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  1. Emerging studies have demonstrated that circular RNAs (circRNAs) are key regulators for tumorigenesis in cancers, including papillary thyroid carcinoma (PTC). In this study, we aimed to explore the effects of ...

    Authors: Xiaolong Gui, Yan Li, Xiaobin Zhang, Ka Su and Wenlong Cao

    Citation: Cancer Cell International 2020 20:241

    Content type: Primary research

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  2. Endometrial cancer was the commonest gynecological malignancy in developed countries. Despite striking advances in multimodality management, however, for patients in advanced stage, targeted therapy still rema...

    Authors: Hongyu Zhou, Chufan Zhang, Haoran Li, Lihua Chen and Xi Cheng

    Citation: Cancer Cell International 2020 20:240

    Content type: Primary research

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  3. The incidence and mortality of melanoma is increasing around the world. To deeply explain the mechanism insight into it, we conducted a systematic analysis to examine the levels of regulatory genes of the comm...

    Authors: Tengda Li, Mingli Gu, Anmei Deng and Cheng Qian

    Citation: Cancer Cell International 2020 20:239

    Content type: Primary research

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  4. Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN f...

    Authors: Jing Chen, Xu Zhao, Yuan Yuan and Jing-Jing Jing

    Citation: Cancer Cell International 2020 20:238

    Content type: Primary research

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  5. The aberrant expression of microRNA-454 (miR-454) has been confirmed to be involved in the development of cancers. However, the functional role of miR-454 in the progression of ovarian cancer remains unclear.

    Authors: Yunhe An, Jun Zhang, Xiaoyan Cheng, Baoming Li, Yanjie Tian, Xiaoli Zhang and Fangqi Zhao

    Citation: Cancer Cell International 2020 20:237

    Content type: Primary research

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  6. Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma. However, the role of SNHG16 in regulating cisplatin sensitivity in ne...

    Authors: Zhaoying Xu, Yongfa Sun, Danfeng Wang, Huifang Sun and Xiaojun Liu

    Citation: Cancer Cell International 2020 20:236

    Content type: Primary research

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  7. Aberrant DNA methylation patterns are involved in the pathogenesis of papillary renal cell carcinoma (pRCC). This study aimed to investigate the potential of methylation-driven genes as biomarkers in determini...

    Authors: Zeyu Liu, Yuxiang Wan, Ming Yang, Xuewei Qi, Zhenzhen Dong, Jinchang Huang and Jingnan Xu

    Citation: Cancer Cell International 2020 20:235

    Content type: Primary research

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  8. Kinesin superfamily proteins (KIFs) serve as microtubule-dependent molecular motors, and are involved in the progression of many malignant tumors. In this study, we aimed to investigate the expression pattern ...

    Authors: Zhi-Gang Sun, Feng Pan, Jing-Bo Shao, Qian-Qian Yan, Lu Lu and Nan Zhang

    Citation: Cancer Cell International 2020 20:233

    Content type: Primary research

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  9. Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functi...

    Authors: Qiang Fei, Feihong Song, Xinwei Jiang, Han Hong, Xiaoyong Xu, Zhengkang Jin, Xiang Zhu, Binghua Dai, Jiamei Yang, Chengjun Sui and Minhui Xu

    Citation: Cancer Cell International 2020 20:232

    Content type: Primary research

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  10. Emerging evidence suggests that competing endogenous RNAs plays a crucial role in the development and progress of pancreatic adenocarcinoma (PAAD). The objective was to identify a new lncRNA-miRNA-mRNA network...

    Authors: Wanqing Weng, Zhongjing Zhang, Weiguo Huang, Xiangxiang Xu, Boda Wu, Tingbo Ye, Yunfeng Shan, Keqing Shi and Zhuo Lin

    Citation: Cancer Cell International 2020 20:231

    Content type: Research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:282

  11. We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g., cervical squamous cell carcinoma, ovarian serous cystad...

