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  1. Chronic myeloid leukemia (CML) is a hematological tumor derived from hematopoietic stem cells. The aim of this study is to analyze the biological characteristics and identify the diagnostic markers of CML. We ...

    Authors: Fang-Min Zhong, Fang-Yi Yao, Yu-Lin Yang, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Nan Zhang, Yan-Mei Xu, Shu-Qi Li, Ying Cheng, Shuai Xu, Bo Huang and Xiao-Zhong Wang
    Citation: Cancer Cell International 2023 23:61
  2. The alpha-fetoprotein receptor (AFPR) is a novel target for cancer therapeutics. It is expressed on most cancers and myeloid derived suppressor cells (MDSCs) but generally absent on normal tissues. Studies wer...

    Authors: Patricia Griffin, Wendy A. Hill, Fabio Rossi, Rebecca Boohaker, Karr Stinson and Igor Sherman
    Citation: Cancer Cell International 2023 23:60
  3. Non-homologous DNA end joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in human. However, the relationship between NHEJ pathway and hepatocellular carcinoma (HCC) is unclear. We ...

    Authors: Zhu Lin, Zhenkun Huang, Yunxing Shi, Yichuan Yuan, Yi Niu, Binkui Li, Yunfei Yuan and Jiliang Qiu
    Citation: Cancer Cell International 2023 23:59
  4. The incidence of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients is dozens of times higher than that in patients without COPD. Elevated activity of nuclear factor-k-gene binding (NF-κ...

    Authors: Jingjing Lu, Yan Shi, Feng Zhang, Ying Zhang, Xiangwang Zhao, Haiyan Zheng, Lingyu Li, Shiqiao Zhao and Liming Zhao
    Citation: Cancer Cell International 2023 23:58
  5. In vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs. Among these in vivo experimental models, the establishment of highly mali...

    Authors: Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto and Kentaro Semba
    Citation: Cancer Cell International 2023 23:57
  6. Authors: Nouf S. Al‑Numair, Abdulrahman Theyab, Faisal Alzahrani, Anwar M. Shams, Ibrahim O. Al‑Anazi, Atif Abdulwahab A. Oyouni, Osama M. Al‑Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali and Yousef M. Hawsawi
    Citation: Cancer Cell International 2023 23:56

    The original article was published in Cancer Cell International 2022 22:279

  7. Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largel...

    Authors: Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang, Bangchao Li, Jie Hu and Yixin Qi
    Citation: Cancer Cell International 2023 23:54
  8. Abnormal miRNA and mRNA expression and dysregulated immune microenvironment have been found to frequently induce the progression of hepatocellular carcinoma (HCC) in recent reports. In particular, the immune-r...

    Authors: Xia-Hui Lin, Dong-ping Li, Zhi-Yong Liu, Si Zhang, Wen-qing Tang, Rong-xin Chen, Shu-qiang Weng, Yu-jen Tseng, Ru-yi Xue and Ling Dong
    Citation: Cancer Cell International 2023 23:52
  9. Non-small cell lung cancer is a heterogeneous disease driven by extensive molecular alterations. Exosomes are small vesicles with diameters ranging from 30 to 150 nm released by various cell types and are impo...

    Authors: Jingwei Xu, Hui Wang, Baoyu Shi, Ning Li, Guopeng Xu, Xiaopei Yan and Li Xu
    Citation: Cancer Cell International 2023 23:51
  10. As an oncogene, SETD8 can promote tumour growth and tumour cell proliferation. This study aims to reveal the relationship between SETD8 and ferroptosis in pancreatic cancer and its role in pancreatic cancer to pr...

    Authors: Zekun Lu, Qiangsheng Hu, Yi Qin, Hao Yang, Bingkai Xiao, Weibo Chen, Shunrong Ji, Guangchen Zu, Zhiliang Wang, Guixiong Fan, Xiaowu Xu and Xuemin Chen
    Citation: Cancer Cell International 2023 23:50
  11. Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care chemotherapy using temozolomide (TMZ), tumors acquire resistance thereby causing tumor ...

    Authors: Maren Nicole Stillger, Chia-Yi Chen, Zon Weng Lai, Mujia Li, Agnes Schäfer, Axel Pagenstecher, Christopher Nimsky, Jörg Walter Bartsch and Oliver Schilling
    Citation: Cancer Cell International 2023 23:49
  12. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in various cancers including bladder cancer (BC). The precise expression pattern of lncRNA small nucleolar RNA host gene 18 (SNHG18) i...

