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  1. Most of the biological functions of circular RNAs (circRNAs) and the potential underlying mechanisms in hepatocellular carcinoma (HCC) have not yet been discovered.

    Authors: Ying Xie, Xiaofeng Hang, Wensheng Xu, Jing Gu, Yuanjing Zhang, Jianrong Wang, Xiucui Zhang, Xinghao Cao, Junjie Zhan, Junxue Wang and Jianhe Gan

    Citation: Cancer Cell International 2021 21:410

    Content type: Primary research

    Published on:

  2. Cumulating evidence reveals the key role of aberrant lipogenesis and immunogenomic features in hepatocellular carcinoma (HCC). However, there are still obstacles in our understanding of the complicated interac...

    Authors: Yunfeng Xu, Ze Zhang, Da Xu, Xin Yang, Lina Zhou and Ying Zhu

    Citation: Cancer Cell International 2021 21:409

    Content type: Primary research

    Published on:

  3. Epigenetic modulation by noncoding RNAs substantially contributes to human cancer development, but noncoding RNAs involvement in bladder cancer remains poorly understood. This study investigated the role of lo...

    Authors: Ranran Dai, Qingping Jiang, You Zhou, Ruifeng Lin, Hai Lin, Yumin Zhang, Jinhu Zhang and Xingcheng Gao

    Citation: Cancer Cell International 2021 21:408

    Content type: Primary research

    Published on:

  4. Gastrointestinal stromal tumor (GIST) is a common tumor that originates from the alimentary system mesenchyme. Compared to typical gastrointestinal carcinomas, GISTs exhibit unique malignant behaviors. Bioinfo...

    Authors: Xiaobin Cheng, Jinhai Wang, Sen Lu, Weina Fan and Weilin Wang

    Citation: Cancer Cell International 2021 21:407

    Content type: Primary research

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  5. Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells...

    Authors: Gang Cheng, Hui Dong, Chen Yang, Yang Liu, Yi Wu, Lifen Zhu, Xiangmin Tong and Shibing Wang

    Citation: Cancer Cell International 2021 21:406

    Content type: Review

    Published on:

  6. WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies h...

    Authors: Yanqiong Liu, Weijuan Qin, Fuyong Zhang, Jian Wang, Xi Li, Shan Li, Xue Qin and Yuefeng Lu

    Citation: Cancer Cell International 2021 21:405

    Content type: Primary research

    Published on:

  7. Authors: Hua‑fu Zhao, Chang‑peng Wu, Xiu‑ming Zhou, Peng‑yu Diao, Yan‑wen Xu, Jing Liu, Jing Wang, Xian‑jian Huang, Wen‑lan Liu, Zhong‑ping Chen, Guo‑dong Huang and Wei‑ping Li

    Citation: Cancer Cell International 2021 21:403

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:24

  8. The Chromobox (CBX) domain protein family, a core component of polycomb repressive complexes 1, is involved in transcriptional repression, cell differentiation, and program development by binding to methylated...

    Authors: He Zhou, Yongfu Xiong, Zuoliang Liu, Songlin Hou and Tong Zhou

    Citation: Cancer Cell International 2021 21:402

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:449

  9. As previously reported, midazolam anesthesia exerts tumor-suppressing effects in non-small cell lung cancer (NSCLC), but the regulating effects of this drug on cisplatin-resistance in NSCLC have not been studi...

    Authors: Tingting Sun, Jing Chen, Xuechao Sun and Guonian Wang

    Citation: Cancer Cell International 2021 21:401

    Content type: Primary research

    Published on:

  10. Cervical cancer (CC) is one of the most common gynaecological malignancies all around the world. The mechanisms of cervical carcinoma formation remain under close scrutiny. The long non-coding RNAs (lncRNA) an...

    Authors: Yu Zhou, Yuqing Wang, Mingying Lin, Daiqian Wu and Min Zhao

    Citation: Cancer Cell International 2021 21:400

    Content type: Primary research

    Published on:

  11. The tumor microenvironment (TME) has received an increasing amount of attention. CXC chemokines can regulate immune cell transport and tumor cell activity to exert anti-tumor immunity. However, studies on the ...

    Authors: Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo and Xiumin Ma

    Citation: Cancer Cell International 2021 21:399

    Content type: Primary research

    Published on:

  12. Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, ...

