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  1. MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is d...

    Authors: Xuechun Bai, Lianwen Zheng, Ying Xu, Yan Liang and Dandan Li
    Citation: Cancer Cell International 2022 22:381
  2. Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among which HER2 rece...

    Authors: Tiebo Mao, Xiaofei Zhang, Haiyan Xu, Xiao Zhang, Weiyu Ge, Shumin Li, Jingyu Ma, Ming Yue, Shengbai Xue, Jiujie Cui and Liwei Wang
    Citation: Cancer Cell International 2022 22:380
  3. After cardiovascular diseases, cancer is the second main cause of death globally. Mushrooms have been demonstrated to contain amalgamation with properties capable of inhibiting carcinogenesis and microbial gro...

    Authors: John M. Macharia, Lu Zhang, Ruth W. Mwangi, Nora Rozmann, Zsolt Kaposztas, Tímea Varjas, Miklós Sugár, Huda Alfatafta, Márton Pintér and Raposa L. Bence
    Citation: Cancer Cell International 2022 22:379
  4. Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous R...

    Authors: Bashdar Mahmud Hussen, Snur Rasool Abdullah, Goran Sedeeq Hama Faraj, Mohammed Fatih Rasul, Abbas Salihi, Soudeh Ghafouri-Fard, Mohammad Taheri and Majid Mokhtari
    Citation: Cancer Cell International 2022 22:378
  5. Medulloblastoma (MB) is the most common pediatric malignant brain tumor. Despite current therapies, the morbidity and recurrent risk remains significant. Neuropilin-1 receptor (NRP1) has been implicated in the...

    Authors: Manon Douyère, Caifeng Gong, Mylène Richard, Nadia Pellegrini-Moïse, Joël Daouk, Julien Pierson, Pascal Chastagner and Cédric Boura
    Citation: Cancer Cell International 2022 22:377
  6. Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its cytoplasmic interactions have been...

    Authors: Nayra M. Al-Thani, Stephanie Schaefer-Ramadan, Jovana Aleksic, Yasmin A. Mohamoud and Joel A. Malek
    Citation: Cancer Cell International 2022 22:376
  7. During the development of cervical cancer, HPV infection causes a series of changes in transcription factors and microRNAs. But their relationships with pathogenic processes are not clear.

    Authors: Juan Zhou, Yongpeng Li, Ke Xu, Yan Rong, Siting Huang, Hailun Wu, Xianlin Yi and Chanzhen Liu
    Citation: Cancer Cell International 2022 22:375
  8. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types and chemotherapeutic drug resistance is a stumbling block in improving the overall survival of PDAC patients. The nature of specif...

    Authors: Bangbo Zhao, Cheng Qin, Zeru Li, Yuanyang Wang, Tianhao Li, Hongtao Cao, Xiaoying Yang, Tianyu Li and Weibin Wang
    Citation: Cancer Cell International 2022 22:374
  9. Long non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin struc...

    Authors: Lorena Buono, Concetta Iside, Antonia De Matteo, Pio Stellato, Giuliana Beneduce, Roberta Penta de Vera d’Aragona, Rosanna Parasole, Marco Salvatore, Giovanni Smaldone and Peppino Mirabelli
    Citation: Cancer Cell International 2022 22:373
  10. It is unclear which core events drive the malignant progression of gliomas. Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. This study was de...

    Authors: Zhan Ma, Fengyu Zhang, Ji Xiong, Haishi Zhang, Hui-Kuan Lin and Chunfang Liu
    Citation: Cancer Cell International 2022 22:371
  11. Viruses are completely dependent on host cell machinery for their reproduction. As a result, factors that influence the state of cells, such as signaling pathways and gene expression, could determine the outco...

    Authors: Sara Shayan, Arash Arashkia and Kayhan Azadmanesh
    Citation: Cancer Cell International 2022 22:370
  12. Intercellular communication plays an important role in cancer initiation and progression through direct contact and indirect interactions, such as via secretory molecules. Cancer-associated fibroblasts (CAFs) ...

