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  1. The prognostic value of pre-treatment platelet-to-lymphocyte ratio (PLR) in patients with urothelial carcinoma (UC) remains controversial. Therefore, this meta-analysis aimed to identify the prognostic impact ...

    Authors: Yuhai Bao, Yin Wang, Xiaodong Li, Mingjun Pan, Hongze Zhang, Zegen Cheng and Xueyi Wang

    Citation: Cancer Cell International 2019 19:315

    Content type: Primary research

    Published on:

  2. The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the ...

    Authors: Shuai Wu, Chen Luo, Fengjiao Li, N. U. Farrukh Hameed, Qiuyan Jin and Jie Zhang

    Citation: Cancer Cell International 2019 19:314

    Content type: Primary research

    Published on:

  3. Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed t...

    Authors: Huan-yu Zhang, Mao-qing Xing, Jing Guo, Jin-chuan Zhao, Xin Chen, Zhong Jiang, Hong Zhang and Qian Dong

    Citation: Cancer Cell International 2019 19:313

    Content type: Primary research

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  4. Bladder cancer is the most common human urological malignancies with poor prognosis, and the pathophysiology of bladder cancer involves multi-linkages of regulatory networks in the bladder cancer cells. Recent...

    Authors: Jinan Guo, Zhixin Chen, Hongtao Jiang, Zhou Yu, Junming Peng, Jing Xie, ZaiShang Li, Weiqing Wu, Zhiqiang Cheng and Kefeng Xiao

    Citation: Cancer Cell International 2019 19:312

    Content type: Primary research

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  5. Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma subtype with a poor prognosis. LncRNA-LET is a long non-coding RNA (lncRNA) that is down-regulated in ccRCC tissues. However, its...

    Authors: Zhuo Ye, Jiachen Duan, Lihui Wang, Yanli Ji and Baoping Qiao

    Citation: Cancer Cell International 2019 19:311

    Content type: Primary research

    Published on:

  6. Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. This study characterized the clinicopathologic and survival analysis of this tumor, fur...

    Authors: Dan Huang, Fei Ren, Shujuan Ni, Cong Tan, Weiwei Weng, Meng Zhang, Midie Xu, Lei Wang, Qinghua Xu and Weiqi Sheng

    Citation: Cancer Cell International 2019 19:310

    Content type: Primary research

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  7. Galectins constitute a family of β-galactoside-binding proteins, which influence various hallmarks of pancreatic cancer, including cell proliferation, invasion and migration; immune escape; and angiogenesis. A...

    Authors: Qiqing Sun, Yiyin Zhang, Mengqi Liu, Zeng Ye, Xianjun Yu, Xiaowu Xu and Yi Qin

    Citation: Cancer Cell International 2019 19:309

    Content type: Review

    Published on:

  8. MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer ...

    Authors: Wen-Li Liu, Hu-xia Wang, Cheng-xin Shi, Fei-yu Shi, Ling-yu Zhao, Wei Zhao and Guang-hui Wang

    Citation: Cancer Cell International 2019 19:308

    Content type: Primary research

    Published on:

  9. Lymph node metastasis is one of the most important factors affecting the prognosis of tongue cancer, and the molecular mechanism regulating lymph node metastasis of tongue cancer is poorly known.

    Authors: Fang Xiao, Yinhua Dai, Yujiao Hu, Mengmeng Lu and Qun Dai

    Citation: Cancer Cell International 2019 19:307

    Content type: Primary research

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  10. Increased cell mobility is a signature when tumor cells undergo epithelial-to-mesenchymal transition. TGF-β is a key stimulating factor to promote the transcription of a variety of downstream genes to accelera...

    Authors: Jing Huang, Siyuan Chang, Yabin Lu, Jing Wang, Yang Si, Lijian Zhang, Shan Cheng and Wen G. Jiang

    Citation: Cancer Cell International 2019 19:306

    Content type: Primary research

    Published on:

  11. Switch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors. However, the mechanis...

    Authors: Lin Shi, Huize Liu, Yifeng Wang, Yulong Chong, Jie Wang, Guanzheng Liu, Xu Zhang, Xiangyu Chen, Huan Li, Mingshan Niu, Jun Liang, Rutong Yu and Xuejiao Liu

    Citation: Cancer Cell International 2019 19:305

    Content type: Primary research

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  12. Cervical cancer (CC) is the fourth leading cause of cancer-associated death in women worldwide. Recently, long noncoding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) has been demonstrated to ...

    Authors: Qian Zhang, Jindan Zheng and Lili Liu

    Citation: Cancer Cell International 2019 19:304

    Content type: Primary research

    Published on:

  13. Ovarian cancer is the third most common cause of death among gynecologic malignancies worldwide. Understanding the biology and molecular pathogenesis of ovarian epithelial tumors is key to developing improved ...