    Authors: Jia Yao, Man Yang, Lawrence Atteh, Pinyan Liu, Yongcui Mao, Wenbo Meng and Xun Li

    Citation: Cancer Cell International 2021 21:398

    Content type: Review

    Published on:

  13. Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin...

    Authors: Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang and Lifeng Xie

    Citation: Cancer Cell International 2021 21:397

    Content type: Primary research

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  14. Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of t...

    Authors: Chunhui Nie, Bei Wang, Baoquan Wang, Ning Lv, Rui Yu and Enfan Zhang

    Citation: Cancer Cell International 2021 21:396

    Content type: Primary research

    Published on:

  15. Bladder cancer is one of the most commonly diagnosed urological malignant tumor. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis. YAP is one of m...

    Authors: Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu and Tao Liu

    Citation: Cancer Cell International 2021 21:395

    Content type: Primary research

    Published on:

  16. Histological transformation (HT) of follicular lymphoma to a more aggressive lymphoma is a serious event affecting patients’ outcomes. To date, no strong clinical HT predictors present at diagnosis have yet be...

    Authors: Mixue Xie, Lulu Wang, Qi Jiang, Xuxia Luo, Xin Zhao, Xueying Li, Jie Jin, Xiujin Ye and Kui Zhao

    Citation: Cancer Cell International 2021 21:394

    Content type: Primary research

    Published on:

  17. The homeobox gene Homeobox B7 (HOXB7) is overexpressed across a range of cancers and promotes tumorigenesis through varying effects on proliferation, survival, migration and invasion. However, its expression p...

    Authors: Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang and Zhongwu Li

    Citation: Cancer Cell International 2021 21:393

    Content type: Primary research

    Published on:

  18. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in various cancers. However, the functional roles of most lncRNA in papillary thyroid cancer (PTC) are not detailly understood. This study aims ...

    Authors: Luyao Wu, Yu Ding, Houchao Tong, Xi Zhuang, Jingsheng Cai, Yan Si, Hao Zhang, Xiaoting Wang and Meiping Shen

    Citation: Cancer Cell International 2021 21:392

    Content type: Primary research

    Published on:

  19. Glioblastoma, WHO grade IV astrocytoma, is the most aggressive type of brain tumors. These cancerous cells have a rapid growth rate, tendency to penetrate vital brain structures, molecular heterogeneity, etc. ...

    Authors: AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen and Bagher Farhood

    Citation: Cancer Cell International 2021 21:391

    Content type: Review

    Published on:

  20. miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RC...

    Authors: Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si…

    Citation: Cancer Cell International 2021 21:390

    Content type: Primary research

    Published on:

  21. Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsibl...

    Authors: Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Asma Irshad, Ali Akbar, Željko Reiner, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Dinara Satmbekova, Monica Butnariu, Iulia Cristina Bagiu…

    Citation: Cancer Cell International 2021 21:388

    Content type: Review

    Published on:

  22. We have read with great interest the article entitled “Identification of an immune-related signature indicating the dedifferentiation of thyroid cells” by Wang et al. Their data reinforce our own previous resu...

    Authors: Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, José Vassallo and Laura Sterian Ward

    Citation: Cancer Cell International 2021 21:387

    Content type: Commentary

    Published on:

  23. Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tu...

    Authors: Yanming Luo, Shuangshuang Yin, Jia Lu, Shiyue Zhou, Yingying Shao, Xiaomei Bao, Tao Wang, Yuling Qiu and Haiyang Yu

    Citation: Cancer Cell International 2021 21:386

    Content type: Review

    Published on:

  24. N6-Methyladenosine (m6A) is the most common RNA modification and regulates RNA splicing, translation, translocation, and stability. Aberrant expression of m6A has been reported in various types of human cancers.....

    Authors: Zhi-Hao Yu, Shao-Ting Feng, Di Zhang, Xu-Chen Cao, Yue Yu and Xin Wang

    Citation: Cancer Cell International 2021 21:385

    Content type: Primary research

    Published on:

  25. Circular RNAs (circRNAs) have been confirmed to be relevant to the 5-fluorouracil (5-FU) resistance of breast cancer. Nevertheless, how and whether circRNA F-box and leucine-rich repeat protein 5 (circFBXL5) r...