    Authors: Yutaka Naito, Yusuke Yoshioka and Takahiro Ochiya
    Citation: Cancer Cell International 2022 22:367
  13. Hepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly developed from chronic liver diseases such as hepatitis-B infection-associated liver cirrhosis (LC). The progression from LC to HCC ...

    Authors: Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang and Yong Dai
    Citation: Cancer Cell International 2022 22:366
  14. In recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that...

    Authors: Maysoon Al-Haideri, Santalia Banne Tondok, Salar Hozhabri Safa, Ali Heidarnejad maleki, Samaneh Rostami, Abduladheem Turki Jalil, Moaed E. Al-Gazally, Fahad Alsaikhan, Jasur Alimdjanovich Rizaev, Talar Ahmad Merza Mohammad and Safa Tahmasebi
    Citation: Cancer Cell International 2022 22:365
  15. Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges. Three-dimensional (3D) tumor culture models mimic the in vivo grow...

    Authors: Yanhua Fang, Shanshan Liang, Jianong Gao, Zhe Wang, Cheng Li, Ruoyu Wang and Weiting Yu
    Citation: Cancer Cell International 2022 22:364
  16. Although people are more and more aware of the cardiotoxicity caused by immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, its incidence rate has not been systematically analyzed. This study ...

    Authors: Xiao-Tong Zhang, Nan Ge, Zi-Jian Xiang and Tao Liu
    Citation: Cancer Cell International 2022 22:363
  17. Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal. Targeting macrophage and ...

    Authors: Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han and Lixin Wei
    Citation: Cancer Cell International 2022 22:362
  18. Gynecological cancer is one of the most severe diseases that threaten the lives and health of women worldwide. Its incidence rate increases with each passing year and becomes more prevalent among young people....

    Authors: Jia-Jia Zhang, Wei Liu, Guo-Zhen Xing, Li Xiang, Wen-Ming Zheng and Zhen-Ling Ma
    Citation: Cancer Cell International 2022 22:361
  19. Nasopharyngeal carcinoma (NPC) is prevailing in Southern China, characterized by distinct geographical distribution. Aimed to predict the overall survival (OS) of patients with nasopharyngeal carcinoma, this s...

    Authors: Siwei Miao, Haike Lei, Xiaosheng Li, Wei Zhou, Guixue Wang, Anlong Sun, Ying Wang and Yongzhong Wu
    Citation: Cancer Cell International 2022 22:360
  20. Glioblastoma (GBM) is the most common primary malignant tumor in the brain, and its robust proliferation and invasion abilities reduce the survival time of patients. Circular RNAs (circRNAs) play an essential ...

    Authors: Jiang Zhou, Chengbin Wang, Yingliang Liu, Daming Cui, Zhenlin Wang, Yang Jiang and Liang Gao
    Citation: Cancer Cell International 2022 22:359
  21. Tumor suppressor CYLD dysfunction by loss of its expression, triggers malignant transformation, especially drug resistance and tumor invasion/metastasis. Although loss of CYLD expression is significantly assoc...

    Authors: Ayumi Kanemaru, Satoru Shinriki, Mimi Kai, Kanae Tsurekawa, Kazuya Ozeki, Shota Uchino, Naoki Suenaga, Kou Yonemaru, Shunsuke Miyake, Takeshi Masuda, Ryusho Kariya, Seiji Okada, Hisashi Takeshita, Yuki Seki, Hiromu Yano, Yoshihiro Komohara…
    Citation: Cancer Cell International 2022 22:358
  22. Due to the rarity of PBL and the lack of large-scale studies, the prognostic value of IPI in PBL was controversial. Especially in the rituximab era, the ability of IPI to stratify prognosis in patients receivi...

