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  1. The incidence of melanoma, the most lethal form of skin cancer, has increased due to ultraviolet exposure. The treatment of advanced melanoma, particularly metastatic cases, remains challenging with poor outco...

    Authors: Ming-yun Hsieh, Sheng-Kai Hsu, Tzu-Yu Liu, Chang-Yi Wu and Chien-Chih Chiu
    Citation: Cancer Cell International 2024 24:63
  2. m6A modification has close connection with the occurrence, development, and prognosis of tumors. This study aimed to explore the roles of m6A modification and its related mechanisms in non-small cell lung canc...

    Authors: Xianxiu Ji, Xiaoying Wan, Hui Sun, Qinfang Deng, Shuyan Meng, Boxiong Xie and Songwen Zhou
    Citation: Cancer Cell International 2024 24:61
  3. Glioblastoma (GBM) characterized by immune escape is the most malignant primary brain tumors, which has strong immunosuppressive effect. Programmed death ligand-1 (PD-L1) is a recognized immunosuppressive memb...

    Authors: Leilei Zhao, Yudi Wang, Peizheng Mu, Xuehua Zhang, Ruomei Qi, Yurui Zhang, He Zhang, Xiao Zhu, Zhouyan Dong and Yucui Dong
    Citation: Cancer Cell International 2024 24:60
  4. Peroxiredoxin 3 (PRDX3), a mitochondrial hydrogen peroxide scavenger, is known to be upregulated during tumorigenesis and cancer progression. In this study, we provide evidence for the first time that PRDX3 co...

    Authors: Pei-Jou Chua, Suet-Hui Ow, Cheng-Teng Ng, Wan-Hong Huang, Jie-Ting Low, Puay Hoon Tan, Michael W.Y. Chan and Boon-Huat Bay
    Citation: Cancer Cell International 2024 24:59
  5. Tongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analy...

    Authors: Huixin Dou, Can Song, Xiaoyan Wang, Zhien Feng, Yingying Su and Hao Wang
    Citation: Cancer Cell International 2024 24:58
  6. AlkB homolog 1, histone H2A dioxygenase (ALKBH1), a crucial enzyme involved in RNA demethylation in humans, plays a significant role in various cellular processes. While its role in tumor progression is well-e...

    Authors: Renin Chang, Kuan-Hao Tsui, Li-Fei Pan and Chia-Jung Li
    Citation: Cancer Cell International 2024 24:57
  7. About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for the development of innovative therapies. In this direction, the pote...

    Authors: Valeria Pecci, Fabiola Troisi, Aurora Aiello, Sara De Martino, Angela Carlino, Vincenzo Fiorentino, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Maurizio Martini, Manuela Porru, Francesco Pinto, Antonello Mai, Pier Francesco Bassi, Claudio Grassi, Carlo Gaetano…
    Citation: Cancer Cell International 2024 24:56
  8. Emerging data point to the critical role of snoRNA in the emergence of different types of cancer, but scarcely in breast cancer (BC). This study aimed to clarify the differential expressions and potential diag...

    Authors: Xiao Li, Xuan Zhao, Li Xie, Xingguo Song and Xianrang Song
    Citation: Cancer Cell International 2024 24:55
  9. Ovarian cancer (OC) has the highest mortality rate among all gynecological malignancies. A hypoxic microenvironment is a common feature of solid tumors, including ovarian cancer, and an important driving facto...

    Authors: Jiaqi Xu, Fei Wu, Yue Zhu, Tiantian Wu, Tianyue Cao, Wenxin Gao, Meng Liu, Weifeng Qian, Guannan Feng, Xiaoxue Xi and Shunyu Hou
    Citation: Cancer Cell International 2024 24:54
  10. Ovarian cancer (OV) is the most lethal gynecological malignancy worldwide, with high recurrence rates. Anoikis, a newly-acknowledged form of programmed cell death, plays an essential role in cancer progression...

    Authors: Jiani Yang, Yue Zhang, Shanshan Cheng, Yanna Xu, Meixuan Wu, Sijia Gu, Shilin Xu, Yongsong Wu, Chao Wang and Yu Wang
    Citation: Cancer Cell International 2024 24:53
  11. A minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable to immune evasion. Our objective was to formulate a predictive signature rooted in genes associate...

    Authors: Xu Wang, Shixin Chan, Jiajie Chen, Yuanmin Xu, Longfei Dai, Qijun Han, Zhenglin Wang, Xiaomin Zuo, Yang Yang, Hu Zhao, Ming Wang, Chen Wang, Zichen Li, Huabing Zhang and Wei Chen
    Citation: Cancer Cell International 2024 24:52
  12. Engrailed homeobox 1 (EN1) is a candidate oncogene that is epigenetically modified in salivary adenoid cystic carcinoma (SACC). We investigated the expression of EN1 in SACC tissues and cells, EN1 promoter methyl...

