie Zhang, De-run Xia, Rong Cong, Liang-yu Yao, Le-bin Song, Xiang Zhou, Xuan Zhou, Xiang Chen, Jia-dong Xia and Ning-hong Song

NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC

Increasing evidence has demonstrated the critical roles of mRNA modification regulators on multiple types of cancers. However, it is still poorly known about the prognostic and therapeutic value of mRNA modifi...

Authors: Wenjie Tao, Guocai Tian, Shengming Xu, Jiayi Li, Zhiyuan Zhang and Jiang Li

Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B

Circular RNAs (circRNAs) could participate in cis-dichlorodiammineplatinum (DDP) resistance of human cancers. However, circRNAs role in DDP resistance of oral squamous cell carcinoma (OSCC) progression remains la...

Authors: Feng Qiu, Bin Qiao, Nan Zhang, Zheng Fang, Lu Feng, Shanfeng Zhang and Weiliu Qiu

Plastin-3 is a diagnostic and prognostic marker for pancreatic adenocarcinoma and distinguishes from diffuse large B-cell lymphoma

Altered Plastin-3 (PLS3; an actin-binding protein) expression was associated with human carcinogenesis, including pancreatic ductal adenocarcinoma (PDA). This study first assessed differentially expressed gene...

Authors: Fei Xiong, Guan-Hua Wu, Bing Wang and Yong-Jun Chen

CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway

Most of the biological functions of circular RNAs (circRNAs) and the potential underlying mechanisms in hepatocellular carcinoma (HCC) have not yet been discovered.

Authors: Ying Xie, Xiaofeng Hang, Wensheng Xu, Jing Gu, Yuanjing Zhang, Jianrong Wang, Xiucui Zhang, Xinghao Cao, Junjie Zhan, Junxue Wang and Jianhe Gan

Identification and integrative analysis of ACLY and related gene panels associated with immune microenvironment reveal prognostic significance in hepatocellular carcinoma

Cumulating evidence reveals the key role of aberrant lipogenesis and immunogenomic features in hepatocellular carcinoma (HCC). However, there are still obstacles in our understanding of the complicated interac...

Authors: Yunfeng Xu, Ze Zhang, Da Xu, Xin Yang, Lina Zhou and Ying Zhu

Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling

Epigenetic modulation by noncoding RNAs substantially contributes to human cancer development, but noncoding RNAs involvement in bladder cancer remains poorly understood. This study investigated the role of lo...

Authors: Ranran Dai, Qingping Jiang, You Zhou, Ruifeng Lin, Hai Lin, Yumin Zhang, Jinhu Zhang and Xingcheng Gao

Aurora kinase A (AURKA) promotes the progression and imatinib resistance of advanced gastrointestinal stromal tumors

Gastrointestinal stromal tumor (GIST) is a common tumor that originates from the alimentary system mesenchyme. Compared to typical gastrointestinal carcinomas, GISTs exhibit unique malignant behaviors. Bioinfo...

Authors: Xiaobin Cheng, Jinhai Wang, Sen Lu, Weina Fan and Weilin Wang

A review on the advances and challenges of immunotherapy for head and neck cancer

Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells...

Authors: Gang Cheng, Hui Dong, Chen Yang, Yang Liu, Yi Wu, Lifen Zhu, Xiangmin Tong and Shibing Wang

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies h...

Authors: Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Qin and Yuefeng Lu

Correction to: Synergism between the phosphatidylinositol 3-kinase p110β isoform inhibitor AZD6482 and the mixed lineage kinase 3 inhibitor URMC-099 on the blockade of glioblastoma cell motility and focal adhesion formation

Authors: Hua‑fu Zhao, Chang‑peng Wu, Xiu‑ming Zhou, Peng‑yu Diao, Yan‑wen Xu, Jing Liu, Jing Wang, Xian‑jian Huang, Wen‑lan Liu, Zhong‑ping Chen, Guo‑dong Huang and Wei‑ping Li

Expression and prognostic significance of CBX2 in colorectal cancer: database mining for CBX family members in malignancies and vitro analyses

The Chromobox (CBX) domain protein family, a core component of polycomb repressive complexes 1, is involved in transcriptional repression, cell differentiation, and program development by binding to methylated...