    Authors: Shitong Lin, Yifan Meng, Canhui Cao, Ping Wu, Peipei Gao, Wenhua Zhi, Ting Peng and Peng Wu

    Citation: Cancer Cell International 2020 20:229

    Content type: Primary research

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  12. Lung adenocarcinoma has surpassed lung squamous cell carcinoma as the most common type of non-small cell lung cancer. In this study, we had tested the biological role of TRIM2 in lung adenocarcinoma.

    Authors: Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang and Yangyun Huang

    Citation: Cancer Cell International 2020 20:228

    Content type: Primary research

    Published on:

  13. MicroRNAs (miRNAs) serve as important regulators of the tumorigenesis and progression of many human cancers. Therefore, we evaluated the biological function and underlying mechanism of miR-363 in clear cell re...

    Authors: Yongpeng Xie, Luyao Chen, Yu Gao, Xin Ma, Weiyang He, Yu Zhang, Fan Zhang, Yang Fan, Liangyou Gu, Pin Li, Xu Zhang and Xin Gou

    Citation: Cancer Cell International 2020 20:227

    Content type: Primary research

    Published on:

  14. Hepatocellular carcinoma (HCC) is a common tumor characterized by high morbidity and mortality rates. The importance of circRNA in cancer diagnosis has been established. The study aimed to identify differentia...

    Authors: Xiang-Hong Sun, Yu-Tong Wang, Guo-Fu Li, Nan Zhang and Ling Fan

    Citation: Cancer Cell International 2020 20:226

    Content type: Primary research

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  15. Pancreatic cancer is a highly malignant gastrointestinal cancer that can widely metastasize during the early stage of disease, and it is associated with one of the worst prognoses among cancers. In this study,...

    Authors: Yongping Zhou, Zhiyuan Hua, Ye Zhu, Liying Wang, Fangming Chen, Ting Shan, Yunhai Zhou and Tu Dai

    Citation: Cancer Cell International 2020 20:225

    Content type: Primary research

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  16. Osteosarcoma (OS) is a common malignant bone cancer and is still a growing threat to young people. Circular RNAs (CircRNAs) are reported to be involved in the development of diverse human cancers. However, the...

    Authors: Haojie Wu, Weihua Li, Shutao Zhu, Dengfeng Zhang and Minghui Zhang

    Citation: Cancer Cell International 2020 20:223

    Content type: Primary research

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  17. A novel systemic immune-inflammation index (SII), based on the neutrophils, lymphocytes and platelet counts, is associated with the prognosis of several cancers. The present study evaluates the prognostic sign...

    Authors: Xu Hu, Yan-Xiang Shao, Zhi-Qiang Yang, Wei-Chao Dou, San-Chao Xiong and Xiang Li

    Citation: Cancer Cell International 2020 20:222

    Content type: Primary research

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  18. Because cell movement is primarily driven by the connection between F-actin and integrin through a physical linkage, cellular elasticity and adhesion strength have been considered as biomarkers of cell motilit...

    Authors: Sangwoo Kwon, Woochul Yang, Donggerami Moon and Kyung Sook Kim

    Citation: Cancer Cell International 2020 20:217

    Content type: Primary research

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  19. ZKSCAN3, a zinc-finger transcription factor containing KRAB and SCAN domains, has been reported to be regulated in several human cancers. However, its expression and function in hepatocellular carcinoma (HCC) ...

    Authors: Jieqiong Li, Nan Hao, Juan Han, Mi Zhang, Xiaomei Li and Nan Yang

    Citation: Cancer Cell International 2020 20:216

    Content type: Primary research

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  20. Understanding the molecular mechanism of long non-coding RNAs (lncRNAs) in carcinogenesis is conducive for providing potential target for cancers. The role of FLVCR1-AS1 in breast cancer (BC) has not been prob...

