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  1. Although people are more and more aware of the cardiotoxicity caused by immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, its incidence rate has not been systematically analyzed. This study ...

    Authors: Xiao-Tong Zhang, Nan Ge, Zi-Jian Xiang and Tao Liu
    Citation: Cancer Cell International 2022 22:363
    Content type: Review Published on:

  2. Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential ...

    Authors: Jiang Zhou, Chengbin Wang, Yingliang Liu, Daming Cui, Zhenlin Wang, Yang Jiang and Liang Gao
    Citation: Cancer Cell International 2022 22:359
    Content type: Research Published on:

  3. Tumor suppressor CYLD dysfunction by loss of its expression, triggers malignant transformation, especially drug resistance and tumor invasion/metastasis. Although loss of CYLD expression is significantly assoc...

    Authors: Ayumi Kanemaru, Satoru Shinriki, Mimi Kai, Kanae Tsurekawa, Kazuya Ozeki, Shota Uchino, Naoki Suenaga, Kou Yonemaru, Shunsuke Miyake, Takeshi Masuda, Ryusho Kariya, Seiji Okada, Hisashi Takeshita, Yuki Seki, Hiromu Yano, Yoshihiro Komohara…
    Citation: Cancer Cell International 2022 22:358
    Content type: Research Published on:

  4. Due to the rarity of PBL and the lack of large-scale studies, the prognostic value of IPI in PBL was controversial. Especially in the rituximab era, the ability of IPI to stratify prognosis in patients receivi...

    Authors: Kexin Feng, Shuangtao Zhao, Qingyao Shang, Guangdong Qiao, Jiaxiang Liu, Chenxuan Yang, Ya Wei, Yalun Li, Fei Ren, Lixue Xuan, Xiang Wang and Xin Wang
    Citation: Cancer Cell International 2022 22:357
    Content type: Research Published on:

  6. The distinctive properties and high activity of calcium titanate nanoparticles (CaTiO3-NPs) increase their use in many products. However, the cytotoxic and genotoxic effects of CaTiO3-NPs in human cancer cell lin...

    Authors: Hanan R. H. Mohamed, Maria M. H. Ibrahim and Ayman Diab
    Citation: Cancer Cell International 2022 22:355
    Content type: Research Published on:

  7. Recent technological advances in nanoscience and material designing have led to the development of point-of-care devices for biomolecule sensing and cancer diagnosis. In situ and portable sensing devices for b...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Jesús Herrera-Bravo, Haleema Sadia, Faiza Anum, Shahid Raza, Arifa Tahir, Muhammad Naeem Shahwani, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:354
    Content type: Review Published on:

  8. N6-methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in human cancer progression. However, the biological function of m6A methylation requires further st...

    Authors: Wenyi Shen, Juan Pu, Zhi Zuo, Shanye Gu, Jing Sun, Bing Tan, Lili Wang, Jianmeng Cheng and Yangsong Zuo
    Citation: Cancer Cell International 2022 22:353
    Content type: Research Published on:

  9. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms ...

    Authors: Naoki Katase, Shin-ichiro Nishimatsu, Akira Yamauchi, Shinji Okano and Shuichi Fujita
    Citation: Cancer Cell International 2022 22:352
    Content type: Research Published on:

  10. Asymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling of methylated proteins and serves as a precursor for resynthesis of a...

    Authors: Yi-Ling Chen, AKaychia T. Lowery, Samuel Lin, Ameae M. Walker and Kuan-Hui E. Chen
    Citation: Cancer Cell International 2022 22:351
    Content type: Research Published on:

  11. Human epidermal growth factor receptor 2 (HER2) positive breast carcinomas due to HER2 amplification are associated with aggressive behavior and a poor prognosis. Anti-HER2-targeted therapies are widely used to t...

    Authors: Laura Morsberger, Aparna Pallavajjala, Patty Long, Melanie Hardy, Rebecca Park, Rebecca Parish, Azin Nozari and Ying S. Zou
    Citation: Cancer Cell International 2022 22:350
    Content type: Research Published on:

  13. We investigate the correlation between programmed cell death-ligand 1 (PD-L1) and tumor-associated immune cell (TAIC) density in small-cell neuroendocrine carcinoma of the uterine cervix (SCNEC) and their corr...

    Authors: Xiaoying Sun, Lili Liu, Ting Wan, Qidan Huang, Jieping Chen, Rongzhen Luo and Jihong Liu
    Citation: Cancer Cell International 2022 22:348
    Content type: Research Published on:

  14. Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, th...

