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  1. Content type: Primary research

    We have characterized the human cell line arised from the Epstein–Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation. This cell line has acquired the ability to form fre...

    Authors: Evgeniya V. Dolgova, Daria D. Petrova, Anastasia S. Proskurina, Genrikh S. Ritter, Polina E. Kisaretova, Ekaterina A. Potter, Yaroslav R. Efremov, Sergey I. Bayborodin, Tatiana V. Karamysheva, Margarita V. Romanenko, Sergey V. Netesov, Oleg S. Taranov, Aleksandr A. Ostanin, Elena R. Chernykh and Sergey S. Bogachev

    Citation: Cancer Cell International 2019 19:120

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  2. Content type: Primary research

    Lung cancer is one of the most common and deadly tumors around the world. Targeted therapy for patients with certain mutations, especially by use of tyrosine kinase inhibitors (TKIs) targeting epidermal growth...

    Authors: Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun and Xiao-Ju Zhang

    Citation: Cancer Cell International 2019 19:117

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  3. Content type: Primary research

    Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological be...

    Authors: Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao and Jing Zhang

    Citation: Cancer Cell International 2019 19:116

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  4. Content type: Primary research

    miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relat...

    Authors: Zhihui Wang, Zhiquan Zhu, Zhong Lin, Youli Luo, Zibin Liang, Caibin Zhang, Jianxu Chen and Peijian Peng

    Citation: Cancer Cell International 2019 19:115

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  5. Content type: Primary research

    As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of...

    Authors: Si-Li Wang, Yun Huang, Rui Su and Yong-Yang Yu

    Citation: Cancer Cell International 2019 19:114

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  6. Content type: Primary research

    Although contemporary chemotherapy has improved the cure rate of childhood acute lymphoblastic leukemia (ALL) to nearly 90%, relapsed/refractory ALL is still a leading cause of tumor-related death in children....

    Authors: Yiping Zhu, Rong Yang, Ju Gao, Yanle Zhang, Ge Zhang and Ling Gu

    Citation: Cancer Cell International 2019 19:113

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  7. Content type: Primary research

    Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. A better u...

    Authors: Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique and Carmen Jerónimo

    Citation: Cancer Cell International 2019 19:112

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  8. Content type: Primary research

    Acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Therefore, subtype classification is important and indispensable in ALL diagnosis. In ...

    Authors: Yanran Sun, Qiaosheng Zhang, Guoshuang Feng, Zhen Chen, Chao Gao, Shuguang Liu, Ruidong Zhang, Han Zhang, Xueling Zheng, Wenyu Gong, Yadong Wang, Yong Wu, Jie Li and Huyong Zheng

    Citation: Cancer Cell International 2019 19:110

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  9. Content type: Primary research

    The aim of this study is to explore the effect of microRNA-103a (miR-103a) on astrocytes activation and hippocampal neuron injury in epilepsy rats by targeting brain-derived neurotrophic factor (BDNF).

    Authors: Ping Zheng, He Bin and Wei Chen

    Citation: Cancer Cell International 2019 19:109

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  10. Content type: Primary research

    MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown.

    Authors: Xin Huang, Fen Tang, Zeping Weng, Mengyao Zhou and Qing Zhang

    Citation: Cancer Cell International 2019 19:108

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  11. Content type: Primary research

    Compelling lines of evidence indicate that DNA methylation of non-coding RNAs (ncRNAs) plays critical roles in various tumour progression. In addition, the differential methylation of ncRNAs can predict progno...

    Authors: Jie Zhang, Keqing Shi, Weiguo Huang, Wanqing Weng, Zhongjing Zhang, Yangyang Guo, Tuo Deng, Yukai Xiang, Xiaofeng Ni, Bicheng Chen and Mengtao Zhou

    Citation: Cancer Cell International 2019 19:107

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  12. Content type: Primary research

    Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

    Authors: Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou and Jingting Jiang

    Citation: Cancer Cell International 2019 19:106

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  13. Content type: Primary research

    Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case–c...