    Authors: Meixia Ke, Ning Sun, Zhenni Lin, Peipei Zhang, Yan Hu, Shuilian Wu, Zhijian Zheng, Yongyong Lu and Honglei Jin
    Citation: Cancer Cell International 2023 23:48
  13. The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregulation of desmosomal proteins has been associated with malignant progression and metast...

    Authors: Francesca Reimer, Sarah Bryan, Karen Legler, Thomas Karn, Serenella Eppenberger-Castori, Jakob Matschke, Thais Pereira-Veiga, Harriet Wikman, Isabell Witzel, Volkmar Müller, Barbara Schmalfeldt, Karin Milde-Langosch, Udo Schumacher, Christine Stürken and Leticia Oliveira-Ferrer
    Citation: Cancer Cell International 2023 23:47
  14. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize contributes to an extremely high patient mortality. However, the molecular mechanisms tha...

    Authors: Jian-Hua Chang, Bo-Wen Xu, Di Shen, Wei Zhao, Yue Wang, Jia-liang Liu, Guang-Xiao Meng, Guang-Zhen Li and Zong-Li Zhang
    Citation: Cancer Cell International 2023 23:46
  15. Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and tr...

    Authors: Kuan-Yi Lee, Chia-Ming Liu, Li-Han Chen, Chien-Yueh Lee, Tzu-Pin Lu, Li-Ling Chuang and Liang-Chuan Lai
    Citation: Cancer Cell International 2023 23:45
  16. STIL centriolar assembly protein (STIL) is a cytoplasmic protein implicated in cellular growth and proliferation as well as chromosomal stability, which abnormal condition affected tumor immunity and tumor pro...

    Authors: Longwen Xu, Shirong Zhang, Jinteng Feng, Deli Tan, Hong Sun and Hui Guo
    Citation: Cancer Cell International 2023 23:44
  17. In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported...

    Authors: Yasin Ahmadi, Javad Khalili Fard, Dlzar Ghafoor, Ali H. Eid and Amirhossein Sahebkar
    Citation: Cancer Cell International 2023 23:43
  18. Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and the second most common cause of cancer-related death worldwide. The survival rate of sor...

    Authors: Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Ching‑Chuan Hsieh, Yang-Hsiang Lin, Pei-Ming Chu, Yuh-Harn Wu, Yi-Ching Huang and Cheng-Yi Chen
    Citation: Cancer Cell International 2023 23:42
  19. Radiotherapy is the first-line regimen for treating oral squamous cell carcinoma (OSCC) in current clinics. However, the development of therapeutic resistance impacts the anticancer efficacy of irradiation in ...

    Authors: Tsu-Zong Yuan, Hui-Yu Lin, Chia-Hao Kuei, Che-Hsuan Lin, Hsun-Hua Lee, Hsin-Lun Lee, Hsiao-Wei Lu, Chia-Yi Su, Hui-Wen Chiu and Yuan-Feng Lin
    Citation: Cancer Cell International 2023 23:41
  20. The aim of this study was to establish a nomogram graph model to accurately predict the venous thromboembolism (VTE) risk probability in the general population with lung cancer.

    Authors: Haike Lei, Dan Tao, Ningning Zhang, Mao Sun, Lisi Sun, Dingyi Yang, Yong Jiang, Wei Zhou, Yue Xie and Ying Wang
    Citation: Cancer Cell International 2023 23:40
  21. The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM p...

    Authors: Yanqing Li, Tianxiang Xu, Xin Wang, Xiangdong Jia, Meng Ren and Xiaoxia Wang
    Citation: Cancer Cell International 2023 23:39
  22. Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity again...

    Authors: Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen and Claudia Maletzki
    Citation: Cancer Cell International 2023 23:38
  23. Head and neck squamous cell carcinoma (HNSCC) remains an unmet medical challenge. Metabolic reprogramming is a hallmark of diverse cancers, including HNSCC.

    Authors: Zekun Zhou, Jianfei Tang, Yixuan Lu, Jia Jia, Tiao Luo, Kaixin Su, Xiaohan Dai, Haixia Zhang and Ousheng Liu
    Citation: Cancer Cell International 2023 23:37
  24. Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 com...