    Authors: Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He and Fang Wang
    Citation: Cancer Cell International 2022 22:347
    Content type: Research Published on:

  15. Prostate cancer (PCa) is currently the major malignancy in men. It is becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation networks are important in a wide variety of cancers. Neverth...

    Authors: Qinyu Li, Bingliang Chen, Guoda Song, Kai Zeng, Xin Chen, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang and Bo Liu
    Citation: Cancer Cell International 2022 22:346
    Content type: Research Published on:

  16. Head and neck squamous cell cancer (HNSCC) is a common malignant cancer. We aimed to explore prognostic cuproptosis-related lncRNAs (CRLs) and prognostic risk models for HNSCC.

    Authors: Xiajing Liu, Wenwei Cheng, Heqing Li and Yexun Song
    Citation: Cancer Cell International 2022 22:345
    Content type: Research Published on:

  17. Intestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activating factor associated with digestion and inhibition of cancer. There is few study to analyze the correlated f...

    Authors: Jiang Zhu, Lingqi Wang, Zhongwu Guo, Tao Zhang and Ping Zhang
    Citation: Cancer Cell International 2022 22:344
    Content type: Research Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:372

  18. Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating me...

    Authors: Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi and Yujuan Zhou
    Citation: Cancer Cell International 2022 22:343
    Content type: Review Published on:

  19. miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointest...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:342
    Content type: Review Published on:

  20. Metastasis is the leading cause of death in colorectal cancer (CRC) patients, and the liver is the most common site of metastasis. Tumor cell metastasis can be thought of as an invasion-metastasis cascade and ...

    Authors: Yaru Niu, Wenwei Yang, Haili Qian and Yongkun Sun
    Citation: Cancer Cell International 2022 22:341
    Content type: Review Published on:

  21. Pancreatic cancer is one of the most lethal disease with highly fatal and aggressive properties. Lymph node ratio (LNR), the ratio of the number of metastatic lymph nodes to the total number of examined lymph ...

    Authors: Cheng Qin, Tianhao Li, Yuanyang Wang, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Cancer Cell International 2022 22:340
    Content type: Research Published on:

  22. Transcription factors (TFs) are essential for many biological processes and regulate the expression of several genes. This study’s objective was to analyze the abnormalities in TF expression, their impact on p...

    Authors: Manizheh Sajadi, Mohammad Fazilti, Habibollah Nazem, Mohammad Mahdevar and Kamran Ghaedi
    Citation: Cancer Cell International 2022 22:339
    Content type: Research Published on:

    The Correction to this article has been published in Cancer Cell International 2023 23:53

  23. Non-small cell lung cancer (NSCLC) accounts for more than 85% of the total cases with lung cancer. NSCLC is characterized by easy metastasis, which often spreads to bones, brains and livers. RNA-binding motif ...

    Authors: Shan Cong, Xin Di, Ranwei Li, Yingshu Cao, Xin Jin, Chang Tian, Min Zhao and Ke Wang
    Citation: Cancer Cell International 2022 22:338
    Content type: Research Published on:

  24. Long non-coding RNAs (lncRNAs) are involved in a variety of mechanisms related to tumorigenesis by functioning as oncogenes or tumor-suppressors or even harboring oncogenic and tumor-suppressing effects; repre...

    Authors: Mohammad Amin Kerachian and Marjan Azghandi
    Citation: Cancer Cell International 2022 22:337
    Content type: Primary research Published on:

  25. Ovarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments. The therapeutic potential of histone methyltransferase DOT1L inhibito...

    Authors: Elena Alexandrova, Jessica Lamberti, Domenico Memoli, Claudia Quercia, Viola Melone, Francesca Rizzo, Roberta Tarallo, Giorgio Giurato, Giovanni Nassa and Alessandro Weisz
    Citation: Cancer Cell International 2022 22:336
    Content type: Research Published on:

  26. Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although va...

    Authors: Shirin Azizidoost, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Bartosz Kempisty, Paul Mozdziak, Klaudia Radoszkiewicz and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:335
    Content type: Review Published on:

  27. Pancreatic ductal adenocarcinoma (PDAC) is one of the leading cancers worldwide and has a poor survival, with a 5-year survival rate of only 8.5%. In this study we investigated altered DNA methylation associat...

    Authors: Ankita Chatterjee, Akash Bararia, Debopriyo Ganguly, Pronoy Kanti Mondal, Paromita Roy, Sudeep Banerjee, Shibajyoti Ghosh, Sumit Gulati, Supriyo Ghatak, Bitan Kumar Chattopadhay, Priyadarshi Basu, Aniruddha Chatterjee and Nilabja Sikdar
    Citation: Cancer Cell International 2022 22:334
    Content type: Research Published on:

  28. Hepatocellular carcinoma (HCC) is the most common neoplasm among primary liver malignancies, accounting for 70%–85% of total liver cancer cases worldwide. It is also the second-leading cause of cancer-related ...