    Authors: Yajuan Cui, Ye Zhang, Yuping Liu, Zheng Zhou, Lijing Zhu and Chuan-Xiang Zhou
    Citation: Cancer Cell International 2024 24:51
  13. Although a combination of immune checkpoint inhibitors (ICIs) is recommended as the first line treatment option for metastatic renal cell carcinoma (mRCC), several immune-related adverse events (irAEs) occur, ...

    Authors: Jee Soo Park, Myung Eun Lee, Jongchan Kim, Keunhee Oh, Namhee Lee, Minsun Jung, Won Sik Jang and Won Sik Ham
    Citation: Cancer Cell International 2024 24:50
  14. Luminal breast cancer (BC) is a prevalent subtype associated with an increased risk of late disease recurrence and mortality. Long noncoding RNAs (lncRNAs) likely play significant roles in regulating tissue-sp...

    Authors: Yue Meng, Dianrong Zhou, Ying Luo, Jierong Chen and Hui Li
    Citation: Cancer Cell International 2024 24:49
  15. The diagnosis of T-cell lymphomas is typically established through a multiparameter approach that combines clinical, morphologic, immunophenotypic, and genetic features, utilizing a variety of histopathologic ...

    Authors: Muhammad Sufyan Bin Masroni, Gracie Wee Ling Eng, Ah-Jung Jeon, Yuan Gao, He Cheng, Sai Mun Leong, Jit Kong Cheong, Susan Swee-Shan Hue and Soo Yong Tan
    Citation: Cancer Cell International 2024 24:48
  16. Long noncoding RNAs (lncRNAs) are significant contributors to various human malignancies. The aberrant expression of lncRNA LINC00894 has been reported in various human malignancies. We aimed to illustrate the...

    Authors: Xiang Zhou, Lisha Chang, Qiaoqiao Liang, Rongjie Zhao, Yong Xiao, Zheng Xu and Leitao Yu
    Citation: Cancer Cell International 2024 24:47
  17. Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment of cancer cell. Targeted drug delivery systems using NPs have shown great promise in improving the eff...

    Authors: Akram Firouzi Amandi, Zahra Bahmanyar, Mehdi Dadashpour, Mehrnoosh Lak, Mohammad Natami, Yusuf Döğüş, Mahsa Alem and Omid Ali Adeli
    Citation: Cancer Cell International 2024 24:46
  18. Pyroptosis, an inflammatory form of programmed cell death, has been implicated in the pathogenesis and progression of several cancers. However, the significance of pyroptosis-related genes (PRGs) in papillary ...

    Authors: Fang Li, Rui Du, Jiedong Kou, Jingting Li, Le Zhou, Daqi Zhang, Yantao Fu, Gianlorenzo Dionigi, Simona Bertoli, Hui Sun and Nan Liang
    Citation: Cancer Cell International 2024 24:45
  19. Gastric cancer (GC) ranks fifth for morbidity and third for mortality worldwide. The N6-methyladenosine (m6A) mRNA methylation is crucial in cancer biology and progression. However, the relationship between m6A m...

    Authors: Zehua Wang, Chen Chen, Jiao Shu, Jiaoyu Ai, Yihan Liu, Haoyue Cao, Yongxu Jia and Yanru Qin
    Citation: Cancer Cell International 2024 24:44
  20. The FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting the FGF/FGFR pathway, in epithelial ovarian cancer (EOC) and strategi...

    Authors: Yoo-Young Lee, Ji-Yoon Ryu, Young-Jae Cho, Ju-Yeon Choi, Jung-Joo Choi, Chel Hun Choi, Jason K. Sa, Jae Ryoung Hwang and Jeong-Won Lee
    Citation: Cancer Cell International 2024 24:43
  21. Circular RNAs (circRNAs) are involved in the regulation of progression and drug resistance in ovarian cancer (OC). In the present study, we aimed to explore the role of circRAD23B, a newly identified circRNA, ...

    Authors: Hui Wang, Yashuang Zhang, Huixian Miao, Ting Xu, Xianglin Nie and Wenjun Cheng
    Citation: Cancer Cell International 2024 24:42
  22. Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patie...

