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  1. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Costimulatory molecules have been proven to be the foundation of immunotherapy. However, the potential roles of costimulatory mo...

    Authors: Yinan Hu, Jingyi Liu, Jiahao Yu, Fangfang Yang, Miao Zhang, Yansheng Liu, Shuoyi Ma, Xia Zhou, Jingbo Wang and Ying Han
    Citation: Cancer Cell International 2022 22:97
  2. Prognostic assessment is imperative for clinical management of patients with hepatocellular carcinoma (HCC). Most reported prognostic signatures are based on risk scores summarized from quantitative expression...

    Authors: Xiaoyun Bu, Luyao Ma, Shuang Liu, Dongsheng Wen, Anna Kan, Yujie Xu, Xuanjia Lin and Ming Shi
    Citation: Cancer Cell International 2022 22:95
  3. To investigate the genotype distribution of human papillomavirus (HPV) in infected Uygur and Han women in Xinjiang, China; analyze the HPV16 E6 gene polymorphism site and relationship with the development of c...

    Authors: Huizhen Xin, Zhenzhen Pan, Xiangyi Zhe, Chunhe Zhang, Hongtao Li, Weinan Zheng, Haichen Long, Renfu Shao, Dongmei Li and Zemin Pan
    Citation: Cancer Cell International 2022 22:94
  4. Long non-coding RNAs (lncRNAs) regulate tumor development and metastasis in several types of cancers through various molecular mechanisms. However, the biological role of most lncRNAs in pancreatic cancer (PC)...

    Authors: Min Zhong, Zhi Fang, Bin Ruan, Jianping Xiong, Junhe Li and Zhiwang Song
    Citation: Cancer Cell International 2022 22:93
  5. Long non-coding RNAs and microRNAs have recently attained much attention regarding their role in the development of B cell lineage as well as participation in the lymphomagenesis. These transcripts have a high...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Elena Jamali
    Citation: Cancer Cell International 2022 22:91
  6. Esophageal squamous cell carcinoma (ESCC) is a severe disease with high mortality, and is associated with poor prognosis and frequent lymphatic metastasis. Therefore, prognostic indicators for ESCC are urgentl...

    Authors: Qiu-yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-fei Xia, Yong Du, Run-duan Lin, Li-qiong Yang, Yu-ting Sun, Da-Jun Yang, Jian Sun and Lin Zhang
    Citation: Cancer Cell International 2022 22:90
  7. To evaluate the efficacy and safety of P-ALG (porcine anti-lymphocyte globulin) and R-ATG (rabbit anti-thymocyte globulin) in the conditioning regime for patients with acquired aplastic anemia who underwent HL...

    Authors: Juan Chen, Yuanfeng Zhang, Xin Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou…
    Citation: Cancer Cell International 2022 22:89
  8. KRAS mutation accounts for 30–50% of human colorectal cancer (CRC) cases. Due to the scarcity of effective treatment options, KRAS mutant CRC is difficult to treat in the clinic. Metastasis is still the major ...

    Authors: Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao and Qing Wang
    Citation: Cancer Cell International 2022 22:88
  9. Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may be in part due to so called glioma stem cells. However, there is no established marker to identify these stem cells.

    Authors: Bülent Polat, Gisela Wohlleben, Rebekka Kosmala, Dominik Lisowski, Frederick Mantel, Victor Lewitzki, Mario Löhr, Robert Blum, Petra Herud, Michael Flentje and Camelia-Maria Monoranu
    Citation: Cancer Cell International 2022 22:87
  10. Increasing evidence suggests that aberrant methylation is involved in 5-fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that Methyl-CpG binding protein 2 (MeCP2) promote...

    Authors: Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma and Lingyu Zhao
    Citation: Cancer Cell International 2022 22:86
  11. The role of hydrogen sulfide (H2S) in cancer biology is controversial, including colorectal cancer. The bell-shaped effect of H2S refers to pro-cancer action at lower doses and anti-cancer effect at higher concen...

    Authors: Yuyang Zhang, Shanwen Chen, Jing Zhu, Shihao Guo, Taohua Yue, Hao Xu, Jianwen Hu, Zhihao Huang, Zeyang Chen, Pengyuan Wang and Yucun Liu
    Citation: Cancer Cell International 2022 22:85
  12. In addition to its role in cellular progression and cancer, SIRT6, a member of nicotinamide adenine dinucleotide (NAD+)-dependent class III deacylase sirtuin family, serves a variety of roles in the body's immune...

