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  1. Dysregulated miRNAs play an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In this study, we ...

    Authors: Qiang Sun, Shuai Chen, Xue Zhao, Ming Yan, Zheng Fang, Haibin Wang, Junfang Zhao, Minglei Sun, Xinguang Han, Wantao Chen and Xinming Li
    Citation: Cancer Cell International 2015 15:87
    Content type: Primary research Published on:

  2. MicroRNAs (miRNAs) play key roles in cancer development and progression. The purpose of the present study was to determine the expression levels of miR-133a and miR-539 in osteosarcoma patients and to further ...

    Authors: Alireza Mirghasemi, Afshin Taheriazam, Seyyed Hasan Karbasy, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi and Aram Mokarizadeh
    Citation: Cancer Cell International 2015 15:86
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:84

  3. Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15–20 %, with a m...

    Authors: Shanshan Chen, Ping Li, Rui Yang, Ruirui Cheng, Furui Zhang, Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Yuwen Du, Guoqiang Zhao and Guojun Zhang
    Citation: Cancer Cell International 2015 15:85
    Content type: Primary research Published on:

  4. Lung cancer, predominantly non-small-cell lung cancer (NSCLC), is the leading cause of cancer deaths worldwide. There is a great need to identify critical effectors involved in metastasis of NSCLC that will fa...

    Authors: Qinchuan Li, Yang Han, Chunhong Wang, Shan Shan, Yuanyuan Wang, Jingang Zhang and Tao Ren
    Citation: Cancer Cell International 2015 15:84
    Content type: Primary research Published on:

  5. Prolactin (PRL) has been implicated in the development of different types of cancer. However, signaling pathways might be activated depending on various forms of prolactin receptor (PRLR). JAK/STAT is an impor...

    Authors: Adrián Ramírez de Arellano, Edgar I. Lopez-Pulido, Priscila A. Martínez-Neri, Ciro Estrada Chávez, Renee González Lucano, Mary Fafutis-Morris, A. Aguilar-Lemarroy, José. F. Muñoz-Valle and Ana Laura Pereira-Suárez
    Citation: Cancer Cell International 2015 15:83
    Content type: Primary research Published on:

  6. The purpose of this study was to assess the antitumoral effect of the methanol extract (MeOH) from Nitraria retusa leaves and to investigate its immunomodulatory activity that mediated the prevention of tumor pro...

    Authors: Jihed Boubaker, Fadwa Chaabane, Ahmed Bedoui, Rihab Aloui, Besma Ben Ahmed, Kamel Ghedira and Leila Chekir-Ghedira
    Citation: Cancer Cell International 2015 15:82
    Content type: Primary research Published on:

  7. Rhodiola algida var. tangutica is a traditional Tibetan herb. Its root and rhizome have been successfully used as an effective clinical remedy for the prevention and treatment of cance...

    Authors: Yu-juan Qi, Sen Cui, Dian-xiang Lu, Ying-zhong Yang, Yushuang Luo, Lan Ma, Yan Ma, Tana Wuren, Rong Chang, Lei Qi, Ba-ji Ben, Jun Han and Ri-Li Ge
    Citation: Cancer Cell International 2015 15:81
    Content type: Primary research Published on:

  8. Aberrant expression of miR-193a-3p and astrocyte elevated gene-1 (AEG-1) have been revealed to be related to the tumorigenesis of various cancers, including non-small cell lung cancer (NSCLC). However, the sig...

    Authors: Fanghui Ren, Hua Ding, Suning Huang, Hanlin Wang, Mei Wu, Dianzhong Luo, Yiwu Dang, Lihua Yang and Gang Chen
    Citation: Cancer Cell International 2015 15:80
    Content type: Primary research Published on:

  9. Etoposide has been used clinically in cancer treatment, as well as in numerous research studies, for many years. However, there is incomplete information about its exact mechanism of action in induction of cel...

    Authors: Sarwat Jamil, Irene Lam, Maryam Majd, Shu-Huei Tsai and Vincent Duronio
    Citation: Cancer Cell International 2015 15:79
    Content type: Primary research Published on:

  10. Pachymic acid (PA), a lanostane-type triterpenoid from Poria cocos, has been reported to possess anti-emetic, anti-inflammatory, and anti-cancer properties. Nonetheless, the anti-tumor effect of PA in lung cancer...

    Authors: Jun Ma, Jun Liu, Chunwei Lu and Dingfang Cai
    Citation: Cancer Cell International 2015 15:78
    Content type: Primary research Published on:

  11. Colon carcinoma is one of the commonly tumors that threaten human beings as its highly morbidity and mortality. Recent evidences suggested that microRNA-21 (miR-21) played an important role in the development ...