    Authors: Kexin Feng, Shuangtao Zhao, Qingyao Shang, Guangdong Qiao, Jiaxiang Liu, Chenxuan Yang, Ya Wei, Yalun Li, Fei Ren, Lixue Xuan, Xiang Wang and Xin Wang
    Citation: Cancer Cell International 2022 22:357
  23. The distinctive properties and high activity of calcium titanate nanoparticles (CaTiO3-NPs) increase their use in many products. However, the cytotoxic and genotoxic effects of CaTiO3-NPs in human cancer cell lin...

    Authors: Hanan R. H. Mohamed, Maria M. H. Ibrahim and Ayman Diab
    Citation: Cancer Cell International 2022 22:355
  24. Recent technological advances in nanoscience and material designing have led to the development of point-of-care devices for biomolecule sensing and cancer diagnosis. In situ and portable sensing devices for b...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Jesús Herrera-Bravo, Haleema Sadia, Faiza Anum, Shahid Raza, Arifa Tahir, Muhammad Naeem Shahwani, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:354
  25. N6-methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in human cancer progression. However, the biological function of m6A methylation requires further st...

    Authors: Wenyi Shen, Juan Pu, Zhi Zuo, Shanye Gu, Jing Sun, Bing Tan, Lili Wang, Jianmeng Cheng and Yangsong Zuo
    Citation: Cancer Cell International 2022 22:353
  26. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms ...

    Authors: Naoki Katase, Shin-ichiro Nishimatsu, Akira Yamauchi, Shinji Okano and Shuichi Fujita
    Citation: Cancer Cell International 2022 22:352
  27. Asymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling of methylated proteins and serves as a precursor for resynthesis of a...

    Authors: Yi-Ling Chen, AKaychia T. Lowery, Samuel Lin, Ameae M. Walker and Kuan-Hui E. Chen
    Citation: Cancer Cell International 2022 22:351
  28. Human epidermal growth factor receptor 2 (HER2) positive breast carcinomas due to HER2 amplification are associated with aggressive behavior and a poor prognosis. Anti-HER2-targeted therapies are widely used to t...

    Authors: Laura Morsberger, Aparna Pallavajjala, Patty Long, Melanie Hardy, Rebecca Park, Rebecca Parish, Azin Nozari and Ying S. Zou
    Citation: Cancer Cell International 2022 22:350
  29. We investigate the correlation between programmed cell death-ligand 1 (PD-L1) and tumor-associated immune cell (TAIC) density in small-cell neuroendocrine carcinoma of the uterine cervix (SCNEC) and their corr...

    Authors: Xiaoying Sun, Lili Liu, Ting Wan, Qidan Huang, Jieping Chen, Rongzhen Luo and Jihong Liu
    Citation: Cancer Cell International 2022 22:348
  30. Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, th...

    Authors: Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He and Fang Wang
    Citation: Cancer Cell International 2022 22:347
  31. Prostate cancer (PCa) is currently the major malignancy in men. It is becoming increasingly clear that competitive endogenous RNA (ceRNA) regulation networks are important in a wide variety of cancers. Neverth...

    Authors: Qinyu Li, Bingliang Chen, Guoda Song, Kai Zeng, Xin Chen, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang and Bo Liu
    Citation: Cancer Cell International 2022 22:346
  32. Head and neck squamous cell cancer (HNSCC) is a common malignant cancer. We aimed to explore prognostic cuproptosis-related lncRNAs (CRLs) and prognostic risk models for HNSCC.

    Authors: Xiajing Liu, Wenwei Cheng, Heqing Li and Yexun Song
    Citation: Cancer Cell International 2022 22:345
  33. Intestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activating factor associated with digestion and inhibition of cancer. There is few study to analyze the correlated f...

    Authors: Jiang Zhu, Lingqi Wang, Zhongwu Guo, Tao Zhang and Ping Zhang
    Citation: Cancer Cell International 2022 22:344

    The Correction to this article has been published in Cancer Cell International 2022 22:372

  34. Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating me...

