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  1. Adhesion molecule interacting with CXADR antigen 1 (AMICA1), also known as Junction Adhesion Molecule Like (JAML), a recently identified member of the JAMs family, plays a critical role in mediating cancer dev...

    Authors: Ziyang Feng, Yan Zhang, Min He, Ying Han, Changjing Cai, Shanshan Liu, Ping Liu, Yihong Chen, Hong Shen and Shan Zeng
    Citation: Cancer Cell International 2022 22:111
  2. Abnormal expression of splicing factor 3A subunit 3 (SF3A3), a component of the spliceosome, has been confirmed to be related to the occurrence and development of various cancers. However, the expression and f...

    Authors: Kai-Long Liu, Yue-Wei Yin, Bao-Sai Lu, Ya-Lin Niu, Dan-Dan Wang, Bei Shi, Hong Zhang, Ping-Ying Guo, Zhan Yang and Wei Li
    Citation: Cancer Cell International 2022 22:109
  3. DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells...

    Authors: Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu and Zihuang Li
    Citation: Cancer Cell International 2022 22:107
  4. Many studies in recent years have found that dysregulation of long non-coding RNAs (lncRNAs) can contribute to disease. Small nucleolar RNA host gene 17 (SNHG17) is a novel cancer-related lncRNA of the SNHG fa...

    Authors: Li Ma, Jin Gao, Niu Zhang, Jiawei Wang, Tianwei Xu, Tianyao Lei, Xiaoteng Zou, Chenchen Wei and Zhaoxia Wang
    Citation: Cancer Cell International 2022 22:104
  5. A hydatidiform mole is a condition caused by abnormal proliferation of trophoblastic cells. MicroRNA miR-30a acts as a tumor suppressor gene in most tumors and participates in the development of various cancer...

    Authors: Zhenzhen Guo, Chenyu Zhu, Youhui Wang, Zhen Li, Lu Wang, Jianhui Fan, Yuefei Xu, Na Zou, Ying Kong, Dong Li and Linlin Sui
    Citation: Cancer Cell International 2022 22:103
  6. The role of CARM1 in tumors is inconsistent. It acts as an oncogene in most cancers but it inhibits the progression of liver and pancreatic cancers. CARM1 has recently been reported to regulate autophagy, but ...

    Authors: Suzhen Yang, Jing Zhang, Di Chen, Jiayi Cao, Ying Zheng, Yuying Han, Yirong Jin, Shuhui Wang, Ting Wang, Lin Ma, Tingting Luo, Yan Wang, Wen Qin and Lei Dong
    Citation: Cancer Cell International 2022 22:102
  7. Emerging evidence suggests that LMNB1 is involved in the development of multiple cancer types. However, there is no study reporting the potential role of LMNB1 in a systematic pan-cancer manner.

    Authors: Haixiang Qin, Yingqiang Lu, Lin Du, Jingyan Shi, Haoli Yin, Bo Jiang, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Xuefeng Qiu, Xiaozhi Zhao and Hongqian Guo
    Citation: Cancer Cell International 2022 22:101
  8. Programmed Cell Death 2 Like (PDCD2L) correlates with cell proliferation, apoptosis and mouse embryonic development. However, the role of PDCD2L in human cancers is unclear.

    Authors: Huabin Gao, Cheng Xu, Jiangtao Liang, Songhan Ge, Fenfen Zhang, Ying Tuo, Huijuan Shi and Anjia Han
    Citation: Cancer Cell International 2022 22:100
  9. The current study aims to find the linker between esophageal epithelial carcinogenesis and chronic inflammation and the origin of hyperproliferative cells in precancerous lesions of esophageal squamous cell ca...

    Authors: Hao Ye, Xiang Li, Jing Lin, Peng Yang and Min Su
    Citation: Cancer Cell International 2022 22:98
  10. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Costimulatory molecules have been proven to be the foundation of immunotherapy. However, the potential roles of costimulatory mo...

    Authors: Yinan Hu, Jingyi Liu, Jiahao Yu, Fangfang Yang, Miao Zhang, Yansheng Liu, Shuoyi Ma, Xia Zhou, Jingbo Wang and Ying Han
    Citation: Cancer Cell International 2022 22:97
  11. Prognostic assessment is imperative for clinical management of patients with hepatocellular carcinoma (HCC). Most reported prognostic signatures are based on risk scores summarized from quantitative expression...

    Authors: Xiaoyun Bu, Luyao Ma, Shuang Liu, Dongsheng Wen, Anna Kan, Yujie Xu, Xuanjia Lin and Ming Shi
    Citation: Cancer Cell International 2022 22:95
  12. To investigate the genotype distribution of human papillomavirus (HPV) in infected Uygur and Han women in Xinjiang, China; analyze the HPV16 E6 gene polymorphism site and relationship with the development of c...

