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  1. Radiotherapy is a major treatment for esophageal squamous cell carcinoma (ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC. The function of SOCS6, which has been shown to be ...

    Authors: Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng and Xiaozhi Zhang

    Citation: Cancer Cell International 2021 21:165

    Content type: Primary research

    Published on:

  2. Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. Thi...

    Authors: Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu and Xiaowen Zhang

    Citation: Cancer Cell International 2021 21:164

    Content type: Review

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  3. Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells. In this study, the positive effe...

    Authors: Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng and Nan Cui

    Citation: Cancer Cell International 2021 21:163

    Content type: Primary research

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  4. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM p...

    Authors: Jiayue Yang, Cheng Yang, Hong Shen, Wenjun Wu, Zhen Tian, Qinghua Xu, Cuiping Cao, Shugao Ye, Le Ban, Xin Tong and Jie Mei

    Citation: Cancer Cell International 2021 21:162

    Content type: Primary research

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  5. Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the pote...

    Authors: Xin Pan, Gang Wang and Baoming Wang

    Citation: Cancer Cell International 2021 21:161

    Content type: Primary research

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  6. CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspect...

    Authors: Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat and Kazem Mousavizadeh

    Citation: Cancer Cell International 2021 21:160

    Content type: Review

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  7. Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to eval...

    Authors: Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou and Guihai Zhang

    Citation: Cancer Cell International 2021 21:159

    Content type: Primary research

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  8. A crosstalk established between tumor microenvironment and tumor cells leads to contribution or inhibition of tumor progression. Mesenchymal stem cells (MSCs) are critical cells that fundamentally participate ...

    Authors: Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev and Majid Ahmadi

    Citation: Cancer Cell International 2021 21:158

    Content type: Review

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  9. Uterine leiomyosarcoma (ULMS) is a malignant tumor found in the smooth muscle lining the walls of the uterus. Cancer stem cells (CSCs) are responsible for metastasis, drug resistance, and relapse of cancer, re...

    Authors: Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang and Jingting Cai

    Citation: Cancer Cell International 2021 21:157

    Content type: Primary research

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  10. Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in gastrointestinal system. MicroRNAs (miRNAs) have been reported to be implicated in cancer development. However, the role of miR-...

    Authors: Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui and Qiang Wang

    Citation: Cancer Cell International 2021 21:155

    Content type: Primary research

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  11. Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant tumors. However, studies have not established glycolysis-related gene signatures that can be used to construct accurate prognostic ...

    Authors: Rong Xia, Hua Tang, Jiemiao Shen, Shuyu Xu, Yinyin Liang, Yuxin Zhang, Xing Gong, Yue Min, Di Zhang, Chenzhe Tao, Shoulin Wang, Yi Zhang, Jinyou Yang and Chao Wang

    Citation: Cancer Cell International 2021 21:154

    Content type: Primary research

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  12. Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs have been experimentally validated and functionally described. In this research, we aime...

    Authors: Lanlan Xi, Quanlin Liu, Wei Zhang, Linshan Luo, Jingfeng Song, Ruitao Liu, Shue Wei and Yong Wang

    Citation: Cancer Cell International 2021 21:153

    Content type: Primary research

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  13. CircRNAs with tissue-specific expression and stable structure may be good tumor prognostic markers. However, the expression of circRNAs in esophageal squamous cell carcinoma (ESCC) remain unknown. We aim to id...

    Authors: Weiwei Wang, Di Zhu, Zhihua Zhao, Miaomiao Sun, Feng Wang, Wencai Li, Jianying Zhang and Guozhong Jiang

    Citation: Cancer Cell International 2021 21:151

    Content type: Primary research

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  14. Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several huma...

    Authors: Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu and Jiansong Ji

    Citation: Cancer Cell International 2021 21:150

    Content type: Primary research

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  15. Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation ...

    Authors: Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi and Hai Wang

    Citation: Cancer Cell International 2021 21:148

    Content type: Primary research

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  16. Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the rol...

