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  1. The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the f...

    Authors: Gao-Qi Wu, Yan-Ming Xu and Andy T. Y. Lau

    Citation: Cancer Cell International 2020 20:142

    Content type: Review

    Published on:

  2. The primary tumor, regional lymph nodes and distant metastasis (TNM) stage is an independent risk factor for 1-year hepatocellular carcinoma (HCC) recurrence but has insufficient predictive efficiency. We atte...

    Authors: Haohan Liu, Yongcong Yan, Ruibing Chen, Mengdi Zhu, Jianhong Lin, Chuanchao He, Bingchao Shi, Kai Wen, Kai Mao and Zhiyu Xiao

    Citation: Cancer Cell International 2020 20:140

    Content type: Primary research

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  3. Canine prostate cancer represents a unique model for human prostate cancer. In vitro systems offer various possibilities but Xenograft in vivo imaging allows studying complex tasks as tumor progression and dru...

    Authors: Wen Liu, Sina Sender, Weibo Kong, Julia Beck, Anett Sekora, Kirsten Bornemann-Kolatzki, Ekkehart Schuetz, Christian Junghanss, Bertram Brenig, Ingo Nolte and Hugo Murua Escobar

    Citation: Cancer Cell International 2020 20:139

    Content type: Primary research

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  4. Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer with dismal prognosis and high relapse rate. The role of long non-coding RNAs (lncRNAs) in NPC has become a research hotspot in recent years....

    Authors: Hongchao Yao, Like Yang, Linli Tian, Yan Guo and Yushan Li

    Citation: Cancer Cell International 2020 20:138

    Content type: Primary research

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  5. The purpose of this study was to explore the regulatory mechanism of the long non-coding RNA (lncRNA) LINC00461 underlying the breast cancer invasion and migration via the miR-144-3p/KPNA2 axis.

    Authors: Qiang Zhang, Xiaoyan Jin, Wenbiao Shi, Xin Chen, Wenyang Pang, Xiaodong Yu and Linjun Yang

    Citation: Cancer Cell International 2020 20:137

    Content type: Primary research

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  6. The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 w...

    Authors: Gang Xu, Yan Zhang, Na Li, Yanling Wu, Jinbiao Zhang, Rui Xu and Hui Ming

    Citation: Cancer Cell International 2020 20:136

    Content type: Primary research

    Published on:

  7. The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant...

    Authors: Abdul Rouf War, Kai Dang, Shanfen Jiang, Zhongwei Xiao, Zhiping Miao, Tuanmin Yang, Yu Li and Airong Qian

    Citation: Cancer Cell International 2020 20:135

    Content type: Review

    Published on:

  8. Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in the occurrence and development of pancreatic cancer (PC), which continues to be one of the deadliest malign...

    Authors: Jingyang Zhou, Haihong Wang, Jinhui Che, Lu Xu, Weizhong Yang, Yunjiu Li and Wuyuan Zhou

    Citation: Cancer Cell International 2020 20:134

    Content type: Primary research

    Published on:

  9. Spinal osteosarcoma (OS) is a rare and aggressive malignancy. Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN-AS2 in spinal ...

    Authors: Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu and Wenming Zhang

    Citation: Cancer Cell International 2020 20:133

    Content type: Primary research

    Published on:

  10. Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are being found to play crucial roles in ATC progression. Herein, we focused on the role...

    Authors: Xiangrong Tan, Peng Wang, Jianlin Lou and Jiazheng Zhao

    Citation: Cancer Cell International 2020 20:132

    Content type: Primary research

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  11. Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. Accor...

    Authors: Mohsen Keshavarz, Ailar Sabbaghi, Seyed Mohammad Miri, Abolhasan Rezaeyan, Yaser Arjeini and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:131

    Content type: Review

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  12. Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen pr...

    Authors: Zijian Da, Long Gao, Gang Su, Jia Yao, Wenkang Fu, Jinduo Zhang, Xu Zhang, Zhaoji Pei, Ping Yue, Bing Bai, Yanyan Lin, Wenbo Meng and Xun Li

    Citation: Cancer Cell International 2020 20:130

    Content type: Primary research

    Published on:

  13. Recent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with several cancers. Previous studies propose that a lattice complex assemble...

