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  1. Content type: Primary Research

    Renal cell carcinoma accounts for 2–3% of all cancers and metastasis increased the malignancy of renal cancer. However, the role of methylation in metastasis of renal cancer is poorly understood.

    Authors: Jianbo Zheng, Yanhui Mei, Ping Xiang, Guangsheng Zhai, Ning Zhao, Chuanbing Xu, Min Liu, Zhengsheng Pan, Kai Tang and Dongsheng Jia

    Citation: Cancer Cell International 2018 18:56

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  2. Content type: Primary Research

    Signal transducer and activator of transcription 3 (STAT3) is persistently activated in a wide variety of epithelial cancers. Aberrant activity of STAT3 correlates with tumor growth, invasion and metastasis, w...

    Authors: Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng and Ping Jiao

    Citation: Cancer Cell International 2018 18:53

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  3. Content type: Primary research

    Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand ...

    Authors: Chang Liu, Chang Su, Yanchun Chen and Guang Li

    Citation: Cancer Cell International 2018 18:54

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  4. Content type: Primary Research

    Gastric cancer presents a major health burden worldwide. Therefore, many molecular targeting agents have been evaluated for treatment of gastric cancer. Gefitinib has shown anticancer activity against gastric ...

    Authors: Jia Huafeng, Zhang Deqing, Ding Yong, Zhang Yulian and Hu Ailing

    Citation: Cancer Cell International 2018 18:50

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  5. Content type: Primary research

    Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of ...

    Authors: Riliang Cao, Jianli Shao, Yabin Hu, Liang Wang, Zhizhong Li, Guodong Sun and Xiaoliang Gao

    Citation: Cancer Cell International 2018 18:49

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  6. Content type: Primary Research

    Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumori...

    Authors: JinHui Liu, ChunYu Li, Yi Jiang, YiCong Wan, ShuLin Zhou and WenJun Cheng

    Citation: Cancer Cell International 2018 18:51

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  7. Content type: Primary Research

    Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates the Wnt signal transduction pathway. Recent studies have showed down-regulation of SFRP1 expression in colorectal canc...

    Authors: Zhongchuan Wang, Rujia Li, Yongshan He and Shiyong Huang

    Citation: Cancer Cell International 2018 18:48

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  8. Content type: Primary Research

    Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients wit...

    Authors: Denghui Liao, Gang Lv, Ting Wang, Jie Min, Yadong Wang and Shengchun Liu

    Citation: Cancer Cell International 2018 18:47

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  9. Content type: Primary Research

    Abnormal expression of long non-coding RNA (lncRNAs) often facilitates unrestricted growth of cancer cells. Long intergenic non-protein coding RNA 1510, an enhancer lncRNA (LINC01510), a lncRNA enhancer is upr...

    Authors: Chaoqun Cen, Jian Li, Jingjing Liu, Mingshi Yang, Tianyi Zhang, Yu Zuo, Changwei Lin and Xiaorong Li

    Citation: Cancer Cell International 2018 18:45

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  10. Content type: Primary Research

    Abnormally high expression of the mammalian de novo lipogenesis (DNL) pathway in various cancer cells promotes cell over-proliferation and resistance to apoptosis. Inhibition of key enzymes in the DNL pathway,...

    Authors: Phuriwat Khiewkamrop, Pattamaphron Phunsomboon, Lysiane Richert, Dumrongsak Pekthong and Piyarat Srisawang

    Citation: Cancer Cell International 2018 18:46

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  11. Content type: Primary Research

    The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of blad...

    Authors: Ran Xu, Xuan Zhu, Fangzhi Chen, Changkun Huang, Kai Ai, Hongtao Wu, Lei Zhang and Xiaokun Zhao

    Citation: Cancer Cell International 2018 18:41

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  12. Content type: Primary Research

    Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheri...

    Authors: Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2018 18:42

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  13. Content type: Primary Research

    Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL).

    Authors: Fei-Fei Liu, Kai-Ling Wang, Li-Ping Deng, Xiao Liu, Min-yuan Wu, Tian-You Wang, Lei Cui and Zhi-Gang Li

    Citation: Cancer Cell International 2018 18:40

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  14. Content type: Primary Research

    MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ...