    Authors: Bo Jia, Junfeng Dao, Jiusong Han, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Shijian Xiang, Huixi Zhou and Shuguang Liu

    Citation: Cancer Cell International 2021 21:147

    Content type: Primary research

    Published on:

  17. Pien Tze Huang (PZH) is a well-known Traditional Chinese Medicine (TCM), characterized by a multitude of pharmacological effects, such as hepatoprotection and inhibition of inflammation and cell proliferative ...

    Authors: Zhiliang Chen

    Citation: Cancer Cell International 2021 21:146

    Content type: Review

    Published on:

  18. Emerging evidence continues to highlight the significant role of microRNAs (miRNAs) in the regulation of cancer growth and metastasis. Herein, the current study aimed to elucidate the role of exosomal miR-183 ...

    Authors: Yanping Dai and Xiaoqin Gao

    Citation: Cancer Cell International 2021 21:145

    Content type: Primary research

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  19. TUBA1C is a microtubule component that is involved in a variety of cancers. Our main objective was to investigate TUBA1C expression, its prognostic value, its potential biological functions, and its impact on ...

    Authors: Tingting Bian, Miaosen Zheng, Daishan Jiang, Jian Liu, Hui Sun, Xiaoli Li, Lei Liu, Jianguo Zhang and Yifei Liu

    Citation: Cancer Cell International 2021 21:144

    Content type: Primary research

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  20. Long non-coding RNAs (lncRNAs) have been reported to exert crucial functions in regulating the progression of human cancers. However, the function and mechanism of long intergenic non-protein coding RNA 01089 ...

    Authors: Huixian Zhang, Hao Zhang, Xingya Li, Siyuan Huang, Qianqian Guo and Di Geng

    Citation: Cancer Cell International 2021 21:143

    Content type: Primary research

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  21. Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of mRNAs in euk...

    Authors: Zhenyuan Han, Biao Yang, Qin Wang, Yuhua Hu, Yuqiong Wu and Zhen Tian

    Citation: Cancer Cell International 2021 21:142

    Content type: Primary research

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  22. Diffuse large B-cell lymphoma (DLBCL) is a common type of the Non-Hodgkin lymphomas (NHLs) formed by the neoplastic transformation of mature B cells. As the first-line therapeutics, CHOP (cyclophosphamide/doxo...

    Authors: Yu Zhang, Jingjing Xiang, Xianfu Sheng, Ni Zhu, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Chenjun Lin and Jianping Shen

    Citation: Cancer Cell International 2021 21:141

    Content type: Primary research

    Published on:

  23. Cell division cycle-associated 7 (CDCA7), as a member of the cell division cycle associated family, was reported to be aberrantly expressed in both solid tumors and hematological tumors, suggesting its essenti...

    Authors: Shouyong Liu, Yi Wang, Chenkui Miao, Qianwei Xing and Zengjun Wang

    Citation: Cancer Cell International 2021 21:140

    Content type: Primary research

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  24. Gastric cancer (GC) is considered one of the most lethal malignancies worldwide, which is accompanied by a poor prognosis. Although reports regarding the importance of cancer stem cell (CSC) markers in gastric...

    Authors: Mahdieh Razmi, Roya Ghods, Somayeh Vafaei, Maryam Sahlolbei, Leili Saeednejad Zanjani and Zahra Madjd

    Citation: Cancer Cell International 2021 21:139

    Content type: Review

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  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jingxian Liu, Jinghong Yang, Yuhe Hou, Zhenwei Zhu, Jie He, Hao Zhao, Xidong Ye, Dengke Li, Zhaohui Wu, Zhongxi Huang, Bingtao Hao and Kaitai Yao

    Citation: Cancer Cell International 2021 21:138

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2019 19:348

  26. Emerging evidence has shown that intra-tumor immune features are associated with response to immune checkpoint blockade (ICB) therapy. Accordingly, patient stratification is needed for identifying target patie...

    Authors: Jingkai Liu, Qiaofei Liu, Xiang Zhang, Ming Cui, Tong Li, Yalu Zhang and Quan Liao

    Citation: Cancer Cell International 2021 21:137

    Content type: Primary research

    Published on:

  27. Pemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However, factors affecting its efficacy and resistance have not been fully elu...