    Authors: Masashi Numata, Noriyasu Haginoya, Machiko Shiroishi, Tsuyoshi Hirata, Aiko Sato-Otsubo, Kenji Yoshikawa, Yoshimi Takata, Reina Nagase, Yoshinori Kashimoto, Makoto Suzuki, Nina Schulte, Gernot Polier, Akiko Kurimoto, Yumiko Tomoe, Akiko Toyota, Tomoko Yoneyama…
    Citation: Cancer Cell International 2023 23:36
  25. Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and...

    Authors: Haoying Wang, Hao Yuan, Qinghong Guo, Xi Zeng, Mengxiao Liu, Rui Ji, Zhaofeng Chen, Quanlin Guan, Ya Zheng, Yuping Wang and Yongning Zhou
    Citation: Cancer Cell International 2023 23:35
  26. The chorioallantoic membrane (CAM) assay is a well-established technique to evaluate tumor invasion and angiogenesis and may overcome the shortcoming of the patient-derived xenograft (PDX) mouse model. Current...

    Authors: Kenji Miura, Michiyo Koyanagi-Aoi, Yoshimasa Maniwa and Takashi Aoi
    Citation: Cancer Cell International 2023 23:34
  27. Cancer immunotherapy is a major breakthrough in the history of tumor therapy in the last decade. Immune checkpoint inhibitors blocking CTLA-4/B7 or PD-1/PD-L1 pathways have greatly prolonged the survival of pa...

    Authors: Xuan Pan, Chenchen Li and Jifeng Feng
    Citation: Cancer Cell International 2023 23:30
  28. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological f...

    Authors: Mahboobeh Faramin Lashkarian, Nasrin Hashemipour, Negin Niaraki, Shahrad Soghala, Ali Moradi, Sareh Sarhangi, Mahsa Hatami, Fatemehsadat Aghaei-Zarch, Mina Khosravifar, Alireza Mohammadzadeh, Sajad Najafi, Jamal Majidpoor, Poopak Farnia and Seyed Mohsen Aghaei-Zarch
    Citation: Cancer Cell International 2023 23:29
  29. Long non-coding RNAs (lncRNAs) play important roles in the biology of colorectal cancer (CRC). There are several lncRNAs associated with invasion and metastasis have been characterized in CRC. However, studies...

    Authors: Mingzhou Li, Chengmei Huang, Yuanyuan Wu, Lina Zhu, Yaxin Zhang, Yi Zhou, Huali Li, Zhihao Liu, Xinyan Pan, Xin Wang, Junfeng Qiu, Fengtian Li and Wenting Liao
    Citation: Cancer Cell International 2023 23:27
  30. Mounting evidence supports that matrix metalloproteinase (MMPs) are highly associated with tumor progression and that targeting MMPs may overcome the barrier of immune suppression. Among these, whether MMP2 fu...

    Authors: Kunwei Peng, Yanyan Zhang, Deyi Liu and Jingqi Chen
    Citation: Cancer Cell International 2023 23:26
  31. Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect. Growth hormone overproducing GH-producing PitNETs cause acro...

    Authors: Rihards Saksis, Olesja Rogoza, Helvijs Niedra, Kaspars Megnis, Ilona Mandrika, Inga Balcere, Liva Steina, Janis Stukens, Austra Breiksa, Jurijs Nazarovs, Jelizaveta Sokolovska, Ilze Konrade, Raitis Peculis and Vita Rovite
    Citation: Cancer Cell International 2023 23:25
  32. After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast cancer (BCa) can happen in all kinds of people, but it's much more common in women. One ...

    Authors: Min Yang, Ying Zhang, Min Li, Xinglong Liu and Mohammad Darvishi
    Citation: Cancer Cell International 2023 23:24

    The Correction to this article has been published in Cancer Cell International 2023 23:55

  33. It is well-documented that the interplay between tumor-infiltrating lymphocytes (TILs) and tumor cells is a major determining factor in cancer progression. CD45RO seems to be a reliable indicator for predictin...

    Authors: Shirin Tavana, Zahra Mokhtari, Mohammad Hossein Sanei, Zahra Heidari, Amir-Reza Dehghanian, Zahra Faghih and Marzieh Rezaei
    Citation: Cancer Cell International 2023 23:23
  34. Relevant studies suggest that serum vitamin level is related to the risk of breast cancer, and dietary pattern and drug supplementation can significantly affect the level of vitamin in the body. Therefore, int...