    Authors: Yi-Jing Tao, Yong-ju Li, Wen Zheng, Juan-juan Zhao, Meng-meng Guo, Ya Zhou, Na-lin Qin, Jing Zheng and Lin Xu
    Citation: Cancer Cell International 2015 15:77
    Content type: Primary research Published on:

  12. Neuroblastoma is a neural crest-derived tumor and is the most common cancer in children less than 1 year of age. We hypothesized that aberrations in genes that control the cell cycle could play an important ro...

    Authors: Ali Rihani, Jo Vandesompele, Frank Speleman and Tom Van Maerken
    Citation: Cancer Cell International 2015 15:76
    Content type: Primary research Published on:

  13. Rhabdomyosarcoma is a rare malignant skeletal muscle tumor. It mainly occurs in children and young adults and has an unsatisfactory prognosis. Prior studies showed a direct myotoxic effect of bupivacaine on di...

    Authors: Thomas Metterlein, Petra Hoffmann, Ruth Späth, Michael Gruber, Bernhard M Graf and Wolfgang Zink
    Citation: Cancer Cell International 2015 15:75
    Content type: Primary research Published on:

  14. Squamous cell carcinoma of the oral cavity (SCCOC) is the dominant origin of cancer associated mortality. Previous findings by our study reported that acquisition of anoikis resistance has a significant role i...

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Joygopal Roy, Sukumar Maity, Indranil kulavi and Mahitosh Mandal
    Citation: Cancer Cell International 2015 15:74
    Content type: Primary research Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2021 21:82

    The Erratum to this article has been published in Cancer Cell International 2015 15:94

  15. A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis. A20 is frequently inactivated by deletions and/or mut...

    Authors: Yi Xu, Junyan Hu, Xu Wang, Li Xuan, Jing Lai, Ling Xu, Shaohua Chen, Lijian Yang, Gengxin Luo, Kanger Zhu, Xiuli Wu and Yangqiu Li
    Citation: Cancer Cell International 2015 15:73
    Content type: Primary research Published on:

  16. Interleukin (IL)-18 gene polymorphisms have been found to play multiple roles in various diseases. However, studies focused on its involvement in hepatocellular carcinoma (HCC) remains...

    Authors: Jingui Bao, Yu Lu, Yan Deng, Chengzhi Rong, Yanqiong Liu, Xiuli Huang, Liuying Song, Shan Li and Xue Qin
    Citation: Cancer Cell International 2015 15:72
    Content type: Primary Research Published on:

  17. Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemothera...

    Authors: Khalid O Alfarouk, Christian-Martin Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H H Bashir, Osama Y Mohammed, Gamal O Elhassan, Salvador Harguindey, Stephan J Reshkin, Muntaser E Ibrahim and Cyril Rauch
    Citation: Cancer Cell International 2015 15:71
    Content type: Review Published on:

  18. Glycogen synthase kinase-3β (GSK3β) expression and activity are upregulated in pancreatic cancer tissues. In our previous study, we found that stromal cell-derived factor-1/ chemokine receptor C-X-C motif chem...

    Authors: Xu Ying, Li Jing, Shijie Ma, Qianjun Li, Xiaoling Luo, Zhenguo Pan, Yanling Feng and Pan Feng
    Citation: Cancer Cell International 2015 15:70
    Content type: Primary research Published on:

  19. Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with carcinogenesis, which is suspected to promote angiogenesis and tissue...

    Authors: Liyan Qu and Bing Liu
    Citation: Cancer Cell International 2015 15:69
    Content type: Review Published on:

  20. Variants in the axis inhibition 2 (AXIN2) gene might alter the protein’s structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual’s susceptibil...

    Authors: Zhitong Wu, Yifan Sun, Shifu Tang, Chunming Liu, Shengbo Zhu, Lili Wei and Hong Xu
    Citation: Cancer Cell International 2015 15:68
    Content type: Primary research Published on:

  23. Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on cell proliferatio...

    Authors: Chuntuan Li, Pengliang Xin, Huifang Xiao, Yan Zheng, Yuanling Huang and Xiongpeng Zhu
    Citation: Cancer Cell International 2015 15:65
    Content type: Primary research Published on:

  24. The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis.

    Authors: Nives Pećina-Šlaus and Marko Pećina
    Citation: Cancer Cell International 2015 15:64
    Content type: Review Published on:

  25. Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays...

    Authors: Jun Zeng, Rong Shi, Cui-xia Cai, Xin-rui Liu, Yan-bin Song, Min Wei and Wen-li Ma
    Citation: Cancer Cell International 2015 15:63
    Content type: Primary research Published on:

  26. Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the...