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu

    Citation: Cancer Cell International 2021 21:136

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:183

  28. The anti-epidermal growth factor receptor (EGFR) antibody introduces adaptable variations to the transcriptome and triggers tumor immune infiltration, resulting in colorectal cancer (CRC) treatment resistance....

    Authors: Li Liang, Mengling Liu, Xun Sun, Yitao Yuan, Ke Peng, Khalid Rashid, Yiyi Yu, Yuehong Cui, Yanjie Chen and Tianshu Liu

    Citation: Cancer Cell International 2021 21:135

    Content type: Primary research

    Published on:

  29. Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the co...

    Authors: Rui Wu, Hao Zhuang, Yu-Kun Mei, Jin-Yu Sun, Tao Dong, Li-Li Zhao, Zhi-Ning Fan and Li Liu

    Citation: Cancer Cell International 2021 21:134

    Content type: Primary research

    Published on:

  30. Circular RNAs (circRNAs) have been demonstrated to play significant roles in regulating gene expression in tumorigenesis, including breast cancer (BC). This study was designed to explore the role and underlyin...

    Authors: Liqiang Qi, Bo Sun, Beibei Yang and Su Lu

    Citation: Cancer Cell International 2021 21:133

    Content type: Primary research

    Published on:

  31. Hepatocellular carcinoma (HCC) is a common cancer leading to high morbidity and mortality in worldwide. Previous studies revealed that SEC61 translocon alpha 1 subunit1 (SEC61A) can act as an oncogene in colon...

    Authors: Xinxin Fa, Ping Song, Yu Fu, Yu Deng and Kai Liu

    Citation: Cancer Cell International 2021 21:131

    Content type: Primary research

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  32. Breast cancer (BC) remains a prevalent and common form of cancer with high heterogeneity. Making efforts to explore novel molecular biomarkers and serve as potential disease indicators, which is essential to e...

    Authors: Yaqian Liu, Bo Pan, Weikun Qu, Yilong Cao, Jun Li and Haidong Zhao

    Citation: Cancer Cell International 2021 21:130

    Content type: Primary research

    Published on:

  33. Renal cell carcinoma (RCC) is one of the most common malignant tumors originating from the renal parenchymal urinary epithelial system. Tripartite motif 47 (TRIM47) is a member of the TRIM family proteins, whi...

    Authors: Jia-xin Chen, Da Xu, Jian-wei Cao, Li Zuo, Zhi-tao Han, Yi-jun Tian, Chuan-min Chu, Wang Zhou, Xiu-wu Pan and Xin-gang Cui

    Citation: Cancer Cell International 2021 21:129

    Content type: Primary research

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  34. Abnormal energy metabolism is one of the characteristics of tumor cells, and it is also a research hotspot in recent years. Due to the complexity of digestive system structure, the frequency of tumor is relati...

    Authors: Ji Li, Chen Zhu, Peipei Yue, Tianyu Zheng, Yan Li, Biao Wang, Xin Meng and Yao Zhang

    Citation: Cancer Cell International 2021 21:128

    Content type: Primary research

    Published on:

  35. Gastric cancer (GC) is one of the most common cancers and the third leading cause of cancer related mortality worldwide. The 5-year survival rate is rather low owing to advanced unresectable and distant metast...

    Authors: Chuanqian Huang, Renli Chen, Fangjing Zheng, Yirong Tang, Xiukang Wang, Zichun Chen and Xiaolan Lai

    Citation: Cancer Cell International 2021 21:127

    Content type: Primary research

    Published on:

  36. Controlling Nutritional Status (CONUT) score is a novel nutrition-based biomarker that has been reported for predicting survival in various cancers. However, the relationship between CONUT score and prognosis ...

    Authors: Xinhao Niu, Zhe Zhu and Juan Bao

    Citation: Cancer Cell International 2021 21:126

    Content type: Review

    Published on:

  37. Ferroptosis is a recently recognized non-apoptotic cell death that is distinct from the apoptosis, necroptosis and pyroptosis. Considerable studies have demonstrated ferroptosis is involved in the biological p...