    Authors: Siqi Xie, Mingjian Tan, Hongwan Li, Lv Li, Hengyu Zhang, Qing Wang, Sijia Li, Jiali Yang, Haoling Xie, Pengyan Chen, Dequan Liu, Rong Guo and Shicong Tang
    Citation: Cancer Cell International 2023 23:22
  35. Apatinib (YN968D1) is the first small-molecule-targeting drug with anti-tumor activity created in China for the treatment of advanced gastric cancer (GC) and hepatocellular carcinoma (HCC). It showed significa...

    Authors: Jiani Chen, Jingwen Zhai, Mingming Li, Shiyi Liu, Xiaobin Gong, Hongyu Yu, Hua Wei and Wansheng Chen
    Citation: Cancer Cell International 2023 23:21
  36. Despite the rapid development of therapeutic strategies in cancer treatment, metastasis remains the major cause of cancer-related death and scientific challenge. Epithelial-Mesenchymal Transition (EMT) plays a...

    Authors: Yanyang Cao, Eileen Chen, Xuan Wang, Jingwen Song, Haiyun Zhang and Xiaozhuo Chen
    Citation: Cancer Cell International 2023 23:20
  37. MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell prol...

    Authors: Amir Abbas Hamidi, Negin Taghehchian, Amir Sadra Zangouei, Iman Akhlaghipour, Amirhosein Maharati, Zahra Basirat and Meysam Moghbeli
    Citation: Cancer Cell International 2023 23:19
  38. Human epidermal growth factor receptor-3 (HER3) is a member of the epidermal growth factor receptor family of receptor tyrosine kinases, and its overexpression is associated with inferior prognosis in several ...

    Authors: Yuki Kojima, Kazuki Sudo, Hiroshi Yoshida, Shu Yazaki, Momoko Tokura, Chiharu Mizoguchi, Hitomi S. Okuma, Shosuke Kita, Kasumi Yamamoto, Tadaaki Nishikawa, Emi Noguchi, Tatsunori Shimoi, Yasuhito Tanase, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato…
    Citation: Cancer Cell International 2023 23:18
  39. Melanocytic neoplasms range from banal nevi to malignant melanomas. The genetic background has been extensively studied in the Caucasian population. BRAF mutations were reported among the early driver mutations i...

    Authors: Nada M. Yakout, Dina M. Abdallah, Doaa A. Abdelmonsif, Hassan Mahmoud Kholosy, Iman M. Talaat and Omayma Elsakka
    Citation: Cancer Cell International 2023 23:17
  40. Renal cell carcinoma (RCC) is the second lethal urogenital malignancy with the increasing incidence and mortality in the world. Clear cell renal cell carcinoma (ccRCC) is one major subtype of RCC, which accoun...

    Authors: Qi Zhang, Hao Ren, Luqi Ge, Wen Zhang, Feifeng Song and Ping Huang
    Citation: Cancer Cell International 2023 23:16
  41. While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an ...

    Authors: María Magdalena Canali, Mélanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnès Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel…
    Citation: Cancer Cell International 2023 23:15
  42. As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then releases 5-FU in the gut to exert the anti-tumor ac...

    Authors: Chun Ge, Xintong Huang, Sujie Zhang, Man Yuan, Zhaoyi Tan, Chen Xu, Qiong Jie, Jingjing Zhang, Jianjun Zou, Yubing Zhu, Dong Feng, Yue Zhang and Jiye Aa
    Citation: Cancer Cell International 2023 23:14
  43. Multiple perioperative inflammatory markers are considered important factors affecting the long-term survival of esophageal cancer (EC) patients. Hematological parameters, whether single or combined, have high...

    Authors: Hui-Ke Wang, Qian Wei, Ya-Lan Yang, Tai-Ying Lu, Yan Yan and Feng Wang
    Citation: Cancer Cell International 2023 23:13
  44. The NF-κB signaling pathway is overactivated in tumor cells, and the activation of the NF-κB signaling pathway releases a large number of inflammatory factors, which enhance tumor immunosuppression and promote...

    Authors: Anqi Zeng, Xinyue Yu, Bao Chen, Lu Hao, Ping Chen, Xue Chen, Yuan Tian, Jing Zeng, Hua Hua, Ying Dai and Junning Zhao
    Citation: Cancer Cell International 2023 23:12

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