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  1. Hepatocellular carcinoma (HCC), the most common primary cancer of the liver, is one of the most common malignancies and the leading cause of cancer-related death worldwide. Leucine-rich repeat and sterile alph...

    Authors: Lili Pian, Xiaofeng Huang, Min Zhao, Yaolin Zhang, Cheng Qin, Jiyan Zhang, Jun Zhang and Qingyang Wang

    Citation: Cancer Cell International 2019 19:255

    Content type: Primary research

    Published on:

  2. Extracellular ATP (eATP) was shown to induce epithelial–mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact inducti...

    Authors: Yanyang Cao, Xuan Wang, Yunsheng Li, Maria Evers, Haiyun Zhang and Xiaozhuo Chen

    Citation: Cancer Cell International 2019 19:254

    Content type: Primary research

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  3. Phosphoglucomutase (PGM), a key enzyme in the metabolism of glucose-1-phosphate and glucose-6-phosphate, has been found to be associated with proliferation, invasion, and metastasis of cancer. However, the exp...

    Authors: Yifan Sun, Haihua Long, Lin Sun, Xiujuan Sun, Liping Pang, Jianlin Chen, Qingqun Yi, Tianwei Liang and Yongqi Shen

    Citation: Cancer Cell International 2019 19:253

    Content type: Primary research

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  4. Circular RNA (circRNA) CDR1as plays an important role in the occurrence and development of human tumors. The purpose of this study is to investigate the molecular mechanism of circRNA CDR1as in the development...

    Authors: Qiong Zhong, Juncong Huang, Jiawang Wei and Renrui Wu

    Citation: Cancer Cell International 2019 19:252

    Content type: Primary research

    Published on:

  5. Exosomal nucleic acid (exoNA) is a feasible target to improve the sensitivity of EGFR mutation testing in non-small cell lung cancer patients with limited cell-free DNA (cfDNA) mutant copies. However, the type an...

    Authors: Yoonjung Kim, Saeam Shin, Boyeon Kim and Kyung-A Lee

    Citation: Cancer Cell International 2019 19:251

    Content type: Primary research

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  6. Esophageal squamous cell carcinoma (ESCC) is the eighth most common cancer worldwide and is one of the most lethal malignancies. Cisplatin (DDP) is a key drug for ESCC treatment, but the presence of chemothera...

    Authors: Tian-Liang Zheng, De-Ping Li, Zhan-Feng He and Song Zhao

    Citation: Cancer Cell International 2019 19:250

    Content type: Primary research

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  7. Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis. However, its expression, ...

    Authors: Tao Yan, Fang Liu, Jiajia Gao, Haizhen Lu, Jianqiang Cai, Xiaohang Zhao and Yulin Sun

    Citation: Cancer Cell International 2019 19:249

    Content type: Primary research

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  8. Neuropilin-1 (NRP-1) is a non-tyrosine kinase receptor interacting with multiple signaling pathways that underpin the biological behavior and fate of cancer cells. However, in pancreatic cancer, the mechanisms...

    Authors: Lixin Ma, Bo Zhai, Huaqiang Zhu, Weidong Li, Wenjing Jiang, Liwang Lei, Shujun Zhang, Haiquan Qiao, Xian Jiang and Xueying Sun

    Citation: Cancer Cell International 2019 19:248

    Content type: Primary research

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  9. CD146 alternatively called melanoma cell adhesion molecule (MCAM), is a biomarker and therapeutic target of clinical significance. It is found on different cells including the endothelial cells and lymphocytes...

    Authors: Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao and Xiaoju Zhang

    Citation: Cancer Cell International 2019 19:247

    Content type: Review

    Published on:

  10. Recently, some studies reported the prognostic value of platelet-to-lymphocyte ratio (PLR) in patients with diffuse large B-cell lymphoma (DLBCL), however, the results varied from different studies. Therefore,...

    Authors: Ying Chen, Zongxin Zhang, Qiu Fang and Huiqin Jian

    Citation: Cancer Cell International 2019 19:245

    Content type: Primary research

    Published on:

  11. Following publication of the original article [1], it has been brought to our attention that an incorrect Sequenom MassArray trace and an incorrect nomenclature were used to represent the PIK3CA p.E545A mutati...