    Authors: Lei Zhu, Fugui Yang, Lingwei Wang, Lin Dong, Zhiyuan Huang, Guangxue Wang, Guohan Chen and Qinchuan Li

    Citation: Cancer Cell International 2021 21:124

    Content type: Primary research

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  38. Esophageal squamous cell carcinoma (ESCC) has become one of the most serious diseases affecting populations worldwide and is the primary subtype of esophageal cancer (EC). However, the molecular mechanisms gov...

    Authors: Yexun Song, Xianyao Wang, Fengjun Wang, Xiaowei Peng, Peiyu Li, Shaojun Liu and Decai Zhang

    Citation: Cancer Cell International 2021 21:123

    Content type: Primary research

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  39. Hepatocellular carcinoma (HCC) is the third cause of cancer death in the world, and few molecularly targeted anticancer therapies have been developed to treat it. The E3 ubiquitin ligase RNF152 has been report...

    Authors: Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang, Wei Liu, Jing Ji and Bin Liu

    Citation: Cancer Cell International 2021 21:122

    Content type: Primary research

    Published on:

  40. Calmodulin1 (CALM1) has been identified as one of the overexpression genes in a variety of cancers and EGFR inhibitor have been widely used in clinical treatment but it is unknown whether CALM1 and epidermal g...

    Authors: Tao Liu, Xiujuan Han, Shutao Zheng, Qing Liu, Aerziguli Tuerxun, Qiqi Zhang, Lifei Yang and Xiaomei Lu

    Citation: Cancer Cell International 2021 21:121

    Content type: Primary research

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  41. Curcumin is extracted from turmeric and shows a variety of properties that make it a useful agent for treating diseases and targeting different biological mechanisms, including apoptosis, angiogenesis, inflamm...

    Authors: Fahime Jahanbakhshi, Parisa Maleki Dana, Bita Badehnoosh, Bahman Yousefi, Mohammad Ali Mansournia, Moghadeseh Jahanshahi, Zatollah Asemi and Jamal Halajzadeh

    Citation: Cancer Cell International 2021 21:120

    Content type: Review

    Published on:

  42. High immunogenicity is an important feature of ccRCC, but its underlying immune-related molecular mechanisms remain unclear. This study aimed to investigate the effect of immune-related gene TEK on ccRCC and i...

    Authors: Siming Chen, Mengxue Yu, Lingao Ju, Gang Wang, Kaiyu Qian, Yu Xiao and Xinghuan Wang

    Citation: Cancer Cell International 2021 21:119

    Content type: Primary research

    Published on:

  43. Gastric cancer (GC) is among the most common and deadliest cancers globally. Many long non-coding RNAs (lncRNAs) are key regulators of GC pathogenesis. This study aimed to define the role of HOXA-AS3 in this o...

    Authors: Feng Qu, Bin Zhu, Yi-Lin Hu, Qin-Sheng Mao and Ying Feng

    Citation: Cancer Cell International 2021 21:118

    Content type: Primary research

    Published on:

  44. Gastric cancer (GC) has a high mortality rate and is one of the most fatal malignant tumours. Male sex has been proven as an independent risk factor for GC. This study aimed to identify immune-related genes (I...

    Authors: Xin Xu, Yida Lu, Youliang Wu, Mingliang Wang, Xiaodong Wang, Huizhen Wang, Bo Chen and Yongxiang Li

    Citation: Cancer Cell International 2021 21:117

    Content type: Primary research

    Published on:

  45. Platinum-based chemotherapy is a mainstay for treating esophageal cancer patients. In this manuscript, we have provided clues for influence of platinum on overall m6A level and further investigated the potenti...

    Authors: Mingxin Zhang, Minghua Bai, Li Wang, Ning Lu, Jia Wang, Rong Yan, Manli Cui, Honglin Yan and Lingmin Zhang

    Citation: Cancer Cell International 2021 21:114

    Content type: Primary research

    Published on:

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