    Authors: Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang and Fei Sun

    Citation: Cancer Cell International 2020 20:129

    Content type: Primary research

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  14. Cisplatin is a platinum-based first-line drug for treating ovarian cancer. However, chemotherapy tolerance has limited the efficacy of cisplatin for ovarian cancer patients. Research has demonstrated that cisp...

    Authors: Xiao-Yu Yan, Xian-Zhi Qu, Long Xu, Si-Hang Yu, Rui Tian, Xin-Ru Zhong, Lian-Kun Sun and Jing Su

    Citation: Cancer Cell International 2020 20:128

    Content type: Review

    Published on:

  15. Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients. While TK1 has been well established as a tumor biomarker,...

    Authors: Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber and Kim L. O’Neill

    Citation: Cancer Cell International 2020 20:127

    Content type: Primary research

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  16. Colorectal carcinoma is one of the most deadly cancers that requests effective and safe chemotherapy. Evaluation of natural product-based anticancer drugs as adjuvant treatment with fewer side effects is large...

    Authors: Omar Al-Obeed, Adila Salih El-Obeid, Sabine Matou-Nasri, Mansoor-Ali Vaali-Mohammed, Yazeid AlHaidan, Mohammed Elwatidy, Hamad Al Dosary, Zeyad Alehaideb, Khayal Alkhayal, Adil Haseeb, James McKerrow, Rehan Ahmad and Maha-Hamadien Abdulla

    Citation: Cancer Cell International 2020 20:126

    Content type: Primary research

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  17. Kinesin superfamily proteins (KIFs) can transport membranous organelles and protein complexes in an ATP-dependent manner. Kinesin family member 15 (KIF15) is overexpressed in various cancers. However, the func...

    Authors: Lixian Ding, Bin Li, Xiaotong Yu, Zhongsheng Li, Xinglong Li, Shuwei Dang, Qiang Lv, Jiufeng Wei, Haixia Sun, Hongsheng Chen, Ming Liu and Guodong Li

    Citation: Cancer Cell International 2020 20:125

    Content type: Primary research

    Published on:

  18. LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To date, little studies have examined a...

    Authors: Jianxin Lv, Wei Yu, Yanan Zhang, Xinhua Cao, Lifei Han, Haolin Hu and Chenfei Wang

    Citation: Cancer Cell International 2020 20:124

    Content type: Primary research

    Published on:

  19. Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our st...

    Authors: Tian-Fu Li, Hui-Juan Zeng, Zhen Shan, Run-Yi Ye, Tuck-Yun Cheang, Yun-Jian Zhang, Si-Hong Lu, Qi Zhang, Nan Shao and Ying Lin

    Citation: Cancer Cell International 2020 20:123

    Content type: Primary research

    Published on:

  20. Tenascin-C (TNC) is an extracellular matrix protein that is widely expressed in the stromal fibroblasts of various cancers. However, the roles of TNC in colorectal cancer (CRC) cells remain unclear.

    Authors: Zhaoting Yang, Chengye Zhang, Ying Feng, Mingji Quan, Yan Cui and Yanhua Xuan

    Citation: Cancer Cell International 2020 20:122

    Content type: Primary research

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  21. As one of the many breast cancer subtypes, human epidermal growth factor receptor 2 (Her2)-positive breast cancer has higher invasiveness and poor prognosis, although the advent of anti-Her2 drugs has brought ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu, Fubin Feng, Changgang Sun and Jibiao Wu

    Citation: Cancer Cell International 2020 20:121

    Content type: Primary research

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  22. Splicing factor SRSF3 is an oncogene and overexpressed in various kinds of cancers, however, the function and mechanism involved in colorectal cancer (CRC) remained unclear. The aim of this study was to explor...

    Authors: Ji-Lin Wang, Chun-Rong Guo, Tian-Tian Sun, Wen-Yu Su, Qiang Hu, Fang-Fang Guo, Lun-Xi Liang, Jie Xu, Hua Xiong and Jing-Yuan Fang

    Citation: Cancer Cell International 2020 20:120

    Content type: Primary research

    Published on:

  23. Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pa...

    Authors: Fei Zhu, Cheng Cheng, Hong qin, Hongsheng Wang and Hailong Yu

    Citation: Cancer Cell International 2020 20:118

    Content type: Primary research

    Published on:

  24. The carcinogenesis and progression of cervical cancer is a complex process in which numerous microRNAs are involved. The purpose of this study is to investigate the role of miR-125a-5p in progression of cervic...