    Authors: Xiaojing Wu, Shuyuan Wang, Xuanzhu Zhao, Sizhen Lai, Zhen Yuan, Yixiang Zhan, Kemin Ni, Zhaoce Liu, Lina Liu, Ran Xin, Xingyu Zhou, Xin Yin, Xinyu Liu, Xipeng Zhang, Wei Cui and Chunze Zhang
    Citation: Cancer Cell International 2022 22:84
  13. Osimertinib resistance limits the treatment of epidermal growth factor receptor-(EGFR)-mutated non-small-cell lung carcinoma (NSCLC). The mechanisms of osimertinib resistance need to be elucidated to determine...

    Authors: Xiaoying Wan, Boxiong Xie, Hui Sun, Weiqing Gu, Chunyan Wang, Qinfang Deng and Songwen Zhou
    Citation: Cancer Cell International 2022 22:83
  14. Approximately 50%–60% of secondary resistance to primary EGFR- tyrosine kinase inhibitors (TKI) therapy is caused by acquired p.Thr790Met (T790M) mutation; however, highly fragmented, low-quantity circulating tum...

    Authors: Boyeon Kim, Yoonjung Kim, Saeam Shin, Seung-Tae Lee, Jae Yong Cho and Kyung-A. Lee
    Citation: Cancer Cell International 2022 22:82
  15. Breast cancer (BC) threatens the health of women around the world. Researchers have proved that hsa_circ_0005505 (circ_IRAK3) facilitates BC cell invasion and migration, but the regulatory mechanisms of circ_I...

    Authors: Fang Wang, Jingruo Li, Lin Li, Zhuo Chen, Nan Wang, Mingzhi Zhu, Hailong Mi, Youyi Xiong, Guangcheng Guo and Yuanting Gu
    Citation: Cancer Cell International 2022 22:81
  16. The gasdermins (GSDMs) family is proposed to be pore-forming effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our increasing knowledge of GSDMD, GSDME and GSDMB, the biologic...

    Authors: Mingchao Mu, Qiaoling Yu, Qin Zhang, Jing Guo, Xingjie Wang, Xuejun Sun and Junhui Yu
    Citation: Cancer Cell International 2022 22:80
  17. The role of circular RNAs (circRNAs) and microRNAs (miRNAs) in osteosarcoma (OS) development has not been fully elucidated. Further, the contribution of the immune response to OS progression is not well define...

    Authors: Zhihao Chen, Liubing Li, Ziyuan Li, Xi Wang, Mingxiao Han, Zongshuai Gao, Min Wang, Gangfeng Hu, Xiaolu Xie, Hong Du, Zonggang Xie and Haifang Zhang
    Citation: Cancer Cell International 2022 22:78
  18. Thyroid cancer is the most common malignant endocrine tumour, and metastasis has become the main reason for treatment failure. However, the underlying molecular mechanism of thyroid cancer metastasis remains p...

    Authors: Yankun Zhang, Min Sun, Lifen Gao, Xiaohong Liang, Chunhong Ma, Jinghui Lu and Xuetian Yue
    Citation: Cancer Cell International 2022 22:76
  19. Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women in China. In previous studies, Sestrin2 was demonstrated to have functions in CRC. However, the relationship between ...

    Authors: Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li and Zhongxue Fu
    Citation: Cancer Cell International 2022 22:75
  20. Although the prognosis for most patients with papillary thyroid cancer (PTC) is good, the present treatment is ineffective for 5–10% patients. Several studies found sodium–glucose cotransporter 2 (SGLT2) inhib...

    Authors: Yan Wang, Longyan Yang, Lin Mao, Lijie Zhang, Yingjun Zhu, Yongsong Xu, Yanan Cheng, Rongxin Sun, Yuanyuan Zhang, Jing Ke and Dong Zhao
    Citation: Cancer Cell International 2022 22:74
  21. Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced hepatocellular carcinoma. Sorafeni...

    Authors: Ruyin Chen, Qiong Li, Shuaishuai Xu, Chanqi Ye, Tian Tian, Qi Jiang, Jianzhen Shan and Jian Ruan
    Citation: Cancer Cell International 2022 22:73
  22. N6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications of RNA. However, there is limited information about the potential roles of m6A regulators in tumor immunity. Therefore, in t...

    Authors: Jianfeng Cui, Yaofeng Zhu, Xiaochen Liu, Wenfu Wang, Xuewen Jiang, Yangyang Xia, Guanwen Zhou, Shouzhen Chen and Benkang Shi
    Citation: Cancer Cell International 2022 22:72
  23. Colorectal cancer (CRC) is the second most common cause of cancer mortality and a major health challenge worldwide. Despite advances in therapeutic and diagnostic methods, there is still a poor prognosis in CR...