    Authors: Mingzhi Zhu, Yanyan Wang, Fang Wang, Lin Li and Xinguang Qiu

    Citation: Cancer Cell International 2021 21:384

    Content type: Primary research

    Published on:

  26. Methyltransferase-like 7B (METTL7B) is a member of the methyltransferase-like protein family that plays an important role in the development and progression of tumors. However, its prognostic value and the cor...

    Authors: Zhipeng Jiang, Wen Yin, Hecheng Zhu, Jun Tan, Youwei Guo, Zhaoqi Xin, Quanwei Zhou, Yudong Cao, Zhaoping Wu, Yirui Kuang, Can Li, Dongcheng Xie, Hailong Huang, Ming Zhao, Xingjun Jiang, Lei Wang…

    Citation: Cancer Cell International 2021 21:383

    Content type: Primary research

    Published on:

  27. Ginsenosides have been reported to possess a variety of biological activities. Synthesized from the ginsenoside protopanaxadiol (PPD), the octanone pseudoginsengenin DQ (PDQ) may have robust pharmacological ef...

    Authors: Sanchun Wang, Yu Cai, Qingjie Feng, Jing Gao and Bo Teng

    Citation: Cancer Cell International 2021 21:382

    Content type: Primary research

    Published on:

  28. Osteosarcoma was the most common primary bone malignancy in children and adolescents. It was imperative to identify effective prognostic biomarkers for this cancer. This study was aimed to identify potential ...

    Authors: Feng Yao, Zhao Feng Zhu, Jun Wen, Fu Yong Zhang, Zheng Zhang, Lun Qing Zhu, Guang Hao Su, Quan Wen Yuan, Yun Fang Zhen and Xiao Dong Wang

    Citation: Cancer Cell International 2021 21:381

    Content type: Review

    Published on:

  29. Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. However, the regulation mechanism o...

    Authors: Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li and Xinzhi Peng

    Citation: Cancer Cell International 2021 21:380

    Content type: Primary research

    Published on:

  30. Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa)...

    Authors: Deping Yang, Bo Yang, Yanjun Zhu, Qianlin Xia, Yan Zhang, Xin Zhu, Jianming Guo, Tao Ding and Jianghua Zheng

    Citation: Cancer Cell International 2021 21:379

    Content type: Primary research

    Published on:

  31. Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer. The effect of traditional anti-tumor therapy is not ideal for the patients with recurrence, metastasis and radioiodine ...

    Authors: Rujia Qin, Chunyan Li, Xuemin Wang, Zhaoming Zhong and Chuanzheng Sun

    Citation: Cancer Cell International 2021 21:378

    Content type: Primary research

    Published on:

  32. This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.

    Authors: Weihang Li, Ziyi Ding, Dong Wang, Chengfei Li, Yikai Pan, Yingjing Zhao, Hongzhe Zhao, Tianxing Lu, Rui Xu, Shilei Zhang, Bin Yuan, Yunlong Zhao, Yanjiang Yin, Yuan Gao, Jing Li and Ming Yan

    Citation: Cancer Cell International 2021 21:377

    Content type: Primary research

    Published on:

  33. Gastric cancer (GC) remains an important cancer worldwide. Further understanding of the molecular mechanisms of gastric carcinogenesis will enhance the diagnosis and treatment of GC.

    Authors: Shuyi Han, Yan Qi, Yihui Xu, Min Wang, Jun Wang, Jing Wang, Mingjie Yuan, Yanfei Jia, Xiaoli Ma, Yunshan Wang and Xiangdong Liu

    Citation: Cancer Cell International 2021 21:376

    Content type: Primary research

    Published on:

  34. Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) i...

    Authors: Chao Jing, Dandan Liu, Qingchuan Lai, Linqi Li, Mengqian Zhou, Beibei Ye, Yue Wu, Hong Li, Kai Yue, Yansheng Wu, Yuansheng Duan and Xudong Wang

    Citation: Cancer Cell International 2021 21:375

    Content type: Primary research

    Published on:

  35. Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Gi...

    Authors: Zhibo Shen, Wenhua Xue, Yuanyuan Zheng, Qishun Geng, Le Wang, Zhirui Fan, Wenbin Wang, Ying Yue, Yunkai Zhai, Lifeng Li and Jie Zhao

    Citation: Cancer Cell International 2021 21:374

    Content type: Primary research

    Published on:

  36. Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast ...

