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  1. Glioblastoma (GBM) is an aggressive type of cancer that originates in the cells called astrocytes, which support the functioning of nerve cells. It can develop in either the brain or the spinal cord and is als...

    Authors: Arianaz Hosseini, Hami Ashraf, Fatemeh Rahimi, Iraj Alipourfard, Vahid Alivirdiloo, Behnam Hashemi, Yalda Yazdani, Farhood Ghazi, Majid Eslami, Mahdieh Ameri Shah Reza and Mehdi Dadashpour
    Citation: Cancer Cell International 2023 23:98
  2. Development of precision medicine requires the identification of easily detectable and druggable biomarkers. Despite recent targeted drug approvals, prognosis of acute myeloid leukemia (AML) patients needs to ...

    Authors: Laia Cuesta-Casanovas, Jennifer Delgado-Martínez, Josep M. Cornet-Masana, José M. Carbó, Antònia Banús-Mulet, Francesca Guijarro, Jordi Esteve and Ruth M. Risueño
    Citation: Cancer Cell International 2023 23:97
  3. Changes in Polyamine metabolism (PAM) have been shown to establish a suppressive tumor microenvironment (TME) and substantially influence the progression of cancer in the recent studies. However, newly emergin...

    Authors: Enkui Zhang, Chengsheng Ding, Shuchun Li, Batuer Aikemu, Xueliang Zhou, Xiaodong Fan, Jing Sun, Xiao Yang and Minhua Zheng
    Citation: Cancer Cell International 2023 23:96
  4. Emerging studies have shown that pyroptosis plays a non-negligible role in the development and treatment of tumors. However, the mechanism of pyroptosis in colorectal cancer (CRC) remains still unclear. Theref...

    Authors: Chengsheng Ding, Xiao Yang, Shuchun Li, Enkui Zhang, Xiaodong Fan, Ling Huang, Zirui He, Jing Sun, Junjun Ma, Lu Zang and Minhua Zheng
    Citation: Cancer Cell International 2023 23:95
  5. Our study and several studies have reported that in some cancers, including pancreatic ductal adenocarcinoma (PDAC), the expression of squamous lineage markers, such as esophagus-tissue-specific genes, correla...

    Authors: Kohei Yamakawa, Michiyo Koyanagi-Aoi, Akihito Machinaga, Nobuyuki Kakiuchi, Tomonori Hirano, Yuzo Kodama and Takashi Aoi
    Citation: Cancer Cell International 2023 23:94
  6. Colorectal tumor differentially expressed (CRNDE) is specifically expressed in human brains and is the most highly expressed lncRNA in gliomas. Nevertheless, its implications in low grade glioma (LGG) are stil...

    Authors: Chen Yang, Yingchuan Jiang, Fan Hu, Qiuping Li and Biao Qi
    Citation: Cancer Cell International 2023 23:93
  7. Rather low vaccination rates for Human papillomavirus (HPV) and pre-existing cervical cancer patients with limited therapeutic strategies ask for more precise prognostic model development. On the other side, t...

    Authors: Yuchong Yu, Yao Liu, Yuhong Li, Xiaoming Yang, Mi Han and Qiong Fan
    Citation: Cancer Cell International 2023 23:92

    The Correction to this article has been published in Cancer Cell International 2023 23:125

  8. Triple-Negative Breast Cancer (TNBC) is a lethal subtype of breast cancer with limited treatment options. The purpose of this Network Meta-Analysis (NMA) is to compare the efficacy and safety of inhibitors of ...

    Authors: Ibrahim Elmakaty, Ruba Abdo, Ahmed Elsabagh, Abdelrahman Elsayed and Mohammed Imad Malki
    Citation: Cancer Cell International 2023 23:90
  9. Cancer stem-like cells (CSCs) are a subpopulation of tumor cells responsible for tumor initiation, metastasis, chemoresistance, and relapse. Recently, CSCs have been identified in Uveal Melanoma (UM), which re...

    Authors: Alessandra Loda, Stefano Calza, Arianna Giacomini, Cosetta Ravelli, Adwaid Manu Krishna Chandran, Chiara Tobia, Giovanna Tabellini, Silvia Parolini, Francesco Semeraro, Roberto Ronca and Sara Rezzola
    Citation: Cancer Cell International 2023 23:89
  10. Although doxorubicin chemotherapy is commonly applied for treating different malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical use. The use of silymarin/silibinin m...