    Authors: Huizhen Xin, Zhenzhen Pan, Xiangyi Zhe, Chunhe Zhang, Hongtao Li, Weinan Zheng, Haichen Long, Renfu Shao, Dongmei Li and Zemin Pan
    Citation: Cancer Cell International 2022 22:94
  13. Long non-coding RNAs (lncRNAs) regulate tumor development and metastasis in several types of cancers through various molecular mechanisms. However, the biological role of most lncRNAs in pancreatic cancer (PC)...

    Authors: Min Zhong, Zhi Fang, Bin Ruan, Jianping Xiong, Junhe Li and Zhiwang Song
    Citation: Cancer Cell International 2022 22:93
  14. DHX15 is one of the RNA helicase family members involving in several biological processes. Studies have reported that overexpression of DHX15 is related to cancer progression. However, the role of DHX15 in Bur...

    Authors: Yuan Chen, Xianglei Chen, Lili Pan, Yuanmao Huang, Yuanhua Cai, Jinggang Li, Yang Li and Shaoyuan Wang
    Citation: Cancer Cell International 2022 22:92
  15. Long non-coding RNAs and microRNAs have recently attained much attention regarding their role in the development of B cell lineage as well as participation in the lymphomagenesis. These transcripts have a high...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Elena Jamali
    Citation: Cancer Cell International 2022 22:91
  16. Esophageal squamous cell carcinoma (ESCC) is a severe disease with high mortality, and is associated with poor prognosis and frequent lymphatic metastasis. Therefore, prognostic indicators for ESCC are urgentl...

    Authors: Qiu-yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-fei Xia, Yong Du, Run-duan Lin, Li-qiong Yang, Yu-ting Sun, Da-Jun Yang, Jian Sun and Lin Zhang
    Citation: Cancer Cell International 2022 22:90
  17. To evaluate the efficacy and safety of P-ALG (porcine anti-lymphocyte globulin) and R-ATG (rabbit anti-thymocyte globulin) in the conditioning regime for patients with acquired aplastic anemia who underwent HL...

    Authors: Juan Chen, Yuanfeng Zhang, Xin Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou…
    Citation: Cancer Cell International 2022 22:89
  18. KRAS mutation accounts for 30–50% of human colorectal cancer (CRC) cases. Due to the scarcity of effective treatment options, KRAS mutant CRC is difficult to treat in the clinic. Metastasis is still the major ...

    Authors: Yunzhi Dang, Jiao Yu, Shuhong Zhao, Ximing Cao and Qing Wang
    Citation: Cancer Cell International 2022 22:88
  19. Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may be in part due to so called glioma stem cells. However, there is no established marker to identify these stem cells.

    Authors: Bülent Polat, Gisela Wohlleben, Rebekka Kosmala, Dominik Lisowski, Frederick Mantel, Victor Lewitzki, Mario Löhr, Robert Blum, Petra Herud, Michael Flentje and Camelia-Maria Monoranu
    Citation: Cancer Cell International 2022 22:87
  20. Increasing evidence suggests that aberrant methylation is involved in 5-fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that Methyl-CpG binding protein 2 (MeCP2) promote...

    Authors: Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma and Lingyu Zhao
    Citation: Cancer Cell International 2022 22:86
  21. The role of hydrogen sulfide (H2S) in cancer biology is controversial, including colorectal cancer. The bell-shaped effect of H2S refers to pro-cancer action at lower doses and anti-cancer effect at higher concen...

    Authors: Yuyang Zhang, Shanwen Chen, Jing Zhu, Shihao Guo, Taohua Yue, Hao Xu, Jianwen Hu, Zhihao Huang, Zeyang Chen, Pengyuan Wang and Yucun Liu
    Citation: Cancer Cell International 2022 22:85
  22. In addition to its role in cellular progression and cancer, SIRT6, a member of nicotinamide adenine dinucleotide (NAD+)-dependent class III deacylase sirtuin family, serves a variety of roles in the body's immune...

    Authors: Xiaojing Wu, Shuyuan Wang, Xuanzhu Zhao, Sizhen Lai, Zhen Yuan, Yixiang Zhan, Kemin Ni, Zhaoce Liu, Lina Liu, Ran Xin, Xingyu Zhou, Xin Yin, Xinyu Liu, Xipeng Zhang, Wei Cui and Chunze Zhang
    Citation: Cancer Cell International 2022 22:84
  23. Osimertinib resistance limits the treatment of epidermal growth factor receptor-(EGFR)-mutated non-small-cell lung carcinoma (NSCLC). The mechanisms of osimertinib resistance need to be elucidated to determine...