    Authors: Tianbo Liu, Liangliang Jiang, Libo Yu, Tingting Ge, Jing Wang and Hongyu Gao

    Citation: Cancer Cell International 2019 19:105

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  14. Content type: Primary research

    Increasing reports demonstrated that dysregulated expression of microRNAs (miRNAs) leads to the progression of various tumors. Previous studies revealed that miR-328-3p exhibited dysregulated expression in var...

    Authors: Jianhui Shi, Gang An, Ying Guan, Tianli Wei, Zhibin Peng, Min Liang and Yansong Wang

    Citation: Cancer Cell International 2019 19:104

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  15. Content type: Primary research

    Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and sign...

    Authors: Kelin She, Shenghua Fang, Wei Du, Xingxing Fan, Jiaxi He, Hui Pan, Liyan Huang, Ping He and Jun Huang

    Citation: Cancer Cell International 2019 19:103

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  16. Content type: Primary research

    Most colorectal cancer (CRC) patients are diagnosed at an advanced or metastatic stage with poor prognosis. Ubiquitin-specific protease 6 N-terminal-like protein (USP6NL) with high expression in CRC tissues re...

    Authors: Kang Sun, Song-Bing He, Yi-Zhou Yao, Jian-Guo Qu, Rong Xie, Yu-Qiao Ma, Ming-Hui Zong and Ji-Xiang Chen

    Citation: Cancer Cell International 2019 19:102

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  17. Content type: Primary research

    It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an importan...

    Authors: Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang, Huijing Feng, Junping Zhang and Jingting Jiang

    Citation: Cancer Cell International 2019 19:101

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  18. Content type: Primary research

    Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a subs...

    Authors: Yanfang Wang, Quanli Zhang, Zhaojia Gao, Shan Xin, Yanbo Zhao, Kai Zhang, Run Shi and Xuanwen Bao

    Citation: Cancer Cell International 2019 19:100

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  19. Content type: Primary research

    Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deub...

    Authors: Zhiqiang Wu, Minghan Qiu, Yu Guo, Jinlin Zhao, Zhuang Liu, Hui Wang, Maobin Meng, Zhiyong Yuan and Zeyun Mi

    Citation: Cancer Cell International 2019 19:99

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  20. Content type: Primary research

    Currently offered therapeutics to treat colon cancer (CoCa) are toxic when given at maximum tolerated dose to achieve optimal clinical response. Hence, less toxic therapeutic intervention is needed to treat Co...

    Authors: Ian T. Saunders, Hina Mir, Neeraj Kapur and Shailesh Singh

    Citation: Cancer Cell International 2019 19:98

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  21. Content type: Primary research

    5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment ...

    Authors: Weilong Yao, Shengtao Zhu, Peng Li and Shutian Zhang

    Citation: Cancer Cell International 2019 19:97

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  22. Content type: Primary research

    The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD).

    Authors: Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang and Yi Shen

    Citation: Cancer Cell International 2019 19:96

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  23. Content type: Correction

    After publication of the original article [1], the authors have notified us of 5 errors which are highlighted below. The authors apologize for any inconvenience.

    Authors: Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang and Dong-Qiu Dai

    Citation: Cancer Cell International 2019 19:95

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    The original article was published in Cancer Cell International 2019 19:27

  24. Content type: Primary research

    In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppres...

    Authors: Lin Tang, Jian-Bo Wen, Ping Wen, Xing Li, Min Gong and Qiang Li

    Citation: Cancer Cell International 2019 19:94

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  25. Content type: Primary research

    Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of...

    Authors: Jia Cao, Xi Wang, Danni Wang, Rong Ma, Xiaohan Li, Huimin Feng, Jia Wang, Shihai Liu and Libin Wang

    Citation: Cancer Cell International 2019 19:93

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  26. Content type: Review

    In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been s...