    Authors: Mandeep Singh, Mustafa M. Kadhim, Abduladheem Turki Jalil, Shamam Kareem Oudah, Zafar Aminov, Fahad Alsaikhan, Zanko Hassan Jawhar, Andrés Alexis Ramírez-Coronel and Bagher Farhood
    Citation: Cancer Cell International 2023 23:88
  11. Tumor microenvironment and metabolic reprogramming are critical for tumor metastasis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are widely involved in the formation of tumor microenvironment and pre...

    Authors: Jiaying Huang, Xiang Wang, Jing Wen, Xinxin Zhao, Chen Wu, Lin Wang, Xiaoli Cao, Haibo Dong, Xuejing Xu, Feng Huang, Wei Zhu and Mei Wang
    Citation: Cancer Cell International 2023 23:87
  12. As a novel type of the prevalent post-transcriptional modifications, N7-methylguanosine (m7G) modification is essential in the tumorigenesis, progression, and invasion of many cancers, including bladder cancer...

    Authors: Lei Ren, Xu Yang, Jinwen Liu, Weifeng Wang, Zixiong Liu, Qingyuan Lin, Bin Huang, Jincheng Pan and Xiaopeng Mao
    Citation: Cancer Cell International 2023 23:85
  13. The clinical application of microRNAs in modern therapeutics holds great promise to uncover molecular limitations and conquer the unbeatable castle of cancer metastasis. miRNAs play a decisive role that regula...

    Authors: Muhammad Javed Iqbal, Zeeshan Javed, Haleema Sadia, Sajid Mehmood, Ali Akbar, Benish Zahid, Tariq Nadeem, Sadia Roshan, Elena Maria Varoni, Marcello Iriti, Eda Sönmez Gürer, Javad Sharifi-Rad and Daniela Calina
    Citation: Cancer Cell International 2023 23:84
  14. Reprogrammed metabolic network is a key hallmark of cancer. Profiling cancer metabolic alterations with spatial signatures not only provides clues for understanding cancer biochemical heterogeneity, but also h...

    Authors: Fukai Wang, Shuangshuang Ma, Panpan Chen, Yuhao Han, Zhaoyun Liu, Xinzhao Wang, Chenglong Sun and Zhiyong Yu
    Citation: Cancer Cell International 2023 23:83
  15. Hepatocellular carcinoma (HCC) is a malignancy worldwide with one of the worst prognoses. Emerging studies have revealed that long noncoding RNAs (lncRNAs) contribute to HCC progression. This research probes t...

    Authors: Jiang Huang, Yunfang Yang, Fulan Zhao, Zhuo Zhang, Jian Deng, Wei Lu and Xian Jiang
    Citation: Cancer Cell International 2023 23:82
  16. As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G protein signaling (RGS) proteins facilitate various downstream cellular signalings through regulating kinds of heterotri...

    Authors: Lin Li, Qiang Xu and Chao Tang
    Citation: Cancer Cell International 2023 23:81
  17. Chemotherapy is one of the most common therapeutic methods in advanced and metastatic tumors. Cisplatin (CDDP) is considered as one of the main first-line chemotherapy drugs in solid tumors. However, there is ...

    Authors: Faezeh Tolue Ghasaban, Amirhosein Maharati, Iman Akhlaghipour and Meysam Moghbeli
    Citation: Cancer Cell International 2023 23:80
  18. Oral squamous cell carcinoma (OSCC) is a highly malignant tumor that is frequently associated with lymph node metastasis, resulting in poor prognosis and survival in patients. In the tumor microenvironment, hy...

    Authors: Shihyun Kim, Suyeon Park, Eun-Hye Moon, Gi Jin Kim and Jongho Choi
    Citation: Cancer Cell International 2023 23:79
  19. Metastatic disease is the major cause of cancer-related deaths. Increasing evidence shows that primary tumor cells can promote metastasis by preparing the local microenvironment of distant organs, inducing the...