Authors: He Zhou, Yongfu Xiong, Zuoliang Liu, Songlin Hou and Tong Zhou

Midazolam increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via the miR-194-5p/HOOK3 axis

As previously reported, midazolam anesthesia exerts tumor-suppressing effects in non-small cell lung cancer (NSCLC), but the regulating effects of this drug on cisplatin-resistance in NSCLC have not been studi...

Authors: Tingting Sun, Jing Chen, Xuechao Sun and Guonian Wang

LncRNA HOTAIR promotes proliferation and inhibits apoptosis by sponging miR-214-3p in HPV16 positive cervical cancer cells

Cervical cancer (CC) is one of the most common gynaecological malignancies all around the world. The mechanisms of cervical carcinoma formation remain under close scrutiny. The long non-coding RNAs (lncRNA) an...

Authors: Yu Zhou, Yuqing Wang, Mingying Lin, Daiqian Wu and Min Zhao

Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment

The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity. However, studies on the ...

Authors: Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo and Xiumin Ma

A pancreas tumor derived organoid study: from drug screen to precision medicine

Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, ...

Authors: Jia Yao, Man Yang, Lawrence Atteh, Pinyan Liu, Yongcui Mao, Wenbo Meng and Xun Li

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway

Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin...

Authors: Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang and Lifeng Xie

Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma

Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of t...

Authors: Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu and Enfan Zhang

MINDY1 promotes bladder cancer progression by stabilizing YAP

Bladder cancer is one of the most commonly diagnosed urological malignant tumor. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis. YAP is one of m...

Authors: Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu and Tao Liu

Significance of initial, interim and end-of-therapy ¹⁸F-FDG PET/CT for predicting transformation risk in follicular lymphoma

Histological transformation (HT) of follicular lymphoma to a more aggressive lymphoma is a serious event affecting patients’ outcomes. To date, no strong clinical HT predictors present at diagnosis have yet be...

Authors: Mixue Xie, Lulu Wang, Qi Jiang, Xuxia Luo, Xin Zhao, Xueying Li, Jie Jin, Xiujin Ye and Kui Zhao

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma

The homeobox gene Homeobox B7 (HOXB7) is overexpressed across a range of cancers and promotes tumorigenesis through varying effects on proliferation, survival, migration and invasion. However, its expression p...

Authors: Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang and Zhongwu Li

Long noncoding RNA FER1L4 promotes the malignant processes of papillary thyroid cancer by targeting the miR-612/ Cadherin 4 axis

Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in various cancers. However, the functional roles of most lncRNA in papillary thyroid cancer (PTC) are not detailly understood. This study aims ...

Authors: Luyao Wu, Yu Ding, Houchao Tong, Xi Zhuang, Jingsheng Cai, Yan Si, Hao Zhang, Xiaoting Wang and Meiping Shen

Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review

Glioblastoma, WHO grade IV astrocytoma, is the most aggressive type of brain tumors. These cancerous cells have a rapid growth rate, tendency to penetrate vital brain structures, molecular heterogeneity, etc. ...

Authors: AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen and Bagher Farhood

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5

miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RC...

Authors: Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si…

New insights into M1/M2 macrophages: key modulators in cancer progression

Infiltration of macrophages in and around tumor nest represents one of the most crucial hallmarks during tumor progression. The mutual interactions with tumor cells and stromal microenvironment contribute to p...

Authors: Jiuyang Liu, Xiafei Geng, Jinxuan Hou and Gaosong Wu

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsibl...

Authors: Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Asma Irshad, Ali Akbar, Željko Reiner, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Dinara Satmbekova, Monica Butnariu, Iulia Cristina Bagiu…

The immune landscape of the microenvironment of thyroid cancer is closely related to differentiation status

We have read with great interest the article entitled “Identification of an immune-related signature indicating the dedifferentiation of thyroid cells” by Wang et al. Their data reinforce our own previous resu...

Authors: Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, José Vassallo and Laura Sterian Ward