    Authors: Qinxue Cao, Ning Wang, Lu Ren, Jun Tian, Shaoqin Yang and Hailing Cheng

    Citation: Cancer Cell International 2020 20:117

    Content type: Primary research

    Published on:

  25. The significance of long non-coding RNAs (lncRNAs) in mediating oxidative stress of cancers has been implicated recently. This study proposed a potential therapeutic target lncRNA growth arrest-specific transc...

    Authors: Wei Xu, Zeqiang Yan, Fen Hu, Wei Wei, Chao Yang and Zhihua Sun

    Citation: Cancer Cell International 2020 20:116

    Content type: Primary research

    Published on:

  26. Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study.

    Authors: Chao Tu, Xiaolei Ren, Jieyu He, Shuangqing Li, Lin Qi, Zhixi Duan, Wanchun Wang and Zhihong Li

    Citation: Cancer Cell International 2020 20:115

    Content type: Primary research

    Published on:

  27. Acute myeloid leukemia (AML) is a heterogeneous hematological disease. Our purpose of the research was to investigate the regulatory influence of long non-coding RNA (lncRNA) nuclear enriched abundant transcri...

    Authors: Song Feng, Na Liu, Xiaoguang Chen, Yufeng Liu and Jindou An

    Citation: Cancer Cell International 2020 20:112

    Content type: Primary research

    Published on:

  28. Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development.

    Authors: Xinli Zhao, Fazheng Shen, Jiwei Ma, Shupeng Zhao, Lei Meng, Xiangyang Wang, Shufeng Liang, Jianing Liang, Chaoshuai Hu and Xinzhong Zhang

    Citation: Cancer Cell International 2020 20:111

    Content type: Primary research

    Published on:

  29. A number of studies have demonstrated the critical role of long non-coding RNA gastric cancer high expressed transcript 1 (GHET1) in many cancers. This meta-analysis provides an evidence-based evaluation of th...

    Authors: Dingding Wang, Hong Zhang, Xiaolian Fang, Xue Zhang and Honggang Liu

    Citation: Cancer Cell International 2020 20:109

    Content type: Review

    Published on:

  30. Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly compre...

    Authors: Zhijun Yan, Qilian Yang, Min Xue, Sheng Wang, Weijun Hong and Xiwen Gao

    Citation: Cancer Cell International 2020 20:108

    Content type: Primary research

    Published on:

  31. Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is generall...

    Authors: Ishita Gupta, Gheyath K. Nasrallah, Anju Sharma, Ayesha Jabeen, Maria K. Smatti, Hamda A. Al-Thawadi, Ali A. Sultan, Moussa Alkhalaf, Semir Vranic and Ala-Eddin Al Moustafa

    Citation: Cancer Cell International 2020 20:107

    Content type: Primary research

    Published on:

  32. Lung cancer is the leading cause of cancer-related mortality globally. Discovering effective biomarkers for early diagnosis and prognosis is important to reduce the mortality rate and ensure efficient therapy ...

    Authors: Jiaxing Sun, Tian Xie, Muhammad Jamal, Zhenbo Tu, Xinran Li, Yingjie Wu, Jingyuan Li, Qiuping Zhang and Xiaoxing Huang

    Citation: Cancer Cell International 2020 20:106

    Content type: Primary research

    Published on:

  33. Tumor progression and distant metastasis are the main causes of deaths in colorectal cancer (CRC) patients, and the molecular mechanisms in CRC metastasis have not been completely discovered.

    Authors: Wenping Lian, Huifang Jin, Jingjing Cao, Xinyu Zhang, Tao Zhu, Shuai Zhao, Sujun Wu, Kailu Zou, Xinyun Zhang, Mingliang Zhang, Xiaoyong Zheng and Mengle Peng

    Citation: Cancer Cell International 2020 20:105

    Content type: Primary research

    Published on:

  34. Colorectal cancer (CRC) is a malignant tumor, and the overall prognosis of patients with advanced CRC is still unsatisfactory. Circular RNAs (circRNAs) vesicle-associated membrane protein-associated protein A ...

