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  1. Triple-negative breast cancer (TNBC) is more commonly associated with young patients, featuring high histological grade, visceral metastasis, and distant recurrence. Follistatin (FST) is a secreted extracellul...

    Authors: Sainan Liu, Bin Liu, Qian Zhao, Jikang Shi, Yulu Gu, Yanbo Guo, Yong Li, Yunkai Liu, Yi Cheng, Yichun Qiao and Yawen Liu

    Citation: Cancer Cell International 2021 21:267

    Content type: Primary research

    Published on:

  2. The clinical outcome of patients with a diagnosis of hormone receptor (HR)+ breast cancer has improved remarkably since the arrival of endocrine therapy. Yet, resistance to standard treatments is a major clini...

    Authors: Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Marco Invernizzi, Elena Guerini-Rocco, Svasti Haricharan and Nicola Fusco

    Citation: Cancer Cell International 2021 21:266

    Content type: Review

    Published on:

  3. Gastric cancer (GC) is general disease in human digestive system with malignancy. Emerging findings indicated that hsa_circ_0031452 (circHECTD1) was strictly associated with carcinogenesis. Nevertheless, the r...

    Authors: Yizhuo Lu, Long Li, Lianghui Li, Guoyang Wu and Guoyan Liu

    Citation: Cancer Cell International 2021 21:264

    Content type: Primary research

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  4. It has been intensively reported that the immunosuppressive tumor microenvironment (TME) results in tumor resistance to immunotherapy, especially immune checkpoint blockade and chimeric T cell antigen therapy....

    Authors: Yalei Zhang, Ye Li, Kun Chen, Ling Qian and Peng Wang

    Citation: Cancer Cell International 2021 21:262

    Content type: Review

    Published on:

  5. Burkitt lymphoma (BL) is a highly aggressive, fast-growing B-cell non-Hodgkin's lymphoma, manifested in several subtypes, including sporadic, endemic, and immunodeficiency-related forms, the mechanism of which...

    Authors: Zhao Wang, Meiting Chen, Xiaojie Fang, Huangming Hong, Yuyi Yao and He Huang

    Citation: Cancer Cell International 2021 21:261

    Content type: Primary research

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  6. Exploring the molecular mechanisms of lung adenocarcinoma (LUAD) is beneficial for developing new therapeutic strategies and predicting prognosis. This study was performed to select core genes related to LUAD ...

    Authors: Huan Deng, Qingqing Hang, Dijian Shen, Yibi Zhang and Ming Chen

    Citation: Cancer Cell International 2021 21:259

    Content type: Primary research

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  7. Colorectal cancer (CRC), with a growing incidence trend worldwide, is resistant to apoptosis and has uncontrolled proliferation. It is recently reported that probiotic microorganisms exert anticancer effects. ...

    Authors: Zeinab Faghfoori, Mohammad Hasan Faghfoori, Amir Saber, Azimeh Izadi and Ahmad Yari Khosroushahi

    Citation: Cancer Cell International 2021 21:258

    Content type: Primary research

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  8. CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, howe...

    Authors: Dexin Shen, Yayun Fang, Fenfang Zhou, Zhao Deng, Kaiyu Qian, Gang Wang, Yu Xiao, Lingao Ju and Xinghuan Wang

    Citation: Cancer Cell International 2021 21:257

    Content type: Primary research

    Published on:

  9. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01958-0

    Authors: Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu and Hua Tang

    Citation: Cancer Cell International 2021 21:255

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2017 17:36

  10. Hepatocellular carcinoma is one of the most common malignant tumors worldwide and the fourth leading cause of cancer-related deaths. The prognosis of hepatocellular carcinoma patients is extremely poor due to ...

    Authors: Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen and Shuying Chen

    Citation: Cancer Cell International 2021 21:254

    Content type: Review

    Published on:

  11. Regulatory factor X1 (RFX1) is an evolutionary conserved transcriptional factor that influences a wide range of cellular processes such as cell cycle, cell proliferation, differentiation, and apoptosis, by reg...

    Authors: Joby Issac, Pooja S. Raveendran and Ani V. Das

    Citation: Cancer Cell International 2021 21:253

    Content type: Review

    Published on:

  12. The role of HHLA2, a new immune checkpoint ligand, is gradually being elucidated in various solid tumours. However, its role in ovarian cancer remains unclear; thus, its expression profile and clinical signifi...