    Authors: Amata Amy Soriano, Tiziana de Cristofaro, Tina Di Palma, Serena Dotolo, Priyanka Gokulnath, Antonella Izzo, Gaetano Calì, Angelo Facchiano and Mariastella Zannini

    Citation: Cancer Cell International 2019 19:303

    Content type: Primary research

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  14. Tongue squamous cell carcinoma (TSCC) is a most invasive cancer with high mortality and poor prognosis. It is reported that lncRNA DANCR has implications in multiple types of cancers. However, its biological r...

    Authors: Ying Zheng, Bowen Zheng, Xue Meng, Yuwen Yan, Jia He and Yi Liu

    Citation: Cancer Cell International 2019 19:302

    Content type: Primary research

    Published on:

  15. The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complem...

    Authors: Ronghua Zhang, Qiaofei Liu, Tong Li, Quan Liao and Yupei Zhao

    Citation: Cancer Cell International 2019 19:300

    Content type: Review

    Published on:

  16. Photoimmunotherapy (PIT) employing antibody-photosensitizer conjugates is a promising treatment for cancer. However, the fixed antigen specificity severely limits the efficacy and the applicability. Here we de...

    Authors: Naoto Shirasu, Hirotomo Shibaguchi, Hiromi Yamada, Masahide Kuroki and Shin’ichiro Yasunaga

    Citation: Cancer Cell International 2019 19:299

    Content type: Primary research

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  17. Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family of proteins and its deregulation has been implicated in the malignancy of several cancer types. Dlg5 ...

    Authors: Dongping Wang, Qi Zhang, Fenfen Li, Chan Wang, Changming Yang and Hong Yu

    Citation: Cancer Cell International 2019 19:298

    Content type: Primary research

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  18. Transcription factors (TFs) are responsible for the regulation of various activities related to cancer like cell proliferation, invasion, and migration. It is thought that, the measurement of TFs levels could ...

    Authors: Boxin Zhang, Haihui Wang, Ziyan Guo and Xinhai Zhang

    Citation: Cancer Cell International 2019 19:297

    Content type: Primary research

    Published on:

  19. Endometrial cancer (EC) is one of the three major gynecological malignancies. Numerous biomarkers that may be associated with survival and prognosis have been identified through database mining in previous stu...

    Authors: Zi-Hao Wang, Yun-Zheng Zhang, Yu-Shan Wang and Xiao-Xin Ma

    Citation: Cancer Cell International 2019 19:296

    Content type: Primary research

    Published on:

  20. The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is formed by one of t...

    Authors: Peng Wang, Yonghui Yuan, Wenda Lin, Hongshan Zhong, Ke Xu and Xun Qi

    Citation: Cancer Cell International 2019 19:295

    Content type: Review

    Published on:

  21. Glioma is considered one of the most common tumors and has a poor prognosis. Recently, microRNAs (miRNAs) have been reported to be strongly linked to various human tumors including glioma. In this study, we in...

    Authors: Yangyang Li, Jia Xu, Jiale Zhang, Jie Zhang, Jian Zhang and Xiaoming Lu

    Citation: Cancer Cell International 2019 19:294

    Content type: Primary research

    Published on:

  22. Although leukemic blast cells of Pro-B cell acute lymphoblastic leukemia (ALL) are arrested at the same stage of B cell differentiation, the immature B cell subtype is still biologically heterogeneous and is a...

    Authors: Chao Gao, Shu-Guang Liu, Zhi-Xia Yue, Yi Liu, Jing Liang, Jun Li, Yuan-Yuan Zhang, Jiao-Le Yu, Ying Wu, Wei Lin, Hu-Yong Zheng and Rui-Dong Zhang

    Citation: Cancer Cell International 2019 19:293

    Content type: Primary research

    Published on:

  23. During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokin...

    Authors: Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz and Kinga A. Kocemba-Pilarczyk

    Citation: Cancer Cell International 2019 19:292

    Content type: Hypothesis

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  24. Previous genome-wide transcriptome profiling found circ_ZNF124 was highly expressed in lung adenocarcinoma, however, the role of circ_ZNF124 in non-small cell lung cancer (NSCLC) is still unknown. The purpose ...

    Authors: Qianping Li, Qin Huang, Shaofei Cheng, Song Wu, Hongyang Sang and Junyi Hou

    Citation: Cancer Cell International 2019 19:291

    Content type: Primary research

    Published on:

  25. Hepatocellular carcinoma (HCC) is a serious threat to public health due to its poor prognosis. The current study aimed to develop and validate a prognostic nomogram to predict the overall survival of HCC patie...