    Authors: Xiaoyu Zhang, Yingying Xu, Kenji Yamaguchi, Jinping Hu, Lianbo Zhang, Jianfeng Wang, Jifeng Tian and Wanying Chen

    Citation: Cancer Cell International 2020 20:103

    Content type: Primary research

    Published on:

  35. This study aimed to screen osteosarcoma (OS) prognosis relevant genes for methylation dysregulation, and the functional mechanisms of FES overexpression in OS cells were investigated.

    Authors: Yang Zhao, Zhimeng Wang, Qian Wang, Liang Sun, Ming Li, Cheng Ren, Hanzhong Xue, Zhong Li, Kun Zhang, Dingjun Hao, Na Yang, Zhe Song, Teng Ma and Yao Lu

    Citation: Cancer Cell International 2020 20:102

    Content type: Primary research

    Published on:

  36. A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the ...

    Authors: Min Li, Jingmin Cheng, Yuan Ma, Heng Guo, Haifeng Shu, Haidong Huang, Yongqin Kuang and Tao Yang

    Citation: Cancer Cell International 2020 20:101

    Content type: Primary research

    Published on:

  37. Osteosarcoma (OS) is one of the most common types of primary bone tumors which poses negative effects on the bones of both young children and adolescents. LncRNA LINC00472 has been reported to be involved with...

    Authors: Jingwei Zhang, Jieyuan Zhang, Dong Zhang, Weifeng Ni, Haijun Xiao and Bizeng Zhao

    Citation: Cancer Cell International 2020 20:100

    Content type: Primary research

    Published on:

  38. Osteosarcoma is a malignant bone tumor. Increasing evidences have revealed that a disintegrin and metalloproteinase 10 (ADAM10) is implicated in tumor development. The main purpose of this study is to explore ...

    Authors: Quan Yuan, Honghao Yu, Jianhua Chen, Xiaoyu Song and Li Sun

    Citation: Cancer Cell International 2020 20:99

    Content type: Primary research

    Published on:

  39. Pancreatic ductal adenocarcinoma (PDAC) is a lethal human malignancy, and previous researches support the contribution of microRNA (miRNA) to cancer progression. MiR-122-5p is reported to participate in the re...

    Authors: Chen Dai, Yan Zhang, Zhihua Xu and Mengxian Jin

    Citation: Cancer Cell International 2020 20:98

    Content type: Primary research

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  40. Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, an...

    Authors: Xuejiao Liu, Yiming Tu, Yifeng Wang, Di Zhou, Yulong Chong, Lin Shi, Guanzheng Liu, Xu Zhang, Sijin Wu, Huan Li, Shangfeng Gao, Mingshan Niu and Rutong Yu

    Citation: Cancer Cell International 2020 20:97

    Content type: Primary research

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  41. Programmed death-ligand 1 (PD-L1) was the first identified ligand of programmed death-1 (PD-1). PD-1/PD-L1 interactions inhibit T cell-mediated immune responses, limit cytokine production, and promote tumor im...

    Authors: Jing Yang, Meilian Dong, Yifang Shui, Yue Zhang, Zhigang Zhang, Yin Mi, Xiaoxiao Zuo, Li Jiang, Ke Liu, Zheyan Liu, Xiaobin Gu and Yonggang Shi

    Citation: Cancer Cell International 2020 20:96

    Content type: Primary research

    Published on:

  42. Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD) with a poor prognosis because it is often diagnosed in advanced stages with local progression or metastasis. Compared with ...

    Authors: Shuang Meng, Yingjie Li, Xiaozhen Zang, Zheng Jiang, Huahan Ning and Jing Li

    Citation: Cancer Cell International 2020 20:95

    Content type: Primary research

    Published on:

  43. Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss the effect of M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 ...

    Authors: Fan Yang, Tiecheng Wang, Peng Du, Haitao Fan, Xushuai Dong and Hua Guo

    Citation: Cancer Cell International 2020 20:93

    Content type: Primary research

    Published on:

  44. Immunotherapies targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have been approved for gastric cancer (GC) patients. However, a large proportion of patients with T-cell-inflamed ...

    Authors: Qianqian Ren, Peng Zhu, Hui Zhang, Tianhe Ye, Dehan Liu, Zhao Gong and Xiangwen Xia

    Citation: Cancer Cell International 2020 20:92

    Content type: Primary research

    Published on:

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