    Authors: Marzia Pucci, Marta Moschetti, Ornella Urzì, Marco Loria, Alice Conigliaro, Maria Antonietta Di Bella, Rossella Crescitelli, Roger Olofsson Bagge, Alessia Gallo, Mark F. Santos, Caterina Puglisi, Stefano Forte, Aurelio Lorico, Riccardo Alessandro and Simona Fontana
    Citation: Cancer Cell International 2023 23:77
  20. Immune checkpoint inhibitors are the most studied forms of immunotherapy for triple-negative breast cancer (TNBC). The Cancer Genome Map (TCGA) and METABRIC project provide large-scale cancer samples that can ...

    Authors: Ying Zhong, Fangyuan Li, Sumei Zhang, Zhenli Yang, Xinyu Ren, Xi Cao, Yali Xu, Dan Guo, Yidong Zhou, Feng Mao, Songjie Shen and Qiang Sun
    Citation: Cancer Cell International 2023 23:76
  21. KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnes...

    Authors: Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe and Shozo Nishida
    Citation: Cancer Cell International 2023 23:73
  22. Accumulating evidence demonstrated that nuclear factor erythroid 2-related factor 2 (NRF2) expression plays a crucial role in the proliferation, invasion and metastasis of hepatocellular carcinoma (HCC). Howev...

    Authors: Yanqiong Liu, Qiulian Wu, Fuyong Zhang and Xue Qin
    Citation: Cancer Cell International 2023 23:72
  23. Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide. Deep understanding of chemoresistance will lead to remarkable progress in lung cancer treat...

    Authors: Hongmei Yuan, Hongge Wu, Jing Cheng and Jie Xiong
    Citation: Cancer Cell International 2023 23:71
  24. Cancer-associated fibroblasts (CAFs) play an essential role in tumorigenesis and development of cancers. Nevertheless, the specific molecular mechanism of tumorigenesis and development in Laryngeal squamous ce...

    Authors: Liyun Yang, Shiqi Gong, Peipei Qiao, Runyu Zhao, Shuixian Huang, Jieyu Zhou and An Hu
    Citation: Cancer Cell International 2023 23:70
  25. Stomach adenocarcinoma (STAD) is the third leading cause of cancer-related deaths and the fifth most prevalent malignancy worldwide. Mitochondrial respiratory chain complexes play a crucial role in STAD pathog...

    Authors: Jing Yang, Feifan Jin, Huanjuan Li, Yuhuan Shen, Weilin Shi, Lina Wang, Lei Zhong, Gongqiang Wu, Qiaoliang Wu and Yanchun Li
    Citation: Cancer Cell International 2023 23:69
  26. Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in gluconeogenesis. PCK1 is considered an anti-oncogene in several human cancers. In this study, we aimed to determine the functions of PC...

    Authors: Xiangyan Zhang, Geru Tao, Jie Jiang, Tingting Qu, Shuchao Zhao, Ping Xu, Ya’nan Zhao, Xiaoming Xing and Shucun Qin
    Citation: Cancer Cell International 2023 23:68
  27. Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiqu...

    Authors: Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky and Aaron Ciechanover
    Citation: Cancer Cell International 2023 23:67
  28. Reprogrammed lipid metabolism is a hallmark of cancer that provides energy, materials, and signaling molecules for rapid cancer cell growth. Cancer cells acquire fatty acids primarily through de novo synthesis...

    Authors: Jie Hong, Jie Liu, Yanan Zhang, Lihua Ding and Qinong Ye
    Citation: Cancer Cell International 2023 23:66
  29. Sphingosine-1-phosphate (S1P) is a lipid mediator and its binding to the S1P receptor 2 (S1PR2) is reported to regulate cytoskeletal organization. Epidermal growth factor (EGF) has been shown to induce migrati...

    Authors: Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward and Gabriel Landini
    Citation: Cancer Cell International 2023 23:65
  30. Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has...

    Authors: Hany E. Marei, Anwarul Hasan, Giacomo Pozzoli and Carlo Cenciarelli
    Citation: Cancer Cell International 2023 23:64
  31. Autophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in cancer progression.  Phosphorylation of ATG4B is crucial for activation of its protease ac...

    Authors: Wan-Hsiang Hu, Ting-Ting Liu, Pei-Feng Liu, Paul Morgan, I-Ling Lin, Wei-Lun Tsai, Yi-Yun Cheng, Ang-Tsen Hsieh, Tsung-Hui Hu and Chih-Wen Shu
    Citation: Cancer Cell International 2023 23:63
  32. Glioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and chemotherapy, Temozolomide (TMZ). However, tumors tend to develop TMZ resi...