    Authors: Zhiqiao Zhang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Qingbo Liu, Peng Wang and Jianqiang Ding

    Citation: Cancer Cell International 2019 19:290

    Content type: Primary research

    Published on:

  26. SNAI2, a member of the snail zinc finger protein family, plays an important role in the metastasis of several types of carcinoma.

    Authors: Jie Ding, Yu Xia, Zhaoyan Yu, Jing Wen, Zhuxue Zhang, Zhongmin Zhang, Zhenhua Liu, Zhuan Jiang, Hang Liu and Guoqing Liao

    Citation: Cancer Cell International 2019 19:289

    Content type: Primary research

    Published on:

  27. The study aimed to explore the associations between the interactions of serum vitamin B2 or B12 levels, aberrant DNA methylation of p16 or p53 and MTHFR C677T polymorphism and the risks of esophageal squamous cel...

    Authors: Da Pan, Ming Su, Guiling Huang, Pengfei Luo, Ting Zhang, Lingmeng Fu, Jie Wei, Shaokang Wang and Guiju Sun

    Citation: Cancer Cell International 2019 19:288

    Content type: Primary research

    Published on:

  28. The authors have retracted this article [1] because Figure 4a has been duplicated from Figure 5d in a previously published article [2]. In addition, the article contains sections that substantially overlap wit...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke

    Citation: Cancer Cell International 2019 19:286

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2018 18:165

  29. Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na+/H+ exchanger NHE1 plays a significant part in human melanoma ...

    Authors: Dennis Keurhorst, Ivan Liashkovich, Fabian Frontzek, Svenja Nitzlaff, Verena Hofschröer, Rita Dreier and Christian Stock

    Citation: Cancer Cell International 2019 19:285

    Content type: Primary research

    Published on:

  30. Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in certain human tumors. However, the detailed biological function of TRIM11 in ch...

    Authors: Bin Wang, Gang Wang, Qingfeng Wang, Ziqiang Zhu, Yunqing Wang, Kangwu Chen and Huilin Yang

    Citation: Cancer Cell International 2019 19:284

    Content type: Primary research

    Published on:

  31. Tripartite motif‑containing 27 (TRIM27) belongs to the TRIM protein family, which is closely related to the progression of some certain human cancers. Nevertheless, the biological function of TRIM27 in esophag...

    Authors: Liang Ma, Ninghua Yao, Ping Chen and Zhixiang Zhuang

    Citation: Cancer Cell International 2019 19:283

    Content type: Primary research

    Published on:

  32. Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly maligna...

    Authors: Jian-Xian Lin, Xiong-Feng Weng, Xin-Sheng Xie, Ning-Zi Lian, Sheng-Liang Qiu, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Si-Jia Liu, Min Hu, Yi-Ke Lin, Chang-Ming Huang…

    Citation: Cancer Cell International 2019 19:282

    Content type: Primary research

    Published on:

  33. Recently, the impact of microRNAs (miRNAs) and exosome on ovarian cancer has been assessed in many studies. We aim to explore the mechanism of exosomes transferring miR-205 in ovarian cancer, and confirm its d...

    Authors: Lijun Wang, Fei Zhao, Zhongqing Xiao and Liang Yao

    Citation: Cancer Cell International 2019 19:281

    Content type: Primary research

    Published on:

  34. Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.

    Authors: Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao and Feng Zhi

    Citation: Cancer Cell International 2019 19:280

    Content type: Primary research

    Published on:

  35. Radiation sensitive 52 (RAD52) is an important protein that mediates DNA repair in tumors. However, little is known about the impact of RAD52 on hepatocellular carcinoma (HCC). We investigated the expression o...

    Authors: Ping Li, YanZhen Xu, Qinle Zhang, Yu Li, Wenxian Jia, Xiao Wang, Zhibin Xie, Jiayi Liu, Dong Zhao, Mengnan Shao, Suixia Chen, Nanfang Mo, Zhiwen Jiang, Liuyan Li, Run Liu, Wanying Huang…

    Citation: Cancer Cell International 2019 19:279

    Content type: Primary research

    Published on:

  36. Long noncoding RNAs (lncRNAs) are involved in different pathogenesis pathways including cancer pathogenesis. The adenoma-carcinoma pathway in colorectal cancer may involve the aberrant and variable gene expres...