    Authors: Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli…

    Citation: Cancer Cell International 2019 19:244

    Content type: Correction

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    The original article was published in Cancer Cell International 2018 18:131

  12. The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome...

    Authors: Yi-feng Zou, Yu-ming Rong, Ying-xin Tan, Jian Xiao, Zhao-liang Yu, Yu-feng Chen, Jia Ke, Cheng-hang Li, Xi Chen, Xiao-jian Wu, Ping Lan, Xu-tao Lin and Feng Gao

    Citation: Cancer Cell International 2019 19:243

    Content type: Primary research

    Published on:

  13. Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are...

    Authors: Weiguang Liu, Jianjun Han, Sufang Shi, Yuna Dai and Jianchao He

    Citation: Cancer Cell International 2019 19:242

    Content type: Primary research

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  14. Persistent infection with high-risk human papillomavirus (hrHPV) is associated with cervical cancer development. This process involves the virus-encoded E6 and E7 oncoproteins, which are maintained and express...

    Authors: Chao Li, Yanfei Li, Lanxia Sui, Jian Wang and Fang Li

    Citation: Cancer Cell International 2019 19:241

    Content type: Primary research

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  15. Long non-coding RNAs (lncRNAs) are a family of non-protein-coding RNAs, which have the ability to influence the chemo-resistance of lung adenocarcinoma (LAC). In this study, we explored the mechanism by which ...

    Authors: Wei Zuo, Wei Zhang, Fei Xu, Jing Zhou and Wei Bai

    Citation: Cancer Cell International 2019 19:240

    Content type: Primary research

    Published on:

  16. Lung cancer has been a common malignant tumor with a leading cause of morbidity and mortality, current molecular targets are woefully lacking comparing to the highly progressive cancer. The study is designed t...

    Authors: Wenxia Ma, Bin Wang, Yaping Zhang, Ziyue Wang, Dan Niu, Siyu Chen, Zhirong Zhang, Ningning Shen, Weixia Han, Xiaoqin Zhang, Rong Wei and Chen Wang

    Citation: Cancer Cell International 2019 19:239

    Content type: Primary research

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  17. Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages t...

    Authors: Jingping Yuan, Huihua He, Chuang Chen, Juan Wu, Jie Rao and Honglin Yan

    Citation: Cancer Cell International 2019 19:238

    Content type: Primary research

    Published on:

  18. The basal transcription/repair factor TFIIH is a ten sub-unit complex essential for RNA polymerase II (RNAP2) transcription initiation and DNA repair. In both these processes TFIIH acts as a DNA helix opener, ...

    Authors: Lise-Marie Donnio, Catherine Miquel, Wim Vermeulen, Giuseppina Giglia-Mari and Pierre-Olivier Mari

    Citation: Cancer Cell International 2019 19:237

    Content type: Primary research

    Published on:

  19. Hyperoside (Hy) is a plant-derived quercetin 3-d-galactoside that exhibits inhibitory activities on various tumor types. The objective of the current study was to explore Hy effects on cervical cancer cell prolif...

    Authors: Weikang Guo, Hui Yu, Lu Zhang, Xiuwei Chen, Yunduo Liu, Yaoxian Wang and Yunyan Zhang

    Citation: Cancer Cell International 2019 19:235

    Content type: Primary research

    Published on:

  20. Chemotherapy resistance is one of the main causes of recurrence in colorectal cancer (CRC) patients and leads to poor prognosis. Long noncoding RNAs (lncRNAs) have been reported to regulate chemoresistance. We...

    Authors: Xinke Wang, Zhixian Lan, Juan He, Qiuhua Lai, Xiang Yao, Qingyuan Li, Yongfeng Liu, Huasheng Lai, Chuncai Gu, Qun Yan, Yuxin Fang, Yue Zhang, Aimin Li and Side Liu

    Citation: Cancer Cell International 2019 19:234

    Content type: Primary research

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  21. Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibod...

    Authors: Cui Jiang, SunRun Cao, Na Li, Lei Jiang and Tao Sun

    Citation: Cancer Cell International 2019 19:233

    Content type: Primary research

    Published on:

  22. Methyl-CpG binding domain protein 1 (MBD1), which couples DNA methylation to transcriptional repression, has been implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell cy...

    Authors: Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun and Xu Xiaowu

    Citation: Cancer Cell International 2019 19:232

    Content type: Primary research

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  23. MicroRNA-200c-3p (miR-200c-3p) has been revealed to be related to renal cell carcinoma (RCC) progression, while the inner mechanisms remain unknown. In our study, we intend to unearth the capability of miR-200...