    Authors: Amir Abbas Hamidi, Ghazaleh Khalili-Tanha, Zahra Nasrpour Navaei and Meysam Moghbeli
    Citation: Cancer Cell International 2022 22:71
  24. Fermitin family member 1 (FERMT1) is significantly overexpressed in human cancers and associated with poor prognosis, but its contributions to tumorigenesis and nasopharyngeal carcinoma (NPC) progression remai...

    Authors: Lingling Li, Piao Li, Wei Zhang, Haiting Zhou, Ergang Guo, Guoqing Hu and Linli Zhang
    Citation: Cancer Cell International 2022 22:70
  25. Gastric cancer (GC), the most commonly diagnosed cancer worldwide with poor 5-year survival rate in advanced stages. Although immune-related and survival-related biomarkers, which typically comprise aberrantly...

    Authors: Jun Wang, Beidi Wang, Biting Zhou, Jing Chen, Jia Qi, Le Shi, Shaojun Yu, Guofeng Chen, Muxing Kang, Xiaoli Jin, Lie Wang, Jinghong Xu, Linghua Zhu and Jian Chen
    Citation: Cancer Cell International 2022 22:69
  26. The Kirsten ras oncogene KRAS is a member of the small GTPase superfamily participating in the RAS/MAPK pathway. A single amino acid substitution in KRAS gene has been shown to activate the encoded protein result...

    Authors: Soudeh Ghafouri-Fard, Zeinab Shirvani-Farsani, Bashdar Mahmud Hussen, Mohammad Taheri and Reza Jalili Khoshnoud
    Citation: Cancer Cell International 2022 22:68
  27. Copine1 (CPNE1), the first discovered CPNE1 family member, participates in the process of carcinogenesis and development of diverse tumors. Our study aimed to investigate the expression and prognostic value of...

    Authors: Jinfang Su, Yongbiao Huang, Yali Wang, Rui Li, Wanjun Deng, Hao Zhang and Huihua Xiong
    Citation: Cancer Cell International 2022 22:67
  28. Clear cell renal cell carcinoma (ccRCC) is one of the most lethal malignancies in the urinary system and the existing immunotherapy has not achieved satisfactory outcomes. Therefore, this study aims at establi...

    Authors: Daojia Miao, Jian Shi, Zhiyong Xiong, Wen Xiao, Xiangui Meng, Qingyang Lv, Kairu Xie, Hongmei Yang and Xiaoping Zhang
    Citation: Cancer Cell International 2022 22:66
  29. Tumor microenvironments are characterized by resistance to chemotherapeutic agents and radiotherapy. Hypoxia plays an important role in the development of tumor resistance, as well as the generation of metasta...

    Authors: Dengke Zhang, Fazong Wu, Jingjing Song, Miaomiao Meng, Xiaoxi Fan, Chenying Lu, Qiaoyou Weng, Shiji Fang, Liyun Zheng, Bufu Tang, Yang Yang, Jianfei Tu, Min Xu, Zhongwei Zhao and Jiansong Ji
    Citation: Cancer Cell International 2022 22:65
  30. Osteosarcoma (OS) is a tumour with a high malignancy level and a poor prognosis. First-line chemotherapy for OS has not been improved for many decades. Bromodomain and extraterminal domain (BET) and histone de...

    Authors: Bo Yu, Lang Liu, Feng Cai, Yuanxiang Peng, Xiaofeng Tang, Duo Zeng, Teng Li, Feifei Zhang, Yiping Liang, Xuhui Yuan, Jiayu Li, Zhengzai Dai, Qi Liao and Xiao-Bin Lv
    Citation: Cancer Cell International 2022 22:64
  31. Authors: Feng Qiu, Bin Qiao, Nan Zhang, Zheng Fang, Lu Feng, Shanfeng Zhang and Weiliu Qiu
    Citation: Cancer Cell International 2022 22:63

    The original article was published in Cancer Cell International 2021 21:412

  32. Head and neck squamous cell carcinoma (HNSCC) is a major threat to public health. Pyroptosis is a form of inflammatory programmed cell death that is still incompletely understood. The role of pyroptotic cell d...

    Authors: Weiwen Zhu, Jiayi Zhang, Mengyao Wang, Rundong Zhai, Yanbin Xu, Jie Wang, Mengqi Wang, Hang Zhang and Laikui Liu
    Citation: Cancer Cell International 2022 22:62
  33. Radioiodine (RAI) is the mainstay of treatment for differentiated thyroid carcinoma (DTC) following total thyroidectomy. Nevertheless, about 5% of patients with DTC are RAI-refractory (RAI-R). Understanding th...