    Authors: Guocai Xu, Yuanyuan Shi, Xiaoting Ling, Dongyan Wang, Yunyun Liu, Huaiwu Lu, Yongpai Peng and Bingzhong Zhang

    Citation: Cancer Cell International 2021 21:252

    Content type: Primary research

    Published on:

  13. Bladder cancer is the leading causes of cancer-associated mortality and seriously affects population health. Hypoxia plays a key role in tumor development and immune escape, which contributes to malignant beha...

    Authors: Xianchao Sun, Zhen Zhou, Ying Zhang, Jinyou Wang, Xiaofeng Zhao, Liang Jin, Tingshuai Zhai, Xiang Liu, Jiaxin Zhang, Wangli Mei, Bihui Zhang, Ming Luo, Xudong Yao and Lin Ye

    Citation: Cancer Cell International 2021 21:251

    Content type: Primary research

    Published on:

  14. The hsa_circ_0004771 derived from NRIP1 (called circ_NRIP1) is a recently identified oncogenic circRNA. Here, we intended to investigate the role and mechanism of circ_NRIP1 in esophageal squamous cell carcino...

    Authors: Shifan Zhou, Zhizhong Guo, Chaofeng Zhou, Yu Zhang and Sai Wang

    Citation: Cancer Cell International 2021 21:250

    Content type: Primary research

    Published on:

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang

    Citation: Cancer Cell International 2021 21:248

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:167

  16. In vivo imaging using fluorescence is used in cancer biology for the detection, measurement and monitoring of tumours. This can be achieved with the expression of fluorescent proteins such as iRFP, which emits...

    Authors: C. Hall, Y. von Grabowiecki, S. P. Pearce, C. Dive, S. Bagley and P. A. J. Muller

    Citation: Cancer Cell International 2021 21:247

    Content type: Primary research

    Published on:

  17. Renal clear cell carcinoma (ccRCC) is one of the most common malignant tumors, whose incidence is increasing year by year. IRF6 plays an important role in the occurrence of tumors, although there is yet no rep...

    Authors: Xinwei Ma, Xiaoqi Wang, Qian Dong, Hongquan Pang, Jianming Xu, Junkang Shen and Jianbing Zhu

    Citation: Cancer Cell International 2021 21:246

    Content type: Primary research

    Published on:

  18. Osteosarcoma patients often experience poor outcomes despite chemotherapy treatment, likely due in part to various mechanisms of tumor cell innate and/or acquired drug resistance. Exosomes, microvesicles secre...

    Authors: Marcus A. Weinman, Stephen A. Ramsey, Haley J. Leeper, Jacqueline V. Brady, Andrew Schlueter, Stanislau Stanisheuski, Claudia S. Maier, Tasha Miller, Carl E. Ruby and Shay Bracha

    Citation: Cancer Cell International 2021 21:245

    Content type: Primary research

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  19. Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems. Therefore, to enhance the delivery and ...

    Authors: Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi and Ala Habibian

    Citation: Cancer Cell International 2021 21:244

    Content type: Primary research

    Published on:

  20. S100A11 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. The dysregulated expression of the S100A11 gene has been implicated in tumour metastasis. However, the role of ...

    Authors: Yuxin Cui, Liting Li, Zhilei Li, Jie Yin, Jane Lane, Jiafu Ji and Wen G. Jiang

    Citation: Cancer Cell International 2021 21:243

    Content type: Primary research

    Published on:

  21. Bladder cancer is a frequently diagnosed urinary system tumor, whose mortality remains rising. Minichromosome maintenance eight homologous recombination repair factor (MCM8), a newly discovered MCM family memb...

    Authors: Wei Zhu, Fei Gao, Hongyi Zhou, Ke Jin, Jianfeng Shao and Zhuoqun Xu

    Citation: Cancer Cell International 2021 21:242

    Content type: Primary research

    Published on:

  22. Although miR-190 has been reported to be related to human diseases, especially in the development and progression of cancer, its expression in human bladder cancer (BC) and potential contribution to BC remain ...