    Authors: Aya M. Hussein, Nadia M. El-Beih, Menha Swellam and Enas A. El-Hussieny
    Citation: Cancer Cell International 2022 22:333
    Content type: Research Published on:

  29. To evaluate the efficacy of autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with favorable-risk acute myeloid leukemia in first remission.

    Authors: Juan Chen, Li Liu, Runzhi Ma, Aiming Pang, Donglin Yang, Xin Chen, Jialin Wei, Yi He, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou and Sizhou Feng
    Citation: Cancer Cell International 2022 22:332
    Content type: Research Published on:

  30. To summarize the impact of radiotherapy (RT) and chemotherapy delays on patients with nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic.

    Authors: Cheng-Long Huang, Xue-Liang Fang, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Si-Si Xu, Jun Ma, Lei Chen and Ling-Long Tang
    Citation: Cancer Cell International 2022 22:331
    Content type: Research Published on:

  31. Long non-coding RNA X-inactive specific transcript (XIST) regulates the progression of a variety of tumors, including osteosarcoma. Bone marrow mesenchymal stem cells (BMSCs) can be recruited into osteosarcoma...

    Authors: Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li and Tao Xiao
    Citation: Cancer Cell International 2022 22:330
    Content type: Research Published on:

  32. We identified here mechanism by which hAECs exert their anti-cancer effects. We showed that vaccination with live hAEC conferred effective protection against murine colon cancer and melanoma but not against br...

    Authors: Mohammad-Reza Bolouri, Roya Ghods, Kayhan Zarnani, Sedigheh Vafaei, Reza Falak and Amir-Hassan Zarnani
    Citation: Cancer Cell International 2022 22:329
    Content type: Research Published on:

  33. Cuproptosis (copper death) is a recently found cell death type produced by copper iron; nonetheless, the properties of cuproptosis molecular subtypes and possible involvement of cuproptosis-related genes (CRGs...

    Authors: Jingjing Zhang, Miao Lu, Haoya Xu, Fang Ren and Liancheng Zhu
    Citation: Cancer Cell International 2022 22:328
    Content type: Research Published on:

  34. Oncoviruses, known as cancer-causing viruses, are typically involved in cancer progression by inhibiting tumor suppressor pathways and uncontrolled cell division. Myeloid cells are the most frequent population...

    Authors: Azin Aghamajidi, Pooya Farhangnia, Salar Pashangzadeh, Amirmasoud Rayati Damavandi and Reza Jafari
    Citation: Cancer Cell International 2022 22:327
    Content type: Review Published on:

  35. Ferroptosis is an iron-dependent mode of cell death that could be induced by erastin and exert antitumor effects. However, the clinical and biological roles of ferroptosis-related gene (FRG) signature and the ...

    Authors: Bibo Fu, Ruonan Shao, Huizhong Wang, Guanjun Chen, Shenrui Bai and Hua Wang
    Citation: Cancer Cell International 2022 22:326
    Content type: Research Published on:

  36. The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad and Nader Akbari Dilmaghani
    Citation: Cancer Cell International 2022 22:325
    Content type: Review Published on:

  37. Secreted phosphoprotein 1 (SPP1), an extracellular secreted glycol phosphoprotein, is closely related to tumor biologies, such as proliferation, migration, and invasion. However, the role and biological functi...

    Authors: Xuan Yi, Linlin Luo, Yanzhen Zhu, Hong Deng, Huitian Liao, Yang Shen and Yan Zheng
    Citation: Cancer Cell International 2022 22:324
    Content type: Research Published on:

  38. Exosomes are naturally occurring nanosized particles that aid intercellular communication by transmitting biological information between cells. Exosomes have therapeutic efficacy that can transfer their conten...

    Authors: Bashdar Mahmud Hussen, Goran Sedeeq Hama Faraj, Mohammad Fatih Rasul, Hazha Jamal Hidayat, Abbas Salihi, Aria Baniahmad, Mohammad Taheri and Soudeh Ghafouri-Frad
    Citation: Cancer Cell International 2022 22:323
    Content type: Review Published on:

  39. Osteosarcoma is a highly malignant tumor, with very high disability and fatality rates. However, the overall prognosis is not optimistic. Pyroptosis is a newly discovered cell death modality accompanied by inf...