    Authors: Fang Li, Jia-Hua Lv, Long Liang, Jun-chao Wang, Chu-Rong Li, Lei Sun and Tao Li

    Citation: Cancer Cell International 2018 18:39

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  15. Content type: Primary Research

    Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in China. Considering the poor prognosis of ESCC, the aim of this study is to dissect the effects of l...

    Authors: Bin Liu, Chun-Feng Pan, Guo-Liang Yao, Ke Wei, Yang Xia and Yi-Jiang Chen

    Citation: Cancer Cell International 2018 18:38

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  16. Content type: Primary Research

    MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. Here, we show that miRNAs play an important function in the down-regulation of FAS expressio...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura

    Citation: Cancer Cell International 2018 18:37

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  17. Content type: Primary Research

    Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with MYO5B and plays an important role in regulating plasma membrane recycling. However, little is known about the clinical significance of DUSP2 in...

    Authors: Wenjie Dong and Xinai Wu

    Citation: Cancer Cell International 2018 18:35

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  18. Content type: Review

    The aberrant expression of long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been demonstrated to be involved in the tumourigenesis and the development of various cancers. Therefore, we ...

    Authors: Huihui Mao, Kai Wang, Yuehua Feng, Jun Zhang, Lili Pan, Yuxia Zhan, Haijun Sheng and Guanghua Luo

    Citation: Cancer Cell International 2018 18:34

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  19. Content type: Primary Research

    Apoptosis plays an important role in the development and homeostasis of multicellular organisms and its deregulation may result in many serious diseases, including cancer. Now it is clear that some oncogenic m...

    Authors: Andrea Vazanova, Jana Jurecekova, Tomas Balharek, Juraj Marcinek, Jan Stasko, Anton Dzian, Lukas Plank, Pavol Zubor, Peter Racay and Jozef Hatok

    Citation: Cancer Cell International 2018 18:33

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  20. Content type: Review

    Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and is frequently accompanied by the genetic features of von Hippel–Lindau (VHL) loss. VHL loss increases the e...

    Authors: Yongchang Lai, Zhijian Zhao, Tao Zeng, Xiongfa Liang, Dong Chen, Xiaolu Duan, Guohua Zeng and Wenqi Wu

    Citation: Cancer Cell International 2018 18:31

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  21. Content type: Primary research

    Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patient...

    Authors: Kyung Sook Hong, Eun-Young Jeon, Soon Sup Chung, Kwang Ho Kim and Ryung-Ah Lee

    Citation: Cancer Cell International 2018 18:32

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  22. Content type: Primary Research

    Store-operated Ca2+ entry (SOCE) has been implicated in the migration of some cancer cell lines. The canonical SOCE is defined as the Ca2+ entry that occurs in response to near-maximal depletion of Ca2+ within th...

    Authors: Priyodarshan Goswamee, Tamar Pounardjian and David R. Giovannucci

    Citation: Cancer Cell International 2018 18:30

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  23. Content type: Primary Research

    New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in...

    Authors: Elaine Silveira, Isadora Pontes Cavalcante, Jean Lucas Kremer, Pedro Omori Ribeiro de Mendonça and Claudimara Ferini Pacicco Lotfi

    Citation: Cancer Cell International 2018 18:29

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  24. Content type: Primary Research

    CD44 encoded by a single gene is a cell surface transmembrane glycoprotein. Exon 2 is one of the important exons to bind CD44 protein to hyaluronan. Experimental evidences show that hyaluronan–CD44 interaction...

    Authors: Rezvan Esmaeili, Nasrin Abdoli, Fatemeh Yadegari, Mohamadreza Neishaboury, Leila Farahmand, Ahmad Kaviani and Keivan Majidzadeh-A

    Citation: Cancer Cell International 2018 18:28

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  25. Content type: Primary Research

    Lung cancer is a malignant tumor with the highest incidence and mortality around the world. Recent advances in RNA sequencing technology have enabled insights into long non-coding RNAs (lncRNAs), a previously ...