    Authors: Xiaoying Wan, Boxiong Xie, Hui Sun, Weiqing Gu, Chunyan Wang, Qinfang Deng and Songwen Zhou
    Citation: Cancer Cell International 2022 22:83
  24. Approximately 50%–60% of secondary resistance to primary EGFR- tyrosine kinase inhibitors (TKI) therapy is caused by acquired p.Thr790Met (T790M) mutation; however, highly fragmented, low-quantity circulating tum...

    Authors: Boyeon Kim, Yoonjung Kim, Saeam Shin, Seung-Tae Lee, Jae Yong Cho and Kyung-A. Lee
    Citation: Cancer Cell International 2022 22:82
  25. Breast cancer (BC) threatens the health of women around the world. Researchers have proved that hsa_circ_0005505 (circ_IRAK3) facilitates BC cell invasion and migration, but the regulatory mechanisms of circ_I...

    Authors: Fang Wang, Jingruo Li, Lin Li, Zhuo Chen, Nan Wang, Mingzhi Zhu, Hailong Mi, Youyi Xiong, Guangcheng Guo and Yuanting Gu
    Citation: Cancer Cell International 2022 22:81
  26. The gasdermins (GSDMs) family is proposed to be pore-forming effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our increasing knowledge of GSDMD, GSDME and GSDMB, the biologic...

    Authors: Mingchao Mu, Qiaoling Yu, Qin Zhang, Jing Guo, Xingjie Wang, Xuejun Sun and Junhui Yu
    Citation: Cancer Cell International 2022 22:80
  27. The role of circular RNAs (circRNAs) and microRNAs (miRNAs) in osteosarcoma (OS) development has not been fully elucidated. Further, the contribution of the immune response to OS progression is not well define...

    Authors: Zhihao Chen, Liubing Li, Ziyuan Li, Xi Wang, Mingxiao Han, Zongshuai Gao, Min Wang, Gangfeng Hu, Xiaolu Xie, Hong Du, Zonggang Xie and Haifang Zhang
    Citation: Cancer Cell International 2022 22:78
  28. Thyroid cancer is the most common malignant endocrine tumour, and metastasis has become the main reason for treatment failure. However, the underlying molecular mechanism of thyroid cancer metastasis remains p...

    Authors: Yankun Zhang, Min Sun, Lifen Gao, Xiaohong Liang, Chunhong Ma, Jinghui Lu and Xuetian Yue
    Citation: Cancer Cell International 2022 22:76
  29. Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women in China. In previous studies, Sestrin2 was demonstrated to have functions in CRC. However, the relationship between ...

    Authors: Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li and Zhongxue Fu
    Citation: Cancer Cell International 2022 22:75
  30. Although the prognosis for most patients with papillary thyroid cancer (PTC) is good, the present treatment is ineffective for 5–10% patients. Several studies found sodium–glucose cotransporter 2 (SGLT2) inhib...

    Authors: Yan Wang, Longyan Yang, Lin Mao, Lijie Zhang, Yingjun Zhu, Yongsong Xu, Yanan Cheng, Rongxin Sun, Yuanyuan Zhang, Jing Ke and Dong Zhao
    Citation: Cancer Cell International 2022 22:74
  31. Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Tyrosine kinase inhibitors (TKIs) remain the backbone of systematic therapy for advanced hepatocellular carcinoma. Sorafeni...

    Authors: Ruyin Chen, Qiong Li, Shuaishuai Xu, Chanqi Ye, Tian Tian, Qi Jiang, Jianzhen Shan and Jian Ruan
    Citation: Cancer Cell International 2022 22:73
  32. N6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications of RNA. However, there is limited information about the potential roles of m6A regulators in tumor immunity. Therefore, in t...

    Authors: Jianfeng Cui, Yaofeng Zhu, Xiaochen Liu, Wenfu Wang, Xuewen Jiang, Yangyang Xia, Guanwen Zhou, Shouzhen Chen and Benkang Shi
    Citation: Cancer Cell International 2022 22:72
  33. Colorectal cancer (CRC) is the second most common cause of cancer mortality and a major health challenge worldwide. Despite advances in therapeutic and diagnostic methods, there is still a poor prognosis in CR...

    Authors: Amir Abbas Hamidi, Ghazaleh Khalili-Tanha, Zahra Nasrpour Navaei and Meysam Moghbeli
    Citation: Cancer Cell International 2022 22:71
  34. Fermitin family member 1 (FERMT1) is significantly overexpressed in human cancers and associated with poor prognosis, but its contributions to tumorigenesis and nasopharyngeal carcinoma (NPC) progression remai...

    Authors: Lingling Li, Piao Li, Wei Zhang, Haiting Zhou, Ergang Guo, Guoqing Hu and Linli Zhang
    Citation: Cancer Cell International 2022 22:70
  35. Gastric cancer (GC), the most commonly diagnosed cancer worldwide with poor 5-year survival rate in advanced stages. Although immune-related and survival-related biomarkers, which typically comprise aberrantly...