    Authors: Zhiyu Pan, Junbin Ding, Zhen Yang, Huaqing Li, Hongjian Ding and Qian Chen

    Citation: Cancer Cell International 2020 20:214

    Content type: Primary research

    Published on:

  21. One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasiv...

    Authors: Kai Liu, Minying Zheng, Rui Lu, Jiaxing Du, Qi Zhao, Zugui Li, Yuwei Li and Shiwu Zhang

    Citation: Cancer Cell International 2020 20:213

    Content type: Review

    Published on:

  22. Dietary fiber is effective for colorectal cancer (CRC) treatment. Interleukin-6 (IL-6) and its adaptors are potential targets for CRC therapy. Butyrate, a metabolite of dietary fiber, is a new, highly safe typ...

    Authors: Yin Yuan, Bo Li, Yanbin Kuang, Shuo Ni, Aoxiang Zhuge, Jing Yang, Longxian Lv, Silan Gu, Ren Yan, Yating Li, Kaicen Wang, Liya Yang, Xueling Zhu, Jingjing Wu, Xiaoyuan Bian and Lanjuan Li

    Citation: Cancer Cell International 2020 20:212

    Content type: Primary research

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  23. Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological pr...

    Authors: Huixin Song, Qiaofei Liu and Quan Liao

    Citation: Cancer Cell International 2020 20:211

    Content type: Review

    Published on:

  24. Hydroxysteroid 17-Beta Dehydrogenase 6 (HSD17B6), a key protein involved in synthetizing dihydrotestosterone, is abundant in the liver. Previous studies have suggested a role for dihydrotestosterone in modulat...

    Authors: Lei Lv, Yujia Zhao, Qinqin Wei, Ye Zhao and Qiyi Yi

    Citation: Cancer Cell International 2020 20:210

    Content type: Primary research

    Published on:

  25. GSK-J4 is the inhibitor of H3K27me3 demethylase. Recent studies demonstrated that GSK-J4 could affect the proliferation and apoptosis of a variety of cancer cells. However, the effects and underlying mechanism...

    Authors: Xuan Chu, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Wenran Dan, Jiao Ye, Chen Liu, Xu Luo and Beizhong Liu

    Citation: Cancer Cell International 2020 20:209

    Content type: Primary research

    Published on:

  26. Lung cancer is the most common cancer worldwide, and metastasis is the leading cause of lung cancer related death. However, the molecular network involved in lung cancer metastasis remains incompletely describ...

    Authors: Qing Cao, Zewen Dong, Shuzhen Liu, Guoyan An, Bianbian Yan and Lei Lei

    Citation: Cancer Cell International 2020 20:208

    Content type: Primary research

    Published on:

  27. The pathogenesis and developmental mechanism of early-stage (FIGO 2009 IA2-IIA2) cervical cancer (CC) remain unclear. Seeking novel molecular biomarkers based on The Cancer Genome Atlas (TCGA) will facilitate ...

    Authors: Shuhang Qin, Yuandong Liao, Qiqiao Du, Wei Wang, Jiaming Huang, Pan Liu, Chunliang Shang, Tianyu Liu, Meng Xia and Shuzhong Yao

    Citation: Cancer Cell International 2020 20:206

    Content type: Primary research

    Published on:

  28. Inflammation is one of a main reason for colon cancer progression and poor prognosis. The high-mobility group box-1 (HMGB1) and glutathione peroxidase 4 (GPX4) are responsible for inflammation, but the relatio...

    Authors: Yuhan Yang, Ling Yang, Sheng Jiang, Ting Yang, Jingbin Lan, Yun Lei, Hao Tan and Kejian Pan

    Citation: Cancer Cell International 2020 20:205

    Content type: Primary research

    Published on:

  29. Papillary thyroid cancer (PTC) is a type of malignant tumor with excellent prognosis, accounting for more than 80% of thyroid cancer. Recently, numerous studies illustrated the importance of N6-methyladenosine (m

    Authors: Xinyi Wang, Xiaorui Fu, Junjia Zhang, Chengfeng Xiong, Shuyong Zhang and Yunxia Lv

    Citation: Cancer Cell International 2020 20:203

    Content type: Primary research

    Published on:

  30. Circ-centro-some/spindle pole-associated protein (CSPP1) has been confirmed to be characterized in diverse human malignancies and its ectopic expression may regulate tumor progression and development. However,...