    Authors: Milad Shademan, Azam Naseri Salanghuch, Khadijeh Zare, Morteza Zahedi, Mohammad Ali Foroughi, Kambiz Akhavan Rezayat, Hooman Mosannen Mozaffari, Kamran Ghaffarzadegan, Ladan Goshayeshi and Hesam Dehghani

    Citation: Cancer Cell International 2019 19:278

    Content type: Primary research

    Published on:

  37. CKS1 is highly expressed in colon cancer tissues, and is essential for cancer cell proliferation. The downstream molecular mechanism of CKS1 has been fully studied, but the upstream regulatory mechanism of it ...

    Authors: Zhengbin Chai, Li Wang, Yabing Zheng, Na Liang, Xiwei Wang, Yingying Zheng, Zhiwei Zhang, Chuanxi Zhao, Tingting Zhu and Chunyan Liu

    Citation: Cancer Cell International 2019 19:277

    Content type: Primary research

    Published on:

  38. The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) is involved in various cancers and often functions through microRNAs. The pro-survival protein PTP1B is known to play important roles i...

    Authors: Yi Li, Qingan Zeng, Jiliang Qiu, Ting Pang, Jianzhong Xian and Xuexia Zhang

    Citation: Cancer Cell International 2019 19:275

    Content type: Primary research

    Published on:

  39. Daily experience tells us that breast cancer can be controlled using standard protocols up to the advent of a relapse. Now new frontiers in precision medicine like liquid biopsy of cell free DNA (cfDNA) give u...

    Authors: Maria Palmieri, Margherita Baldassarri, Francesca Fava, Alessandra Fabbiani, Giuseppe Maria Campennì, Maria Antonietta Mencarelli, Rossella Tita, Stefania Marsili, Alessandra Renieri and Elisa Frullanti

    Citation: Cancer Cell International 2019 19:274

    Content type: Commentary

    Published on:

  40. This study is performed to investigate the effects of adenovirus-mediated X-linked inhibitor of apoptosis protein (XIAP) overexpressed bone marrow mesenchymal stem cells (BMSCs) on brain injury in rats with ce...

    Authors: Wenjing Deng, Chenghe Fan, Yanbo Fang, Yanan Zhao, Yamin Wei, Meng Li and Junfang Teng

    Citation: Cancer Cell International 2019 19:273

    Content type: Primary research

    Published on:

  41. To investigate the value of dynamic monitoring peripheral blood lymphocyte-to-monocyte (LMR) ratio in evaluating the treatment response and prognosis of patients with extranodal NK/T cell lymphoma (ENKTL).

    Authors: Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song and Qingsong Yin

    Citation: Cancer Cell International 2019 19:272

    Content type: Review

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:21

  42. Prostate cancer (PCa) is a common disease that often occurs among older men and a frequent cause of malignancy associated death in this group. microRNA (miR)-129-5p has been identified as an essential regulato...

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Pingeng Wu and Dong Chen

    Citation: Cancer Cell International 2019 19:271

    Content type: Primary research

    Published on:

  43. LncRNAs may exert a regulatory effect in tumorigenesis. Although the expression of lncRNA HOTAIR has been confirmed to be notably elevated in the tissues of CSCC, its biological mechanism in CSCC is still unknown...

    Authors: Guo-Jun Yu, Yong Sun, Da-Wei Zhang and Peng Zhang

    Citation: Cancer Cell International 2019 19:270

    Content type: Primary research

    Published on:

  44. Malignant glioma is one of the essentially incurable tumors with chemoresistance and tumor recurrence. As a histone methyltransferase, SUV39H2 can trimethylate H3K9. SUV39H2 is highly expressed in many types o...

    Authors: Ran Wang, Lilin Cheng, Xi Yang, Xin Chen, Yifeng Miao, Yongming Qiu and Zhiyi Zhou

    Citation: Cancer Cell International 2019 19:269

    Content type: Primary research

    Published on:

  45. Circular RNAs (circRNAs) are involved in regulating tumor pathogenesis. The mechanism of circRNAs in gastric cancer (GC) is still unknown. Our study aimed to identify differentially expressed circRNAs and asse...

    Authors: Jianming Wei, Jinmiao Wang, Xibo Gao and Feng Qi

    Citation: Cancer Cell International 2019 19:268

    Content type: Primary research

    Published on:

  46. Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal...

    Authors: Rongrong Zhong, Zhuozhi Chen, Ting Mo, Zimo Li and Peng Zhang

    Citation: Cancer Cell International 2019 19:267

    Content type: Primary research

    Published on:

  47. Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The inhibition of epidermal growth factor receptor (EGFR) signaling by tyrosine kinase inhibitors or monoclonal antibo...

    Authors: Jing Wang, Peiyuan Sun, Qi Wang, Pan Zhang, Yuna Wang, Chengting Zi, Xuanjun Wang and Jun Sheng

    Citation: Cancer Cell International 2019 19:266

    Content type: Primary research

    Published on:

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