    Authors: Pei-Chi Chang, Yu-Chieh Lin, Hui-Ju Yen, Dueng-Yuan Hueng, Shih-Ming Huang and Yao-Feng Li
    Citation: Cancer Cell International 2023 23:62
  33. Chronic myeloid leukemia (CML) is a hematological tumor derived from hematopoietic stem cells. The aim of this study is to analyze the biological characteristics and identify the diagnostic markers of CML. We ...

    Authors: Fang-Min Zhong, Fang-Yi Yao, Yu-Lin Yang, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Nan Zhang, Yan-Mei Xu, Shu-Qi Li, Ying Cheng, Shuai Xu, Bo Huang and Xiao-Zhong Wang
    Citation: Cancer Cell International 2023 23:61
  34. The alpha-fetoprotein receptor (AFPR) is a novel target for cancer therapeutics. It is expressed on most cancers and myeloid derived suppressor cells (MDSCs) but generally absent on normal tissues. Studies wer...

    Authors: Patricia Griffin, Wendy A. Hill, Fabio Rossi, Rebecca Boohaker, Karr Stinson and Igor Sherman
    Citation: Cancer Cell International 2023 23:60
  35. Non-homologous DNA end joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in human. However, the relationship between NHEJ pathway and hepatocellular carcinoma (HCC) is unclear. We ...

    Authors: Zhu Lin, Zhenkun Huang, Yunxing Shi, Yichuan Yuan, Yi Niu, Binkui Li, Yunfei Yuan and Jiliang Qiu
    Citation: Cancer Cell International 2023 23:59
  36. The incidence of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients is dozens of times higher than that in patients without COPD. Elevated activity of nuclear factor-k-gene binding (NF-κ...

    Authors: Jingjing Lu, Yan Shi, Feng Zhang, Ying Zhang, Xiangwang Zhao, Haiyan Zheng, Lingyu Li, Shiqiao Zhao and Liming Zhao
    Citation: Cancer Cell International 2023 23:58
  37. In vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs. Among these in vivo experimental models, the establishment of highly mali...

    Authors: Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto and Kentaro Semba
    Citation: Cancer Cell International 2023 23:57
  38. Authors: Nouf S. Al‑Numair, Abdulrahman Theyab, Faisal Alzahrani, Anwar M. Shams, Ibrahim O. Al‑Anazi, Atif Abdulwahab A. Oyouni, Osama M. Al‑Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali and Yousef M. Hawsawi
    Citation: Cancer Cell International 2023 23:56

    The original article was published in Cancer Cell International 2022 22:279

  39. Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largel...

    Authors: Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang, Bangchao Li, Jie Hu and Yixin Qi
    Citation: Cancer Cell International 2023 23:54
  40. Abnormal miRNA and mRNA expression and dysregulated immune microenvironment have been found to frequently induce the progression of hepatocellular carcinoma (HCC) in recent reports. In particular, the immune-r...

    Authors: Xia-Hui Lin, Dong-ping Li, Zhi-Yong Liu, Si Zhang, Wen-qing Tang, Rong-xin Chen, Shu-qiang Weng, Yu-jen Tseng, Ru-yi Xue and Ling Dong
    Citation: Cancer Cell International 2023 23:52
  41. Non-small cell lung cancer is a heterogeneous disease driven by extensive molecular alterations. Exosomes are small vesicles with diameters ranging from 30 to 150 nm released by various cell types and are impo...

    Authors: Jingwei Xu, Hui Wang, Baoyu Shi, Ning Li, Guopeng Xu, Xiaopei Yan and Li Xu
    Citation: Cancer Cell International 2023 23:51
  42. As an oncogene, SETD8 can promote tumour growth and tumour cell proliferation. This study aims to reveal the relationship between SETD8 and ferroptosis in pancreatic cancer and its role in pancreatic cancer to pr...

    Authors: Zekun Lu, Qiangsheng Hu, Yi Qin, Hao Yang, Bingkai Xiao, Weibo Chen, Shunrong Ji, Guangchen Zu, Zhiliang Wang, Guixiong Fan, Xiaowu Xu and Xuemin Chen
    Citation: Cancer Cell International 2023 23:50

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