    Authors: Xuehai Wang, Gang Li, Qingsong Luo, Jiayong Xie and Chongzhi Gan

    Citation: Cancer Cell International 2018 18:27

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  26. Content type: Primary Research

    Cholangiocarcinoma (CCA) is one of the worst prognosis cancer. The survival time of CCA patients is related to serum estrogen levels and estrogen has been found to enhance the proliferation and invasiveness of...

    Authors: Ekapot Singsuksawat, Chanitra Thuwajit, Komgrid Charngkaew and Peti Thuwajit

    Citation: Cancer Cell International 2018 18:25

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  27. Content type: Primary Research

    Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell de...

    Authors: Mukesh Kumar, Karuna Irungbam and Meena Kataria

    Citation: Cancer Cell International 2018 18:23

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  28. Content type: Primary Research

    Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC)...

    Authors: Jiajie Xu, Xin Zhu, Qingling Li, Chao Chen, Zhenying Guo, Zhuo Tan, Chuanming Zheng and Minghua Ge

    Citation: Cancer Cell International 2018 18:22

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  29. Content type: Primary Research

    Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the BCRABL1 fusion oncogene. Tyrosine kinase inhibitors ...

    Authors: Doralina do Amaral Rabello, Vivian D’Afonseca da Silva Ferreira, Maria Gabriela Berzoti-Coelho, Sandra Mara Burin, Cíntia Leticia Magro, Maira da Costa Cacemiro, Belinda Pinto Simões, Felipe Saldanha-Araujo, Fabíola Attié de Castro and Fabio Pittella-Silva

    Citation: Cancer Cell International 2018 18:26

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  30. Content type: Primary Research

    Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying r...

    Authors: Christophe Glorieux and Pedro Buc Calderon

    Citation: Cancer Cell International 2018 18:24

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  31. Content type: Primary Research

    We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.

    Authors: Chao Duan, Han Wang, Ying Chen, Ping Chu, Tianyu Xing, Chao Gao, Zhixia Yue, Jie Zheng, Mei Jin, Weiyue Gu and Xiaoli Ma

    Citation: Cancer Cell International 2018 18:21

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  32. Content type: Primary Research

    Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Desp...

    Authors: Feng Chen, Yaqiong Jin, Lin Feng, Jie Zhang, Jun Tai, Jin Shi, Yongbo Yu, Jie Lu, Shengcai Wang, Xin Li, Ping Chu, Shujing Han, Shujun Cheng, Yongli Guo and Xin Ni

    Citation: Cancer Cell International 2018 18:20

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  33. Content type: Primary Research

    Visfatin has been reported to be associated with breast cancer progression, but the interaction between the visfatin and clinicopathologic factors in breast cancer progression status requires further investiga...

    Authors: Sin-Hua Moi, Yi-Chen Lee, Li-Yeh Chuang, Shyng-Shiou F. Yuan, Fu Ou-Yang, Ming-Feng Hou, Cheng-Hong Yang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2018 18:19

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  34. Content type: Primary Research

    The ability to metastasize is one of the most important characteristics of neoplastic cells. An imbalance between the action of some matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs drives the in...

    Authors: Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Iran A. Silva, Katia R. Leite, José Pontes-Junior, Gustavo Inoue, William C. Nahas, Miguel Srougi and Sabrina T. Reis

    Citation: Cancer Cell International 2018 18:18

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  35. Content type: Correction

    After publication of the original article [1] it was noted that the names of two authors, Han-Juan Xiao and Jun-Ming Hu were incorrectly published as Hai-Juan Xiao and Jun-Ming Hou. These errors were introduce...

    Authors: Jin Li, Yuan Wang, Cheng-Gong Zhang, Han-Juan Xiao, Jun-Ming Hu and Jing-Dong He

    Citation: Cancer Cell International 2018 18:17

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    The original article was published in Cancer Cell International 2018 18:4

  36. Content type: Primary Research

    Recent studies have shown that laminin subunit alpha 4 (LAMA4) plays an important role in carcinogenesis. However, its molecular biological function in triple-negative breast cancer (TNBC) has not been entirel...