    Authors: Xinyue Guo, Licheng Xu, Luan Nie, Chenyu Zhang, Yaohui Liu, Rui Zhao, Jing Cao, Linli Tian and Ming Liu
    Citation: Cancer Cell International 2024 24:41
  23. Drug resistance remains a challenge in ovarian cancer. In addition to aberrant activation of relevant signaling pathways, the adaptive stress response is emerging as a new spotlight of drug resistance in cance...

    Authors: Nan Lin, Liankun Sun, Jiannan Chai, Hang Qi, Yuanxin Zhao, Jiaoyan Ma, Meihui Xia and Xiaoqing Hu
    Citation: Cancer Cell International 2024 24:38
  24. One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no pro...

    Authors: Shizhen Li, Mingjing Peng, Shiming Tan, Linda Oyang, Jinguan Lin, Longzheng Xia, Jiewen Wang, Nayiyuan Wu, Xianjie Jiang, Qiu Peng, Yujuan Zhou and Qianjin Liao
    Citation: Cancer Cell International 2024 24:37
  25. Although meningioma is the most common primary brain tumor, treatments rely on surgery and radiotherapy, and recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant rese...

    Authors: Dokyeong Kim, Junseong Park, Hyeon-Chun Park, Songzi Zhang, Minyoung Park, Soon A. Park, Sug Hyung Lee, Youn Soo Lee, Jae-Sung Park, Sin-Soo Jeun, Yeun-Jun Chung and Stephen Ahn
    Citation: Cancer Cell International 2024 24:36
  26. It is well known that tumor-associated macrophages (TAMs) play essential roles in brain tumor resistance to chemotherapy. However, the detailed mechanisms of how TAMs are involved in brain tumor resistance are...

    Authors: Sheng-Yan Wu, Wen-Jui Yu, Ting-Yi Chien, Yu-An Ren, Chi-Shuo Chen and Chi-Shiun Chiang
    Citation: Cancer Cell International 2024 24:35
  27. Male patients with papillary thyroid carcinoma (PTC) tend to have poorer prognosis compared to females, partially attributable to a higher rate of lymph node metastasis (LNM). Developing a precise predictive m...

    Authors: Jianlin Zhang, Xumin Zhou, Fan Yao, JiaLi Zhang and Qiang Li
    Citation: Cancer Cell International 2024 24:34
  28. Gastric cancer is a highly prevalent cancer type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several type...

    Authors: Rongfu Tu, Ye Kang, Yiwen Pan, Yanyan Da, Doudou Ren, Ru Zhang, Zeqiong Cai, Yijia Liu, Jiao Xu, Junpeng Ma, Zhiyong Zhou, Shupeng Yin, Xiaozhuang Li, Peng Zhang, Qi Zhang, Jingchao Wang…
    Citation: Cancer Cell International 2024 24:33
  29. Bladder cancer is the second most common genitourinary malignancy worldwide. The death rate of bladder cancer has increased every year. However, the molecular mechanism of bladder cancer is not sufficiently st...

    Authors: Hui-hui Zhang, An-qi Zhang, Peng Peng, Liang Huang, Cai-ying Liu, Xin-rui Nie, De-fu Hou, Xia Zhang and Shang-ze Li
    Citation: Cancer Cell International 2024 24:32
  30. Hepatocellular carcinoma (HCC) stands as a prevalent malignancy globally, characterized by significant morbidity and mortality. Despite continuous advancements in the treatment of HCC, the prognosis of patient...

    Authors: Lixia Xu, Shu Chen, Qiaoqiao Li, Xinyi Chen, Yuan Xu, Yongjian Zhou, Juan Li, Zhixian Guo, Jiyuan Xing and Di Chen
    Citation: Cancer Cell International 2024 24:30
  31. Platinum-based drugs are cytotoxic drugs commonly used in cancer treatment. They cause DNA damage, effects of which on chromatin and cellular responses are relatively well described. Yet, the nuclear stress re...

    Authors: Enkhzaya Batnasan, Minttu Kärkkäinen, Sonja Koivukoski, Nithin Sadeesh, Sylvain Tollis, Pekka Ruusuvuori, Mauro Scaravilli and Leena Latonen
    Citation: Cancer Cell International 2024 24:29
  32. Primary cell lines are invaluable for exploring cancer biology and investigating novel treatments. Despite their numerous advantages, primary cultures are laborious to obtain and maintain in culture. Hence, es...

    Authors: Oliwia Piwocka, Marika Musielak, Karolina Ampuła, Igor Piotrowski, Beata Adamczyk, Magdalena Fundowicz, Wiktoria Maria Suchorska and Julian Malicki
    Citation: Cancer Cell International 2024 24:28
  33. Breast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose mechanism remains unclear. We recently revealed the specific contribution o...