    Authors: Shuai Li, Ziyu Feng, Xuechong Zhang, Dongyang Lan and Yudong Wu

    Citation: Cancer Cell International 2019 19:231

    Content type: Primary research

    Published on:

  24. Despite several reports describing the dual role of miR-145 as an oncogene and a tumor suppressor in cancer, not much has been resolved and understood.

    Authors: Siddharth Manvati, Kailash Chandra Mangalhara, Ponnuswamy Kalaiarasan, Rupali Chopra, Gaurav Agarwal, Rakesh Kumar, Sunil Kumar Saini, Monika Kaushik, Ankita Arora, Usha Kumari, Rameshwar Nath Koul Bamezai and Pawan Kumar Dhar

    Citation: Cancer Cell International 2019 19:230

    Content type: Primary research

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  25. The fatality and recurrence rates of bladder cancer (BC) have progressively increased. DNA methylation is an influential regulator associated with gene transcription in the pathogenesis of BC. We describe a co...

    Authors: Liwei Wang, Jiazhong Shi, Yaqin Huang, Sha Liu, Jingqi Zhang, Hua Ding, Jin Yang and Zhiwen Chen

    Citation: Cancer Cell International 2019 19:229

    Content type: Primary research

    Published on:

  26. Hepatocellular carcinoma (HCC) is one of the most fatal cancers, and its molecular basis needs to be delineated to identify biomarkers for its potential treatment. The purpose of this study was to identify a n...

    Authors: Yong Le, Anna Kan, Qi-Jiong Li, Min-Ke He, Hai-Long Chen and Ming Shi

    Citation: Cancer Cell International 2019 19:228

    Content type: Primary research

    Published on:

  27. Cervical cancer (CC) is the second most common cancer in less developed countries and the second leading cause of death by cancer in women worldwide. The 99% of CC patients are infected with the Human Papillom...

    Authors: Inocencia Guadalupe Ramírez-López, Adrián Ramírez de Arellano, Luis Felipe Jave-Suárez, Christian David Hernández-Silva, Mariel García-Chagollan, Jorge Hernández-Bello, Edgar I. Lopez-Pulido, José Macias-Barragan, Margarita Montoya-Buelna, José Francisco Muñoz-Valle and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2019 19:227

    Content type: Primary research

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  28. Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-M...

    Authors: Xiangyu Zhang, Jiali Wang, Yunlong Jia, Tianxu Liu, Mengjie Wang, Wei Lv, Rong Zhang, Juan Shi and Lihua Liu

    Citation: Cancer Cell International 2019 19:226

    Content type: Primary research

    Published on:

  29. Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic si...

    Authors: Jingyue Sun, Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao and Shuang Liu

    Citation: Cancer Cell International 2019 19:225

    Content type: Primary research

    Published on:

  30. Cap-dependent mRNA translation is essential for the translation of key oncogenic proteins at optimal levels and is highly regulated by the rate limiting, initiation step in protein synthesis. Eukaryotic Transl...

    Authors: Praveen Kumar Jaiswal, Sweaty Koul, Nallasivam Palanisamy and Hari K. Koul

    Citation: Cancer Cell International 2019 19:224

    Content type: Primary research

    Published on:

  31. Neoplastic cells promote a hypercoagulable state by the expression of cell surface proteins, such as tissue factor. In BRAFv600 mutated melanoma patients upon BRAF inhibitors, a hypercoagulable state correlates w...

    Authors: Cristian Scatena, Sara Franceschi, Maria Franzini, Chiara Sanguinetti, Nadia Romiti, Laura Caponi, Mario Mandalà, Chiara Maria Mazzanti and Antonio Giuseppe Naccarato

    Citation: Cancer Cell International 2019 19:223

    Content type: Primary research

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  32. Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is de...

    Authors: Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin…

    Citation: Cancer Cell International 2019 19:222

    Content type: Primary research

    Published on:

  33. Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation...

    Authors: Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong and Wenqi Wu

    Citation: Cancer Cell International 2019 19:221

    Content type: Review

    Published on:

  34. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and human papillomavirus (HPV) has been increasingly recognized as a pathogenic factor for the initiation and development...

    Authors: Yu Jin, Yuexiu Li, Xin Wang and Ya Yang

    Citation: Cancer Cell International 2019 19:220

    Content type: Primary research

    Published on:

  35. Lung cancer is one of the most common malignant tumors worldwide. CD36 is a receptor for fatty acids and plays an important role in regulating fatty acid metabolism, which is closely related to tumorigenesis a...