    Authors: Zhi-Xue Yang, Bo Zhang, Jinrong Wei, Guo-Qin Jiang, Yan-Lin Wu, Bing-Jing Leng and Chun-Gen Xing

    Citation: Cancer Cell International 2018 18:16

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  37. Content type: Primary Research

    p53 is a tumor suppressor and key regulator of glycolysis in cancer cells, however highly mutated in tumors. In ovarian cancer, studies concerning p53 mutations focus on the DNA binding domain since the majori...

    Authors: Stephanie Antoun, David Atallah, Roula Tahtouh, Nada Alaaeddine, Malak Moubarak, Abir Khaddage, Eliane Nasr Ayoub, George Chahine and George Hilal

    Citation: Cancer Cell International 2018 18:14

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  38. Content type: Primary Research

    The antitumoral effects of different Toll-like receptor (TLRs) agonists is mediated by activating immune responses to suppress tumors growth, although TLR ligands may also have a direct effect on tumoral cells...

    Authors: Eva Villamón, Javier González-Fernández, Esperanza Such, José Vicente Cervera, Daniel Gozalbo and M. Luisa Gil

    Citation: Cancer Cell International 2018 18:15

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  39. Content type: Primary Research

    G protein-coupled receptors (GPR) are involved in a wide range of physiological processes, some of which, however, can be hijacked by tumor cells. Over-expression of G protein-coupled receptors 137 (GPR137) ar...

    Authors: Li-Jie Men, Ji-Zhu Liu, Hai-Ying Chen, Li Zhang, Shuang-Feng Chen, Tai-Wu Xiao, Jing-Xia Wang, Guang-Yao Li and Ya-Ping Wu

    Citation: Cancer Cell International 2018 18:13

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  40. Content type: Primary Research

    Triple-negative breast cancer is a biological subtype of breast cancer, which is unresponsive to conventional chemotherapies and has a poor prognosis. C-Phycocyanin (C-PC), a marine natural purified from Spirulin...

    Authors: Liangqian Jiang, Yujuan Wang, Guoxiang Liu, Huihui Liu, Feng Zhu, Huanhuan Ji and Bing Li

    Citation: Cancer Cell International 2018 18:12

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  41. Content type: Primary Research

    Exosomes mediated transfer of lncRNA 91H may play a critical role in the development of CRC. However, few studies have proved the mechanism. So we performed this study to deeply explore the biological function...

    Authors: Tianyi Gao, Xiangxiang Liu, Bangshun He, Zhenlin Nie, Chengbin Zhu, Pei Zhang and Shukui Wang

    Citation: Cancer Cell International 2018 18:11

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  42. Content type: Primary Research

    Our previous work showed that miR-10b was overexpressed in hepatocellular carcinoma (HCC) and promoted HCC cell migration and invasion. Epithelial–mesenchymal transition (EMT) is involved in HCC metastasis. So...

    Authors: Gulibaha Hujie, Sheng-hua Zhou, Hua Zhang, Jie Qu, Xiao-wei Xiong, Outikuer Hujie, Cheng-gong Liao and Shun-e Yang

    Citation: Cancer Cell International 2018 18:10

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  43. Content type: Hypothesis

    Conventional cancer treatments such as surgery, radiotherapy, chemotherapy and targeted therapy, not only destruct tumors, but also injure the normal tissues, resulting in limited efficacy. Recent advances in ...

    Authors: Chi-Ping Huang, Chi-Cheng Chen and Chih-Rong Shyr

    Citation: Cancer Cell International 2018 18:9

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  44. Content type: Primary Research

    Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particula...

    Authors: Alessio Metere, Francesca Frezzotti, Claire Elizabeth Graves, Massimo Vergine, Alessandro De Luca, Donatella Pietraforte and Laura Giacomelli

    Citation: Cancer Cell International 2018 18:7

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  45. Content type: Primary Research

    Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malig...

    Authors: Yang Zheng, Zhao Wang, Xu Ding, Wei Zhang, Gang Li, Laikui Liu, Heming Wu, Wenyi Gu, Yunong Wu and Xiaomeng Song

    Citation: Cancer Cell International 2018 18:6

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