    Authors: Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang and Jiaxin Li

    Citation: Cancer Cell International 2021 21:372

    Content type: Primary research

    Published on:

  37. Programmed death- ligand 1 (PD-L1) seems to be associated with the immune escape of tumors, and immunotherapy may be a favorable treatment for PD-L1-positive patients. We evaluated intrahepatic cholangiocarcin...

    Authors: Min Deng, Shao-Hua Li, Xu Fu, Xiao-Peng Yan, Jun Chen, Yu-Dong Qiu and Rong-Ping Guo

    Citation: Cancer Cell International 2021 21:371

    Content type: Primary research

    Published on:

  38. LncRNA prostate cancer-associated transcript 6 (PCAT6) has been reported to be dysregulated in several cancers and is associated with tumor progression. Here, we have performed a meta-analysis to assess the ge...

    Authors: Song-bo Shi, Qing-hao Cheng, Shi-yi Gong, Ting-ting Lu, Shi-fang Guo, Shao-ming Song, Yu-ping Yang, Qi Cui, Ke-hu Yang and Yao-wen Qian

    Citation: Cancer Cell International 2021 21:370

    Content type: Review

    Published on:

  39. Epstein-Barr virus-associated gastric cancer (EBVaGC) is the most common EBV-related malignancy. A comprehensive research for the protein expression patterns in EBVaGC established by high-throughput assay rema...

    Authors: Zeyang Wang, Zhi Lv, Qian Xu, Liping Sun and Yuan Yuan

    Citation: Cancer Cell International 2021 21:368

    Content type: Primary research

    Published on:

  40. Long non-coding RNAs (lncRNAs) are vital regulators of gene expression and cellular processes in multiple cancers, including melanoma. Nevertheless, the function of lncRNA NCK1-antisense 1 (NCK1-AS1) in melano...

    Authors: Quan Lin, Yan Jia, Duo Zhang and Hongjuan Jin

    Citation: Cancer Cell International 2021 21:367

    Content type: Primary research

    Published on:

  41. Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol...

    Authors: Lei Gao, Jialin Meng, Chuang Yue, Xingyu Wu, Quanxin Su, Hao Wu, Ze Zhang, Qinzhou Yu, Shenglin Gao, Song Fan and Li Zuo

    Citation: Cancer Cell International 2021 21:366

    Content type: Primary research

    Published on:

  42. Uterus corpus endometrial cancer (UCEC) is the main malignant tumor in gynecology, with a high degree of heterogeneity, especially in terms of prognosis and immunotherapy efficacy. DNA methylation is one of th...

    Authors: JinHui Liu, ChengJian Ji, Yichun Wang, Cheng Zhang and HongJun Zhu

    Citation: Cancer Cell International 2021 21:365

    Content type: Primary research

    Published on:

  43. Exosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Ex...

    Authors: Zheng Zhao, Guiping Zhao, Shuyue Yang, Shengtao Zhu, Shutian Zhang and Peng Li

    Citation: Cancer Cell International 2021 21:364

    Content type: Review

    Published on:

  44. Both N6-methyladenosine (m6A) modification and lncRNAs play an important role in the carcinogenesis and cancer inhibition of ovarian cancer (OC). However, lncRNAs involved in m6A regulation (LI-m6As) have neve...

    Authors: Jianfeng Zheng, Jialu Guo, Benben Cao, Ying Zhou and Jinyi Tong

    Citation: Cancer Cell International 2021 21:363

    Content type: Primary research

    Published on:

  45. Growing evidence has shown that long noncoding RNA: microRNA: mRNA is implicated in tumor initiation, development, and progression. Long noncoding RNA HAND2-AS1 exhibits anti-cancer effects in diverse cancers....

    Authors: Liping Shan, Wei Liu and Yunhong Zhan

    Citation: Cancer Cell International 2021 21:361

    Content type: Primary research

    Published on:

  46. Long non-coding RNAs (lncRNAs) and microRNAs (miRs) are differentially expressed in ovarian cancer (OC) cells and influence OC progression. This study intended to explore the underlying roles of LINC00115 and ...

    Authors: Rui Hou and Luo Jiang

    Citation: Cancer Cell International 2021 21:360

    Content type: Primary research

    Published on:

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