    Authors: Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen and Zhiqiang Meng

    Citation: Cancer Cell International 2019 19:92

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  27. Content type: Review

    Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional...

    Authors: Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George and Heidi Abrahamse

    Citation: Cancer Cell International 2019 19:91

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  28. Content type: Primary research

    Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network an...

    Authors: Junyu Long, Yi Bai, Xiaobo Yang, Jianzhen Lin, Xu Yang, Dongxu Wang, Li He, Yongchang Zheng and Haitao Zhao

    Citation: Cancer Cell International 2019 19:90

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  29. Content type: Primary research

    Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading ...

    Authors: Kashif Rafiq Zahid, Mingyang Su, Abdur Rehman Raza Khan, Shiming Han, Gou Deming and Umar Raza

    Citation: Cancer Cell International 2019 19:89

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  30. Content type: Retraction Note

    The Editor-in-Chief has retracted this article [1] because Figure 6a and 6b show overlap with Figure 4b in [2]. An investigation by Zhengzhou University has confirmed that these figures overlap. The data repor...

    Authors: Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong and Guoqiang Zhao

    Citation: Cancer Cell International 2019 19:88

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    The original article was published in Cancer Cell International 2016 16:85

  31. Content type: Primary research

    To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

    Authors: Chia-Cheng Yu, Lih-Chyang Chen, Chih-Yung Chiou, Yu-Jia Chang, Victor C. Lin, Chao-Yuan Huang, I-Ling Lin, Ta-Yuan Chang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang and Bo-Ying Bao

    Citation: Cancer Cell International 2019 19:87

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  32. Content type: Primary research

    Ovarian cancer is known as one of the most common cancers in the world among women. ST6GALNAC1 is highly expressed in cancer stem cells (CSCs), which correlates to high tumor-initiating, self-renewal and diffe...

    Authors: Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou, Bing Wei, Lei Zhan and Shi-Ying Sun

    Citation: Cancer Cell International 2019 19:86

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  33. Content type: Primary research

    DA-9401 was prepared as a mixture of Chinese medicinal herb extracts from roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliceae) and seeds of Cuscuta chinensis Lamark (Convolvulac...

    Authors: Keshab Kumar Karna, Bo Ram Choi, Jae Hyung You, Yu Seob Shin, Kiran Kumar Soni, Wan Shou Cui, Sung Won Lee, Chul Young Kim, Hye Kyung Kim and Jong Kwan Park

    Citation: Cancer Cell International 2019 19:85

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  34. Content type: Primary research

    GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive o...

    Authors: Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng, Jiayi Wang, Guoyu Hu, Sufang Liu, Yewei Wang, Yunxiao Xu, Hongling Peng and Guangsen Zhang

    Citation: Cancer Cell International 2019 19:84

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  35. Content type: Primary research

    In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an...

    Authors: Serena Salehzadeh, Francesca Guerrini, Umberto Pizzano, Susanna Grassi, Elena Ciabatti, Lorenzo Iovino, Gabriele Buda, Francesco Caracciolo, Edoardo Benedetti, Enrico Orciuolo, Matteo Pelosini, Giovanni Consani, Giovanni Carulli, Maria Rita Metelli, Francesca Martini, Francesco Mazziotta…

    Citation: Cancer Cell International 2019 19:83

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  36. Content type: Primary research

    lncRNAs have been proved to play crucial parts in various human cytopathology and cell physiology, including tumorigenesis. Down-regulated lncRNAs SNHG6 have shown great cell proliferation inhibitory effects i...

    Authors: Xin Zhu, Guangling Yang, Jisheng Xu and Chuanlin Zhang

    Citation: Cancer Cell International 2019 19:82

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  37. Content type: Primary research

    Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used i...

    Authors: Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu and Yan Li

    Citation: Cancer Cell International 2019 19:81

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  38. Content type: Primary research

    Invasion and metastasis are determinant events in the prognosis of Colorectal cancer (CRC), a common neoplasm worldwide. An important factor for metastasis is the acquired capacity of the cell to proliferate a...