    Authors: Shirui Huang, Xiaohui Hua, Mengjiao Kuang, Junlan Zhu, Haiqi Mu, Zhongxian Tian, Xiaoqun Zheng and Qipeng Xie

    Citation: Cancer Cell International 2021 21:241

    Content type: Primary research

    Published on:

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei and Huawei Yang

    Citation: Cancer Cell International 2021 21:240

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:55

  24. Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. The majority of clinically used PD-1/PD-L1 inhibitors are monoclonal...

    Authors: Chang Liu, Navindra P. Seeram and Hang Ma

    Citation: Cancer Cell International 2021 21:239

    Content type: Review

    Published on:

  25. Colon cancer is a malignant gastrointestinal tumour with high incidence, mortality and metastasis rates worldwide. Aloe-emodin is a monomer compound derived from hydroxyanthraquinone. Aloe-emodin produces a wi...

    Authors: Dongxiao Jiang, Shufei Ding, Zhujun Mao, Liyan You and Yeping Ruan

    Citation: Cancer Cell International 2021 21:238

    Content type: Primary research

    Published on:

  26. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu and Dong Chen

    Citation: Cancer Cell International 2021 21:237

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2019 19:271

  27. Prostate cancer is the most common malignant tumor of male genitourinary system, molecular mechanism of which is still not clear. PSMC2 (proteasome 26S subunit ATPase 2) is a key member of the 19S regulatory s...

    Authors: Qingke Chen, Lingmin Fu, Jieping Hu, Guanghua Guo and An Xie

    Citation: Cancer Cell International 2021 21:235

    Content type: Primary research

    Published on:

  28. Non-small cell lung cancer (NSCLC) is a common malignancy around the globe. Increasing long non-coding RNAs (lncRNAs) have been confirmed to be associated with the progression of cancers, including NSCLC. Long...

    Authors: Yanchao Deng, Liwei Zhang and Ruiying Luo

    Citation: Cancer Cell International 2021 21:234

    Content type: Primary research

    Published on:

  29. Invasive bladder tumors cause a worse prognosis in patients and remain a clinical challenge. Epithelial–mesenchymal transition (EMT) is associated with bladder cancer metastasis. In the present research, we at...

    Authors: Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He and Lin Qi

    Citation: Cancer Cell International 2021 21:233

    Content type: Primary research

    Published on:

  30. Anoikis resistance plays a critical role in the tumor metastasis by allowing survival of cancer cells in the systemic circulation. We previously showed that long non-coding RNAs APOC1P1-3 (lncRNA APOC1P1-3) in...

    Authors: Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin and Ping Zhou

    Citation: Cancer Cell International 2021 21:232

    Content type: Primary research

    Published on:

  31. Immune cells account for a large proportion of the tumour microenvironment in anaplastic thyroid carcinomas (ATCs). However, the expression pattern of immune-related genes (IRGs) in ATCs is unclear. Our study ...

    Authors: Xuemin Wang, Wen Peng, Chunyan Li, Rujia Qin, Zhaoming Zhong and Chuanzheng Sun

    Citation: Cancer Cell International 2021 21:231

    Content type: Primary research

    Published on:

  32. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, with relapse due to drug resistance. Recent studies show that bromodomains and extr...

    Authors: Shuiyan Wu, You Jiang, Yi Hong, Xinran Chu, Zimu Zhang, Yanfang Tao, Ziwei Fan, Zhenjiang Bai, Xiaolu Li, Yanling Chen, Zhiheng Li, Xin Ding, Haitao Lv, Xiaoli Du, Su Lin Lim, Yongping Zhang…

    Citation: Cancer Cell International 2021 21:230

    Content type: Primary research

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  33. Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers and signature.

    Authors: Cui Zhao, Jian Liu, Haomiao Zhou, Xin Qian, Hui Sun, Xuewen Chen, Miaosen Zheng, Tingting Bian, Lei Liu, Yifei Liu and Jianguo Zhang

    Citation: Cancer Cell International 2021 21:228

    Content type: Primary research

    Published on:

  34. The purpose of this study is to explore the effect of miRNA-539 on osteosarcoma (OS) and the underlying mechanism, so as to find a new method for early diagnosis and treatment of osteosarcoma.