    Authors: Hilda Samimi and Vahid Haghpanah
    Citation: Cancer Cell International 2022 22:61
  34. Present work systematically reviewed relevant literature based on 18F-FDG PET parameters and conducted a meta-analysis to examine the prognostic value of maximal standard uptake value (SUVmax), total lesional ...

    Authors: Weibo Wen, Dongyuan Xu, Yongnan Piao and Xiangdan Li
    Citation: Cancer Cell International 2022 22:60
  35. The prevalence of lung adenocarcinoma (LUAD) has increased, thus novel biomarkers for its early diagnosis is becoming more important than ever. tRNA-derived small RNA (tsRNA) is a new class of non-coding RNA w...

    Authors: Jun Wang, Xianyu Liu, Weifang Cui, Qun Xie, Wei Peng, Heng Zhang, Yang Gao, Chunfang Zhang and Chaojun Duan
    Citation: Cancer Cell International 2022 22:59
  36. Colorectal cancer (CRC) has become the second deadliest cancer in the world and severely threatens human health. An increasing number of studies have focused on the role of the RNA helicase DEAD-box (DDX) fami...

    Authors: Xin Zhou, Zhihong Liu, Tengfei He, Cuifeng Zhang, Manman Jiang, Yuxiao Jin, Ziyu Wu, Changji Gu, Wei Zhang and Xiaodong Yang
    Citation: Cancer Cell International 2022 22:58
  37. Hepatocellular carcinoma (HCC) often presents with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge in personalized medicine....

    Authors: Nan Zhao, Yanhui Zhang, Runfen Cheng, Danfang Zhang, Fan Li, Yuhong Guo, Zhiqiang Qiu, Xueyi Dong, Xinchao Ban, Baocun Sun and Xiulan Zhao
    Citation: Cancer Cell International 2022 22:57
  38. Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) are typically characterized by metastasis and chemoresistance. Cell lines are important model systems for developing new therapeutic s...

    Authors: Eva-Maria Packeiser, Leila Taher, Weibo Kong, Mathias Ernst, Julia Beck, Marion Hewicker-Trautwein, Bertram Brenig, Ekkehard Schütz, Hugo Murua Escobar and Ingo Nolte
    Citation: Cancer Cell International 2022 22:54
  39. Cysteine cathepsin C encoded by the CTSC gene is an important member of the cysteine cathepsin family that plays a key role regulation of many types of tumors. However, whether CTSC is involved in the pathologica...

    Authors: Xingbo Cheng, Zhishuai Ren, Zhendong Liu, Xiang Sun, Rongjun Qian, Chen Cao, Binfeng Liu, Jialin Wang, Hongbo Wang, Yuqi Guo and Yanzheng Gao
    Citation: Cancer Cell International 2022 22:53
  40. Triple-receptor negative breast cancer (TNBC) is an aggressive breast tumor subtype that generally has a poor prognosis. This study aimed to investigate the role and regulatory mechanisms of Zinc finger MIZ-ty...

    Authors: Xiaopan Zou, Yan Liu, Jun Di, Wei Wei, Nobumoto Watanabe, Jiang Li and Xiaomeng Li
    Citation: Cancer Cell International 2022 22:52
  41. Colorectal cancer (CRC) is a malignant tumor affecting people worldwide. Long noncoding RNAs (lncRNAs) is a crucial factor modulating various cancer progression, including CRC. Long intergenic non-protein codi...

    Authors: Shoushan Nan, Shuangxia Zhang, Rong Jin and Juelei Wang
    Citation: Cancer Cell International 2022 22:51
  42. Gastric cancer (GC) has a poor prognosis and limited therapeutic options. As a new promising cancer therapeutic approach, chimeric antigen receptor (CAR)-T cells represent a potential GC treatment. We investig...

    Authors: Fengqiang Sun, Xiaomei Yu, Ruixue Ju, Zhanzhao Wang and Yuhui Wang
    Citation: Cancer Cell International 2022 22:50
  43. Authors: Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang and Hongyun Zhao
    Citation: Cancer Cell International 2022 22:46

    The original article was published in Cancer Cell International 2021 21:458

  44. Authors: Ishita Gupta, Gheyath K. Nasrallah, Anju Sharma, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Ali A. Sultan, Moussa Alkhalaf, Semir Vranic and Ala-Eddin Al Moustafa
    Citation: Cancer Cell International 2022 22:45

    The original article was published in Cancer Cell International 2020 20:107

  45. Malignant melanoma (MM) is highly metastatic and has the highest mortality rate in patients with skin cancer. The ERBB3 binding protein 1 (Ebp1) has been linked to the onset and progression of a number of mali...

    Authors: Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li and Lan Liu
    Citation: Cancer Cell International 2022 22:44

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