    Authors: Yongru Liu, Fanghui Ren, Minhua Rong, Yihuan Luo, Yiwu Dang and Gang Chen
    Citation: Cancer Cell International 2015 15:62
    Content type: Primary research Published on:

  27. Increasing evidence indicates that dysregulation of microRNAs is involved in tumor progression and development. The aim of this study was to investigate the expression of microRNA-24 (miR-24) and its function ...

    Authors: Li Xu, Zhifeng Chen, Fei Xue, Wei Chen, Ruina Ma, Shiyin Cheng and Pengcheng Cui
    Citation: Cancer Cell International 2015 15:61
    Content type: Primary research Published on:

  28. This study is to explore the pathological features of transplanted tumor established by CD133 positive TJ905 glioblastoma stem-like cells.

    Authors: Feng Jin, Ran Zhang, Song Feng, Chuan-Tao Yuan, Ren-Ya Zhang, Guang-Kui Han, Gen-Hua Li, Xi-Zhen Yu, Yang Liu, Ling-Sheng Kong, Shu-Ling Zhang and Lei Zhao
    Citation: Cancer Cell International 2015 15:60
    Content type: Primary research Published on:

  29. This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells.

    Authors: Yongchao Ma, Fazhang Zou, Junping Xiong, Wei Wan, Li Yin, Xianjia Li, Zhanyu Bei, Lei Yuan, Song Meng, Jianguo Wang and Guohua Song
    Citation: Cancer Cell International 2015 15:59
    Content type: Primary research Published on:

  30. Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-...

    Authors: Mario Orozco-Morales, Francisco Javier Sánchez-García, Irene Golán-Cancela, Norma Hernández-Pedro, Jose A. Costoya, Verónica Pérez de la Cruz, Sergio Moreno-Jiménez, Julio Sotelo and Benjamín Pineda
    Citation: Cancer Cell International 2015 15:57
    Content type: Primary research Published on:

  31. Radiotherapy is an important therapeutic method for lung cancer. However, in clinical situations, cellular resistance to radiotherapy is a significant component of tumor treatment failure. Thus, clarification ...

    Authors: Chen Liao, Wei Xiao, Nuo Zhu, Zhiyuan Liu, Jiu Yang, Yanhu Wang and Mei Hong
    Citation: Cancer Cell International 2015 15:56
    Content type: Primary research Published on:

  32. Recently, we have reported the induction of apoptosis by 2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-NC) in HepG2, T47D and HCT116 cells with low nano molar IC50 values. In this study, anti...

    Authors: Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand and Shima Hallaj Neishabouri
    Citation: Cancer Cell International 2015 15:55
    Content type: Primary research Published on:

  33. Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome re...

    Authors: Siaw Shi Boon and Sai-Peng Sim
    Citation: Cancer Cell International 2015 15:54
    Content type: Primary research Published on:

  34. The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsi...

    Authors: Chang-Yi Xiao, Bing-Bing Fu, Zhi-Ying Li, Gohar Mushtaq, Mohammad Amjad Kamal, Jia-Hua Li, Gui-Cheng Tang and Shuo-Shuang Xiao
    Citation: Cancer Cell International 2015 15:53
    Content type: Primary research Published on:

  35. Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors of Hpa can prevent the growth and metastasis of malignant tumor cells, and suramin...

    Authors: HuaPing Li, HuaLi Li, HongJie Qu, MingZhu Zhao, Bo Yuan, MingHua Cao and JinQuan Cui
    Citation: Cancer Cell International 2015 15:52
    Content type: Primary research Published on:

  36. The WASP (Wiskott-Aldrich syndrome protein) and WAVE (WASP Verpolin homologous) family of proteins are structurally related and responsible for regulation of actin polymerization through their interaction with...

    Authors: Muhammad Moazzam, Lin Ye, Ping-Hui Sun, Howard Kynaston and Wen G Jiang
    Citation: Cancer Cell International 2015 15:51
    Content type: Primary research Published on:

  37. Despite the clinical response of conventional anticancer therapy, including chemotherapeutic treatments, radiation therapy and corticosteroids, tumorigenic B-cell lymphomas show an incomplete response to clini...

    Authors: Nunzia Migliaccio, Camillo Palmieri, Immacolata Ruggiero, Giuseppe Fiume, Nicola M Martucci, Iris Scala, Ileana Quinto, Giuseppe Scala, Annalisa Lamberti and Paolo Arcari
    Citation: Cancer Cell International 2015 15:50
    Content type: Primary research Published on:

  38. MicroRNA is a type of endogenous non-coding RNA implicated in various cellular processes, and has been intensely investigated in the field of cancer research for many years. Here, we investigated the functions...