    Authors: Jun Wang, Beidi Wang, Biting Zhou, Jing Chen, Jia Qi, Le Shi, Shaojun Yu, Guofeng Chen, Muxing Kang, Xiaoli Jin, Lie Wang, Jinghong Xu, Linghua Zhu and Jian Chen
    Citation: Cancer Cell International 2022 22:69
  36. The Kirsten ras oncogene KRAS is a member of the small GTPase superfamily participating in the RAS/MAPK pathway. A single amino acid substitution in KRAS gene has been shown to activate the encoded protein result...

    Authors: Soudeh Ghafouri-Fard, Zeinab Shirvani-Farsani, Bashdar Mahmud Hussen, Mohammad Taheri and Reza Jalili Khoshnoud
    Citation: Cancer Cell International 2022 22:68
  37. Copine1 (CPNE1), the first discovered CPNE1 family member, participates in the process of carcinogenesis and development of diverse tumors. Our study aimed to investigate the expression and prognostic value of...

    Authors: Jinfang Su, Yongbiao Huang, Yali Wang, Rui Li, Wanjun Deng, Hao Zhang and Huihua Xiong
    Citation: Cancer Cell International 2022 22:67
  38. Clear cell renal cell carcinoma (ccRCC) is one of the most lethal malignancies in the urinary system and the existing immunotherapy has not achieved satisfactory outcomes. Therefore, this study aims at establi...

    Authors: Daojia Miao, Jian Shi, Zhiyong Xiong, Wen Xiao, Xiangui Meng, Qingyang Lv, Kairu Xie, Hongmei Yang and Xiaoping Zhang
    Citation: Cancer Cell International 2022 22:66
  39. Tumor microenvironments are characterized by resistance to chemotherapeutic agents and radiotherapy. Hypoxia plays an important role in the development of tumor resistance, as well as the generation of metasta...

    Authors: Dengke Zhang, Fazong Wu, Jingjing Song, Miaomiao Meng, Xiaoxi Fan, Chenying Lu, Qiaoyou Weng, Shiji Fang, Liyun Zheng, Bufu Tang, Yang Yang, Jianfei Tu, Min Xu, Zhongwei Zhao and Jiansong Ji
    Citation: Cancer Cell International 2022 22:65
  40. Osteosarcoma (OS) is a tumour with a high malignancy level and a poor prognosis. First-line chemotherapy for OS has not been improved for many decades. Bromodomain and extraterminal domain (BET) and histone de...

    Authors: Bo Yu, Lang Liu, Feng Cai, Yuanxiang Peng, Xiaofeng Tang, Duo Zeng, Teng Li, Feifei Zhang, Yiping Liang, Xuhui Yuan, Jiayu Li, Zhengzai Dai, Qi Liao and Xiao-Bin Lv
    Citation: Cancer Cell International 2022 22:64
  41. Authors: Feng Qiu, Bin Qiao, Nan Zhang, Zheng Fang, Lu Feng, Shanfeng Zhang and Weiliu Qiu
    Citation: Cancer Cell International 2022 22:63

    The original article was published in Cancer Cell International 2021 21:412

  42. Head and neck squamous cell carcinoma (HNSCC) is a major threat to public health. Pyroptosis is a form of inflammatory programmed cell death that is still incompletely understood. The role of pyroptotic cell d...

    Authors: Weiwen Zhu, Jiayi Zhang, Mengyao Wang, Rundong Zhai, Yanbin Xu, Jie Wang, Mengqi Wang, Hang Zhang and Laikui Liu
    Citation: Cancer Cell International 2022 22:62
  43. Radioiodine (RAI) is the mainstay of treatment for differentiated thyroid carcinoma (DTC) following total thyroidectomy. Nevertheless, about 5% of patients with DTC are RAI-refractory (RAI-R). Understanding th...

    Authors: Hilda Samimi and Vahid Haghpanah
    Citation: Cancer Cell International 2022 22:61
  44. Present work systematically reviewed relevant literature based on 18F-FDG PET parameters and conducted a meta-analysis to examine the prognostic value of maximal standard uptake value (SUVmax), total lesional ...

    Authors: Weibo Wen, Dongyuan Xu, Yongnan Piao and Xiangdan Li
    Citation: Cancer Cell International 2022 22:60
  45. The prevalence of lung adenocarcinoma (LUAD) has increased, thus novel biomarkers for its early diagnosis is becoming more important than ever. tRNA-derived small RNA (tsRNA) is a new class of non-coding RNA w...

    Authors: Jun Wang, Xianyu Liu, Weifang Cui, Qun Xie, Wei Peng, Heng Zhang, Yang Gao, Chunfang Zhang and Chaojun Duan
    Citation: Cancer Cell International 2022 22:59

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