    Authors: Kewei Ni, Dimin Wang, Heyun Xu, Fuyang Mei, Changhao Wu, Zhifang Liu and Bing Zhou

    Citation: Cancer Cell International 2019 19:219

    Content type: Primary research

    Published on:

  36. Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relap...

    Authors: Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu and He Huang

    Citation: Cancer Cell International 2019 19:218

    Content type: Primary research

    Published on:

  37. Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a no...

    Authors: Fei Ding, Jindong Lai, Yang Gao, Genhui Wang, Jingwen Shang, Daojun Zhang and Shumao Zheng

    Citation: Cancer Cell International 2019 19:217

    Content type: Primary research

    Published on:

  38. The long non-coding RNA H19 plays critical roles in cancer occurrence, development, and progression. The present study is for the first time to evaluate the association of genetic variations in the H19 promoter r...

    Authors: Wenyan Qin, Xiaodong Wang, Yilin Wang, Yalun Li, Qiuchen Chen, Xiaoyun Hu, Zhikun Wu, Pengfei Zhao, Shanqiong Li, Haishan Zhao, Weifan Yao, Jian Ding, Minjie Wei and Huizhe Wu

    Citation: Cancer Cell International 2019 19:215

    Content type: Primary research

    Published on:

  39. Gene expression profiles have demonstrated that miR-21 expression is altered in almost all types of cancers and it has been classified as an oncogenic microRNA. Persistent HPV infection is the main etiologic a...

    Authors: Sacnite del Mar Díaz-González, Eduardo Daniel Rodríguez-Aguilar, Angélica Meneses-Acosta, Viviana Valadez-Graham, Jessica Deas, Claudia Gómez-Cerón, Carlos Alberto Tavira-Montalván, Alitzel Arizmendi-Heras, Julián Ramírez-Bello, Mario Enrique Zurita-Ortega, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez, Gloria Fernández-Tilapa, Víctor Hugo Bermúdez-Morales, Vicente Madrid-Marina, Mauricio Rodríguez-Dorantes…

    Citation: Cancer Cell International 2019 19:214

    Content type: Primary research

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  40. Gastric cancer (GC) is one of the most common malignant tumours with high mortality and metastasis rates. E2F3, miR-125a and DKK3 have been reported to be involved in various cancer types, but their detailed r...

    Authors: Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao, Bozhen Xie and Xin Zhang

    Citation: Cancer Cell International 2019 19:212

    Content type: Primary research

    Published on:

  41. CircRNA myosin light chain kinase (circRNA MYLK) has been shown to promote the progression of various tumor diseases. The purpose of this study was to explore the potential molecular mechanism of circMYLK in h...

    Authors: Zhiqin Li, Yushu Hu, Qinglei Zeng, Hongyan Wang, Jingya Yan, Hua Li and Zujiang Yu

    Citation: Cancer Cell International 2019 19:211

    Content type: Primary research

    Published on:

  42. Long non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We ...

    Authors: Sheng Huang, Yayun Chi, Weiru Chi, Rong Guo, Yonghui Su, Jingyan Xue, Shaoqiang Zhou, Jiankui Wang, Zhuangqing Yang, Jianyun Nie, Zhimin Shao, Dedian Chen and Jiong Wu

    Citation: Cancer Cell International 2019 19:210

    Content type: Primary research

    Published on:

  43. The recent advent of immunomodulatory therapies into the clinic has demanded the identification of innovative predictive biomarkers to identify patients most likely to respond to immunotherapy and support the ...

    Authors: Francesca Galuppini, Carlo Alberto Dal Pozzo, Jutta Deckert, Fotios Loupakis, Matteo Fassan and Raffaele Baffa

    Citation: Cancer Cell International 2019 19:209

    Content type: Minireview

    Published on:

  44. Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients.

    Authors: Wen Jiang, Qing Guo, Chenghe Wang and Yu Zhu

    Citation: Cancer Cell International 2019 19:208

    Content type: Primary research

    Published on:

  45. Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy i...

    Authors: Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes and Floriano Paes Silva-Jr

    Citation: Cancer Cell International 2019 19:207

    Content type: Review

    Published on:

  46. Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.

    Authors: Erkang Jiang, Lianping Wei, Fang Tao, Mei Yu, Shu Wang, Xiuhong Zhou, Daxiang Li and Zhongwen Xie

    Citation: Cancer Cell International 2019 19:206

    Content type: Primary research

    Published on:

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