    Authors: Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi and Yujuan Zhou
    Citation: Cancer Cell International 2022 22:343
  35. miR-16-5p is microRNA with important roles in the development of diverse malignancies including neuroblastoma, osteosarcoma, hepatocellular carcinoma, cervical cancer, breast cancer, brain tumors, gastrointest...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:342
  36. Metastasis is the leading cause of death in colorectal cancer (CRC) patients, and the liver is the most common site of metastasis. Tumor cell metastasis can be thought of as an invasion-metastasis cascade and ...

    Authors: Yaru Niu, Wenwei Yang, Haili Qian and Yongkun Sun
    Citation: Cancer Cell International 2022 22:341
  37. Pancreatic cancer is one of the most lethal disease with highly fatal and aggressive properties. Lymph node ratio (LNR), the ratio of the number of metastatic lymph nodes to the total number of examined lymph ...

    Authors: Cheng Qin, Tianhao Li, Yuanyang Wang, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Cancer Cell International 2022 22:340
  38. Transcription factors (TFs) are essential for many biological processes and regulate the expression of several genes. This study’s objective was to analyze the abnormalities in TF expression, their impact on p...

    Authors: Manizheh Sajadi, Mohammad Fazilti, Habibollah Nazem, Mohammad Mahdevar and Kamran Ghaedi
    Citation: Cancer Cell International 2022 22:339

    The Correction to this article has been published in Cancer Cell International 2023 23:53

  39. Non-small cell lung cancer (NSCLC) accounts for more than 85% of the total cases with lung cancer. NSCLC is characterized by easy metastasis, which often spreads to bones, brains and livers. RNA-binding motif ...

    Authors: Shan Cong, Xin Di, Ranwei Li, Yingshu Cao, Xin Jin, Chang Tian, Min Zhao and Ke Wang
    Citation: Cancer Cell International 2022 22:338
  40. Long non-coding RNAs (lncRNAs) are involved in a variety of mechanisms related to tumorigenesis by functioning as oncogenes or tumor-suppressors or even harboring oncogenic and tumor-suppressing effects; repre...

    Authors: Mohammad Amin Kerachian and Marjan Azghandi
    Citation: Cancer Cell International 2022 22:337
  41. Ovarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments. The therapeutic potential of histone methyltransferase DOT1L inhibito...

    Authors: Elena Alexandrova, Jessica Lamberti, Domenico Memoli, Claudia Quercia, Viola Melone, Francesca Rizzo, Roberta Tarallo, Giorgio Giurato, Giovanni Nassa and Alessandro Weisz
    Citation: Cancer Cell International 2022 22:336
  42. Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although va...

    Authors: Shirin Azizidoost, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Bartosz Kempisty, Paul Mozdziak, Klaudia Radoszkiewicz and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:335
  43. Pancreatic ductal adenocarcinoma (PDAC) is one of the leading cancers worldwide and has a poor survival, with a 5-year survival rate of only 8.5%. In this study we investigated altered DNA methylation associat...

    Authors: Ankita Chatterjee, Akash Bararia, Debopriyo Ganguly, Pronoy Kanti Mondal, Paromita Roy, Sudeep Banerjee, Shibajyoti Ghosh, Sumit Gulati, Supriyo Ghatak, Bitan Kumar Chattopadhay, Priyadarshi Basu, Aniruddha Chatterjee and Nilabja Sikdar
    Citation: Cancer Cell International 2022 22:334
  44. Hepatocellular carcinoma (HCC) is the most common neoplasm among primary liver malignancies, accounting for 70%–85% of total liver cancer cases worldwide. It is also the second-leading cause of cancer-related ...

    Authors: Aya M. Hussein, Nadia M. El-Beih, Menha Swellam and Enas A. El-Hussieny
    Citation: Cancer Cell International 2022 22:333
  45. To summarize the impact of radiotherapy (RT) and chemotherapy delays on patients with nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic.

    Authors: Cheng-Long Huang, Xue-Liang Fang, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Si-Si Xu, Jun Ma, Lei Chen and Ling-Long Tang
    Citation: Cancer Cell International 2022 22:331

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