    Authors: Wei Zhang, Ye-qing Mao, Hua Wang, Wen-juan Yin, Shao-xing Zhu and Wei-cheng Wang
    Citation: Cancer Cell International 2015 15:49
    Content type: Primary research Published on:

  39. Lung adenocarcinoma (LAC), the primary histological type of non-small cell lung cancer (NSCLC), has displayed an increasing incidence and mortality worldwide. However, therapeutic approaches were limited. Dysr...

    Authors: Juan Li, Ping Li, Wei Zhao, Rui Yang, Shanshan Chen, Yong Bai, Shaozhi Dun, Xiaonan Chen, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Guoqiang Zhao and Guojun Zhang
    Citation: Cancer Cell International 2015 15:48
    Content type: Primary research Published on:

  40. Most of the knowledge about the mechanisms of multidrug resistance in lung cancer has been achieved through the use of cell lines isolated from tumours cultivated either in suspensions of isolated cells or in ...

    Authors: Raúl Barrera-Rodríguez and Jorge Morales Fuentes
    Citation: Cancer Cell International 2015 15:47
    Content type: Primary research Published on:

  41. Natural products with diverse bioactivities are becoming an important source of novel agents with medicinal potential. Cancer is a devastating disease that causes the death of millions of people each year. Thu...

    Authors: Mohamed Salah I Abaza, Khaled Y Orabi, Ebtehal Al-Quattan and Raja’a J Al-Attiyah
    Citation: Cancer Cell International 2015 15:46
    Content type: Primary research Published on:

  42. B7-homologue 3 (B7-H3), a recently identified immunoregulatory protein, has been shown to be overexpressed in human hepatocellular carcinoma (HCC). However, whether the dynamic expression pattern of B7-H3 cont...

    Authors: Fu-biao Kang, Ling Wang, Heng-chuan Jia, Dong Li, Hai-jun Li, Yin-ge Zhang and Dian-xing Sun
    Citation: Cancer Cell International 2015 15:45
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:570

  43. Wilms’ tumor (WT) is one of the most common malignant neoplasms of the urinary tract in children. Anaplastic histology (unfavorable histology) accounts for about 10% of whole WTs, and it is the single most imp...

    Authors: Jun Lu, Yan-Fang Tao, Zhi-Heng Li, Lan Cao, Shao-Yan Hu, Na-Na Wang, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Li-xiao Xu, Yan-Hong Li, Gang Li, He Zhao, Jian Ni…
    Citation: Cancer Cell International 2015 15:44
    Content type: Primary research Published on:

  44. The primary purpose of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of ATP binding cassette superfamily G member 2 (ABCG2) and outcome of tyrosine kinase inhibition...

    Authors: Xueqin Chen, Dadong Chen, Shaoyu Yang, Ruobing Ma, Yuelong Pan, Xin Li and Shenglin Ma
    Citation: Cancer Cell International 2015 15:43
    Content type: Primary research Published on:

  45. Mesenchymal stem cells (MSCs) in tumors have emerged as progenitors involved in stroma formation and metastasis of cancers, partially owing to their abilities to differentially express paracrine factors relate...

    Authors: Dongmei Chen, Shudan Liu, Huiming Ma, Xueyun Liang, Haibin Ma, Xiurui Yan, Bao Yang, Jun Wei and Xiaoming Liu
    Citation: Cancer Cell International 2015 15:42
    Content type: Primary research Published on:

  47. MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-378-5p is dysregulated in numerous human cancers ...

    Authors: Zhenlei Wang, Bin Ma, Xiaopin Ji, Yang Deng, Tao Zhang, Xiaojian Zhang, Haoji Gao, Hanxing Sun, Haoxuan Wu, Xianze Chen and Ren Zhao
    Citation: Cancer Cell International 2015 15:40
    Content type: Primary research Published on:

  48. Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in respons...

    Authors: Umar Wazir, Mona MAW Orakzai, Zubair S Khanzada, Wen G Jiang, Anup K Sharma, Abdul Kasem and Kefah Mokbel
    Citation: Cancer Cell International 2015 15:39
    Content type: Review Published on:

  49. In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes. miRNAs are a family of small ...

    Authors: Kaladhar B Reddy
    Citation: Cancer Cell International 2015 15:38
    Content type: Review Published on:

  50. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease and still continues to have the worst prognosis of all gastrointestinal malignancies. Reports have demonstrated that secretory leukocyte proteas...

    Authors: Wei Zhang, Jian-Long Yao, Shan-Chao Dong, Feng-Qiang Hou and He-Ping Shi
    Citation: Cancer Cell International 2015 15:37
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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