    Authors: Jossimar Coronel-Hernández, Eduardo López-Urrutia, Carlos Contreras-Romero, Izamary Delgado-Waldo, Gabriela Figueroa-González, Alma D. Campos-Parra, Rebeca Salgado-García, Antonio Martínez-Gutierrez, Miguel Rodríguez-Morales, Nadia Jacobo-Herrera, Luis Ignacio Terrazas, Abraham Silva-Carmona, César López-Camarillo and Carlos Pérez-Plasencia

    Citation: Cancer Cell International 2019 19:80

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  39. Content type: Primary research

    The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple hum...

    Authors: Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu and Ninghong Song

    Citation: Cancer Cell International 2019 19:79

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  40. Content type: Primary research

    Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in various kinds of cancers. Here, we aimed to determine whether the expressi...

    Authors: Ziping Wu, Lei Zhang, Shuguang Xu, Yanping Lin, Wenjin Yin, Jinglu Lu, Rui Sha, Xiaonan Sheng, Liheng Zhou and Jinsong Lu

    Citation: Cancer Cell International 2019 19:78

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  41. Content type: Primary research

    The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pa...

    Authors: Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage and Konrad Steinestel

    Citation: Cancer Cell International 2019 19:77

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  42. Content type: Primary research

    It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such ...

    Authors: Shanli Li, Feng Xue, Yi Zheng, Pengtao Yang, Shuai Lin, Yujiao Deng, Peng Xu, Linghui Zhou, Qian Hao, Zhen Zhai, Ying Wu, Zhijun Dai and Shu Chen

    Citation: Cancer Cell International 2019 19:76

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  43. Content type: Primary research

    The role of TMED3 involved in cancers has been seldom described, let alone in breast cancer. To explore the clinicopathological significance of TMED3 expression and the biological roles involved in breast canc...

    Authors: Jing Pei, Jing Zhang, Xiaowei Yang, Zhengsheng Wu, Chenyun Sun, Zhaorui Wang and Benzhong Wang

    Citation: Cancer Cell International 2019 19:75

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  44. Content type: Primary research

    Gastric cardia adenocarcinoma (GCA) is an aggressive subtype of gastric cancer with a high metastatic rate. However, the metastatic biomarker of GCA has not been established.

    Authors: Jing Wei, Lincui Wang, Jun Zhu, Aiqin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Genbao Shao, Wannian Yang and Qiong Lin

    Citation: Cancer Cell International 2019 19:74

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  45. Content type: Primary research

    Pediatric cancer survival rates overall have been improving, but neuroblastoma (NBL) and acute lymphoblastic leukemia (ALL), two of the more prevalent pediatric cancers, remain particularly challenging. One is...

    Authors: Andrea Diviney, Boris I. Chobrutskiy, Saif Zaman and George Blanck

    Citation: Cancer Cell International 2019 19:73

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  46. Content type: Primary research

    Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal cancer (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon cancer remains largely...

    Authors: Shurui Ouyang, Xin Zhou, Zhengquan Chen, Maijian Wang, Xinbin Zheng and Ming Xie

    Citation: Cancer Cell International 2019 19:72

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  47. Content type: Primary research

    Oxaliplatin-based chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Recent studies suggested that therapeutic resistance of tumors was affected by tumor microenvironment (TME). As a major co...

    Authors: Xiu-Tao Fu, Kang Song, Jian Zhou, Ying-Hong Shi, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Zhen-Bin Ding and Jia Fan

    Citation: Cancer Cell International 2019 19:71

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  48. Content type: Primary research

    Pretreatment inflammatory factors, including neutrophil, lymphocyte, platelet and monocyte counts as well as the ratios between them such as neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) a...

    Authors: Hao Peng and Xiaogang Luo

    Citation: Cancer Cell International 2019 19:70

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