    Authors: Huowen Liu, Min Yang, Yufeng Zhang, Zhiqiang Yang, Zhe Chen, Yuanlong Xie, Binglong Peng and Lin Cai

    Citation: Cancer Cell International 2021 21:227

    Content type: Primary research

    Published on:

  35. Urothelial carcinoma (UC) is the second most common malignancy of the urinary system with high rate of recurrence, UC patients therefore needed to be treated with surgery followed by chemotherapy. Development ...

    Authors: Yeong-Chin Jou, Guan-Ling Lin, Hon-Yi Lin, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Pie-Che Chen, Shu-Fen Wu, Cheng-Huang Shen and Michael W. Y. Chan

    Citation: Cancer Cell International 2021 21:226

    Content type: Primary research

    Published on:

  36. Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant hepatic tumor and has a high postoperative recurrence rate and a poor prognosis. The key roles of most tumor recurrence-associated mol...

    Authors: Fengwei Li, Qinjunjie Chen, Yang Yang, Meihui Li, Lei Zhang, Zhenlin Yan, Junjie Zhang and Kui Wang

    Citation: Cancer Cell International 2021 21:225

    Content type: Primary research

    Published on:

  37. We aimed to understand the clinical characteristics and better predict the prognosis of patients with mucosal melanoma of the head and neck (MMHN) using a nomogram.

    Authors: Qing-Qing Xu, Qing-Jie Li, Liu Chen, Xin-Yi Su, Jing-Xia Song, Juan Du, Lei Chen and Li-Xia Lu

    Citation: Cancer Cell International 2021 21:224

    Content type: Primary research

    Published on:

  38. Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing ...

    Authors: Xiaoqin Zhang, Ziyue Wang, Zixin Zeng, Ningning Shen, Bin Wang, Yaping Zhang, Honghong Shen, Wei Lu, Rong Wei, Wenxia Ma and Chen Wang

    Citation: Cancer Cell International 2021 21:222

    Content type: Primary research

    Published on:

  39. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules containing only 20–22 nucleotides. MiRNAs play a role in gene silencing and translation suppression by targeting and binding to mRNA. Proper cont...

    Authors: Yufei Tang, Shaoqi Zong, Hailun Zeng, Xiaofeng Ruan, Liting Yao, Susu Han and Fenggang Hou

    Citation: Cancer Cell International 2021 21:221

    Content type: Review

    Published on:

  40. Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported to play a crucial role in the progression ...

    Authors: Yan Liao, Fang Wang, Yadong Zhang, Hongshi Cai, Fan Song and Jinsong Hou

    Citation: Cancer Cell International 2021 21:220

    Content type: Primary research

    Published on:

  41. Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong patient survival. Alkaline phosphatase (ALPL), a ...

    Authors: Zhefeng Lou, Weiwei Lin, Huirong Zhao, Xueli Jiao, Cong Wang, He Zhao, Lu Liu, Yu Liu, Qipeng Xie, Xing Huang, Haishan Huang and Lingling Zhao

    Citation: Cancer Cell International 2021 21:217

    Content type: Primary research

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  42. The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active ...

    Authors: Yuting Meng, Xixi Qian, Li Zhao, Nan Li, Shengjie Wu, Baoan Chen, Tong Sun and Xuerong Wang

    Citation: Cancer Cell International 2021 21:216

    Content type: Primary research

    Published on:

  43. Epithelial-mesenchymal transition (EMT) has been associated with wound healing, tumorigenesis, and metastasis. Circular RNAs (circRNAs) are functional non-coding RNAs involved in multiple human cancers. Howeve...

    Authors: Guili Xu, Peng Zhang, Hansi Liang, Yunhua Xu, Jian Shen, Wansheng Wang, Mingming Li, Jintao Huang, Caifang Ni, Xueguang Zhang and Xiaoli Zhu

    Citation: Cancer Cell International 2021 21:212

    Content type: Primary research

    Published on:

  44. Cancers located on the right and left sides of the colon have distinct clinical and molecular characteristics. This study aimed to explore the regulatory mechanisms of location-specific long noncoding RNAs (ln...

    Authors: Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding and Bang-li Hu

    Citation: Cancer Cell International 2021 21:211

    Content type: Primary research

    Published on:

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