    Authors: Mauriane Maja, Marie Verfaillie, Patrick Van Der Smissen, Patrick Henriet, Christophe E. Pierreux, Nor Eddine Sounni and Donatienne Tyteca
    Citation: Cancer Cell International 2024 24:27
  34. This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RN...

    Authors: Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi and Mohammad-Reza Ghasemi
    Citation: Cancer Cell International 2024 24:26
  35. Cervical cancer (CC) is a potential clinical application of PD-1/PD-L1 inhibitor. We aimed to study the mechanism of DNA mismatch repair (MMR) system regulating the expression of PD-L1 in CC through DNA methyl...

    Authors: Fan Guo, Ruijiao Lu, Weina Kong, Miyessar Anwar and Yangchun Feng
    Citation: Cancer Cell International 2024 24:25
  36. Single nucleotide polymorphisms (SNPs) have been linked with prostate cancer (PCa) and have shown potential as prognostic markers for advanced stages. Loss of function mutations in PKCι have been linked with i...

    Authors: Amna Hafeez, Maria Shabbir, Khushbukhat Khan, Janeen H. Trembley, Yasmin Badshah, Sameen Zafar, Kanza Shahid, Hania Shah, Naeem Mahmood Ashraf, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Afifa Marium and Suhail Razak
    Citation: Cancer Cell International 2024 24:24
  37. Patients with recurrent or metastatic cervical cancer are in urgent need of novel prognosis assessment or treatment approaches. In this study, a novel prognostic gene signature was discovered by utilizing cupr...

    Authors: Jiawen Kang, Jingwen Jiang, Xiaoqing Xiang, Yong Zhang, Jie Tang and Lesai Li
    Citation: Cancer Cell International 2024 24:23
  38. According to statistics, the incidence of liver cancer is increasing yearly, and effective treatment of liver cancer is imminent. For early liver cancer, resection surgery is currently the most effective treat...

    Authors: Jia-qian Mo, Shen-yan Zhang, Qiang Li, Mo-xian Chen, Yue-qing Zheng, Xin Xie, Rongxin Zhang and Shan-shan Wang
    Citation: Cancer Cell International 2024 24:22
  39. Threonine and tyrosine kinase (TTK) is associated with invasion and metastasis in various tumors. However, the prognostic importance of TTK and its correlation with immune infiltration in endometrial cancer (E...

    Authors: Hongxiang Du, Li Zhang, Jia Chen, Xinyi Chen, Ronghui Qiang, Xiaoyi Ding, Yilang Wang and Xiaoqing Yang
    Citation: Cancer Cell International 2024 24:20
  40. Disulfidptosis is a type of programmed cell death caused by excessive cysteine-induced disulfide bond denaturation leading to actin collapse. Liver cancer has a poor prognosis and requires more effective inter...

    Authors: Jun Tang, Xintong Peng, Desheng Xiao, Shuang Liu, Yongguang Tao and Long Shu
    Citation: Cancer Cell International 2024 24:19
  41. Although non-invasive radiological techniques are widely applied in kidney renal clear cell carcinoma (KIRC) diagnosis, more than 50% of KIRCs are detected incidentally during the diagnostic procedures to iden...

    Authors: Zhenyu Wen, Yingqi Li, Zhengping Zhao, Rongkang Li, Xinji Li, Chong Lu, Chen Sun, Wenkang Chen, Zhenjian Ge, Liangchao Ni and Yongqing Lai
    Citation: Cancer Cell International 2024 24:18
  42. Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits it...

    Authors: Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang and Qiying Yao
    Citation: Cancer Cell International 2024 24:17
  43. In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeuti...

    Authors: Omid Rahbar Farzam, Souzan Najafi, Mohammad Amini, Zohreh Rahimi, Reza Dabbaghipour, Omid Zohdi, Ghazale Asemani Shahgoli, Behzad Baradaran and Bahman Akbari
    Citation: Cancer Cell International 2024 24:16
  44. Osteosarcoma is one of the most common malignant bone tumors with bad prognosis. Necroptosis is a form of programmed cell death. Recent studies showed that targeting necroptosis was a new promising approach fo...

    Authors: Xiang Li, Zhenqian Sun, Jinlong Ma, Miaomiao Yang, Hongxin Cao and Guangjun Jiao
    Citation: Cancer Cell International 2024 24:14
  45. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promo...

    Authors: Hannah Johnson, Satya Narayan and Arun K. Sharma
    Citation: Cancer Cell International 2024 24:11

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