    Authors: Jian Zhang, Jianjian Deng, Rui Ding, Jinghong Yuan, Jiahao Liu, Xiaokun Zhao, Tianlong Wu, Jingyu Jia and Xigao Cheng
    Citation: Cancer Cell International 2022 22:322
    Content type: Research Published on:

  41. Brain metastases (BM) from non-small-cell lung cancer (NSCLC) is the most common brain malignancy. Systemic inflammation biomarkers have recently been evaluated as prognosis indicators in several tumors. The c...

    Authors: Feng Wang, Limin Chen, Zhao Wang, Qiuyan Xu, He Huang, Hairong Wang, Xi Li, Mingjie Yu, Jiangen Chen, Fuhua Lin, Zhenghe Chen, Xiangheng Zhang, Qunying Yang, Yonggao Mou and Chengcheng Guo
    Citation: Cancer Cell International 2022 22:320
    Content type: Research Published on:

  42. LINC00467 is an example of long intergenic non-coding RNAs whose roles in human disorders are being identified. This gene coding LINC00467 is located on chromosome 1: 211,382,736 − 211,435,570 forward strand. ...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Mohammadreza Hajiesmaeili
    Citation: Cancer Cell International 2022 22:319
    Content type: Review Published on:

  43. Ferroptosis have been implicated in tumorigenesis, tumor progression, and chemo- and immuno-therapy in cirrhotic hepatocellular carcinoma (HCC), indicating its association with matrix stiffness and clinical be...

    Authors: Shunxi Wang, Long Chen and Wanqian Liu
    Citation: Cancer Cell International 2022 22:318
    Content type: Research Published on:

  44. Gastric cancer is one of the most common malignancies of the digestive system with a high lethal rate. Studies have shown that inherited and acquired mutations in pyruvate metabolism and citric acid cycle (P-C...

    Authors: Xu Wang, Bing Xu, Jing Du, Jun Xia, Guojie Lei, Chaoting Zhou, Jiayu Hu, Yinhao Zhang, Sufeng Chen, Fangchun Shao, Jiyun Yang and Yanchun Li
    Citation: Cancer Cell International 2022 22:317
    Content type: Research Published on:

  46. Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family o...

    Authors: Shima Dorafshan, Mahdieh Razmi, Sadegh Safaei, Erica Gentilin, Zahra Madjd and Roya Ghods
    Citation: Cancer Cell International 2022 22:315
    Content type: Review Published on:

  47. Hepatocellular carcinoma (HCC) is one of the most malignant solid tumors worldwide. Recent evidence shows that the stimulator of interferon genes (STING) pathway is essential for anti-tumor immunity via induci...

    Authors: Zhangya Pu, Jinghua Liu, Zelong Liu, Fang Peng, Yuanyuan Zhu, Xiaofang Wang, Jiayan He, Panpan Yi, Xingwang Hu, Xuegong Fan and Jiang Chen
    Citation: Cancer Cell International 2022 22:314
    Content type: Research Published on:

  48. Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, p...

    Authors: Mohsen Karami Fath, Ali Azargoonjahromi, Asma Soofi, Faezeh Almasi, Shahnaz Hosseinzadeh, Saeed Khalili, Kamran Sheikhi, Saeid Ferdousmakan, Soroor Owrangi, Minoovash Fahimi, Hamidreza Zalpoor, Mohsen Nabi Afjadi, Zahra Payandeh and Navid Pourzardosht
    Citation: Cancer Cell International 2022 22:313
    Content type: Review Published on:

  49. Midazolam (MDZ) is an anaesthetic that is widely used for anxiolysis and sedation. More recently, MDZ has also been described to be related to the outcome of various types of carcinomas. However, how MDZ influ...

    Authors: Junwei Kang, Zhiying Zheng, Xian Li, Tian Huang, Dawei Rong, Xinyang Liu, Miaomiao Qin, Yuliang Wang, Xiangyi Kong, Jinhua Song, Chengyu Lv and Xiongxiong Pan
    Citation: Cancer Cell International 2022 22:312
    Content type: Research Published on:

  50. The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, w...

    Authors: Jin-Kyoung Shim, Seonah Choi, Seon-Jin Yoon, Ran Joo Choi, Junseong Park, Eun Hee Lee, Hye Joung Cho, Suji Lee, Wan-Yee Teo, Ju Hyung Moon, Hyun Sil Kim, Eui Hyun Kim, Jae-Ho Cheong, Jong Hee Chang, Jong In Yook and Seok-Gu Kang
    Citation: Cancer Cell International 2022 22:309
    Content type: Research Published on:
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Cancer Cell International

ISSN: 1475-2867

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