    Authors: Qian Sun, Rui Yu, Chunfeng Wang, Jianning Yao and Lianfeng Zhang

    Citation: Cancer Cell International 2020 20:202

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:293

  31. Long non-coding RNA H19 (lncRNA H19) has been implicated in tumorigenesis and metastasis of breast cancer through regulating epithelial to mesenchymal transition (EMT); however, the underlying mechanisms remai...

    Authors: Yang Li, Hong-Yu Ma, Xiao-Wei Hu, Yuan-Yuan Qu, Xin Wen, Yu Zhang and Qing-Yong Xu

    Citation: Cancer Cell International 2020 20:200

    Content type: Primary research

    Published on:

  32. Esophageal cancer is the sixth leading cause of cancer-related mortality worldwide, which is partially due to limited progress of therapy. Apatinib, an inhibitor of VEGFR2, has a promising antitumor effect on ...

    Authors: Bin Wei, Yuanyuan Wang, Jiawei Wang, Xiaomin Cai, Lingyan Xu, Jingjing Wu, Ying Wang, Wen Liu, Yanhong Gu, Wenjie Guo and Qiang Xu

    Citation: Cancer Cell International 2020 20:198

    Content type: Primary research

    Published on:

  33. Radiotherapy, chemotherapy, and surgery have made crucial strides in glioblastoma treatment, yet they often fail; thus, new treatment and new detection methods are needed. Aberrant expression of Nanos3 has bee...

    Authors: Fengyu Zhang, Ruilai Liu, Cheng Liu, Haishi Zhang and Yuan Lu

    Citation: Cancer Cell International 2020 20:197

    Content type: Primary research

    Published on:

  34. Forkhead box C2 (FOXC2) is a crucial factor involving in various cancers. However, its functions in hepatocellular carcinoma (HCC) is unknown. Here, we explored the role of FOXC2 in the progression of HCC and ...

    Authors: Jinzhang Chen, Xiaoxiang Rong, Xinhui Liu, Dayong Zheng, Xiaodong Rong, Fengsheng Chen, Peng Zhao, Feiye Liu and Jian Ruan

    Citation: Cancer Cell International 2020 20:196

    Content type: Primary research

    Published on:

  35. Skin cutaneous melanoma (SKCM) is one of the most malignant and aggressive cancers, causing about 72% of deaths in skin carcinoma. Although extensive study has explored the mechanism of recurrence and metastas...

    Authors: Biao Huang, Wei Han, Zu-Feng Sheng and Guo-Liang Shen

    Citation: Cancer Cell International 2020 20:195

    Content type: Primary research

    Published on:

  36. Lung cancer is the most common malignant tumor in the world. The Whole-proteome microarray showed that ubiquitin ligase chromatin assembly factor 1 subunit B (CHAF1B) expression in A549/DDP cells is higher tha...

    Authors: Lian Gong, Yi Hu, Dong He, Yuxing Zhu, Liang Xiang, Mengqing Xiao, Ying Bao, Xiaoming Liu, Qinghai Zeng, Jianye Liu, Ming Zhou, Yanhong Zhou, Yaxin Cheng, Yeyu Zhang, Liping Deng, Rongrong Zhu…

    Citation: Cancer Cell International 2020 20:194

    Content type: Primary research

    Published on:

  37. Gastric cancer (GC) remains one of the most common digestive malignancies worldwide and ranked third causes of cancer-related death. Mounting evidence has revealed that miRNAs exert critical regulatory roles i...

    Authors: Yingfeng Wei, Sheng Guo, Jianhua Tang, Jianjun Wen, Huifen Wang, Xiaobo Hu and Qiuping Gu

    Citation: Cancer Cell International 2020 20:193

    Content type: Primary research

    Published on:

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